PTPRCAP, CD45-AP, LPAP, protein tyrosine phosphatase, receptor type C associated protein, protein tyrosine phosphatase receptor type C associated protein
The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein.[5]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000213402 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000045826 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Schraven B, Schoenhaut D, Bruyns E, Koretzky G, Eckerskorn C, Wallich R, Kirchgessner H, Sakorafas P, Labkovsky B (1994). "LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes". J. Biol. Chem. 269 (46): 29102–11. doi:10.1016/S0021-9258(19)62018-1. PMID 7961877.
Bruyns E, Hendricks-Taylor LR, Meuer S, Koretzky GA, Schraven B (1996). "Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45". J. Biol. Chem. 270 (52): 31372–6. doi:10.1074/jbc.270.52.31372. PMID 8537410.
Bruyns E, Mincheva A, Bruyns RM, Kirchgessner H, Weitz S, Lichter P, Meuer S, Schraven B (1997). "Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes". Genomics. 38 (1): 79–83. doi:10.1006/geno.1996.0595. PMID 8954783.
Kung C, Okumura M, Seavitt JR, Noll ME, White LS, Pingel JT, Thomas ML (2000). "CD45-associated protein is not essential for the regulation of antigen receptor-mediated signal transduction". Eur. J. Immunol. 29 (12): 3951–5. doi:10.1002/(SICI)1521-4141(199912)29:12<3951::AID-IMMU3951>3.0.CO;2-9. PMID 10602003. S2CID 4962507.
Woods ML, Kivens WJ, Adelsman MA, Qiu Y, August A, Shimizu Y (2001). "A novel function for the Tec family tyrosine kinase Itk in activation of β1 integrins by the T-cell receptor". EMBO J. 20 (6): 1232–44. doi:10.1093/emboj/20.6.1232. PMC145515. PMID 11250890.
Kirchgessner H, Dietrich J, Scherer J, Isomaki P, Korinek V, Hilgert I, Bruyns E, Leo A, Cope AP (2001). "The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain". J. Exp. Med. 193 (11): 1269–84. doi:10.1084/jem.193.11.1269. PMC2193385. PMID 11390434.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Vogel A, Strassburg CP, Manns MP (2003). "77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis: evidence for a genetic link". Genes Immun. 4 (1): 79–81. doi:10.1038/sj.gene.6363918. PMID 12595907. S2CID 19853676.
Cocco E, Murru MR, Melis C, Schirru L, Solla E, Lai M, Rolesu M, Marrosu M (2004). "PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients". J. Neurol. 251 (9): 1085–8. doi:10.1007/s00415-004-0485-1. PMID 15372250. S2CID 35718298.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
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ptprcap, protein, tyrosine, phosphatase, receptor, type, associated, protein, enzyme, that, humans, encoded, gene, identifiersaliases, cd45, lpap, protein, tyrosine, phosphatase, receptor, type, associated, protein, protein, tyrosine, phosphatase, receptor, ty. Protein tyrosine phosphatase receptor type C associated protein is an enzyme that in humans is encoded by the PTPRCAP gene 5 PTPRCAPIdentifiersAliasesPTPRCAP CD45 AP LPAP protein tyrosine phosphatase receptor type C associated protein protein tyrosine phosphatase receptor type C associated proteinExternal IDsOMIM 601577 MGI 97811 HomoloGene 48358 GeneCards PTPRCAPGene location Human Chr Chromosome 11 human 1 Band11q13 2Start67 435 510 bp 1 End67 437 682 bp 1 Gene location Mouse Chr Chromosome 19 mouse 2 Band19 A 19 3 86 cMStart4 203 603 bp 2 End4 206 750 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inspleenbloodlymph nodeappendixbone marrow cellsright uterine tubeduodenumfundusmonocyteupper lobe of left lungTop expressed inthymusspleenbone marrowjejunumileumcolonpharynxlungmoruladuodenumMore reference expression dataBioGPSn aOrthologsSpeciesHumanMouseEntrez579019265EnsemblENSG00000213402ENSMUSG00000045826UniProtQ14761Q64697RefSeq mRNA NM 005608NM 016933RefSeq protein NP 005599NP 058629Location UCSC Chr 11 67 44 67 44 MbChr 19 4 2 4 21 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC CD45 a key regulator of T and B lymphocyte activation The interaction with PTPRC may be required for the stable expression of this protein 5 References edit a b c GRCh38 Ensembl release 89 ENSG00000213402 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000045826 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene PTPRCAP protein tyrosine phosphatase receptor type C associated protein Further reading editSchraven B Schoenhaut D Bruyns E Koretzky G Eckerskorn C Wallich R Kirchgessner H Sakorafas P Labkovsky B 1994 LPAP a novel 32 kDa phosphoprotein that interacts with CD45 in human lymphocytes J Biol Chem 269 46 29102 11 doi 10 1016 S0021 9258 19 62018 1 PMID 7961877 Bruyns E Hendricks Taylor LR Meuer S Koretzky GA Schraven B 1996 Identification of the sites of interaction between lymphocyte phosphatase associated phosphoprotein LPAP and CD45 J Biol Chem 270 52 31372 6 doi 10 1074 jbc 270 52 31372 PMID 8537410 Bruyns E Mincheva A Bruyns RM Kirchgessner H Weitz S Lichter P Meuer S Schraven B 1997 Sequence genomic organization and chromosomal localization of the human LPAP PTPRCAP and mouse CD45 AP LSM 1 genes Genomics 38 1 79 83 doi 10 1006 geno 1996 0595 PMID 8954783 Kung C Okumura M Seavitt JR Noll ME White LS Pingel JT Thomas ML 2000 CD45 associated protein is not essential for the regulation of antigen receptor mediated signal transduction Eur J Immunol 29 12 3951 5 doi 10 1002 SICI 1521 4141 199912 29 12 lt 3951 AID IMMU3951 gt 3 0 CO 2 9 PMID 10602003 S2CID 4962507 Woods ML Kivens WJ Adelsman MA Qiu Y August A Shimizu Y 2001 A novel function for the Tec family tyrosine kinase Itk in activation of b1 integrins by the T cell receptor EMBO J 20 6 1232 44 doi 10 1093 emboj 20 6 1232 PMC 145515 PMID 11250890 Kirchgessner H Dietrich J Scherer J Isomaki P Korinek V Hilgert I Bruyns E Leo A Cope AP 2001 The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor Tcr Expression and Tcr Mediated Signaling via an Association with the Tcr z Chain J Exp Med 193 11 1269 84 doi 10 1084 jem 193 11 1269 PMC 2193385 PMID 11390434 Strausberg RL Feingold EA Grouse LH Derge JG Klausner RD Collins FS Wagner L Shenmen CM Schuler GD 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Vogel A Strassburg CP Manns MP 2003 77 C G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis evidence for a genetic link Genes Immun 4 1 79 81 doi 10 1038 sj gene 6363918 PMID 12595907 S2CID 19853676 Cocco E Murru MR Melis C Schirru L Solla E Lai M Rolesu M Marrosu M 2004 PTPRC CD45 C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients J Neurol 251 9 1085 8 doi 10 1007 s00415 004 0485 1 PMID 15372250 S2CID 35718298 Gerhard DS Wagner L Feingold EA Shenmen CM Grouse LH Schuler G Klein SL Old S Rasooly R 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title PTPRCAP amp oldid 1199630637, wikipedia, wiki, book, books, library,
