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POLR2E

August 30, 2023

DNA-directed RNA polymerases I, II, and III subunit RPABC1 is a protein that in humans is encoded by the POLR2E gene.[5]

POLR2E
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPOLR2E, RPABC1, RPB5, XAP4, hRPB25, hsRPB5, polymerase (RNA) II subunit E, RNA polymerase II subunit E, RNA polymerase II, I and III subunit E
External IDsOMIM: 180664 MGI: 1913670 HomoloGene: 2018 GeneCards: POLR2E
Orthologs
SpeciesHumanMouse
Entrez

5434

66420

Ensembl

ENSG00000099817

ENSMUSG00000004667

UniProt

P19388

Q80UW8

RefSeq (mRNA)

NM_002695
NM_001316323
NM_001316324

NM_025554

RefSeq (protein)

NP_001303252
NP_001303253
NP_002686

NP_079830

Location (UCSC)Chr 19: 1.09 – 1.1 MbChr 10: 79.87 – 79.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11.[6]

Interactions Edit

POLR2E has been shown to interact with TAF15,[7] POLR2C,[8] POLR2G,[8] POLR2H,[8] POLR2A,[8] POLR2B,[8] POLR2L[8] and GTF2F2.[9]

References Edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000099817 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004667 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Acker J, Mattei MG, Wintzerith M, Roeckel N, Depetris D, Vigneron M, Kedinger C (Aug 1994). "Chromosomal localization of human RNA polymerase II subunit genes". Genomics. 20 (3): 496–499. doi:10.1006/geno.1994.1208. PMID 8034326.
  6. ^ "Entrez Gene: POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa".
  7. ^ Bertolotti, A; Melot T; Acker J; Vigneron M; Delattre O; Tora L (Mar 1998). "EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes". Mol. Cell. Biol. UNITED STATES. 18 (3): 1489–1497. doi:10.1128/mcb.18.3.1489. ISSN 0270-7306. PMC 108863. PMID 9488465.
  8. ^ a b c d e f Acker, J; de Graaff M; Cheynel I; Khazak V; Kedinger C; Vigneron M (Jul 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. UNITED STATES. 272 (27): 16815–16821. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987.
  9. ^ Wei, W; Dorjsuren D; Lin Y; Qin W; Nomura T; Hayashi N; Murakami S (Apr 2001). "Direct interaction between the subunit RAP30 of transcription factor IIF (TFIIF) and RNA polymerase subunit 5, which contributes to the association between TFIIF and RNA polymerase II". J. Biol. Chem. United States. 276 (15): 12266–12273. doi:10.1074/jbc.M009634200. ISSN 0021-9258. PMID 11278533.

Further reading Edit

  • Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–27. doi:10.1007/BF02253352. PMID 9570510.
  • Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447–9. doi:10.1016/S0960-9822(98)70289-1. PMID 9651670. S2CID 15480646.
  • Romano G, Kasten M, De Falco G, et al. (2000). "Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression". J. Cell. Biochem. 75 (3): 357–368. doi:10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K. PMID 10536359. S2CID 43685090.
  • Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB Life. 51 (3): 175–181. doi:10.1080/152165401753544241. PMID 11547919. S2CID 10931640.
  • Stevens M, De Clercq E, Balzarini J (2007). "The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention". Med Res Rev. 26 (5): 595–625. doi:10.1002/med.20081. PMC 7168390. PMID 16838299.
  • Harrich D, McMillan N, Munoz L, et al. (2007). "Will diverse Tat interactions lead to novel antiretroviral drug targets?". Current Drug Targets. 7 (12): 1595–1606. doi:10.2174/138945006779025338. PMID 17168834.
  • Kato H, Sumimoto H, Pognonec P, et al. (1992). "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors". Genes Dev. 6 (4): 655–666. doi:10.1101/gad.6.4.655. PMID 1559613.
  • Pati UK, Weissman SM (1991). "Isolation and molecular characterization of a cDNA encoding the 23-kDa subunit of human RNA polymerase II". J. Biol. Chem. 266 (20): 13468. doi:10.1016/S0021-9258(18)98863-0. PMID 2071613.
  • Southgate C, Zapp ML, Green MR (1990). "Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein". Nature. 345 (6276): 640–642. Bibcode:1990Natur.345..640S. doi:10.1038/345640a0. PMID 2190099. S2CID 4233742.
  • Pati UK, Weissman SM (1989). "Isolation and molecular characterization of a cDNA encoding the 23-kDa subunit of human RNA polymerase II". J. Biol. Chem. 264 (22): 13114–13121. doi:10.1016/S0021-9258(18)51603-3. PMID 2753903.
  • Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat". Proc. Natl. Acad. Sci. U.S.A. 92 (16): 7153–7157. Bibcode:1995PNAS...92.7153W. doi:10.1073/pnas.92.16.7153. PMC 41297. PMID 7638159.
  • Cheong JH, Yi M, Lin Y, Murakami S (1995). "Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation". EMBO J. 14 (1): 143–150. doi:10.1002/j.1460-2075.1995.tb06984.x. PMC 398061. PMID 7828586.
  • Herrmann CH, Rice AP (1995). "Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor". J. Virol. 69 (3): 1612–1620. doi:10.1128/jvi.69.3.1612-1620.1995. PMC 188757. PMID 7853496.
  • Keen NJ, Gait MJ, Karn J (1996). "Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex". Proc. Natl. Acad. Sci. U.S.A. 93 (6): 2505–2510. Bibcode:1996PNAS...93.2505K. doi:10.1073/pnas.93.6.2505. PMC 39827. PMID 8637904.
  • Yang X, Herrmann CH, Rice AP (1996). "The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function". J. Virol. 70 (7): 4576–4584. doi:10.1128/jvi.70.7.4576-4584.1996. PMC 190394. PMID 8676484.
  • Agostini I, Navarro JM, Rey F, et al. (1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB". J. Mol. Biol. 261 (5): 599–606. doi:10.1006/jmbi.1996.0485. PMID 8800208.
  • Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–610. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID 8849451. S2CID 13266489.
  • Okamoto H, Sheline CT, Corden JL, et al. (1996). "Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11575–11579. Bibcode:1996PNAS...9311575O. doi:10.1073/pnas.93.21.11575. PMC 38099. PMID 8876177.
  • Chun RF, Jeang KT (1996). "Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1". J. Biol. Chem. 271 (44): 27888–27894. doi:10.1074/jbc.271.44.27888. PMID 8910388.
 

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

August 30, 2023
polr2e, directed, polymerases, subunit, rpabc1, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes5iy6, 5iy9, 5iy8, 5iya, 5iyb, 5iy7, 5iyc, 5iydidentifiersaliases, rpabc1, rpb5, xap4, hrpb25, hsrpb5, polymeras. DNA directed RNA polymerases I II and III subunit RPABC1 is a protein that in humans is encoded by the POLR2E gene 5 POLR2EAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes5IY6 5IY9 5IY8 5IYA 5IYB 5IY7 5IYC 5IYDIdentifiersAliasesPOLR2E RPABC1 RPB5 XAP4 hRPB25 hsRPB5 polymerase RNA II subunit E RNA polymerase II subunit E RNA polymerase II I and III subunit EExternal IDsOMIM 180664 MGI 1913670 HomoloGene 2018 GeneCards POLR2EGene location Human Chr Chromosome 19 human 1 Band19p13 3Start1 086 574 bp 1 End1 095 380 bp 1 Gene location Mouse Chr Chromosome 10 mouse 2 Band10 10 C1Start79 871 783 bp 2 End79 875 629 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed instromal cell of endometriumright lobe of liverprefrontal cortexright adrenal glandpopliteal arteryabdominal fatleft coronary arteryright coronary arteryright uterine tubecingulate gyrusTop expressed inyolk sacmorulasomitemaxillary prominenceotic placodeabdominal wallinterventricular septumneural tubedermisseminal vesiculaMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding RNA polymerase II activity RNA polymerase III activity protein binding RNA polymerase I activity DNA directed 5 3 RNA polymerase activityCellular componentcytosol RNA polymerase I complex RNA polymerase III complex RNA polymerase II core complex nucleus nucleoplasmBiological processtermination of RNA polymerase I transcription mRNA splicing via spliceosome epigenetic maintenance of chromatin in transcription competent conformation transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase II promoter 7 methylguanosine mRNA capping transcription by RNA polymerase II transcription coupled nucleotide excision repair transcription initiation from RNA polymerase II promoter viral process transcription by RNA polymerase III fibroblast growth factor receptor signaling pathway snRNA transcription by RNA polymerase II RNA metabolic process regulation of gene silencing by miRNA transcription DNA templated transcription elongation from RNA polymerase I promoter positive regulation of type I interferon production somatic stem cell population maintenance positive regulation of viral transcriptionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez543466420EnsemblENSG00000099817ENSMUSG00000004667UniProtP19388Q80UW8RefSeq mRNA NM 002695NM 001316323NM 001316324NM 025554RefSeq protein NP 001303252NP 001303253NP 002686NP 079830Location UCSC Chr 19 1 09 1 1 MbChr 10 79 87 79 88 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene encodes the fifth largest subunit of RNA polymerase II the polymerase responsible for synthesizing messenger RNA in eukaryotes This subunit is shared by the other two DNA directed RNA polymerases and is present in two fold molar excess over the other polymerase subunits An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit A pseudogene is located on chromosome 11 6 Interactions EditPOLR2E has been shown to interact with TAF15 7 POLR2C 8 POLR2G 8 POLR2H 8 POLR2A 8 POLR2B 8 POLR2L 8 and GTF2F2 9 References Edit a b c GRCh38 Ensembl release 89 ENSG00000099817 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000004667 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Acker J Mattei MG Wintzerith M Roeckel N Depetris D Vigneron M Kedinger C Aug 1994 Chromosomal localization of human RNA polymerase II subunit genes Genomics 20 3 496 499 doi 10 1006 geno 1994 1208 PMID 8034326 Entrez Gene POLR2E polymerase RNA II DNA directed polypeptide E 25kDa Bertolotti A Melot T Acker J Vigneron M Delattre O Tora L Mar 1998 EWS but not EWS FLI 1 is associated with both TFIID and RNA polymerase II interactions between two members of the TET family EWS and hTAFII68 and subunits of TFIID and RNA polymerase II complexes Mol Cell Biol UNITED STATES 18 3 1489 1497 doi 10 1128 mcb 18 3 1489 ISSN 0270 7306 PMC 108863 PMID 9488465 a b c d e f Acker J de Graaff M Cheynel I Khazak V Kedinger C Vigneron M Jul 1997 Interactions between the human RNA polymerase II subunits J Biol Chem UNITED STATES 272 27 16815 16821 doi 10 1074 jbc 272 27 16815 ISSN 0021 9258 PMID 9201987 Wei W Dorjsuren D Lin Y Qin W Nomura T Hayashi N Murakami S Apr 2001 Direct interaction between the subunit RAP30 of transcription factor IIF TFIIF and RNA polymerase subunit 5 which contributes to the association between TFIIF and RNA polymerase II J Biol Chem United States 276 15 12266 12273 doi 10 1074 jbc M009634200 ISSN 0021 9258 PMID 11278533 Further reading EditJeang KT 1998 Tat Tat associated kinase and transcription J Biomed Sci 5 1 24 27 doi 10 1007 BF02253352 PMID 9570510 Yankulov K Bentley D 1998 Transcriptional control Tat cofactors and transcriptional elongation Curr Biol 8 13 R447 9 doi 10 1016 S0960 9822 98 70289 1 PMID 9651670 S2CID 15480646 Romano G Kasten M De Falco G et al 2000 Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression J Cell Biochem 75 3 357 368 doi 10 1002 SICI 1097 4644 19991201 75 3 lt 357 AID JCB1 gt 3 0 CO 2 K PMID 10536359 S2CID 43685090 Marcello A Zoppe M Giacca M 2002 Multiple modes of transcriptional regulation by the HIV 1 Tat transactivator IUBMB Life 51 3 175 181 doi 10 1080 152165401753544241 PMID 11547919 S2CID 10931640 Stevens M De Clercq E Balzarini J 2007 The regulation of HIV 1 transcription molecular targets for chemotherapeutic intervention Med Res Rev 26 5 595 625 doi 10 1002 med 20081 PMC 7168390 PMID 16838299 Harrich D McMillan N Munoz L et al 2007 Will diverse Tat interactions lead to novel antiretroviral drug targets Current Drug Targets 7 12 1595 1606 doi 10 2174 138945006779025338 PMID 17168834 Kato H Sumimoto H Pognonec P et al 1992 HIV 1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors Genes Dev 6 4 655 666 doi 10 1101 gad 6 4 655 PMID 1559613 Pati UK Weissman SM 1991 Isolation and molecular characterization of a cDNA encoding the 23 kDa subunit of human RNA polymerase II J Biol Chem 266 20 13468 doi 10 1016 S0021 9258 18 98863 0 PMID 2071613 Southgate C Zapp ML Green MR 1990 Activation of transcription by HIV 1 Tat protein tethered to nascent RNA through another protein Nature 345 6276 640 642 Bibcode 1990Natur 345 640S doi 10 1038 345640a0 PMID 2190099 S2CID 4233742 Pati UK Weissman SM 1989 Isolation and molecular characterization of a cDNA encoding the 23 kDa subunit of human RNA polymerase II J Biol Chem 264 22 13114 13121 doi 10 1016 S0021 9258 18 51603 3 PMID 2753903 Wu Baer F Sigman D Gaynor RB 1995 Specific binding of RNA polymerase II to the human immunodeficiency virus trans activating region RNA is regulated by cellular cofactors and Tat Proc Natl Acad Sci U S A 92 16 7153 7157 Bibcode 1995PNAS 92 7153W doi 10 1073 pnas 92 16 7153 PMC 41297 PMID 7638159 Cheong JH Yi M Lin Y Murakami S 1995 Human RPB5 a subunit shared by eukaryotic nuclear RNA polymerases binds human hepatitis B virus X protein and may play a role in X transactivation EMBO J 14 1 143 150 doi 10 1002 j 1460 2075 1995 tb06984 x PMC 398061 PMID 7828586 Herrmann CH Rice AP 1995 Lentivirus Tat proteins specifically associate with a cellular protein kinase TAK that hyperphosphorylates the carboxyl terminal domain of the large subunit of RNA polymerase II candidate for a Tat cofactor J Virol 69 3 1612 1620 doi 10 1128 jvi 69 3 1612 1620 1995 PMC 188757 PMID 7853496 Keen NJ Gait MJ Karn J 1996 Human immunodeficiency virus type 1 Tat is an integral component of the activated transcription elongation complex Proc Natl Acad Sci U S A 93 6 2505 2510 Bibcode 1996PNAS 93 2505K doi 10 1073 pnas 93 6 2505 PMC 39827 PMID 8637904 Yang X Herrmann CH Rice AP 1996 The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl terminal domain of RNA polymerase II for function J Virol 70 7 4576 4584 doi 10 1128 jvi 70 7 4576 4584 1996 PMC 190394 PMID 8676484 Agostini I Navarro JM Rey F et al 1996 The human immunodeficiency virus type 1 Vpr transactivator cooperation with promoter bound activator domains and binding to TFIIB J Mol Biol 261 5 599 606 doi 10 1006 jmbi 1996 0485 PMID 8800208 Zhou Q Sharp PA 1996 Tat SF1 cofactor for stimulation of transcriptional elongation by HIV 1 Tat Science 274 5287 605 610 Bibcode 1996Sci 274 605Z doi 10 1126 science 274 5287 605 PMID 8849451 S2CID 13266489 Okamoto H Sheline CT Corden JL et al 1996 Trans activation by human immunodeficiency virus Tat protein requires the C terminal domain of RNA polymerase II Proc Natl Acad Sci U S A 93 21 11575 11579 Bibcode 1996PNAS 9311575O doi 10 1073 pnas 93 21 11575 PMC 38099 PMID 8876177 Chun RF Jeang KT 1996 Requirements for RNA polymerase II carboxyl terminal domain for activated transcription of human retroviruses human T cell lymphotropic virus I and HIV 1 J Biol Chem 271 44 27888 27894 doi 10 1074 jbc 271 44 27888 PMID 8910388 This article on a gene on human chromosome 19 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title POLR2E amp oldid 1170136531, wikipedia, wiki, book, books, library,

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