Orotate reductase (NADPH)

In enzymology, an orotate reductase (NADPH) (EC 1.3.1.15) is an enzyme that catalyzes the chemical reaction

orotate reductase (NADPH)
Identifiers
EC no.	1.3.1.15
CAS no.	37255-27-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

(S)-dihydroorotate + NADP⁺ ${\displaystyle \rightleftharpoons }$ orotate + NADPH + H⁺

Thus, the two substrates of this enzyme are (S)-dihydroorotate and NADP⁺, whereas its 3 products are orotate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-dihydroorotate:NADP+ oxidoreductase. Other names in common use include orotate reductase, dihydroorotate dehydrogenase, dihydro-orotic dehydrogenase, L-5,6-dihydro-orotate:NAD+ oxidoreductase, and orotate reductase (NADPH). It has one cofactor, FAD.

References

• Taylor WH, Taylor ML, Eames DF (1966). "Two functionally different dihydroorotic dehydrogenases in bacteria". J. Bacteriol. 91 (6): 2251–6. PMC 316202. PMID 4380263.
• Ukada S, Vennesland B (1962). "Properties of triphosphopyridine nucleotide-linked dihydroorotic dehydrogenase". J. Biol. Chem. 237: 2018–2024. PMID 13923427.