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Wikipedia

PES1

August 29, 2023

Pescadillo homolog is a protein that in humans is encoded by the PES1 gene.[5][6][7][8]

PES1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPES1, PES, pescadillo ribosomal biogenesis factor 1, NOP7
External IDsOMIM: 605819 MGI: 1890613 HomoloGene: 5984 GeneCards: PES1
Orthologs
SpeciesHumanMouse
Entrez

23481

64934

Ensembl

ENSG00000100029

ENSMUSG00000020430

UniProt

O00541

Q9EQ61

RefSeq (mRNA)

NM_001243225
NM_001282327
NM_001282328
NM_014303

NM_022889

RefSeq (protein)

NP_001230154
NP_001269256
NP_001269257
NP_055118

NP_075027

Location (UCSC)Chr 22: 30.58 – 30.61 MbChr 11: 3.91 – 3.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein that is abnormally elevated in malignant tumors of astrocytic origin. It is a strongly conserved gene containing a BRCT domain that is essential for the activity of this gene product. The gene plays a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression.[8]

References Edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100029 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020430 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Allende ML, Amsterdam A, Becker T, Kawakami K, Gaiano N, Hopkins N (Jan 1997). "Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development". Genes Dev. 10 (24): 3141–55. doi:10.1101/gad.10.24.3141. PMID 8985183.
  6. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  7. ^ Rohrmoser M, Holzel M, Grimm T, Malamoussi A, Harasim T, Orban M, Pfisterer I, Gruber-Eber A, Kremmer E, Eick D (May 2007). "Interdependence of Pes1, Bop1, and WDR12 Controls Nucleolar Localization and Assembly of the PeBoW Complex Required for Maturation of the 60S Ribosomal Subunit". Mol Cell Biol. 27 (10): 3682–94. doi:10.1128/MCB.00172-07. PMC 1899993. PMID 17353269.
  8. ^ a b "Entrez Gene: PES1 pescadillo homolog 1, containing BRCT domain (zebrafish)".

Further reading Edit

  • Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Kinoshita Y, Jarell AD, Flaman JM, et al. (2001). "Pescadillo, a novel cell cycle regulatory protein abnormally expressed in malignant cells". J. Biol. Chem. 276 (9): 6656–65. doi:10.1074/jbc.M008536200. PMID 11071894.
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
  • Oeffinger M, Leung A, Lamond A, et al. (2002). "Yeast Pescadillo is required for multiple activities during 60S ribosomal subunit synthesis". RNA. 8 (5): 626–36. doi:10.1017/S1355838202020022. PMC 1370283. PMID 12022229.
  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Lapik YR, Fernandes CJ, Lau LF, Pestov DG (2004). "Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis". Mol. Cell. 15 (1): 17–29. doi:10.1016/j.molcel.2004.05.020. PMID 15225545.
  • Maiorana A, Tu X, Cheng G, Baserga R (2004). "Role of pescadillo in the transformation and immortalization of mammalian cells". Oncogene. 23 (42): 7116–24. doi:10.1038/sj.onc.1207916. PMID 15273728.
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
  • Killian A, Le Meur N, Sesboüé R, et al. (2004). "Inactivation of the RRB1-Pescadillo pathway involved in ribosome biogenesis induces chromosomal instability". Oncogene. 23 (53): 8597–602. doi:10.1038/sj.onc.1207845. PMID 15467761.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Hölzel M, Rohrmoser M, Schlee M, et al. (2005). "Mammalian WDR12 is a novel member of the Pes1–Bop1 complex and is required for ribosome biogenesis and cell proliferation". J. Cell Biol. 170 (3): 367–78. doi:10.1083/jcb.200501141. PMC 2171466. PMID 16043514.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
 

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

August 29, 2023
pes1, pescadillo, homolog, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2ep8identifiersaliases, pescadillo, ribosomal, biogenesis, factor, nop7external, idsomim, 605819, 1890613, homologene, 5984, genecar. Pescadillo homolog is a protein that in humans is encoded by the PES1 gene 5 6 7 8 PES1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2EP8IdentifiersAliasesPES1 PES pescadillo ribosomal biogenesis factor 1 NOP7External IDsOMIM 605819 MGI 1890613 HomoloGene 5984 GeneCards PES1Gene location Human Chr Chromosome 22 human 1 Band22q12 2Start30 576 625 bp 1 End30 607 083 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 11 A1Start3 913 975 bp 2 End3 930 004 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insural nervebody of pancreasislet of Langerhansskin of abdomenstromal cell of endometriumbody of stomachleft adrenal glandright adrenal glandleft uterine tuberight lobe of thyroid glandTop expressed ininterventricular septumyolk sacspermatocytespermatidlipotic placodesacculevisual cortexmorulaankle jointMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding RNA binding ribonucleoprotein complex bindingCellular componentmembrane PeBoW complex chromosome nucleolus condensed chromosome nucleus nucleoplasm cytosol preribosome large subunit precursorBiological processprotein localization to organelle ribosome biogenesis regulation of cell cycle nucleolus organization maturation of LSU rRNA from tricistronic rRNA transcript SSU rRNA 5 8S rRNA LSU rRNA cell population proliferation rRNA processing maturation of 5 8S rRNA from tricistronic rRNA transcript SSU rRNA 5 8S rRNA LSU rRNA ribosomal large subunit biogenesisSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez2348164934EnsemblENSG00000100029ENSMUSG00000020430UniProtO00541Q9EQ61RefSeq mRNA NM 001243225NM 001282327NM 001282328NM 014303NM 022889RefSeq protein NP 001230154NP 001269256NP 001269257NP 055118NP 075027Location UCSC Chr 22 30 58 30 61 MbChr 11 3 91 3 93 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene encodes a protein that is abnormally elevated in malignant tumors of astrocytic origin It is a strongly conserved gene containing a BRCT domain that is essential for the activity of this gene product The gene plays a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression 8 References Edit a b c GRCh38 Ensembl release 89 ENSG00000100029 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000020430 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Allende ML Amsterdam A Becker T Kawakami K Gaiano N Hopkins N Jan 1997 Insertional mutagenesis in zebrafish identifies two novel genes pescadillo and dead eye essential for embryonic development Genes Dev 10 24 3141 55 doi 10 1101 gad 10 24 3141 PMID 8985183 Dunham I Shimizu N Roe BA Chissoe S Hunt AR Collins JE Bruskiewich R Beare DM Clamp M Smink LJ Ainscough R Almeida JP Babbage A Bagguley C Bailey J Barlow K Bates KN Beasley O Bird CP Blakey S Bridgeman AM Buck D Burgess J Burrill WD O Brien KP et al Dec 1999 The DNA sequence of human chromosome 22 Nature 402 6761 489 95 Bibcode 1999Natur 402 489D doi 10 1038 990031 PMID 10591208 Rohrmoser M Holzel M Grimm T Malamoussi A Harasim T Orban M Pfisterer I Gruber Eber A Kremmer E Eick D May 2007 Interdependence of Pes1 Bop1 and WDR12 Controls Nucleolar Localization and Assembly of the PeBoW Complex Required for Maturation of the 60S Ribosomal Subunit Mol Cell Biol 27 10 3682 94 doi 10 1128 MCB 00172 07 PMC 1899993 PMID 17353269 a b Entrez Gene PES1 pescadillo homolog 1 containing BRCT domain zebrafish Further reading EditSanger Centre The Washington University Genome Sequencing Cente The 1999 Toward a complete human genome sequence Genome Res 8 11 1097 108 doi 10 1101 gr 8 11 1097 PMID 9847074 Kinoshita Y Jarell AD Flaman JM et al 2001 Pescadillo a novel cell cycle regulatory protein abnormally expressed in malignant cells J Biol Chem 276 9 6656 65 doi 10 1074 jbc M008536200 PMID 11071894 Andersen JS Lyon CE Fox AH et al 2002 Directed proteomic analysis of the human nucleolus Curr Biol 12 1 1 11 doi 10 1016 S0960 9822 01 00650 9 PMID 11790298 Oeffinger M Leung A Lamond A et al 2002 Yeast Pescadillo is required for multiple activities during 60S ribosomal subunit synthesis RNA 8 5 626 36 doi 10 1017 S1355838202020022 PMC 1370283 PMID 12022229 Scherl A Coute Y Deon C et al 2003 Functional Proteomic Analysis of Human Nucleolus Mol Biol Cell 13 11 4100 9 doi 10 1091 mbc E02 05 0271 PMC 133617 PMID 12429849 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Lapik YR Fernandes CJ Lau LF Pestov DG 2004 Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis Mol Cell 15 1 17 29 doi 10 1016 j molcel 2004 05 020 PMID 15225545 Maiorana A Tu X Cheng G Baserga R 2004 Role of pescadillo in the transformation and immortalization of mammalian cells Oncogene 23 42 7116 24 doi 10 1038 sj onc 1207916 PMID 15273728 Collins JE Wright CL Edwards CA et al 2005 A genome annotation driven approach to cloning the human ORFeome Genome Biol 5 10 R84 doi 10 1186 gb 2004 5 10 r84 PMC 545604 PMID 15461802 Killian A Le Meur N Sesboue R et al 2004 Inactivation of the RRB1 Pescadillo pathway involved in ribosome biogenesis induces chromosomal instability Oncogene 23 53 8597 602 doi 10 1038 sj onc 1207845 PMID 15467761 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Andersen JS Lam YW Leung AK et al 2005 Nucleolar proteome dynamics Nature 433 7021 77 83 Bibcode 2005Natur 433 77A doi 10 1038 nature03207 PMID 15635413 S2CID 4344740 Holzel M Rohrmoser M Schlee M et al 2005 Mammalian WDR12 is a novel member of the Pes1 Bop1 complex and is required for ribosome biogenesis and cell proliferation J Cell Biol 170 3 367 78 doi 10 1083 jcb 200501141 PMC 2171466 PMID 16043514 Kimura K Wakamatsu A Suzuki Y et al 2006 Diversification of transcriptional modulation Large scale identification and characterization of putative alternative promoters of human genes Genome Res 16 1 55 65 doi 10 1101 gr 4039406 PMC 1356129 PMID 16344560 Ewing RM Chu P Elisma F et al 2007 Large scale mapping of human protein protein interactions by mass spectrometry Mol Syst Biol 3 1 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 This article on a gene on human chromosome 22 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title PES1 amp oldid 1170976770, wikipedia, wiki, book, books, library,

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