The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein–protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000196923 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000021493 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Liu Y, Hair GA, Boden SD, Viggeswarapu M, Titus L (March 2002). "Overexpressed LIM mineralization proteins do not require LIM domains to induce bone". Journal of Bone and Mineral Research. 17 (3): 406–14. doi:10.1359/jbmr.2002.17.3.406. PMID 11874232. S2CID 26089809.
^ ab"Entrez Gene: PDLIM7 PDZ and LIM domain 7 (enigma)".
^Guy PM, Kenny DA, Gill GN (June 1999). "The PDZ domain of the LIM protein enigma binds to beta-tropomyosin". Molecular Biology of the Cell. 10 (6): 1973–84. doi:10.1091/mbc.10.6.1973. PMC25398. PMID 10359609.
Further readingedit
Bach I (March 2000). "The LIM domain: regulation by association". Mechanisms of Development. 91 (1–2): 5–17. doi:10.1016/S0925-4773(99)00314-7. PMID 10704826. S2CID 16093470.
Wu RY, Gill GN (October 1994). "LIM domain recognition of a tyrosine-containing tight turn". The Journal of Biological Chemistry. 269 (40): 25085–90. doi:10.1016/S0021-9258(17)31502-8. PMID 7929196.
Kuroda S, Tokunaga C, Kiyohara Y, Higuchi O, Konishi H, Mizuno K, et al. (December 1996). "Protein-protein interaction of zinc finger LIM domains with protein kinase C". The Journal of Biological Chemistry. 271 (49): 31029–32. doi:10.1074/jbc.271.49.31029. PMID 8940095.
Durick K, Gill GN, Taylor SS (April 1998). "Shc and Enigma are both required for mitogenic signaling by Ret/ptc2". Molecular and Cellular Biology. 18 (4): 2298–308. doi:10.1128/mcb.18.4.2298. PMC121481. PMID 9528800.
Guy PM, Kenny DA, Gill GN (June 1999). "The PDZ domain of the LIM protein enigma binds to beta-tropomyosin". Molecular Biology of the Cell. 10 (6): 1973–84. doi:10.1091/mbc.10.6.1973. PMC25398. PMID 10359609.
Borrello MG, Mercalli E, Perego C, Degl'Innocenti D, Ghizzoni S, Arighi E, et al. (August 2002). "Differential interaction of Enigma protein with the two RET isoforms". Biochemical and Biophysical Research Communications. 296 (3): 515–22. doi:10.1016/S0006-291X(02)00886-0. PMID 12176011.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Sangadala S, Boden SD, Viggeswarapu M, Liu Y, Titus L (June 2006). "LIM mineralization protein-1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads". The Journal of Biological Chemistry. 281 (25): 17212–9. doi:10.1074/jbc.M511013200. PMID 16611643.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Barrès R, Grémeaux T, Gual P, Gonzalez T, Gugenheim J, Tran A, et al. (November 2006). "Enigma interacts with adaptor protein with PH and SH2 domains to control insulin-induced actin cytoskeleton remodeling and glucose transporter 4 translocation". Molecular Endocrinology. 20 (11): 2864–75. doi:10.1210/me.2005-0455. PMC1892539. PMID 16803868.
This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.
pdlim7, domain, protein, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2q3gidentifiersaliases, lmp1, lmp3, domain, 7external, idsomim, 605903, 1914649, homologene, 3980, genecards, gene, location, human, c. PDZ and LIM domain protein 7 is a protein that in humans is encoded by the PDLIM7 gene 5 6 PDLIM7Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2Q3GIdentifiersAliasesPDLIM7 LMP1 LMP3 PDZ and LIM domain 7External IDsOMIM 605903 MGI 1914649 HomoloGene 3980 GeneCards PDLIM7Gene location Human Chr Chromosome 5 human 1 Band5q35 3Start177 483 394 bp 1 End177 497 606 bp 1 Gene location Mouse Chr Chromosome 13 mouse 2 Band13 13 B1Start55 643 608 bp 2 End55 661 489 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright coronary arteryascending aortapopliteal arteryleft uterine tubegastric mucosaleft coronary arterycanal of the cervixstromal cell of endometriumgastrocnemius muscletibial nerveTop expressed insacculeexternal carotid arteryinternal carotid arteryotic placodeascending aortasuperior frontal gyrusuterusmolaraortic valveextensor digitorum longus muscleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding metal ion binding actin binding muscle alpha actinin bindingCellular componentcytoplasm ruffle cytoskeleton nucleus stress fiber focal adhesion actin cytoskeleton cytosol Z disc filamentous actinBiological processmulticellular organism development cell differentiation positive regulation of osteoblast differentiation receptor mediated endocytosis actin cytoskeleton organization ossification axon guidance heart development muscle structure developmentSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez926067399EnsemblENSG00000196923ENSMUSG00000021493UniProtQ9NR12Q3TJD7RefSeq mRNA NM 005451NM 203352NM 203353NM 213636NM 001114087NM 001114088NM 026131RefSeq protein NP 005442NP 976227NP 998801NP 001107559NP 001107560NP 080407Location UCSC Chr 5 177 48 177 5 MbChr 13 55 64 55 66 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains LIM domains are proposed to function in protein protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction The LIM domains of this protein bind to protein kinases whereas the PDZ domain binds to actin filaments The gene product is involved in the assembly of an actin filament associated complex essential for transmission of ret ptc2 mitogenic signaling The biological function is likely to be that of an adapter with the PDZ domain localizing the LIM binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues Alternative splicing of this gene results in multiple transcript variants 6 Interactions editPDLIM7 has been shown to interact with TPM2 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000196923 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000021493 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Liu Y Hair GA Boden SD Viggeswarapu M Titus L March 2002 Overexpressed LIM mineralization proteins do not require LIM domains to induce bone Journal of Bone and Mineral Research 17 3 406 14 doi 10 1359 jbmr 2002 17 3 406 PMID 11874232 S2CID 26089809 a b Entrez Gene PDLIM7 PDZ and LIM domain 7 enigma Guy PM Kenny DA Gill GN June 1999 The PDZ domain of the LIM protein enigma binds to beta tropomyosin Molecular Biology of the Cell 10 6 1973 84 doi 10 1091 mbc 10 6 1973 PMC 25398 PMID 10359609 Further reading editBach I March 2000 The LIM domain regulation by association Mechanisms of Development 91 1 2 5 17 doi 10 1016 S0925 4773 99 00314 7 PMID 10704826 S2CID 16093470 Wu RY Gill GN October 1994 LIM domain recognition of a tyrosine containing tight turn The Journal of Biological Chemistry 269 40 25085 90 doi 10 1016 S0021 9258 17 31502 8 PMID 7929196 Kuroda S Tokunaga C Kiyohara Y Higuchi O Konishi H Mizuno K et al December 1996 Protein protein interaction of zinc finger LIM domains with protein kinase C The Journal of Biological Chemistry 271 49 31029 32 doi 10 1074 jbc 271 49 31029 PMID 8940095 Durick K Gill GN Taylor SS April 1998 Shc and Enigma are both required for mitogenic signaling by Ret ptc2 Molecular and Cellular Biology 18 4 2298 308 doi 10 1128 mcb 18 4 2298 PMC 121481 PMID 9528800 Guy PM Kenny DA Gill GN June 1999 The PDZ domain of the LIM protein enigma binds to beta tropomyosin Molecular Biology of the Cell 10 6 1973 84 doi 10 1091 mbc 10 6 1973 PMC 25398 PMID 10359609 Borrello MG Mercalli E Perego C Degl Innocenti D Ghizzoni S Arighi E et al August 2002 Differential interaction of Enigma protein with the two RET isoforms Biochemical and Biophysical Research Communications 296 3 515 22 doi 10 1016 S0006 291X 02 00886 0 PMID 12176011 Andersen JS Lam YW Leung AK Ong SE Lyon CE Lamond AI Mann M January 2005 Nucleolar proteome dynamics Nature 433 7021 77 83 Bibcode 2005Natur 433 77A doi 10 1038 nature03207 PMID 15635413 S2CID 4344740 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N et al October 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Sangadala S Boden SD Viggeswarapu M Liu Y Titus L June 2006 LIM mineralization protein 1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads The Journal of Biological Chemistry 281 25 17212 9 doi 10 1074 jbc M511013200 PMID 16611643 Lim J Hao T Shaw C Patel AJ Szabo G Rual JF et al May 2006 A protein protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration Cell 125 4 801 14 doi 10 1016 j cell 2006 03 032 PMID 16713569 S2CID 13709685 Barres R Gremeaux T Gual P Gonzalez T Gugenheim J Tran A et al November 2006 Enigma interacts with adaptor protein with PH and SH2 domains to control insulin induced actin cytoskeleton remodeling and glucose transporter 4 translocation Molecular Endocrinology 20 11 2864 75 doi 10 1210 me 2005 0455 PMC 1892539 PMID 16803868 nbsp This article on a gene on human chromosome 5 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title PDLIM7 amp oldid 1170991489, wikipedia, wiki, book, books, library,
