The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000074211 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029120 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Torres R, Ide SE, Dehejia A, Baras A, Polymeropoulos MH (Oct 1999). "Genomic structure and localization of the human protein phosphatase 2A BRgamma regulatory subunit". DNA Research. 6 (5): 323–7. CiteSeerX10.1.1.575.4908. doi:10.1093/dnares/6.5.323. PMID 10574460.
^Hu P, Yu L, Zhang M, Zheng L, Zhao Y, Fu Q, Zhao S (Jul 2000). "Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16". Genomics. 67 (1): 83–6. doi:10.1006/geno.2000.6219. PMID 10945473.
Zolnierowicz S (Oct 2000). "Type 2A protein phosphatase, the complex regulator of numerous signaling pathways". Biochemical Pharmacology. 60 (8): 1225–35. doi:10.1016/S0006-2952(00)00424-X. PMID 11007961.
Andersen JL, Planelles V (Jan 2005). "The role of Vpr in HIV-1 pathogenesis". Current HIV Research. 3 (1): 43–51. doi:10.2174/1570162052772988. PMID 15638722.
Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. doi:10.1186/1742-4690-2-11. PMC554975. PMID 15725353.
Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research. 121 (4): 270–86. PMID 15817944.
Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R (Jan 1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters. 401 (2–3): 197–201. doi:10.1016/S0014-5793(96)01470-6. PMID 9013886. S2CID 23293768.
Ruediger R, Brewis N, Ohst K, Walter G (Nov 1997). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology. 238 (2): 432–43. doi:10.1006/viro.1997.8873. PMID 9400615.
Strack S, Zaucha JA, Ebner FF, Colbran RJ, Wadzinski BE (Mar 1998). "Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits". The Journal of Comparative Neurology. 392 (4): 515–27. doi:10.1002/(SICI)1096-9861(19980323)392:4<515::AID-CNE8>3.0.CO;2-3. PMID 9514514. S2CID 20496320.
Sanger Centre, The; Washington University Genome Sequencing Cente, The (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (Sep 2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, Matushkin YG, Gyanchandani A, Muravenko OV, Levitsky VG, Kolchanov NA, Protopopov AI, Kashuba VI, Kisselev LL, Wasserman W, Wahlestedt C, Zabarovsky ER (Jul 2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Research. 30 (14): 3163–70. doi:10.1093/nar/gkf428. PMC135748. PMID 12136098.
Shern JF, Sharer JD, Pallas DC, Bartolini F, Cowan NJ, Reed MS, Pohl J, Kahn RA (Oct 2003). "Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A". The Journal of Biological Chemistry. 278 (42): 40829–36. doi:10.1074/jbc.M308678200. PMID 12912990.
Chen W, Possemato R, Campbell KT, Plattner CA, Pallas DC, Hahn WC (Feb 2004). "Identification of specific PP2A complexes involved in human cell transformation". Cancer Cell. 5 (2): 127–36. doi:10.1016/S1535-6108(04)00026-1. PMID 14998489.
December 15, 2023
ppp2r2c, serine, threonine, protein, phosphatase, regulatory, subunit, gamma, isoform, enzyme, that, humans, encoded, gene, identifiersaliases, gamma, imypno, imypno1, pr52, pr55g, protein, phosphatase, regulatory, subunit, bgamma, b55gammaexternal, idsomim, 6. Serine threonine protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform is an enzyme that in humans is encoded by the PPP2R2C gene 5 6 7 PPP2R2CIdentifiersAliasesPPP2R2C B55 GAMMA IMYPNO IMYPNO1 PR52 PR55G protein phosphatase 2 regulatory subunit Bgamma B55gammaExternal IDsOMIM 605997 MGI 2442660 HomoloGene 36386 GeneCards PPP2R2CGene location Human Chr Chromosome 4 human 1 Band4p16 1Start6 320 578 bp 1 End6 563 600 bp 1 Gene location Mouse Chr Chromosome 5 mouse 2 Band5 5 B3Start37 025 857 bp 2 End37 112 422 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmiddle temporal gyrusBrodmann area 46superior frontal gyrusparietal lobepostcentral gyrusoccipital lobeBrodmann area 23entorhinal cortexprefrontal cortexinferior ganglion of vagus nerveTop expressed invisual cortexsuperior frontal gyrusprimary motor cortexpiriform cortexprefrontal cortexcingulate gyrusolfactory tuberclecerebellar cortexnucleus accumbensamygdalaMore reference expression dataBioGPSn aGene ontologyMolecular functionprotein binding protein serine threonine phosphatase activity protein phosphatase regulator activityCellular componentprotein phosphatase type 2A complex cytosolBiological processmitotic cell cycle peptidyl serine dephosphorylation developmental process regulation of phosphoprotein phosphatase activitySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez5522269643EnsemblENSG00000074211ENSMUSG00000029120UniProtQ9Y2T4Q8BG02RefSeq mRNA NM 001206994NM 001206995NM 001206996NM 020416NM 181876NM 001363388NM 172994NM 001360003RefSeq protein NP 001193923NP 001193924NP 001193925NP 065149NP 870991NP 001350317NP 766582NP 001346932Location UCSC Chr 4 6 32 6 56 MbChr 5 37 03 37 11 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseFunction editThe product of this gene belongs to the phosphatase 2 regulatory subunit B family Protein phosphatase 2 is one of the four major Ser Thr phosphatases and it is implicated in the negative control of cell growth and division It consists of a common heteromeric core enzyme which is composed of a catalytic subunit and a constant regulatory subunit that associates with a variety of regulatory subunits The B regulatory subunit might modulate substrate selectivity and catalytic activity This gene encodes a gamma isoform of the regulatory subunit B55 subfamily Alternatively spliced transcript variants encoding different isoforms have been identified 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000074211 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000029120 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Torres R Ide SE Dehejia A Baras A Polymeropoulos MH Oct 1999 Genomic structure and localization of the human protein phosphatase 2A BRgamma regulatory subunit DNA Research 6 5 323 7 CiteSeerX 10 1 1 575 4908 doi 10 1093 dnares 6 5 323 PMID 10574460 Hu P Yu L Zhang M Zheng L Zhao Y Fu Q Zhao S Jul 2000 Molecular cloning and mapping of the brain abundant B1gamma subunit of protein phosphatase 2A PPP2R2C to human chromosome 4p16 Genomics 67 1 83 6 doi 10 1006 geno 2000 6219 PMID 10945473 a b Entrez Gene PPP2R2C protein phosphatase 2 formerly 2A regulatory subunit B gamma isoform Further reading editZolnierowicz S Oct 2000 Type 2A protein phosphatase the complex regulator of numerous signaling pathways Biochemical Pharmacology 60 8 1225 35 doi 10 1016 S0006 2952 00 00424 X PMID 11007961 Andersen JL Planelles V Jan 2005 The role of Vpr in HIV 1 pathogenesis Current HIV Research 3 1 43 51 doi 10 2174 1570162052772988 PMID 15638722 Le Rouzic E Benichou S 2006 The Vpr protein from HIV 1 distinct roles along the viral life cycle Retrovirology 2 11 doi 10 1186 1742 4690 2 11 PMC 554975 PMID 15725353 Zhao RY Elder RT Mar 2005 Viral infections and cell cycle G2 M regulation Cell Research 15 3 143 9 doi 10 1038 sj cr 7290279 PMID 15780175 Zhao RY Bukrinsky M Elder RT Apr 2005 HIV 1 viral protein R Vpr amp host cellular responses The Indian Journal of Medical Research 121 4 270 86 PMID 15817944 Tung HY De Rocquigny H Zhao LJ Cayla X Roques BP Ozon R Jan 1997 Direct activation of protein phosphatase 2A0 by HIV 1 encoded protein complex NCp7 vpr FEBS Letters 401 2 3 197 201 doi 10 1016 S0014 5793 96 01470 6 PMID 9013886 S2CID 23293768 Ruediger R Brewis N Ohst K Walter G Nov 1997 Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat stimulated HIV 1 transcription and virus production Virology 238 2 432 43 doi 10 1006 viro 1997 8873 PMID 9400615 Strack S Zaucha JA Ebner FF Colbran RJ Wadzinski BE Mar 1998 Brain protein phosphatase 2A developmental regulation and distinct cellular and subcellular localization by B subunits The Journal of Comparative Neurology 392 4 515 27 doi 10 1002 SICI 1096 9861 19980323 392 4 lt 515 AID CNE8 gt 3 0 CO 2 3 PMID 9514514 S2CID 20496320 Sanger Centre The Washington University Genome Sequencing Cente The Nov 1998 Toward a complete human genome sequence Genome Research 8 11 1097 108 doi 10 1101 gr 8 11 1097 PMID 9847074 Elder RT Yu M Chen M Zhu X Yanagida M Zhao Y Sep 2001 HIV 1 Vpr induces cell cycle G2 arrest in fission yeast Schizosaccharomyces pombe through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25 Virology 287 2 359 70 doi 10 1006 viro 2001 1007 PMID 11531413 Kutsenko AS Gizatullin RZ Al Amin AN Wang F Kvasha SM Podowski RM Matushkin YG Gyanchandani A Muravenko OV Levitsky VG Kolchanov NA Protopopov AI Kashuba VI Kisselev LL Wasserman W Wahlestedt C Zabarovsky ER Jul 2002 NotI flanking sequences a tool for gene discovery and verification of the human genome Nucleic Acids Research 30 14 3163 70 doi 10 1093 nar gkf428 PMC 135748 PMID 12136098 Shern JF Sharer JD Pallas DC Bartolini F Cowan NJ Reed MS Pohl J Kahn RA Oct 2003 Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A The Journal of Biological Chemistry 278 42 40829 36 doi 10 1074 jbc M308678200 PMID 12912990 Chen W Possemato R Campbell KT Plattner CA Pallas DC Hahn WC Feb 2004 Identification of specific PP2A complexes involved in human cell transformation Cancer Cell 5 2 127 36 doi 10 1016 S1535 6108 04 00026 1 PMID 14998489 Retrieved from https en wikipedia org w index php title PPP2R2C amp oldid 1188032274, wikipedia, wiki, book, books, library,
