This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000124171 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000044641 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abcdNoda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H (March 2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C". Genes Cells. 6 (2): 107–19. doi:10.1046/j.1365-2443.2001.00404.x. PMID 11260256. S2CID 8789941.
^ abJoberty G, Petersen C, Gao L, Macara IG (August 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. S2CID 27139234.
Further readingedit
Joberty G, Petersen C, Gao L, Macara IG (2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. S2CID 27139234.
Gao L, Macara IG, Joberty G (2003). "Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties". Gene. 294 (1–2): 99–107. doi:10.1016/S0378-1119(02)00681-9. PMID 12234671.
Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (2003). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem. Biophys. Res. Commun. 299 (4): 641–6. doi:10.1016/S0006-291X(02)02698-0. PMID 12459187.
Hurd TW, Gao L, Roh MH, Macara IG, Margolis B (2003). "Direct interaction of two polarity complexes implicated in epithelial tight junction assembly". Nat. Cell Biol. 5 (2): 137–42. doi:10.1038/ncb923. PMID 12545177. S2CID 25212419.
Yamanaka T, Horikoshi Y, Sugiyama Y, Ishiyama C, Suzuki A, Hirose T, Iwamatsu A, Shinohara A, Ohno S (2004). "Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity". Curr. Biol. 13 (9): 734–43. doi:10.1016/S0960-9822(03)00244-6. PMID 12725730. S2CID 18570360.
Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
Labhart P, Karmakar S, Salicru EM, Egan BS, Alexiadis V, O'Malley BW, Smith CL (2005). "Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1339–44. Bibcode:2005PNAS..102.1339L. doi:10.1073/pnas.0409578102. PMC547886. PMID 15677324.
This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.
pard6b, partitioning, defective, homolog, beta, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1nf3identifiersaliases, par6b, family, cell, polarity, regulator, betaexternal, idsomim, 608975, 2135605, homol. Partitioning defective 6 homolog beta is a protein that in humans is encoded by the PARD6B gene 5 6 PARD6BAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes1NF3IdentifiersAliasesPARD6B PAR6B par 6 family cell polarity regulator betaExternal IDsOMIM 608975 MGI 2135605 HomoloGene 23302 GeneCards PARD6BGene location Human Chr Chromosome 20 human 1 Band20q13 13Start50 731 580 bp 1 End50 756 795 bp 1 Gene location Mouse Chr Chromosome 2 mouse 2 Band2 2 H3Start167 922 924 bp 2 End167 943 123 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed ingerminal epitheliumrenal medullaretinal pigment epitheliumpalpebral conjunctivaamniotic fluidjejunal mucosalower lobe of lungbronchial epithelial cellcorpus epididymisspermTop expressed insecondary oocyteleft lung loberenal corpusclemedullary collecting ductright lung lobeyolk sacjejunumretinal pigment epitheliumepithelium of stomachduodenumMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding protein kinase C bindingCellular componentmembrane bicellular tight junction plasma membrane apical part of cell cell junction cell cortex extracellular exosome nucleus cytoplasm cytosol apical plasma membrane protein containing complexBiological processregulation of cell migration axonogenesis cell division bicellular tight junction assembly cell cycle cell cell junction assembly establishment or maintenance of cell polarity centrosome cycle regulation of cellular localization protein containing complex assemblySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8461258220EnsemblENSG00000124171ENSMUSG00000044641UniProtQ9BYG5Q9JK83RefSeq mRNA NM 032521NM 021409RefSeq protein NP 115910NP 067384Location UCSC Chr 20 50 73 50 76 MbChr 2 167 92 167 94 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further readingFunction editThis gene is a member of the PAR6 family and encodes a protein with a PSD95 Discs large ZO1 PDZ domain an OPR domain and a semi Cdc42 Rac interactive binding CRIB domain This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi protein complex 6 Interactions editPARD6B has been shown to interact with CDC42 5 7 8 Protein kinase Mz 5 RAC1 5 and RHOQ 7 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000124171 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000044641 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b c d Noda Y Takeya R Ohno S Naito S Ito T Sumimoto H March 2001 Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C Genes Cells 6 2 107 19 doi 10 1046 j 1365 2443 2001 00404 x PMID 11260256 S2CID 8789941 a b Entrez Gene PARD6B par 6 partitioning defective 6 homolog beta C elegans a b Neudauer CL Joberty G Macara IG January 2001 PIST a novel PDZ coiled coil domain binding partner for the rho family GTPase TC10 Biochem Biophys Res Commun 280 2 541 7 doi 10 1006 bbrc 2000 4160 PMID 11162552 a b Joberty G Petersen C Gao L Macara IG August 2000 The cell polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42 Nat Cell Biol 2 8 531 9 doi 10 1038 35019573 PMID 10934474 S2CID 27139234 Further reading editJoberty G Petersen C Gao L Macara IG 2000 The cell polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42 Nat Cell Biol 2 8 531 9 doi 10 1038 35019573 PMID 10934474 S2CID 27139234 Gao L Macara IG Joberty G 2003 Multiple splice variants of Par3 and of a novel related gene Par3L produce proteins with different binding properties Gene 294 1 2 99 107 doi 10 1016 S0378 1119 02 00681 9 PMID 12234671 Kohjima M Noda Y Takeya R Saito N Takeuchi K Sumimoto H 2003 PAR3beta a novel homologue of the cell polarity protein PAR3 localizes to tight junctions Biochem Biophys Res Commun 299 4 641 6 doi 10 1016 S0006 291X 02 02698 0 PMID 12459187 Hurd TW Gao L Roh MH Macara IG Margolis B 2003 Direct interaction of two polarity complexes implicated in epithelial tight junction assembly Nat Cell Biol 5 2 137 42 doi 10 1038 ncb923 PMID 12545177 S2CID 25212419 Yamanaka T Horikoshi Y Sugiyama Y Ishiyama C Suzuki A Hirose T Iwamatsu A Shinohara A Ohno S 2004 Mammalian Lgl forms a protein complex with PAR 6 and aPKC independently of PAR 3 to regulate epithelial cell polarity Curr Biol 13 9 734 43 doi 10 1016 S0960 9822 03 00244 6 PMID 12725730 S2CID 18570360 Brajenovic M Joberty G Kuster B Bouwmeester T Drewes G 2004 Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network J Biol Chem 279 13 12804 11 doi 10 1074 jbc M312171200 PMID 14676191 Labhart P Karmakar S Salicru EM Egan BS Alexiadis V O Malley BW Smith CL 2005 Identification of target genes in breast cancer cells directly regulated by the SRC 3 AIB1 coactivator Proc Natl Acad Sci U S A 102 5 1339 44 Bibcode 2005PNAS 102 1339L doi 10 1073 pnas 0409578102 PMC 547886 PMID 15677324 nbsp This article on a gene on human chromosome 20 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title PARD6B amp oldid 1116595869, wikipedia, wiki, book, books, library,
