The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene.[5]
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
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|alt=Statin Pathway edit]]
Statin Pathway edit
^The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".
ReferencesEdit
^ abcGRCh38: Ensembl release 89: ENSG00000100979 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000017754 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: PLTP phospholipid transfer protein".
^ abPussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, Ehnholm C (Jan 1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". J. Lipid Res. 39 (1): 152–61. doi:10.1016/S0022-2275(20)34211-5. PMID 9469594.
Further readingEdit
Jiang XC (2002). "The effect of phospholipid transfer protein on lipoprotein metabolism and atherosclerosis". Front. Biosci. 7 (1–3): d1634-41. doi:10.2741/jiang1. PMID 12086920.
Albers JJ, Cheung MC (2004). "Emerging roles for phospholipid transfer protein in lipid and lipoprotein metabolism". Curr. Opin. Lipidol. 15 (3): 255–60. doi:10.1097/00041433-200406000-00004. PMID 15166780. S2CID 34754445.
Dallinga-Thie GM, Dullaart RP, van Tol A (2007). "Concerted actions of cholesteryl ester transfer protein and phospholipid transfer protein in type 2 diabetes: effects of apolipoproteins". Curr. Opin. Lipidol. 18 (3): 251–7. doi:10.1097/MOL.0b013e3280e12685. PMID 17495597. S2CID 20012553.
Whitmore TE, Day JR, Albers JJ (1995). "Localization of the human phospholipid transfer protein gene to chromosome 20q12-q13.1". Genomics. 28 (3): 599–600. doi:10.1006/geno.1995.1198. PMID 7490104.
Albers JJ, Wolfbauer G, Cheung MC, Day JR, Ching AF, Lok S, Tu AY (1995). "Functional expression of human and mouse plasma phospholipid transfer protein: effect of recombinant and plasma PLTP on HDL subspecies". Biochim. Biophys. Acta. 1258 (1): 27–34. doi:10.1016/0005-2760(95)00091-p. PMID 7654777.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Day JR, Albers JJ, Lofton-Day CE, Gilbert TL, Ching AF, Grant FJ, O'Hara PJ, Marcovina SM, Adolphson JL (1994). "Complete cDNA encoding human phospholipid transfer protein from human endothelial cells". J. Biol. Chem. 269 (12): 9388–91. doi:10.1016/S0021-9258(17)37120-X. PMID 8132678.
Tu AY, Wolfbauer G, Albers JJ (1995). "Functional characterization of the promoter region of the human phospholipid transfer protein gene". Biochem. Biophys. Res. Commun. 217 (3): 705–11. doi:10.1006/bbrc.1995.2830. PMID 8554588.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Hailman E, Albers JJ, Wolfbauer G, Tu AY, Wright SD (1996). "Neutralization and transfer of lipopolysaccharide by phospholipid transfer protein". J. Biol. Chem. 271 (21): 12172–8. doi:10.1074/jbc.271.21.12172. PMID 8647810.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC139146. PMID 9110174.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Pussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, Ehnholm C (1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". J. Lipid Res. 39 (1): 152–61. doi:10.1016/S0022-2275(20)34211-5. PMID 9469594.
Jiang XC, D'Armiento J, Mallampalli RK, Mar J, Yan SF, Lin M (1998). "Expression of plasma phospholipid transfer protein mRNA in normal and emphysematous lungs and regulation by hypoxia". J. Biol. Chem. 273 (25): 15714–8. doi:10.1074/jbc.273.25.15714. PMID 9624168.
Jauhiainen M, Huuskonen J, Baumann M, Metso J, Oka T, Egashira T, Hattori H, Olkkonen VM, Ehnholm C (1999). "Phospholipid transfer protein (PLTP) causes proteolytic cleavage of apolipoprotein A-I". J. Lipid Res. 40 (4): 654–64. doi:10.1016/S0022-2275(20)32144-1. PMID 10191289.
Qu SJ, Fan HZ, Kilinc C, Pownall HJ (1999). "Role of cysteine residues in human plasma phospholipid transfer protein". J. Protein Chem. 18 (2): 193–8. doi:10.1023/A:1020628006453. PMID 10333293. S2CID 1653738.
Lie J, de Crom R, Jauhiainen M, van Gent T, van Haperen R, Scheek L, Jansen H, Ehnholm C, van Tol A (2001). "Evaluation of phospholipid transfer protein and cholesteryl ester transfer protein as contributors to the generation of pre beta-high-density lipoproteins". Biochem. J. 360 (Pt 2): 379–85. doi:10.1042/0264-6021:3600379. PMC1222238. PMID 11716766.
Kärkkäinen M, Oka T, Olkkonen VM, Metso J, Hattori H, Jauhiainen M, Ehnholm C (2002). "Isolation and partial characterization of the inactive and active forms of human plasma phospholipid transfer protein (PLTP)". J. Biol. Chem. 277 (18): 15413–8. doi:10.1074/jbc.M112247200. PMID 11854286.
Murdoch SJ, Wolfbauer G, Kennedy H, Marcovina SM, Carr MC, Albers JJ (2002). "Differences in reactivity of antibodies to active versus inactive PLTP significantly impacts PLTP measurement". J. Lipid Res. 43 (2): 281–9. doi:10.1016/S0022-2275(20)30170-X. PMID 11861670.
This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.
phospholipid, transfer, protein, protein, that, humans, encoded, pltp, gene, pltpidentifiersaliasespltp, bpife, hdlcq9, phospholipid, transfer, proteinexternal, idsmgi, 103151, homologene, 4536, genecards, pltpgene, location, human, chromosome, human, band20q1. Phospholipid transfer protein is a protein that in humans is encoded by the PLTP gene PLTPIdentifiersAliasesPLTP BPIFE HDLCQ9 phospholipid transfer proteinExternal IDsMGI 103151 HomoloGene 4536 GeneCards PLTPGene location Human Chr Chromosome 20 human 1 Band20q13 12Start45 898 621 bp 1 End45 912 155 bp 1 Gene location Mouse Chr Chromosome 2 mouse 2 Band2 H3 2 85 27 cMStart164 681 438 bp 2 End164 699 631 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright coronary arterygastric mucosagallbladderbody of pancreascanal of the cervixleft adrenal glandleft coronary arterythymusleft uterine tubestromal cell of endometriumTop expressed inretinal pigment epitheliumright lung lobehabenulamolarleft lungleft lung lobecerebellar vermisdorsal tegmental nucleusparaventricular nucleus of hypothalamusdorsomedial hypothalamic nucleusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionlipid binding lipid transporter activity phospholipid transporter activity phosphatidylethanolamine binding phosphatidylcholine transporter activity diacylglycerol binding phosphatidylcholine binding phosphatidic acid binding ceramide binding phosphatidylglycerol binding phosphatidylethanolamine transfer activity phosphatidic acid transfer activityCellular componentextracellular region extracellular space high density lipoprotein particleBiological processhigh density lipoprotein particle remodeling flagellated sperm motility positive regulation of cholesterol efflux vitamin E biosynthetic process lipid metabolism transport lipid transport phospholipid transport ceramide transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez536018830EnsemblENSG00000100979ENSMUSG00000017754UniProtP55058P55065RefSeq mRNA NM 182676NM 001242920NM 001242921NM 006227NM 011125RefSeq protein NP 001229849NP 001229850NP 006218NP 872617NP 035255Location UCSC Chr 20 45 9 45 91 MbChr 2 164 68 164 7 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 Interactive pathway map 4 References 5 Further readingFunction EditThe protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma The encoded protein transfers phospholipids from triglyceride rich lipoproteins to high density lipoprotein HDL In addition to regulating the size of HDL particles this protein may be involved in cholesterol metabolism At least two transcript variants encoding different isoforms have been found for this gene 5 Interactions EditPLTP has been shown to interact with Apolipoprotein A1 6 and APOA2 6 Interactive pathway map EditClick on genes proteins and metabolites below to link to respective articles 1 File nbsp nbsp alt Statin Pathway edit Statin Pathway edit The interactive pathway map can be edited at WikiPathways Statin Pathway WP430 References Edit a b c GRCh38 Ensembl release 89 ENSG00000100979 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000017754 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene PLTP phospholipid transfer protein a b Pussinen PJ Jauhiainen M Metso J Pyle LE Marcel YL Fidge NH Ehnholm C Jan 1998 Binding of phospholipid transfer protein PLTP to apolipoproteins A I and A II location of a PLTP binding domain in the amino terminal region of apoA I J Lipid Res 39 1 152 61 doi 10 1016 S0022 2275 20 34211 5 PMID 9469594 Further reading EditJiang XC 2002 The effect of phospholipid transfer protein on lipoprotein metabolism and atherosclerosis Front Biosci 7 1 3 d1634 41 doi 10 2741 jiang1 PMID 12086920 Albers JJ Cheung MC 2004 Emerging roles for phospholipid transfer protein in lipid and lipoprotein metabolism Curr Opin Lipidol 15 3 255 60 doi 10 1097 00041433 200406000 00004 PMID 15166780 S2CID 34754445 Dallinga Thie GM Dullaart RP van Tol A 2007 Concerted actions of cholesteryl ester transfer protein and phospholipid transfer protein in type 2 diabetes effects of apolipoproteins Curr Opin Lipidol 18 3 251 7 doi 10 1097 MOL 0b013e3280e12685 PMID 17495597 S2CID 20012553 Whitmore TE Day JR Albers JJ 1995 Localization of the human phospholipid transfer protein gene to chromosome 20q12 q13 1 Genomics 28 3 599 600 doi 10 1006 geno 1995 1198 PMID 7490104 Albers JJ Wolfbauer G Cheung MC Day JR Ching AF Lok S Tu AY 1995 Functional expression of human and mouse plasma phospholipid transfer protein effect of recombinant and plasma PLTP on HDL subspecies Biochim Biophys Acta 1258 1 27 34 doi 10 1016 0005 2760 95 00091 p PMID 7654777 Maruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Day JR Albers JJ Lofton Day CE Gilbert TL Ching AF Grant FJ O Hara PJ Marcovina SM Adolphson JL 1994 Complete cDNA encoding human phospholipid transfer protein from human endothelial cells J Biol Chem 269 12 9388 91 doi 10 1016 S0021 9258 17 37120 X PMID 8132678 Tu AY Wolfbauer G Albers JJ 1995 Functional characterization of the promoter region of the human phospholipid transfer protein gene Biochem Biophys Res Commun 217 3 705 11 doi 10 1006 bbrc 1995 2830 PMID 8554588 Andersson B Wentland MA Ricafrente JY Liu W Gibbs RA 1996 A double adaptor method for improved shotgun library construction Anal Biochem 236 1 107 13 doi 10 1006 abio 1996 0138 PMID 8619474 Hailman E Albers JJ Wolfbauer G Tu AY Wright SD 1996 Neutralization and transfer of lipopolysaccharide by phospholipid transfer protein J Biol Chem 271 21 12172 8 doi 10 1074 jbc 271 21 12172 PMID 8647810 Yu W Andersson B Worley KC Muzny DM Ding Y Liu W Ricafrente JY Wentland MA Lennon G Gibbs RA 1997 Large scale concatenation cDNA sequencing Genome Res 7 4 353 8 doi 10 1101 gr 7 4 353 PMC 139146 PMID 9110174 Suzuki Y Yoshitomo Nakagawa K Maruyama K Suyama A Sugano S 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Pussinen PJ Jauhiainen M Metso J Pyle LE Marcel YL Fidge NH Ehnholm C 1998 Binding of phospholipid transfer protein PLTP to apolipoproteins A I and A II location of a PLTP binding domain in the amino terminal region of apoA I J Lipid Res 39 1 152 61 doi 10 1016 S0022 2275 20 34211 5 PMID 9469594 Jiang XC D Armiento J Mallampalli RK Mar J Yan SF Lin M 1998 Expression of plasma phospholipid transfer protein mRNA in normal and emphysematous lungs and regulation by hypoxia J Biol Chem 273 25 15714 8 doi 10 1074 jbc 273 25 15714 PMID 9624168 Jauhiainen M Huuskonen J Baumann M Metso J Oka T Egashira T Hattori H Olkkonen VM Ehnholm C 1999 Phospholipid transfer protein PLTP causes proteolytic cleavage of apolipoprotein A I J Lipid Res 40 4 654 64 doi 10 1016 S0022 2275 20 32144 1 PMID 10191289 Qu SJ Fan HZ Kilinc C Pownall HJ 1999 Role of cysteine residues in human plasma phospholipid transfer protein J Protein Chem 18 2 193 8 doi 10 1023 A 1020628006453 PMID 10333293 S2CID 1653738 Lie J de Crom R Jauhiainen M van Gent T van Haperen R Scheek L Jansen H Ehnholm C van Tol A 2001 Evaluation of phospholipid transfer protein and cholesteryl ester transfer protein as contributors to the generation of pre beta high density lipoproteins Biochem J 360 Pt 2 379 85 doi 10 1042 0264 6021 3600379 PMC 1222238 PMID 11716766 Karkkainen M Oka T Olkkonen VM Metso J Hattori H Jauhiainen M Ehnholm C 2002 Isolation and partial characterization of the inactive and active forms of human plasma phospholipid transfer protein PLTP J Biol Chem 277 18 15413 8 doi 10 1074 jbc M112247200 PMID 11854286 Murdoch SJ Wolfbauer G Kennedy H Marcovina SM Carr MC Albers JJ 2002 Differences in reactivity of antibodies to active versus inactive PLTP significantly impacts PLTP measurement J Lipid Res 43 2 281 9 doi 10 1016 S0022 2275 20 30170 X PMID 11861670 nbsp This article on a gene on human chromosome 20 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Phospholipid transfer protein amp oldid 1136362087, wikipedia, wiki, book, books, library,
