The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000118898 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000039457 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ruhrberg C, Williamson JA, Maatta A, Watt FM (Jun 1998). "The periplakin gene maps to 16p13.3 in human and 16A-B1 in mouse". Genomics. 49 (1): 157–9. doi:10.1006/geno.1997.5206. PMID 9570964.
^Aho S, McLean WH, Li K, Uitto J (Jun 1998). "cDNA cloning, mRNA expression, and chromosomal mapping of human and mouse periplakin genes". Genomics. 48 (2): 242–7. doi:10.1006/geno.1997.5188. PMID 9521878.
^Kazerounian, Shideh; Uitto Jouni; Aho Sirpa (Oct 2002). "Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin". Exp. Dermatol. Denmark. 11 (5): 428–38. doi:10.1034/j.1600-0625.2002.110506.x. ISSN 0906-6705. PMID 12366696. S2CID 25735126.
^Karashima, Tadashi; Watt Fiona M (Dec 2002). "Interaction of periplakin and envoplakin with intermediate filaments". J. Cell Sci. England. 115 (Pt 24): 5027–37. doi:10.1242/jcs.00191. ISSN 0021-9533. PMID 12432088.
^Ruhrberg, C; Hajibagheri M A; Parry D A; Watt F M (Dec 1997). "Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin". J. Cell Biol. UNITED STATES. 139 (7): 1835–49. doi:10.1083/jcb.139.7.1835. ISSN 0021-9525. PMC2132639. PMID 9412476.
Further readingedit
Amagai M (1999). "Autoimmunity against desmosomal cadherins in pemphigus". J. Dermatol. Sci. 20 (2): 92–102. doi:10.1016/S0923-1811(99)00016-X. PMID 10379702.
Leung CL, Green KJ, Liem RK (2002). "Plakins: a family of versatile cytolinker proteins". Trends Cell Biol. 12 (1): 37–45. doi:10.1016/S0962-8924(01)02180-8. PMID 11854008.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Ruhrberg C, Hajibagheri MA, Parry DA, Watt FM (1998). "Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin". J. Cell Biol. 139 (7): 1835–49. doi:10.1083/jcb.139.7.1835. PMC2132639. PMID 9412476.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
Aho S, Rothenberger K, Tan EM, et al. (1999). "Human periplakin: genomic organization in a clonally unstable region of chromosome 16p with an abundance of repetitive sequence elements". Genomics. 56 (2): 160–8. doi:10.1006/geno.1998.5704. PMID 10051401.
DiColandrea T, Karashima T, Määttä A, Watt FM (2000). "Subcellular distribution of envoplakin and periplakin: insights into their role as precursors of the epidermal cornified envelope". J. Cell Biol. 151 (3): 573–86. doi:10.1083/jcb.151.3.573. PMC2185584. PMID 11062259.
van den Heuvel AP, de Vries-Smits AM, van Weeren PC, et al. (2003). "Binding of protein kinase B to the plakin family member periplakin". J. Cell Sci. 115 (Pt 20): 3957–66. doi:10.1242/jcs.00069. PMID 12244133.
Kazerounian S, Uitto J, Aho S (2003). "Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin". Exp. Dermatol. 11 (5): 428–38. doi:10.1034/j.1600-0625.2002.110506.x. PMID 12366696. S2CID 25735126.
Karashima T, Watt FM (2003). "Interaction of periplakin and envoplakin with intermediate filaments". J. Cell Sci. 115 (Pt 24): 5027–37. doi:10.1242/jcs.00191. PMID 12432088.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Feng GJ, Kellett E, Scorer CA, et al. (2003). "Selective interactions between helix VIII of the human mu-opioid receptors and the C terminus of periplakin disrupt G protein activation". J. Biol. Chem. 278 (35): 33400–7. doi:10.1074/jbc.M305866200. PMID 12810704.
Kazerounian S, Aho S (2003). "Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope". J. Biol. Chem. 278 (38): 36707–17. doi:10.1074/jbc.M303896200. PMID 12853457.
Straub BK, Boda J, Kuhn C, et al. (2004). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell Sci. 116 (Pt 24): 4985–95. doi:10.1242/jcs.00815. PMID 14625392.
Kalinin AE, Idler WW, Marekov LN, et al. (2004). "Co-assembly of envoplakin and periplakin into oligomers and Ca(2+)-dependent vesicle binding: implications for cornified cell envelope formation in stratified squamous epithelia". J. Biol. Chem. 279 (21): 22773–80. doi:10.1074/jbc.M313660200. PMID 15033990.
Beekman JM, Bakema JE, van de Winkel JG, Leusen JH (2004). "Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity". Proc. Natl. Acad. Sci. U.S.A. 101 (28): 10392–7. Bibcode:2004PNAS..10110392B. doi:10.1073/pnas.0401217101. PMC478582. PMID 15229321.
External linksedit
Overview of all the structural information available in the PDB for UniProt: O60437 (Periplakin) at the PDBe-KB.
This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.
periplakin, protein, that, humans, encoded, gene, pplavailable, structurespdbortholog, search, pdbe, rcsblist, codes4q28identifiersaliasesppl, periplakinexternal, idsomim, 602871, 1194898, homologene, 2026, genecards, pplgene, location, human, chromosome, huma. Periplakin is a protein that in humans is encoded by the PPL gene 5 6 7 PPLAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes4Q28IdentifiersAliasesPPL periplakinExternal IDsOMIM 602871 MGI 1194898 HomoloGene 2026 GeneCards PPLGene location Human Chr Chromosome 16 human 1 Band16p13 3Start4 882 507 bp 1 End4 960 741 bp 1 Gene location Mouse Chr Chromosome 16 mouse 2 Band16 A1 16 2 5 cMStart4 904 155 bp 2 End4 950 285 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed incavity of mouthamniotic fluidgumscervix epitheliumvulvahuman penisbody of tongueskin of abdomenpalpebral conjunctivanippleTop expressed insuperior surface of tonguecorneal stromaesophagusskin of backlipskin of abdomenepidermisbelly cordhair follicleconjunctival fornixMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionstructural constituent of cytoskeleton protein binding cadherin binding structural molecule activityCellular componentcytoplasm cell junction plasma membrane desmosome extracellular exosome cytoskeleton membrane mitochondrion nucleus cornified envelope cytosol intermediate filamentBiological processkeratinization cytoskeleton organization cornification response to mechanical stimulus wound healing intermediate filament cytoskeleton organizationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez549319041EnsemblENSG00000118898ENSMUSG00000039457UniProtO60437Q9R269RefSeq mRNA NM 002705NM 008909RefSeq protein NP 002696NP 032935Location UCSC Chr 16 4 88 4 96 MbChr 16 4 9 4 95 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes The N terminal domain of this protein interacts with the plasma membrane and its C terminus interacts with intermediate filaments Through its rod domain this protein forms complexes with envoplakin This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments AKT1 PKB a protein kinase mediating a variety of cell growth and survival signaling processes is reported to interact with this protein suggesting a possible role for this protein as a localization signal in AKT1 mediated signaling 7 Contents 1 Interactions 2 See also 3 References 4 Further reading 5 External linksInteractions editPPL gene has been shown to interact with Keratin 8 8 and Envoplakin 9 10 See also editList of target antigens in pemphigusReferences edit a b c GRCh38 Ensembl release 89 ENSG00000118898 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000039457 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Ruhrberg C Williamson JA Maatta A Watt FM Jun 1998 The periplakin gene maps to 16p13 3 in human and 16A B1 in mouse Genomics 49 1 157 9 doi 10 1006 geno 1997 5206 PMID 9570964 Aho S McLean WH Li K Uitto J Jun 1998 cDNA cloning mRNA expression and chromosomal mapping of human and mouse periplakin genes Genomics 48 2 242 7 doi 10 1006 geno 1997 5188 PMID 9521878 a b Entrez Gene PPL periplakin Kazerounian Shideh Uitto Jouni Aho Sirpa Oct 2002 Unique role for the periplakin tail in intermediate filament association specific binding to keratin 8 and vimentin Exp Dermatol Denmark 11 5 428 38 doi 10 1034 j 1600 0625 2002 110506 x ISSN 0906 6705 PMID 12366696 S2CID 25735126 Karashima Tadashi Watt Fiona M Dec 2002 Interaction of periplakin and envoplakin with intermediate filaments J Cell Sci England 115 Pt 24 5027 37 doi 10 1242 jcs 00191 ISSN 0021 9533 PMID 12432088 Ruhrberg C Hajibagheri M A Parry D A Watt F M Dec 1997 Periplakin a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin J Cell Biol UNITED STATES 139 7 1835 49 doi 10 1083 jcb 139 7 1835 ISSN 0021 9525 PMC 2132639 PMID 9412476 Further reading editAmagai M 1999 Autoimmunity against desmosomal cadherins in pemphigus J Dermatol Sci 20 2 92 102 doi 10 1016 S0923 1811 99 00016 X PMID 10379702 Leung CL Green KJ Liem RK 2002 Plakins a family of versatile cytolinker proteins Trends Cell Biol 12 1 37 45 doi 10 1016 S0962 8924 01 02180 8 PMID 11854008 Bonaldo MF Lennon G Soares MB 1997 Normalization and subtraction two approaches to facilitate gene discovery Genome Res 6 9 791 806 doi 10 1101 gr 6 9 791 PMID 8889548 Ruhrberg C Hajibagheri MA Parry DA Watt FM 1998 Periplakin a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin J Cell Biol 139 7 1835 49 doi 10 1083 jcb 139 7 1835 PMC 2132639 PMID 9412476 Nagase T Ishikawa K Miyajima N et al 1998 Prediction of the coding sequences of unidentified human genes IX The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro DNA Res 5 1 31 9 doi 10 1093 dnares 5 1 31 PMID 9628581 Aho S Rothenberger K Tan EM et al 1999 Human periplakin genomic organization in a clonally unstable region of chromosome 16p with an abundance of repetitive sequence elements Genomics 56 2 160 8 doi 10 1006 geno 1998 5704 PMID 10051401 DiColandrea T Karashima T Maatta A Watt FM 2000 Subcellular distribution of envoplakin and periplakin insights into their role as precursors of the epidermal cornified envelope J Cell Biol 151 3 573 86 doi 10 1083 jcb 151 3 573 PMC 2185584 PMID 11062259 van den Heuvel AP de Vries Smits AM van Weeren PC et al 2003 Binding of protein kinase B to the plakin family member periplakin J Cell Sci 115 Pt 20 3957 66 doi 10 1242 jcs 00069 PMID 12244133 Kazerounian S Uitto J Aho S 2003 Unique role for the periplakin tail in intermediate filament association specific binding to keratin 8 and vimentin Exp Dermatol 11 5 428 38 doi 10 1034 j 1600 0625 2002 110506 x PMID 12366696 S2CID 25735126 Karashima T Watt FM 2003 Interaction of periplakin and envoplakin with intermediate filaments J Cell Sci 115 Pt 24 5027 37 doi 10 1242 jcs 00191 PMID 12432088 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Feng GJ Kellett E Scorer CA et al 2003 Selective interactions between helix VIII of the human mu opioid receptors and the C terminus of periplakin disrupt G protein activation J Biol Chem 278 35 33400 7 doi 10 1074 jbc M305866200 PMID 12810704 Kazerounian S Aho S 2003 Characterization of periphilin a widespread highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope J Biol Chem 278 38 36707 17 doi 10 1074 jbc M303896200 PMID 12853457 Straub BK Boda J Kuhn C et al 2004 A novel cell cell junction system the cortex adhaerens mosaic of lens fiber cells J Cell Sci 116 Pt 24 4985 95 doi 10 1242 jcs 00815 PMID 14625392 Kalinin AE Idler WW Marekov LN et al 2004 Co assembly of envoplakin and periplakin into oligomers and Ca 2 dependent vesicle binding implications for cornified cell envelope formation in stratified squamous epithelia J Biol Chem 279 21 22773 80 doi 10 1074 jbc M313660200 PMID 15033990 Beekman JM Bakema JE van de Winkel JG Leusen JH 2004 Direct interaction between FcgammaRI CD64 and periplakin controls receptor endocytosis and ligand binding capacity Proc Natl Acad Sci U S A 101 28 10392 7 Bibcode 2004PNAS 10110392B doi 10 1073 pnas 0401217101 PMC 478582 PMID 15229321 External links editOverview of all the structural information available in the PDB for UniProt O60437 Periplakin at the PDBe KB nbsp This article on a gene on human chromosome 16 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Periplakin amp oldid 1171093802, wikipedia, wiki, book, books, library,
