PIK3R2

Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene.^[4][5]

PIK3R2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KT1, 2XS6, 3MTT, 3O5Z
Identifiers
Aliases	PIK3R2, MPPH, MPPH1, P85B, p85, p85-BETA, phosphoinositide-3-kinase regulatory subunit 2
External IDs	OMIM: 603157 MGI: 1098772 HomoloGene: 3687 GeneCards: PIK3R2
Gene location (Mouse) Chr. Chromosome 8 (mouse)^[1] Band 8 B3.3|8 34.15 cM Start 71,220,820 bp^[1] End 71,229,357 bp^[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence stromal cell of endometrium prefrontal cortex hippocampus proper superior frontal gyrus left adrenal gland nucleus accumbens temporal lobe amygdala caudate nucleus Top expressed in superior frontal gyrus hippocampus proper olfactory bulb cerebellum ganglionic eminence lip cerebellar cortex urinary bladder neural tube mesencephalon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol 3-kinase regulator activity receptor tyrosine kinase binding 1-phosphatidylinositol-3-kinase regulator activity protein binding protein heterodimerization activity protein phosphatase binding GTPase activator activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity phosphotyrosine residue binding 1-phosphatidylinositol-3-kinase activity Cellular component cytosol phosphatidylinositol 3-kinase complex nucleus Biological process Fc-gamma receptor signaling pathway involved in phagocytosis cellular glucose homeostasis response to endoplasmic reticulum stress Fc-epsilon receptor signaling pathway phosphatidylinositol phosphate biosynthetic process vascular endothelial growth factor receptor signaling pathway regulation of autophagy regulation of phosphatidylinositol 3-kinase activity cellular response to insulin stimulus protein transport phosphatidylinositol 3-kinase signaling T cell receptor signaling pathway regulation of small GTPase mediated signal transduction phosphatidylinositol-mediated signaling leukocyte migration positive regulation of transcription by RNA polymerase II signal transduction insulin receptor signaling pathway positive regulation of GTPase activity phosphatidylinositol-3-phosphate biosynthetic process negative regulation of MAPK cascade positive regulation of protein kinase B signaling positive regulation of protein import into nucleus phosphatidylinositol biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5296 18709 Ensembl n/a ENSMUSG00000031834 UniProt O00459 O08908 RefSeq (mRNA) NM_005027 NM_008841 RefSeq (protein) NP_005018 NP_032867 Location (UCSC) n/a Chr 8: 71.22 – 71.23 Mb PubMed search ^[2] ^[3]
Wikidata
View/Edit Human View/Edit Mouse

A recent study on gene expression indicated that the PIK3R2 gene might have a key role in pan-cancer prognosis.^[6]

Interactions

PIK3R2 has been shown to interact with:

• CRKL^[7]
• Cbl gene,^[8][9]
• Epidermal growth factor,^[10]
• FYN,^[10]
• HER2/neu,^[10]
• Macrophage colony-stimulating factor,^[10] and
• PIK3CD.^[11]

Clinical relevance

PIK3R2 mutations were recently shown to be associated with polymicrogyria.^[12]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000031834 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Volinia S, Patracchini P, Otsu M, Hiles I, Gout I, Calzolari E, et al. (April 1992). "Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta". Oncogene. 7 (4): 789–793. PMID 1314371.
5. "Entrez Gene: PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)".
6. Chicco D, Alameer A, Rahmati S, Jurman G (November 2022). "Towards a potential pan-cancer prognostic signature for gene expression based on probesets and ensemble machine learning". BioData Mining. 15 (1): 28. doi:10.1186/s13040-022-00312-y. eISSN 1756-0381. PMC 9632055. PMID 36329531.
7. Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". The Journal of Biological Chemistry. 272 (15): 10248–10253. doi:10.1074/jbc.272.15.10248. PMID 9092574.
8. Lin H, Martelli MP, Bierer BE (January 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation". International Immunology. 13 (1): 13–22. doi:10.1093/intimm/13.1.13. PMID 11133830.
9. Hartley D, Meisner H, Corvera S (August 1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl". The Journal of Biological Chemistry. 270 (31): 18260–18263. doi:10.1074/jbc.270.31.18260. PMID 7629144.
10. Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (December 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". The Biochemical Journal. 288 ( Pt 2) (2): 395–405. doi:10.1042/bj2880395. PMC 1132024. PMID 1334406.
11. Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, et al. (April 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proceedings of the National Academy of Sciences of the United States of America. 94 (9): 4330–4335. Bibcode:1997PNAS...94.4330V. doi:10.1073/pnas.94.9.4330. PMC 20722. PMID 9113989.
12. Mirzaa GM, Conti V, Timms AE, Smyser CD, Ahmed S, Carter M, et al. (December 2015). "Characterisation of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next-generation sequencing study". The Lancet. Neurology. 14 (12): 1182–1195. doi:10.1016/S1474-4422(15)00278-1. PMC 4672724. PMID 26520804.

Further reading

• Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG (November 2003). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". Journal of Leukocyte Biology. 74 (5): 676–682. doi:10.1189/jlb.0503206. PMID 12960231. S2CID 11362623.
• Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (December 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". The Biochemical Journal. 288 ( Pt 2) (2): 395–405. doi:10.1042/bj2880395. PMC 1132024. PMID 1334406.
• Carpenter CL, Duckworth BC, Auger KR, Cohen B, Schaffhausen BS, Cantley LC (November 1990). "Purification and characterization of phosphoinositide 3-kinase from rat liver". The Journal of Biological Chemistry. 265 (32): 19704–19711. doi:10.1016/S0021-9258(17)45429-9. PMID 2174051.
• Truitt KE, Hicks CM, Imboden JB (March 1994). "Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells". The Journal of Experimental Medicine. 179 (3): 1071–1076. doi:10.1084/jem.179.3.1071. PMC 2191424. PMID 7509360.
• Herbst R, Shearman MS, Jallal B, Schlessinger J, Ullrich A (May 1995). "Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro". Biochemistry. 34 (17): 5971–5979. doi:10.1021/bi00017a026. PMID 7537096.
• Craparo A, O'Neill TJ, Gustafson TA (June 1995). "Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor". The Journal of Biological Chemistry. 270 (26): 15639–15643. doi:10.1074/jbc.270.26.15639. PMID 7541045.
• He W, O'Neill TJ, Gustafson TA (October 1995). "Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains". The Journal of Biological Chemistry. 270 (40): 23258–23262. doi:10.1074/jbc.270.40.23258. PMID 7559478.
• Kapeller R, Toker A, Cantley LC, Carpenter CL (October 1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin". The Journal of Biological Chemistry. 270 (43): 25985–25991. doi:10.1074/jbc.270.43.25985. PMID 7592789.
• Hartley D, Meisner H, Corvera S (August 1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl". The Journal of Biological Chemistry. 270 (31): 18260–18263. doi:10.1074/jbc.270.31.18260. PMID 7629144.
• Pandey A, Lazar DF, Saltiel AR, Dixit VM (December 1994). "Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity". The Journal of Biological Chemistry. 269 (48): 30154–30157. doi:10.1016/S0021-9258(18)43790-8. PMID 7982920.
• August A, Dupont B (May 1994). "CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase". International Immunology. 6 (5): 769–774. doi:10.1093/intimm/6.5.769. PMID 8080844.
• Fukazawa T, Miyake S, Band V, Band H (June 1996). "Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins". The Journal of Biological Chemistry. 271 (24): 14554–14559. doi:10.1074/jbc.271.24.14554. PMID 8662998.
• Milani D, Mazzoni M, Borgatti P, Zauli G, Cantley L, Capitani S (September 1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells". The Journal of Biological Chemistry. 271 (38): 22961–22964. doi:10.1074/jbc.271.38.22961. PMID 8798481.
• Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". The Journal of Biological Chemistry. 272 (15): 10248–10253. doi:10.1074/jbc.272.15.10248. PMID 9092574.
• Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, et al. (April 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proceedings of the National Academy of Sciences of the United States of America. 94 (9): 4330–4335. Bibcode:1997PNAS...94.4330V. doi:10.1073/pnas.94.9.4330. PMC 20722. PMID 9113989.
• Briand G, Barbeau B, Tremblay M (February 1997). "Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the phosphatidylinositol 3-kinase". Virology. 228 (2): 171–179. doi:10.1006/viro.1996.8399. PMID 9123823.
• Braunger J, Schleithoff L, Schulz AS, Kessler H, Lammers R, Ullrich A, et al. (June 1997). "Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site". Oncogene. 14 (22): 2619–2631. doi:10.1038/sj.onc.1201123. PMID 9178760.
• Shepherd PR, Navé BT, Rincon J, Nolte LA, Bevan AP, Siddle K, et al. (July 1997). "Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle". The Journal of Biological Chemistry. 272 (30): 19000–19007. doi:10.1074/jbc.272.30.19000. PMID 9228082.
• Mazerolles F, Barbat C, Fischer A (September 1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". European Journal of Immunology. 27 (9): 2457–2465. doi:10.1002/eji.1830270946. PMID 9341793. S2CID 33397908.