The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties.[5]
Clinical relevanceedit
Truncating mutations in this gene have been shown to promote breast cancer metastasis to the lungs by allowing cancer cells to survive mechanical stretch in the microcirculation.[6]
Disruptions of this gene have been associated to melanoma tumor progression.[7]
Pannexin 1 is also an important component of membrane channels involved in the formation of thin plasma membrane extensions called apoptopodia and beaded apoptopodia during apoptosis.[8][9]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000110218 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000031934 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Penuela S, Gyenis L, Ablack A, Churko JM, Berger AC, Litchfield DW, Lewis JD, Laird DW (Aug 2012). "Loss of pannexin 1 attenuates melanoma progression by reversion to a melanocytic phenotype". The Journal of Biological Chemistry. 287 (34): 29184–93. doi:10.1074/jbc.M112.377176. PMC3436541. PMID 22753409.
^Poon IK, Chiu YH, Armstrong AJ, Kinchen JM, Juncadella IJ, Bayliss DA, Ravichandran KS (2014). "Unexpected link between an antibiotic, pannexin channels and apoptosis". Nature. 507 (7492): 329–34. Bibcode:2014Natur.507..329P. doi:10.1038/nature13147. PMC4078991. PMID 24646995.
^Atkin-Smith GK, Tixeira R, Paone S, Mathivanan S, Collins C, Liem M, Goodall KJ, Ravichandran KS, Hulett MD, Poon IK (2015). "A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure". Nat Commun. 6: 7439. Bibcode:2015NatCo...6.7439A. doi:10.1038/ncomms8439. PMC4490561. PMID 26074490.
Further readingedit
Pelegrin P, Surprenant A (Nov 2006). "Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor". The EMBO Journal. 25 (21): 5071–82. doi:10.1038/sj.emboj.7601378. PMC1630421. PMID 17036048.
Bruzzone R, Hormuzdi SG, Barbe MT, Herb A, Monyer H (Nov 2003). "Pannexins, a family of gap junction proteins expressed in brain". Proceedings of the National Academy of Sciences of the United States of America. 100 (23): 13644–9. Bibcode:2003PNAS..10013644B. doi:10.1073/pnas.2233464100. PMC263867. PMID 14597722.
Reyes JP, Hernández-Carballo CY, Pérez-Flores G, Pérez-Cornejo P, Arreola J (Feb 2009). "Lack of coupling between membrane stretching and pannexin-1 hemichannels". Biochemical and Biophysical Research Communications. 380 (1): 50–3. doi:10.1016/j.bbrc.2009.01.021. PMC2670310. PMID 19150332.
Orloff M, Peterson C, He X, Ganapathi S, Heald B, Yang YR, Bebek G, Romigh T, Song JH, Wu W, David S, Cheng Y, Meltzer SJ, Eng C (Jul 2011). "Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma". JAMA. 306 (4): 410–9. doi:10.1001/jama.2011.1029. PMC3574553. PMID 21791690.
Ambrosi C, Gassmann O, Pranskevich JN, Boassa D, Smock A, Wang J, Dahl G, Steinem C, Sosinsky GE (Aug 2010). "Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other". The Journal of Biological Chemistry. 285 (32): 24420–31. doi:10.1074/jbc.M110.115444. PMC2915678. PMID 20516070.
Woehrle T, Yip L, Elkhal A, Sumi Y, Chen Y, Yao Y, Insel PA, Junger WG (Nov 2010). "Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse". Blood. 116 (18): 3475–84. doi:10.1182/blood-2010-04-277707. PMC2981474. PMID 20660288.
Boassa D, Ambrosi C, Qiu F, Dahl G, Gaietta G, Sosinsky G (Oct 2007). "Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane". The Journal of Biological Chemistry. 282 (43): 31733–43. doi:10.1074/jbc.M702422200. PMID 17715132.
Baranova A, Ivanov D, Petrash N, Pestova A, Skoblov M, Kelmanson I, Shagin D, Nazarenko S, Geraymovych E, Litvin O, Tiunova A, Born TL, Usman N, Staroverov D, Lukyanov S, Panchin Y (Apr 2004). "The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins". Genomics. 83 (4): 706–16. doi:10.1016/j.ygeno.2003.09.025. PMID 15028292.
Bhalla-Gehi R, Penuela S, Churko JM, Shao Q, Laird DW (Mar 2010). "Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions". The Journal of Biological Chemistry. 285 (12): 9147–60. doi:10.1074/jbc.M109.082008. PMC2838334. PMID 20086016.
This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.
panx1, pannexin, protein, humans, that, encoded, gene, identifiersaliases, mrs1, unq2529, pannexin, oomd7, pannexin1external, idsomim, 608420, 1860055, homologene, 49416, genecards, gene, location, human, chromosome, human, band11q21start94, end94, gene, locat. Pannexin 1 is a protein in humans that is encoded by the PANX1 gene 5 PANX1IdentifiersAliasesPANX1 MRS1 PX1 UNQ2529 pannexin 1 OOMD7 Pannexin1External IDsOMIM 608420 MGI 1860055 HomoloGene 49416 GeneCards PANX1Gene location Human Chr Chromosome 11 human 1 Band11q21Start94 128 841 bp 1 End94 181 968 bp 1 Gene location Mouse Chr Chromosome 9 mouse 2 Band9 9 A2Start14 913 424 bp 2 End14 956 774 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inganglionic eminencestromal cell of endometriumsecondary oocyteislet of LangerhansmonocyteAchilles tendongastrocnemius muscleright coronary arterygallbladderascending aortaTop expressed inintestinal villusganglionic eminencejejunumthymuscrypt of lieberkuhn of small intestineduodenumcumulus cellmedial ganglionic eminencesuperior cervical gangliontrigeminal ganglionMore reference expression dataBioGPSn aGene ontologyMolecular functiontransmembrane transporter binding calcium channel activity channel activity scaffold protein binding gap junction channel activity protease binding actin filament binding leak channel activity protein heterodimerization activity actin binding gap junction hemi channel activity signaling receptor binding wide pore channel activityCellular componentintegral component of membrane endoplasmic reticulum membrane cell junction bleb gap junction membrane endoplasmic reticulum plasma membrane protein containing complexBiological processresponse to ATP cation transport ion transport response to ischemia calcium ion transmembrane transport transmembrane transport protein hexamerization calcium ion transport cell cell signaling transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez2414555991EnsemblENSG00000110218ENSMUSG00000031934UniProtQ96RD7Q9JIP4RefSeq mRNA NM 015368NM 019482RefSeq protein NP 056183NP 062355Location UCSC Chr 11 94 13 94 18 MbChr 9 14 91 14 96 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe protein encoded by this gene belongs to the innexin family Innexin family members are the structural components of gap junctions This protein and pannexin 2 are abundantly expressed in central nerve system CNS and are coexpressed in various neuronal populations Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type specific gap junctions with distinct properties 5 Clinical relevance editTruncating mutations in this gene have been shown to promote breast cancer metastasis to the lungs by allowing cancer cells to survive mechanical stretch in the microcirculation 6 Disruptions of this gene have been associated to melanoma tumor progression 7 Pannexin 1 is also an important component of membrane channels involved in the formation of thin plasma membrane extensions called apoptopodia and beaded apoptopodia during apoptosis 8 9 References edit a b c GRCh38 Ensembl release 89 ENSG00000110218 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000031934 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene Pannexin 1 Retrieved 2012 04 11 Furlow PW Zhang S Soong TD Halberg N Goodarzi H Mangrum C Wu YG Elemento O Tavazoie SF July 2015 Mechanosensitive pannexin 1 channels mediate microvascular metastatic cell survival Nature Cell Biology 17 7 943 952 doi 10 1038 ncb3194 PMC 5310712 PMID 26098574 Penuela S Gyenis L Ablack A Churko JM Berger AC Litchfield DW Lewis JD Laird DW Aug 2012 Loss of pannexin 1 attenuates melanoma progression by reversion to a melanocytic phenotype The Journal of Biological Chemistry 287 34 29184 93 doi 10 1074 jbc M112 377176 PMC 3436541 PMID 22753409 Poon IK Chiu YH Armstrong AJ Kinchen JM Juncadella IJ Bayliss DA Ravichandran KS 2014 Unexpected link between an antibiotic pannexin channels and apoptosis Nature 507 7492 329 34 Bibcode 2014Natur 507 329P doi 10 1038 nature13147 PMC 4078991 PMID 24646995 Atkin Smith GK Tixeira R Paone S Mathivanan S Collins C Liem M Goodall KJ Ravichandran KS Hulett MD Poon IK 2015 A novel mechanism of generating extracellular vesicles during apoptosis via a beads on a string membrane structure Nat Commun 6 7439 Bibcode 2015NatCo 6 7439A doi 10 1038 ncomms8439 PMC 4490561 PMID 26074490 Further reading editPelegrin P Surprenant A Nov 2006 Pannexin 1 mediates large pore formation and interleukin 1beta release by the ATP gated P2X7 receptor The EMBO Journal 25 21 5071 82 doi 10 1038 sj emboj 7601378 PMC 1630421 PMID 17036048 Bruzzone R Hormuzdi SG Barbe MT Herb A Monyer H Nov 2003 Pannexins a family of gap junction proteins expressed in brain Proceedings of the National Academy of Sciences of the United States of America 100 23 13644 9 Bibcode 2003PNAS 10013644B doi 10 1073 pnas 2233464100 PMC 263867 PMID 14597722 Reyes JP Hernandez Carballo CY Perez Flores G Perez Cornejo P Arreola J Feb 2009 Lack of coupling between membrane stretching and pannexin 1 hemichannels Biochemical and Biophysical Research Communications 380 1 50 3 doi 10 1016 j bbrc 2009 01 021 PMC 2670310 PMID 19150332 Orloff M Peterson C He X Ganapathi S Heald B Yang YR Bebek G Romigh T Song JH Wu W David S Cheng Y Meltzer SJ Eng C Jul 2011 Germline mutations in MSR1 ASCC1 and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma JAMA 306 4 410 9 doi 10 1001 jama 2011 1029 PMC 3574553 PMID 21791690 Ambrosi C Gassmann O Pranskevich JN Boassa D Smock A Wang J Dahl G Steinem C Sosinsky GE Aug 2010 Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other The Journal of Biological Chemistry 285 32 24420 31 doi 10 1074 jbc M110 115444 PMC 2915678 PMID 20516070 Woehrle T Yip L Elkhal A Sumi Y Chen Y Yao Y Insel PA Junger WG Nov 2010 Pannexin 1 hemichannel mediated ATP release together with P2X1 and P2X4 receptors regulate T cell activation at the immune synapse Blood 116 18 3475 84 doi 10 1182 blood 2010 04 277707 PMC 2981474 PMID 20660288 Boassa D Ambrosi C Qiu F Dahl G Gaietta G Sosinsky G Oct 2007 Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane The Journal of Biological Chemistry 282 43 31733 43 doi 10 1074 jbc M702422200 PMID 17715132 Baranova A Ivanov D Petrash N Pestova A Skoblov M Kelmanson I Shagin D Nazarenko S Geraymovych E Litvin O Tiunova A Born TL Usman N Staroverov D Lukyanov S Panchin Y Apr 2004 The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins Genomics 83 4 706 16 doi 10 1016 j ygeno 2003 09 025 PMID 15028292 Bhalla Gehi R Penuela S Churko JM Shao Q Laird DW Mar 2010 Pannexin1 and pannexin3 delivery cell surface dynamics and cytoskeletal interactions The Journal of Biological Chemistry 285 12 9147 60 doi 10 1074 jbc M109 082008 PMC 2838334 PMID 20086016 nbsp This article on a gene on human chromosome 11 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title PANX1 amp oldid 1204638008, wikipedia, wiki, book, books, library,
