PEF1 is a Ca(2+)-binding protein that belongs to the penta-EF hand (PEF) protein family, which includes the calpain small subunit (CAPNS1; MIM 114170), sorcin (SRI; MIM 182520), grancalcin (GCA; MIM 607030), and ALG2 (PDCD6; MIM 601057) (Kitaura et al., 2001).[supplied by OMIM][7]
^ abcGRCh38: Ensembl release 89: ENSG00000162517 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000028779 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kitaura Y, Watanabe M, Satoh H, Kawai T, Hitomi K, Maki M (Oct 1999). "Peflin, a novel member of the five-EF-hand-protein family, is similar to the apoptosis-linked gene 2 (ALG-2) protein but possesses nonapeptide repeats in the N-terminal hydrophobic region". Biochem Biophys Res Commun. 263 (1): 68–75. doi:10.1006/bbrc.1999.1189. PMID 10486255.
^Kitaura Y, Satoh H, Takahashi H, Shibata H, Maki M (Mar 2002). "Both ALG-2 and peflin, penta-EF-hand (PEF) proteins, are stabilized by dimerization through their fifth EF-hand regions". Arch Biochem Biophys. 399 (1): 12–8. doi:10.1006/abbi.2001.2736. PMID 11883899.
^Kitaura Y, Matsumoto S, Satoh H, Hitomi K, Maki M (Apr 2001). "Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner". J. Biol. Chem. 276 (17): 14053–8. doi:10.1074/jbc.M008649200. ISSN 0021-9258. PMID 11278427.
Further readingedit
Kitaura Y, Matsumoto S, Satoh H, et al. (2001). "Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner". J. Biol. Chem. 276 (17): 14053–8. doi:10.1074/jbc.M008649200. PMID 11278427.
Satoh H, Nakano Y, Shibata H, Maki M (2002). "The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner". Biochim. Biophys. Acta. 1600 (1–2): 61–7. doi:10.1016/S1570-9639(02)00445-4. PMID 12445460.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Hansen C, Tarabykina S, la Cour JM, et al. (2003). "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro". FEBS Lett. 545 (2–3): 151–4. doi:10.1016/S0014-5793(03)00518-0. PMID 12804766. S2CID 42572647.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Jordanova A, Irobi J, Thomas FP, et al. (2006). "Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy". Nat. Genet. 38 (2): 197–202. doi:10.1038/ng1727. PMID 16429158. S2CID 16668375.
This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.
peflin, protein, that, humans, encoded, pef1, gene, pef1identifiersaliasespef1, abp32, pef1a, penta, hand, domain, containing, 1external, idsomim, 610033, 1915148, homologene, 56569, genecards, pef1gene, location, human, chromosome, human, band1p35, 2start31, . Peflin is a protein that in humans is encoded by the PEF1 gene 5 6 7 PEF1IdentifiersAliasesPEF1 ABP32 PEF1A penta EF hand domain containing 1External IDsOMIM 610033 MGI 1915148 HomoloGene 56569 GeneCards PEF1Gene location Human Chr Chromosome 1 human 1 Band1p35 2Start31 629 866 bp 1 End31 644 896 bp 1 Gene location Mouse Chr Chromosome 4 mouse 2 Band4 4 D2 2Start129 996 351 bp 2 End130 021 928 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inleft lobe of thyroid glandright lobe of thyroid glandascending aortaskin of abdomenpopliteal arteryright coronary arteryleft coronary arteryupper lobe of left lungprefrontal cortexright adrenal glandTop expressed induodenumlipfacial motor nucleusproximal tubulesuperior frontal gyrusesophagusjejunumcolonanterior horn of spinal cordadrenal glandMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioncalcium ion binding protein binding protein dimerization activity metal ion binding calcium dependent cysteine type endopeptidase activity protein heterodimerization activity RNA binding calcium dependent protein binding molecular adaptor activityCellular componentcytoplasm extracellular exosome membrane Golgi membrane COPII vesicle coat Cul3 RING ubiquitin ligase complex endoplasmic reticulum ER to Golgi transport vesicle membrane cytoplasmic vesicleBiological processresponse to calcium ion proteolysis endoplasmic reticulum to Golgi vesicle mediated transport neural crest formation neural crest cell development COPII vesicle coating positive regulation of protein monoubiquitinationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez55311567898EnsemblENSG00000162517ENSMUSG00000028779UniProtQ9UBV8Q8BFY6RefSeq mRNA NM 012392NM 001359651NM 026441RefSeq protein NP 036524NP 001346580NP 080717Location UCSC Chr 1 31 63 31 64 MbChr 4 130 130 02 MbPubMed search 3 4 WikidataView Edit HumanView Edit MousePEF1 is a Ca 2 binding protein that belongs to the penta EF hand PEF protein family which includes the calpain small subunit CAPNS1 MIM 114170 sorcin SRI MIM 182520 grancalcin GCA MIM 607030 and ALG2 PDCD6 MIM 601057 Kitaura et al 2001 supplied by OMIM 7 Interactions editPEF1 has been shown to interact with PDCD6 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000162517 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000028779 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Kitaura Y Watanabe M Satoh H Kawai T Hitomi K Maki M Oct 1999 Peflin a novel member of the five EF hand protein family is similar to the apoptosis linked gene 2 ALG 2 protein but possesses nonapeptide repeats in the N terminal hydrophobic region Biochem Biophys Res Commun 263 1 68 75 doi 10 1006 bbrc 1999 1189 PMID 10486255 Kitaura Y Satoh H Takahashi H Shibata H Maki M Mar 2002 Both ALG 2 and peflin penta EF hand PEF proteins are stabilized by dimerization through their fifth EF hand regions Arch Biochem Biophys 399 1 12 8 doi 10 1006 abbi 2001 2736 PMID 11883899 a b Entrez Gene PEF1 penta EF hand domain containing 1 Kitaura Y Matsumoto S Satoh H Hitomi K Maki M Apr 2001 Peflin and ALG 2 members of the penta EF hand protein family form a heterodimer that dissociates in a Ca2 dependent manner J Biol Chem 276 17 14053 8 doi 10 1074 jbc M008649200 ISSN 0021 9258 PMID 11278427 Further reading editKitaura Y Matsumoto S Satoh H et al 2001 Peflin and ALG 2 members of the penta EF hand protein family form a heterodimer that dissociates in a Ca2 dependent manner J Biol Chem 276 17 14053 8 doi 10 1074 jbc M008649200 PMID 11278427 Satoh H Nakano Y Shibata H Maki M 2002 The penta EF hand domain of ALG 2 interacts with amino terminal domains of both annexin VII and annexin XI in a Ca2 dependent manner Biochim Biophys Acta 1600 1 2 61 7 doi 10 1016 S1570 9639 02 00445 4 PMID 12445460 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Hansen C Tarabykina S la Cour JM et al 2003 The PEF family proteins sorcin and grancalcin interact in vivo and in vitro FEBS Lett 545 2 3 151 4 doi 10 1016 S0014 5793 03 00518 0 PMID 12804766 S2CID 42572647 Clark HF Gurney AL Abaya E et al 2003 The secreted protein discovery initiative SPDI a large scale effort to identify novel human secreted and transmembrane proteins a bioinformatics assessment Genome Res 13 10 2265 70 doi 10 1101 gr 1293003 PMC 403697 PMID 12975309 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Jordanova A Irobi J Thomas FP et al 2006 Disrupted function and axonal distribution of mutant tyrosyl tRNA synthetase in dominant intermediate Charcot Marie Tooth neuropathy Nat Genet 38 2 197 202 doi 10 1038 ng1727 PMID 16429158 S2CID 16668375 nbsp This article on a gene on human chromosome 1 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Peflin amp oldid 1194506222, wikipedia, wiki, book, books, library,
