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Passenger virus

April 13, 2023

A passenger virus is a virus that is frequently found in samples from diseased tissue, such as tumours, but is not a contributing factor in causing the disease.

Experimental demonstration of passenger status

Proving that a virus has no causative role can be difficult. Although none of the following signs is definitive, evidence that a virus found in diseased tissue might be passenger only rather than a causative agent includes:

  • injection of the virus into healthy animals without causing disease;
  • the absence of the virus at the earliest stages of the disease;
  • curing the viral infection using antiviral drugs or vaccination with no effect on the course of the disease.

Examples

A well-established example is lactate dehydrogenase virus, which is often found in mouse tumours.[1] GB virus C and Chandipura virus are possible examples in humans.[2][3] It has also been suggested that a virus related to Alcelaphine herpesvirus 1 is a passenger virus that, unlike AHV1 itself, does not cause bovine malignant catarrhal fever.[4] The discredited[5] Duesberg hypothesis posits that HIV is a passenger virus in the etiology of AIDS.[6]

References

  1. ^ Mongini PK, Rosenberg LT (January 1976). "Inhibition of lymphocyte trapping by a passenger virus in murine ascitic tumors: characterization of lactic dehydrogenase virus (LDV) as the inhibitory component and analysis of the mechanism of inhibition". J. Exp. Med. 143 (1): 100–13. doi:10.1084/jem.143.1.100. PMC 2190100. PMID 1244415.
  2. ^ Mphahlele MJ, Lau GK, Carman WF (June 1998). "HGV: the identification, biology and prevalence of an orphan virus". Liver. 18 (3): 143–55. doi:10.1111/j.1600-0676.1998.tb00142.x. PMID 9716223.
  3. ^ Potharaju NR, Potharaju AK (March 2006). "Is Chandipura virus an emerging human pathogen?". Arch. Dis. Child. 91 (3): 279–80. doi:10.1136/adc.2005.074708. PMC 2065945. PMID 16492900.
  4. ^ Metzler, Alfred E (January 1991). "The malignant catarrhal fever complex". Comparative Immunology, Microbiology and Infectious Diseases. 14 (2): 107–124. doi:10.1016/0147-9571(91)90125-W. PMID 1934998.
  5. ^ Cohen, J. (1994-12-09). "The Duesberg phenomenon". Science. 266 (5191): 1642–1644. Bibcode:1994Sci...266.1642C. doi:10.1126/science.7992043. ISSN 0036-8075. PMID 7992043.
  6. ^ Duesberg P, Rasnick D (1998). "The AIDS dilemma: drug diseases blamed on a passenger virus". Genetica. 104 (2): 85–132. doi:10.1023/A:1003405220186. PMID 10220905.

April 13, 2023
passenger, virus, passenger, virus, virus, that, frequently, found, samples, from, diseased, tissue, such, tumours, contributing, factor, causing, disease, experimental, demonstration, passenger, status, editproving, that, virus, causative, role, difficult, al. A passenger virus is a virus that is frequently found in samples from diseased tissue such as tumours but is not a contributing factor in causing the disease Experimental demonstration of passenger status EditProving that a virus has no causative role can be difficult Although none of the following signs is definitive evidence that a virus found in diseased tissue might be passenger only rather than a causative agent includes injection of the virus into healthy animals without causing disease the absence of the virus at the earliest stages of the disease curing the viral infection using antiviral drugs or vaccination with no effect on the course of the disease Examples EditA well established example is lactate dehydrogenase virus which is often found in mouse tumours 1 GB virus C and Chandipura virus are possible examples in humans 2 3 It has also been suggested that a virus related to Alcelaphine herpesvirus 1 is a passenger virus that unlike AHV1 itself does not cause bovine malignant catarrhal fever 4 The discredited 5 Duesberg hypothesis posits that HIV is a passenger virus in the etiology of AIDS 6 References Edit Mongini PK Rosenberg LT January 1976 Inhibition of lymphocyte trapping by a passenger virus in murine ascitic tumors characterization of lactic dehydrogenase virus LDV as the inhibitory component and analysis of the mechanism of inhibition J Exp Med 143 1 100 13 doi 10 1084 jem 143 1 100 PMC 2190100 PMID 1244415 Mphahlele MJ Lau GK Carman WF June 1998 HGV the identification biology and prevalence of an orphan virus Liver 18 3 143 55 doi 10 1111 j 1600 0676 1998 tb00142 x PMID 9716223 Potharaju NR Potharaju AK March 2006 Is Chandipura virus an emerging human pathogen Arch Dis Child 91 3 279 80 doi 10 1136 adc 2005 074708 PMC 2065945 PMID 16492900 Metzler Alfred E January 1991 The malignant catarrhal fever complex Comparative Immunology Microbiology and Infectious Diseases 14 2 107 124 doi 10 1016 0147 9571 91 90125 W PMID 1934998 Cohen J 1994 12 09 The Duesberg phenomenon Science 266 5191 1642 1644 Bibcode 1994Sci 266 1642C doi 10 1126 science 7992043 ISSN 0036 8075 PMID 7992043 Duesberg P Rasnick D 1998 The AIDS dilemma drug diseases blamed on a passenger virus Genetica 104 2 85 132 doi 10 1023 A 1003405220186 PMID 10220905 Retrieved from https en wikipedia org w index php title Passenger virus amp oldid 1082986522, wikipedia, wiki, book, books, library,

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