This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans.
^ abcGRCh38: Ensembl release 89: ENSG00000146676 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000094483 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Bergemann AD, Ma ZW, Johnson EM (Dec 1992). "Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein". Mol Cell Biol. 12 (12): 5673–82. doi:10.1128/mcb.12.12.5673. PMC360507. PMID 1448097.
^ ab"Entrez Gene: PURB purine-rich element binding protein B".
Further readingedit
Sanger Centre T, Washington University Genome Sequencing Cente T (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Kelm RJ, Cogan JG, Elder PK, Strauch AR, Getz MJ (1999). "Molecular interactions between single-stranded DNA-binding proteins associated with an essential MCAT element in the mouse smooth muscle alpha-actin promoter". J. Biol. Chem. 274 (20): 14238–45. doi:10.1074/jbc.274.20.14238. PMID 10318844.
Lezon-Geyda K, Najfeld V, Johnson EM (2001). "Deletions of PURA, at 5q31, and PURB, at 7p13, in myelodysplastic syndrome and progression to acute myelogenous leukemia". Leukemia. 15 (6): 954–62. doi:10.1038/sj.leu.2402108. PMID 11417483. S2CID 7186291.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-Mcpherson C, Layman D, Maas J, Jaeger S (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Gupta M, Sueblinvong V, Raman J, Jeevanandam V, Gupta MP (2004). "Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure". J. Biol. Chem. 278 (45): 44935–48. doi:10.1074/jbc.M307696200. PMID 12933792.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.
purb, transcriptional, activator, protein, beta, protein, that, humans, encoded, gene, identifiersaliases, purine, rich, element, binding, protein, purine, rich, element, binding, protein, bexternal, idsomim, 608887, 1338779, homologene, 69087, genecards, gene. Transcriptional activator protein Pur beta is a protein that in humans is encoded by the PURB gene 5 6 PURBIdentifiersAliasesPURB PURBETA purine rich element binding protein B purine rich element binding protein BExternal IDsOMIM 608887 MGI 1338779 HomoloGene 69087 GeneCards PURBGene location Human Chr Chromosome 7 human 1 Band7p13Start44 876 299 bp 1 End44 885 530 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 A1 11 4 16 cMStart6 417 599 bp 2 End6 425 917 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed incerebellar vermispancreatic epithelial cellpancreatic ductal cellvisceral pleuraBrodmann area 23tibialis anterior musclevulvamiddle temporal gyrussaphenous veinparietal pleuraTop expressed inRegion I of hippocampus properprimary motor cortexpiriform cortexolfactory tuberclecingulate gyrussuperior colliculuslateral geniculate nucleussubiculumnucleus accumbenscumulus cellMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding transcription factor activity RNA polymerase II transcription regulatory region sequence specific DNA binding DNA binding transcription repressor activity RNA polymerase II specific DNA binding double stranded DNA binding SMAD binding single stranded DNA binding transcription factor binding mRNA binding RNA binding DNA binding transcription factor activity RNA polymerase II specific purine rich negative regulatory element binding sequence specific DNA bindingCellular componentDNA replication factor A complex nucleusBiological processregulation of myeloid cell differentiation regulation of transcription DNA templated negative regulation of transcription by RNA polymerase II cell population proliferation cell differentiation transcription DNA templated negative regulation of transcription DNA templatedSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez581419291EnsemblENSG00000146676ENSMUSG00000094483UniProtQ96QR8O35295RefSeq mRNA NM 033224NM 011221RefSeq protein NP 150093NP 035351Location UCSC Chr 7 44 88 44 89 MbChr 11 6 42 6 43 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse This gene product is a sequence specific single stranded DNA binding protein It binds preferentially to the single strand of the purine rich element termed PUR which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans Thus it is implicated in the control of both DNA replication and transcription Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000146676 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000094483 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Bergemann AD Ma ZW Johnson EM Dec 1992 Sequence of cDNA comprising the human pur gene and sequence specific single stranded DNA binding properties of the encoded protein Mol Cell Biol 12 12 5673 82 doi 10 1128 mcb 12 12 5673 PMC 360507 PMID 1448097 a b Entrez Gene PURB purine rich element binding protein B Further reading editSanger Centre T Washington University Genome Sequencing Cente T 1999 Toward a complete human genome sequence Genome Res 8 11 1097 108 doi 10 1101 gr 8 11 1097 PMID 9847074 Kelm RJ Cogan JG Elder PK Strauch AR Getz MJ 1999 Molecular interactions between single stranded DNA binding proteins associated with an essential MCAT element in the mouse smooth muscle alpha actin promoter J Biol Chem 274 20 14238 45 doi 10 1074 jbc 274 20 14238 PMID 10318844 Lezon Geyda K Najfeld V Johnson EM 2001 Deletions of PURA at 5q31 and PURB at 7p13 in myelodysplastic syndrome and progression to acute myelogenous leukemia Leukemia 15 6 954 62 doi 10 1038 sj leu 2402108 PMID 11417483 S2CID 7186291 Strausberg RL Feingold EA Grouse LH Derge JG Klausner RD Collins FS Wagner L Shenmen CM Schuler GD 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Scherer SW Cheung J MacDonald JR Osborne LR Nakabayashi K Herbrick JA Carson AR Parker Katiraee L Skaug J 2003 Human Chromosome 7 DNA Sequence and Biology Science 300 5620 767 72 Bibcode 2003Sci 300 767S doi 10 1126 science 1083423 PMC 2882961 PMID 12690205 Hillier LW Fulton RS Fulton LA Graves TA Pepin KH Wagner Mcpherson C Layman D Maas J Jaeger S 2003 The DNA sequence of human chromosome 7 Nature 424 6945 157 64 Bibcode 2003Natur 424 157H doi 10 1038 nature01782 PMID 12853948 Gupta M Sueblinvong V Raman J Jeevanandam V Gupta MP 2004 Single stranded DNA binding proteins PURalpha and PURbeta bind to a purine rich negative regulatory element of the alpha myosin heavy chain gene and control transcriptional and translational regulation of the gene expression Implications in the repression of alpha myosin heavy chain during heart failure J Biol Chem 278 45 44935 48 doi 10 1074 jbc M307696200 PMID 12933792 Ota T Suzuki Y Nishikawa T Otsuki T Sugiyama T Irie R Wakamatsu A Hayashi K Sato H 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Beausoleil SA Jedrychowski M Schwartz D Elias JE Villen J Li J Cohn MA Cantley LC Gygi SP 2004 Large scale characterization of HeLa cell nuclear phosphoproteins Proc Natl Acad Sci U S A 101 33 12130 5 Bibcode 2004PNAS 10112130B doi 10 1073 pnas 0404720101 PMC 514446 PMID 15302935 Gerhard DS Wagner L Feingold EA Shenmen CM Grouse LH Schuler G Klein SL Old S Rasooly R 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Olsen JV Blagoev B Gnad F Macek B Kumar C Mortensen P Mann M 2006 Global in vivo and site specific phosphorylation dynamics in signaling networks Cell 127 3 635 48 doi 10 1016 j cell 2006 09 026 PMID 17081983 S2CID 7827573 nbsp This article on a gene on human chromosome 7 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title PURB amp oldid 1199630916, wikipedia, wiki, book, books, library,
