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Wikipedia

CD133

December 15, 2023

CD133 antigen, also known as prominin-1, is a glycoprotein that in humans is encoded by the PROM1 gene.[5][6] It is a member of pentaspan transmembrane glycoproteins, which specifically localize to cellular protrusions. When embedded in the cell membrane, the membrane topology of prominin-1 is such that the N-terminus extends into the extracellular space and the C-terminus resides in the intracellular compartment. The protein consists of five transmembrane segments, with the first and second segments and the third and fourth segments connected by intracellular loops while the second and third as well as fourth and fifth transmembrane segments are connected by extracellular loops.[7] While the precise function of CD133 remains unknown, it has been proposed that it acts as an organizer of cell membrane topology.[8]

PROM1
Identifiers
AliasesPROM1, AC133, CD133, CORD12, MCDR2, MSTP061, PROML1, RP41, STGD4, prominin 1
External IDsOMIM: 604365 MGI: 1100886 HomoloGene: 4390 GeneCards: PROM1
Orthologs
SpeciesHumanMouse
Entrez

8842

19126

Ensembl

ENSG00000007062

ENSMUSG00000029086

UniProt

O43490

O54990

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 4: 15.96 – 16.08 MbChr 5: 44.15 – 44.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tissue distribution edit

CD133 is expressed in hematopoietic stem cells,[9] endothelial progenitor cells,[10] glioblastoma, neuronal and glial stem cells,[11] various pediatric brain tumors,[12] as well as adult kidney, mammary glands, trachea, salivary glands, uterus, placenta, digestive tract, testes, and some other cell types.[13][14][15]

Clinical significance edit

Today CD133 is the most commonly used marker for isolation of cancer stem cell (CSC) population from different tumors, mainly from various gliomas and carcinomas.[16] Initial studies that showed ability of CD133-positive population to efficiently propagate tumor when injected into immune-compromised mice firstly were performed on brain tumors.[17][12][18][19] However, subsequent studies have indicated the difficulty in isolating pure CSC populations.[20] CD133+ melanoma cells are considered a subpopulation of CSC and play a critical role in recurrence.[21] Moreover, CD133+ melanoma cells are immunogenic and can be used as an antimelanoma vaccination. In mice the vaccination with CD133+ melanoma cells mediated strong anti-tumor activity that resulted in the eradication of parental melanoma cells.[22] In addition, it has also been shown that CD133+ melanoma cells preferentially express the RNA helicase DDX3X . As DDX3X also is an immunogenic protein, the same anti-melanoma vaccination strategy can be employed to give therapeutic antitumor immunity in mice.[23]

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000007062 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029086 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yin AH, Miraglia S, Zanjani ED, Almeida-Porada G, Ogawa M, Leary AG, Olweus J, Kearney J, Buck DW (December 1997). "AC133, a novel marker for human hematopoietic stem and progenitor cells". Blood. 90 (12): 5002–12. doi:10.1182/blood.V90.12.5002. PMID 9389720.
  6. ^ Corbeil D, Fargeas CA, Huttner WB (July 2001). "Rat prominin, like its mouse and human orthologues, is a pentaspan membrane glycoprotein". Biochemical and Biophysical Research Communications. 285 (4): 939–44. doi:10.1006/bbrc.2001.5271. PMID 11467842.
  7. ^ Corbeil D, Karbanová J, Fargeas CA, Jászai J (2012-11-05). "Prominin-1 (CD133): Molecular and Cellular Features Across Species". Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology. Advances in Experimental Medicine and Biology. Vol. 777. pp. 3–24. doi:10.1007/978-1-4614-5894-4_1. ISBN 9781461458937. PMID 23161072.
  8. ^ Irollo E, Pirozzi G (September 2013). "CD133: to be or not to be, is this the real question?". American Journal of Translational Research. 5 (6): 563–81. PMC 3786264. PMID 24093054.
  9. ^ Horn PA, Tesch H, Staib P, Kube D, Diehl V, Voliotis D (February 1999). "Expression of AC133, a novel hematopoietic precursor antigen, on acute myeloid leukemia cells". Blood. 93 (4): 1435–7. doi:10.1182/blood.V93.4.1435. PMID 10075457.
  10. ^ Corbeil D, Röper K, Hellwig A, Tavian M, Miraglia S, Watt SM, Simmons PJ, Peault B, Buck DW, Huttner WB (February 2000). "The human AC133 hematopoietic stem cell antigen is also expressed in epithelial cells and targeted to plasma membrane protrusions". The Journal of Biological Chemistry. 275 (8): 5512–20. doi:10.1074/jbc.275.8.5512. PMID 10681530.
  11. ^ Sanai N, Alvarez-Buylla A, Berger MS (August 2005). "Neural stem cells and the origin of gliomas". The New England Journal of Medicine. 353 (8): 811–22. doi:10.1056/NEJMra043666. PMID 16120861.
  12. ^ a b Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J, Dirks PB (September 2003). "Identification of a cancer stem cell in human brain tumors". Cancer Research. 63 (18): 5821–8. PMID 14522905.
  13. ^ Mizrak D, Brittan M, Alison M (January 2008). "CD133: molecule of the moment". The Journal of Pathology. 214 (1): 3–9. doi:10.1002/path.2283. PMID 18067118. S2CID 44681326.
  14. ^ Shmelkov SV, St Clair R, Lyden D, Rafii S (April 2005). "AC133/CD133/Prominin-1". The International Journal of Biochemistry & Cell Biology. 37 (4): 715–9. doi:10.1016/j.biocel.2004.08.010. PMID 15694831.
  15. ^ Dowland SN, Madawala RJ, Poon CE, Lindsay LA, Murphy CR (June 2017). "Prominin-1 glycosylation changes throughout early pregnancy in uterine epithelial cells under the influence of maternal ovarian hormones". Reproduction, Fertility, and Development. 29 (6): 1194–1208. doi:10.1071/RD15432. PMID 27166505.
  16. ^ Kim YS, Kaidina AM, Chiang JH, Yarygin KN, Lupatov AY (2017). "Cancer stem cell molecular markers verified in vivo". Biochem. Moscow Suppl. Ser. B. 11 (1): 43–54. doi:10.1134/S1990750817010036. S2CID 90912166.
  17. ^ Lai IC, Shih PH, Yao CJ, Yeh CT, Wang-Peng J, Lui TN, Chuang SE, Hu TS, Lai TY, Lai GM (2015). "Elimination of cancer stem-like cells and potentiation of temozolomide sensitivity by Honokiol in glioblastoma multiforme cells". PLOS ONE. 10 (3): e0114830. Bibcode:2015PLoSO..1014830L. doi:10.1371/journal.pone.0114830. PMC 4357432. PMID 25763821.
  18. ^ Hemmati HD, Nakano I, Lazareff JA, Masterman-Smith M, Geschwind DH, Bronner-Fraser M, Kornblum HI (December 2003). "Cancerous stem cells can arise from pediatric brain tumors". Proceedings of the National Academy of Sciences of the United States of America. 100 (25): 15178–83. Bibcode:2003PNAS..10015178H. doi:10.1073/pnas.2036535100. PMC 299944. PMID 14645703.
  19. ^ Galli R, Binda E, Orfanelli U, Cipelletti B, Gritti A, De Vitis S, Fiocco R, Foroni C, Dimeco F, Vescovi A (October 2004). "Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma" (PDF). Cancer Research. 64 (19): 7011–21. doi:10.1158/0008-5472.CAN-04-1364. hdl:2434/585643. PMID 15466194. S2CID 14693017.
  20. ^ Wang J, Sakariassen PØ, Tsinkalovsky O, Immervoll H, Bøe SO, Svendsen A, Prestegarden L, Røsland G, Thorsen F, Stuhr L, Molven A, Bjerkvig R, Enger PØ (February 2008). "CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells". International Journal of Cancer. 122 (4): 761–8. doi:10.1002/ijc.23130. PMID 17955491. S2CID 25435240.
  21. ^ Monzani E, Facchetti F, Galmozzi E, Corsini E, Benetti A, Cavazzin C, Gritti A, Piccinini A, Porro D, Santinami M, Invernici G, Parati E, Alessandri G, La Porta CA (March 2007). "Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential". European Journal of Cancer. 43 (5): 935–46. doi:10.1016/j.ejca.2007.01.017. hdl:2434/28996. PMID 17320377.
  22. ^ Miyabayashi T, Kagamu H, Koshio J, Ichikawa K, Baba J, Watanabe S, Tanaka H, Tanaka J, Yoshizawa H, Nakata K, Narita I (November 2011). "Vaccination with CD133(+) melanoma induces specific Th17 and Th1 cell-mediated antitumor reactivity against parental tumor". Cancer Immunology, Immunotherapy. 60 (11): 1597–608. doi:10.1007/s00262-011-1063-x. PMID 21691723. S2CID 25329727.
  23. ^ Koshio J, Kagamu H, Nozaki K, Saida Y, Tanaka T, Shoji S, Igarashi N, Miura S, Okajima M, Watanabe S, Yoshizawa H, Narita I (October 2013). "DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked is an immunogenic target of cancer stem cells". Cancer Immunology, Immunotherapy. 62 (10): 1619–28. doi:10.1007/s00262-013-1467-x. PMID 23974721. S2CID 25347678.

Further reading edit

  • Shimizu K, Itoh T, Shimizu M, Ku Y, Hori Y (November 2009). "CD133 expression pattern distinguishes intraductal papillary mucinous neoplasms from ductal adenocarcinomas of the pancreas" (PDF). Pancreas. 38 (8): e207-14. doi:10.1097/MPA.0b013e3181bb5037. PMID 19786935. S2CID 25675719.
  • Bertolini G, Roz L, Perego P, Tortoreto M, Fontanella E, Gatti L, Pratesi G, Fabbri A, Andriani F, Tinelli S, Roz E, Caserini R, Lo Vullo S, Camerini T, Mariani L, Delia D, Calabrò E, Pastorino U, Sozzi G (September 2009). "Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment". Proceedings of the National Academy of Sciences of the United States of America. 106 (38): 16281–6. Bibcode:2009PNAS..10616281B. doi:10.1073/pnas.0905653106. PMC 2741477. PMID 19805294.
  • Salnikov AV, Gladkich J, Moldenhauer G, Volm M, Mattern J, Herr I (February 2010). "CD133 is indicative for a resistance phenotype but does not represent a prognostic marker for survival of non-small cell lung cancer patients". International Journal of Cancer. 126 (4): 950–8. doi:10.1002/ijc.24822. PMID 19676044. S2CID 23335006.
  • Nishide K, Nakatani Y, Kiyonari H, Kondo T (August 2009). Lowenstein PR (ed.). "Glioblastoma formation from cell population depleted of Prominin1-expressing cells". PLOS ONE. 4 (8): e6869. Bibcode:2009PLoSO...4.6869N. doi:10.1371/journal.pone.0006869. PMC 2729925. PMID 19718438.
  • Na YR, Seok SH, Kim DJ, Han JH, Kim TH, Jung H, Lee BH, Park JH (2009). "Isolation and characterization of spheroid cells from human malignant melanoma cell line WM-266-4". Tumour Biology. 30 (5–6): 300–9. doi:10.1159/000261073. PMID 19940551. S2CID 40841423.
  • Sun Y, Kong W, Falk A, Hu J, Zhou L, Pollard S, Smith A (2009). Chédotal A (ed.). "CD133 (Prominin) negative human neural stem cells are clonogenic and tripotent". PLOS ONE. 4 (5): e5498. Bibcode:2009PLoSO...4.5498S. doi:10.1371/journal.pone.0005498. PMC 2676510. PMID 19430532.
  • Wu X, Spitz MR, Lee JJ, Lippman SM, Ye Y, Yang H, Khuri FR, Kim E, Gu J, Lotan R, Hong WK (July 2009). "Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants". Cancer Prevention Research. 2 (7): 617–24. doi:10.1158/1940-6207.CAPR-09-0025. PMC 2964280. PMID 19584075.
  • Yao J, Zhang T, Ren J, Yu M, Wu G (October 2009). "Effect of CD133/prominin-1 antisense oligodeoxynucleotide on in vitro growth characteristics of Huh-7 human hepatocarcinoma cells and U251 human glioma cells". Oncology Reports. 22 (4): 781–7. doi:10.3892/or_00000500. PMID 19724856.
  • Yasuda H, Tanaka K, Saigusa S, Toiyama Y, Koike Y, Okugawa Y, Yokoe T, Kawamoto A, Inoue Y, Miki C, Kusunoki M (October 2009). "Elevated CD133, but not VEGF or EGFR, as a predictive marker of distant recurrence after preoperative chemoradiotherapy in rectal cancer". Oncology Reports. 22 (4): 709–17. doi:10.3892/or_00000491. PMID 19724847.
  • Yoshikawa S, Zen Y, Fujii T, Sato Y, Ohta T, Aoyagi Y, Nakanuma Y (October 2009). "Characterization of CD133+ parenchymal cells in the liver: histology and culture". World Journal of Gastroenterology. 15 (39): 4896–906. doi:10.3748/wjg.15.4896. PMC 2764966. PMID 19842219.
  • Ferrandina G, Martinelli E, Petrillo M, Prisco MG, Zannoni G, Sioletic S, Scambia G (July 2009). "CD133 antigen expression in ovarian cancer". BMC Cancer. 9: 221. doi:10.1186/1471-2407-9-221. PMC 3224735. PMID 19583859.
  • Wang Q, Chen ZG, Du CZ, Wang HW, Yan L, Gu J (September 2009). "Cancer stem cell marker CD133+ tumour cells and clinical outcome in rectal cancer". Histopathology. 55 (3): 284–93. doi:10.1111/j.1365-2559.2009.03378.x. PMID 19723143. S2CID 12088193.
  • Friedman S, Lu M, Schultz A, Thomas D, Lin RY (2009). Breant B (ed.). "CD133+ anaplastic thyroid cancer cells initiate tumors in immunodeficient mice and are regulated by thyrotropin". PLOS ONE. 4 (4): e5395. Bibcode:2009PLoSO...4.5395F. doi:10.1371/journal.pone.0005395. PMC 2671400. PMID 19404394.
  • Cheng JX, Liu BL, Zhang X (August 2009). "How powerful is CD133 as a cancer stem cell marker in brain tumors?". Cancer Treatment Reviews. 35 (5): 403–8. doi:10.1016/j.ctrv.2009.03.002. PMID 19369008.
  • Horst D, Kriegl L, Engel J, Kirchner T, Jung A (October 2009). "Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166 in colorectal cancer". Cancer Investigation. 27 (8): 844–50. doi:10.1080/07357900902744502. PMID 19626493. S2CID 35888000.
  • Yeh CT, Kuo CJ, Lai MW, Chen TC, Lin CY, Yeh TS, Lee WC (September 2009). "CD133-positive hepatocellular carcinoma in an area endemic for hepatitis B virus infection". BMC Cancer. 9: 324. doi:10.1186/1471-2407-9-324. PMC 2753636. PMID 19744348.
  • Li CY, Li BX, Liang Y, Peng RQ, Ding Y, Xu DZ, Zhang X, Pan ZZ, Wan DS, Zeng YX, Zhu XF, Zhang XS (July 2009). "Higher percentage of CD133+ cells is associated with poor prognosis in colon carcinoma patients with stage IIIB". Journal of Translational Medicine. 7: 56. doi:10.1186/1479-5876-7-56. PMC 2715381. PMID 19583834.
  • Hibi K, Sakata M, Sakuraba K, Shirahata A, Goto T, Mizukami H, Saito M, Ishibashi K, Kigawa G, Nemoto H, Sanada Y (2009). "CD133 gene overexpression is frequently observed in early colorectal carcinoma". Hepato-Gastroenterology. 56 (93): 995–7. PMID 19760928.
  • Pras E, Abu A, Rotenstreich Y, Avni I, Reish O, Morad Y, Reznik-Wolf H, Pras E (August 2009). "Cone-rod dystrophy and a frameshift mutation in the PROM1 gene". Molecular Vision. 15: 1709–16. PMC 2732717. PMID 19718270.
  • Rutella S, Bonanno G, Procoli A, Mariotti A, Corallo M, Prisco MG, Eramo A, Napoletano C, Gallo D, Perillo A, Nuti M, Pierelli L, Testa U, Scambia G, Ferrandina G (July 2009). "Cells with characteristics of cancer stem/progenitor cells express the CD133 antigen in human endometrial tumors". Clinical Cancer Research. 15 (13): 4299–311. doi:10.1158/1078-0432.CCR-08-1883. PMID 19509143.

External links edit

  • GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview
  • Human PROM1 genome location and PROM1 gene details page in the UCSC Genome Browser.

December 15, 2023
cd133, antigen, also, known, prominin, glycoprotein, that, humans, encoded, prom1, gene, member, pentaspan, transmembrane, glycoproteins, which, specifically, localize, cellular, protrusions, when, embedded, cell, membrane, membrane, topology, prominin, such, . CD133 antigen also known as prominin 1 is a glycoprotein that in humans is encoded by the PROM1 gene 5 6 It is a member of pentaspan transmembrane glycoproteins which specifically localize to cellular protrusions When embedded in the cell membrane the membrane topology of prominin 1 is such that the N terminus extends into the extracellular space and the C terminus resides in the intracellular compartment The protein consists of five transmembrane segments with the first and second segments and the third and fourth segments connected by intracellular loops while the second and third as well as fourth and fifth transmembrane segments are connected by extracellular loops 7 While the precise function of CD133 remains unknown it has been proposed that it acts as an organizer of cell membrane topology 8 PROM1IdentifiersAliasesPROM1 AC133 CD133 CORD12 MCDR2 MSTP061 PROML1 RP41 STGD4 prominin 1External IDsOMIM 604365 MGI 1100886 HomoloGene 4390 GeneCards PROM1Gene location Human Chr Chromosome 4 human 1 Band4p15 32Start15 963 076 bp 1 End16 084 378 bp 1 Gene location Mouse Chr Chromosome 5 mouse 2 Band5 5 B3Start44 150 962 bp 2 End44 259 374 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inbronchial epithelial cellparotid glandtracheapylorusrenal medullagallbladdercaput epididymislactiferous ductminor salivary glandcorpus epididymisTop expressed inconjunctival fornixretinal pigment epitheliumseminal vesiculaepithelium of stomachPaneth cellpyloric antrummucous cell of stomachcorneal stromaprimitive streakcrypt of lieberkuhn of small intestineMore reference expression dataBioGPSn aGene ontologyMolecular functionactinin binding cadherin binding protein binding cholesterol bindingCellular componentintegral component of membrane vesicle cell projection membrane plasma membrane photoreceptor outer segment integral component of plasma membrane cilium cell surface apical plasma membrane endoplasmic reticulum photoreceptor outer segment membrane extracellular exosome microvillus membrane endoplasmic reticulum Golgi intermediate compartment extracellular space microvillus prominosomeBiological processretina layer formation camera type eye photoreceptor cell differentiation retina morphogenesis in camera type eye glomerular parietal epithelial cell differentiation glomerular visceral epithelial cell differentiation photoreceptor cell maintenance positive regulation of nephron tubule epithelial cell differentiationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez884219126EnsemblENSG00000007062ENSMUSG00000029086UniProtO43490O54990RefSeq mRNA NM 001145847NM 001145848NM 001145849NM 001145850NM 001145851NM 001145852NM 006017NM 001371406NM 001371407NM 001371408NM 001163577NM 001163578NM 001163581NM 001163582NM 001163583NM 001163584NM 001163585NM 008935RefSeq protein NP 001139319NP 001139320NP 001139321NP 001139322NP 001139323NP 001139324NP 006008NP 001358335NP 001358336NP 001358337NP 001157049NP 001157050NP 001157053NP 001157054NP 001157055NP 001157056NP 001157057NP 032961Location UCSC Chr 4 15 96 16 08 MbChr 5 44 15 44 26 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Tissue distribution 2 Clinical significance 3 See also 4 References 5 Further reading 6 External linksTissue distribution editCD133 is expressed in hematopoietic stem cells 9 endothelial progenitor cells 10 glioblastoma neuronal and glial stem cells 11 various pediatric brain tumors 12 as well as adult kidney mammary glands trachea salivary glands uterus placenta digestive tract testes and some other cell types 13 14 15 Clinical significance editToday CD133 is the most commonly used marker for isolation of cancer stem cell CSC population from different tumors mainly from various gliomas and carcinomas 16 Initial studies that showed ability of CD133 positive population to efficiently propagate tumor when injected into immune compromised mice firstly were performed on brain tumors 17 12 18 19 However subsequent studies have indicated the difficulty in isolating pure CSC populations 20 CD133 melanoma cells are considered a subpopulation of CSC and play a critical role in recurrence 21 Moreover CD133 melanoma cells are immunogenic and can be used as an antimelanoma vaccination In mice the vaccination with CD133 melanoma cells mediated strong anti tumor activity that resulted in the eradication of parental melanoma cells 22 In addition it has also been shown that CD133 melanoma cells preferentially express the RNA helicase DDX3X As DDX3X also is an immunogenic protein the same anti melanoma vaccination strategy can be employed to give therapeutic antitumor immunity in mice 23 See also editStargardt diseaseReferences edit a b c GRCh38 Ensembl release 89 ENSG00000007062 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000029086 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Yin AH Miraglia S Zanjani ED Almeida Porada G Ogawa M Leary AG Olweus J Kearney J Buck DW December 1997 AC133 a novel marker for human hematopoietic stem and progenitor cells Blood 90 12 5002 12 doi 10 1182 blood V90 12 5002 PMID 9389720 Corbeil D Fargeas CA Huttner WB July 2001 Rat prominin like its mouse and human orthologues is a pentaspan membrane glycoprotein Biochemical and Biophysical Research Communications 285 4 939 44 doi 10 1006 bbrc 2001 5271 PMID 11467842 Corbeil D Karbanova J Fargeas CA Jaszai J 2012 11 05 Prominin 1 CD133 Molecular and Cellular Features Across Species Prominin 1 CD133 New Insights on Stem amp Cancer Stem Cell Biology Advances in Experimental Medicine and Biology Vol 777 pp 3 24 doi 10 1007 978 1 4614 5894 4 1 ISBN 9781461458937 PMID 23161072 Irollo E Pirozzi G September 2013 CD133 to be or not to be is this the real question American Journal of Translational Research 5 6 563 81 PMC 3786264 PMID 24093054 Horn PA Tesch H Staib P Kube D Diehl V Voliotis D February 1999 Expression of AC133 a novel hematopoietic precursor antigen on acute myeloid leukemia cells Blood 93 4 1435 7 doi 10 1182 blood V93 4 1435 PMID 10075457 Corbeil D Roper K Hellwig A Tavian M Miraglia S Watt SM Simmons PJ Peault B Buck DW Huttner WB February 2000 The human AC133 hematopoietic stem cell antigen is also expressed in epithelial cells and targeted to plasma membrane protrusions The Journal of Biological Chemistry 275 8 5512 20 doi 10 1074 jbc 275 8 5512 PMID 10681530 Sanai N Alvarez Buylla A Berger MS August 2005 Neural stem cells and the origin of gliomas The New England Journal of Medicine 353 8 811 22 doi 10 1056 NEJMra043666 PMID 16120861 a b Singh SK Clarke ID Terasaki M Bonn VE Hawkins C Squire J Dirks PB September 2003 Identification of a cancer stem cell in human brain tumors Cancer Research 63 18 5821 8 PMID 14522905 Mizrak D Brittan M Alison M January 2008 CD133 molecule of the moment The Journal of Pathology 214 1 3 9 doi 10 1002 path 2283 PMID 18067118 S2CID 44681326 Shmelkov SV St Clair R Lyden D Rafii S April 2005 AC133 CD133 Prominin 1 The International Journal of Biochemistry amp Cell Biology 37 4 715 9 doi 10 1016 j biocel 2004 08 010 PMID 15694831 Dowland SN Madawala RJ Poon CE Lindsay LA Murphy CR June 2017 Prominin 1 glycosylation changes throughout early pregnancy in uterine epithelial cells under the influence of maternal ovarian hormones Reproduction Fertility and Development 29 6 1194 1208 doi 10 1071 RD15432 PMID 27166505 Kim YS Kaidina AM Chiang JH Yarygin KN Lupatov AY 2017 Cancer stem cell molecular markers verified in vivo Biochem Moscow Suppl Ser B 11 1 43 54 doi 10 1134 S1990750817010036 S2CID 90912166 Lai IC Shih PH Yao CJ Yeh CT Wang Peng J Lui TN Chuang SE Hu TS Lai TY Lai GM 2015 Elimination of cancer stem like cells and potentiation of temozolomide sensitivity by Honokiol in glioblastoma multiforme cells PLOS ONE 10 3 e0114830 Bibcode 2015PLoSO 1014830L doi 10 1371 journal pone 0114830 PMC 4357432 PMID 25763821 Hemmati HD Nakano I Lazareff JA Masterman Smith M Geschwind DH Bronner Fraser M Kornblum HI December 2003 Cancerous stem cells can arise from pediatric brain tumors Proceedings of the National Academy of Sciences of the United States of America 100 25 15178 83 Bibcode 2003PNAS 10015178H doi 10 1073 pnas 2036535100 PMC 299944 PMID 14645703 Galli R Binda E Orfanelli U Cipelletti B Gritti A De Vitis S Fiocco R Foroni C Dimeco F Vescovi A October 2004 Isolation and characterization of tumorigenic stem like neural precursors from human glioblastoma PDF Cancer Research 64 19 7011 21 doi 10 1158 0008 5472 CAN 04 1364 hdl 2434 585643 PMID 15466194 S2CID 14693017 Wang J Sakariassen PO Tsinkalovsky O Immervoll H Boe SO Svendsen A Prestegarden L Rosland G Thorsen F Stuhr L Molven A Bjerkvig R Enger PO February 2008 CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells International Journal of Cancer 122 4 761 8 doi 10 1002 ijc 23130 PMID 17955491 S2CID 25435240 Monzani E Facchetti F Galmozzi E Corsini E Benetti A Cavazzin C Gritti A Piccinini A Porro D Santinami M Invernici G Parati E Alessandri G La Porta CA March 2007 Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential European Journal of Cancer 43 5 935 46 doi 10 1016 j ejca 2007 01 017 hdl 2434 28996 PMID 17320377 Miyabayashi T Kagamu H Koshio J Ichikawa K Baba J Watanabe S Tanaka H Tanaka J Yoshizawa H Nakata K Narita I November 2011 Vaccination with CD133 melanoma induces specific Th17 and Th1 cell mediated antitumor reactivity against parental tumor Cancer Immunology Immunotherapy 60 11 1597 608 doi 10 1007 s00262 011 1063 x PMID 21691723 S2CID 25329727 Koshio J Kagamu H Nozaki K Saida Y Tanaka T Shoji S Igarashi N Miura S Okajima M Watanabe S Yoshizawa H Narita I October 2013 DEAD H Asp Glu Ala Asp His box polypeptide 3 X linked is an immunogenic target of cancer stem cells Cancer Immunology Immunotherapy 62 10 1619 28 doi 10 1007 s00262 013 1467 x PMID 23974721 S2CID 25347678 Further reading editShimizu K Itoh T Shimizu M Ku Y Hori Y November 2009 CD133 expression pattern distinguishes intraductal papillary mucinous neoplasms from ductal adenocarcinomas of the pancreas PDF Pancreas 38 8 e207 14 doi 10 1097 MPA 0b013e3181bb5037 PMID 19786935 S2CID 25675719 Bertolini G Roz L Perego P Tortoreto M Fontanella E Gatti L Pratesi G Fabbri A Andriani F Tinelli S Roz E Caserini R Lo Vullo S Camerini T Mariani L Delia D Calabro E Pastorino U Sozzi G September 2009 Highly tumorigenic lung cancer CD133 cells display stem like features and are spared by cisplatin treatment Proceedings of the National Academy of Sciences of the United States of America 106 38 16281 6 Bibcode 2009PNAS 10616281B doi 10 1073 pnas 0905653106 PMC 2741477 PMID 19805294 Salnikov AV Gladkich J Moldenhauer G Volm M Mattern J Herr I February 2010 CD133 is indicative for a resistance phenotype but does not represent a prognostic marker for survival of non small cell lung cancer patients International Journal of Cancer 126 4 950 8 doi 10 1002 ijc 24822 PMID 19676044 S2CID 23335006 Nishide K Nakatani Y Kiyonari H Kondo T August 2009 Lowenstein PR ed Glioblastoma formation from cell population depleted of Prominin1 expressing cells PLOS ONE 4 8 e6869 Bibcode 2009PLoSO 4 6869N doi 10 1371 journal pone 0006869 PMC 2729925 PMID 19718438 Na YR Seok SH Kim DJ Han JH Kim TH Jung H Lee BH Park JH 2009 Isolation and characterization of spheroid cells from human malignant melanoma cell line WM 266 4 Tumour Biology 30 5 6 300 9 doi 10 1159 000261073 PMID 19940551 S2CID 40841423 Sun Y Kong W Falk A Hu J Zhou L Pollard S Smith A 2009 Chedotal A ed CD133 Prominin negative human neural stem cells are clonogenic and tripotent PLOS ONE 4 5 e5498 Bibcode 2009PLoSO 4 5498S doi 10 1371 journal pone 0005498 PMC 2676510 PMID 19430532 Wu X Spitz MR Lee JJ Lippman SM Ye Y Yang H Khuri FR Kim E Gu J Lotan R Hong WK July 2009 Novel susceptibility loci for second primary tumors recurrence in head and neck cancer patients large scale evaluation of genetic variants Cancer Prevention Research 2 7 617 24 doi 10 1158 1940 6207 CAPR 09 0025 PMC 2964280 PMID 19584075 Yao J Zhang T Ren J Yu M Wu G October 2009 Effect of CD133 prominin 1 antisense oligodeoxynucleotide on in vitro growth characteristics of Huh 7 human hepatocarcinoma cells and U251 human glioma cells Oncology Reports 22 4 781 7 doi 10 3892 or 00000500 PMID 19724856 Yasuda H Tanaka K Saigusa S Toiyama Y Koike Y Okugawa Y Yokoe T Kawamoto A Inoue Y Miki C Kusunoki M October 2009 Elevated CD133 but not VEGF or EGFR as a predictive marker of distant recurrence after preoperative chemoradiotherapy in rectal cancer Oncology Reports 22 4 709 17 doi 10 3892 or 00000491 PMID 19724847 Yoshikawa S Zen Y Fujii T Sato Y Ohta T Aoyagi Y Nakanuma Y October 2009 Characterization of CD133 parenchymal cells in the liver histology and culture World Journal of Gastroenterology 15 39 4896 906 doi 10 3748 wjg 15 4896 PMC 2764966 PMID 19842219 Ferrandina G Martinelli E Petrillo M Prisco MG Zannoni G Sioletic S Scambia G July 2009 CD133 antigen expression in ovarian cancer BMC Cancer 9 221 doi 10 1186 1471 2407 9 221 PMC 3224735 PMID 19583859 Wang Q Chen ZG Du CZ Wang HW Yan L Gu J September 2009 Cancer stem cell marker CD133 tumour cells and clinical outcome in rectal cancer Histopathology 55 3 284 93 doi 10 1111 j 1365 2559 2009 03378 x PMID 19723143 S2CID 12088193 Friedman S Lu M Schultz A Thomas D Lin RY 2009 Breant B ed CD133 anaplastic thyroid cancer cells initiate tumors in immunodeficient mice and are regulated by thyrotropin PLOS ONE 4 4 e5395 Bibcode 2009PLoSO 4 5395F doi 10 1371 journal pone 0005395 PMC 2671400 PMID 19404394 Cheng JX Liu BL Zhang X August 2009 How powerful is CD133 as a cancer stem cell marker in brain tumors Cancer Treatment Reviews 35 5 403 8 doi 10 1016 j ctrv 2009 03 002 PMID 19369008 Horst D Kriegl L Engel J Kirchner T Jung A October 2009 Prognostic significance of the cancer stem cell markers CD133 CD44 and CD166 in colorectal cancer Cancer Investigation 27 8 844 50 doi 10 1080 07357900902744502 PMID 19626493 S2CID 35888000 Yeh CT Kuo CJ Lai MW Chen TC Lin CY Yeh TS Lee WC September 2009 CD133 positive hepatocellular carcinoma in an area endemic for hepatitis B virus infection BMC Cancer 9 324 doi 10 1186 1471 2407 9 324 PMC 2753636 PMID 19744348 Li CY Li BX Liang Y Peng RQ Ding Y Xu DZ Zhang X Pan ZZ Wan DS Zeng YX Zhu XF Zhang XS July 2009 Higher percentage of CD133 cells is associated with poor prognosis in colon carcinoma patients with stage IIIB Journal of Translational Medicine 7 56 doi 10 1186 1479 5876 7 56 PMC 2715381 PMID 19583834 Hibi K Sakata M Sakuraba K Shirahata A Goto T Mizukami H Saito M Ishibashi K Kigawa G Nemoto H Sanada Y 2009 CD133 gene overexpression is frequently observed in early colorectal carcinoma Hepato Gastroenterology 56 93 995 7 PMID 19760928 Pras E Abu A Rotenstreich Y Avni I Reish O Morad Y Reznik Wolf H Pras E August 2009 Cone rod dystrophy and a frameshift mutation in the PROM1 gene Molecular Vision 15 1709 16 PMC 2732717 PMID 19718270 Rutella S Bonanno G Procoli A Mariotti A Corallo M Prisco MG Eramo A Napoletano C Gallo D Perillo A Nuti M Pierelli L Testa U Scambia G Ferrandina G July 2009 Cells with characteristics of cancer stem progenitor cells express the CD133 antigen in human endometrial tumors Clinical Cancer Research 15 13 4299 311 doi 10 1158 1078 0432 CCR 08 1883 PMID 19509143 External links editGeneReviews NCBI NIH UW entry on Retinitis Pigmentosa Overview Human PROM1 genome location and PROM1 gene details page in the UCSC Genome Browser Retrieved from https en wikipedia org w index php title CD133 amp oldid 1184217116, wikipedia, wiki, book, books, library,

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