Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitters and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals.[5]
Clinical significanceedit
Variation in the OR6A2 gene has been identified as a likely cause of why some people enjoy the smell and taste of coriander (also known as cilantro)[6] while others have exactly the opposite reaction to the point of repulsion. Depending on ancestry, somewhere between 3% and 21% of the population associate it with unpleasant taste, including a combination of soap and vomit, or say that it is similar to the foul smelling odor emitted by stinkbugs. This is due to the presence of aldehyde chemicals,[7] which are present in soap, various detergents, coriander, and several species of stinkbugs.[citation needed]
^ abcGRCh38: Ensembl release 89: ENSG00000184933 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000070417 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ab"Entrez Gene: OR6A2 olfactory receptor, family 6, subfamily A, member 2".
^Eriksson N; Wu S; Chuong BD; et al. (29 November 2012). "A genetic variant near olfactory receptor genes influences cilantro preference". Flavour. 1. arXiv:1209.2096. doi:10.1186/2044-7248-1-22. S2CID 199627.
^Callaway E (September 2012). "Soapy taste of coriander linked to genetic variants". Nature. doi:10.1038/nature.2012.11398. S2CID 87980895.
Further readingedit
Buettner JA, Glusman G, Ben-Arie N, et al. (1998). "Organization and evolution of olfactory receptor genes on human chromosome 11". Genomics. 53 (1): 56–68. doi:10.1006/geno.1998.5422. PMID 9787077.
Lane RP, Cutforth T, Young J, et al. (2001). "Genomic analysis of orthologous mouse and human olfactory receptor loci". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7390–5. Bibcode:2001PNAS...98.7390L. doi:10.1073/pnas.131215398. PMC34679. PMID 11416212.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC356993. PMID 14983052.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
or6a2, olfactory, receptor, protein, that, humans, encoded, gene, class, tetrapod, specific, olfactory, receptor, rhodopsin, like, receptor, identifiersaliases, or11, or6a1, olfactory, receptor, family, subfamily, member, 2external, idsomim, 608495, 97432, hom. Olfactory receptor 6A2 is a protein that in humans is encoded by the OR6A2 gene 5 It is Class II tetrapod specific olfactory receptor and a rhodopsin like receptor OR6A2IdentifiersAliasesOR6A2 I7 OR11 55 OR6A1 OR6A2P olfactory receptor family 6 subfamily A member 2External IDsOMIM 608495 MGI 97432 HomoloGene 2743 GeneCards OR6A2Gene location Human Chr Chromosome 11 human 1 Band11p15 4Start6 791 736 bp 1 End6 799 689 bp 1 Gene location Mouse Chr Chromosome 7 mouse 2 Band7 7 E3Start106 594 606 bp 2 End106 605 279 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inorgan systemreproductive systemreproductive organmale reproductive systemgonadtesticleTop expressed inJacobson s organsecondary oocyteyolk sacperipheral nervous systemvastus lateralis musclerespiratory epitheliumolfactory epitheliumMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionG protein coupled receptor activity olfactory receptor activity signal transducer activityCellular componentintegral component of membrane plasma membrane membraneBiological processsensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein coupled receptor signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez859018317EnsemblENSG00000184933ENSMUSG00000070417UniProtO95222n aRefSeq mRNA NM 003696NM 010983RefSeq protein NP 003687n aLocation UCSC Chr 11 6 79 6 8 MbChr 7 106 59 106 61 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Clinical significance 3 See also 4 References 5 Further reading 6 External linksFunction editOlfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell The olfactory receptor proteins are members of a large family of G protein coupled receptors GPCR arising from single coding exon genes Olfactory receptors share a 7 transmembrane domain structure with many neurotransmitters and hormone receptors and are responsible for the recognition and G protein mediated transduction of odorant signals 5 Clinical significance editVariation in the OR6A2 gene has been identified as a likely cause of why some people enjoy the smell and taste of coriander also known as cilantro 6 while others have exactly the opposite reaction to the point of repulsion Depending on ancestry somewhere between 3 and 21 of the population associate it with unpleasant taste including a combination of soap and vomit or say that it is similar to the foul smelling odor emitted by stinkbugs This is due to the presence of aldehyde chemicals 7 which are present in soap various detergents coriander and several species of stinkbugs citation needed See also editOlfactory receptorReferences edit a b c GRCh38 Ensembl release 89 ENSG00000184933 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000070417 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene OR6A2 olfactory receptor family 6 subfamily A member 2 Eriksson N Wu S Chuong BD et al 29 November 2012 A genetic variant near olfactory receptor genes influences cilantro preference Flavour 1 arXiv 1209 2096 doi 10 1186 2044 7248 1 22 S2CID 199627 Callaway E September 2012 Soapy taste of coriander linked to genetic variants Nature doi 10 1038 nature 2012 11398 S2CID 87980895 Further reading editBuettner JA Glusman G Ben Arie N et al 1998 Organization and evolution of olfactory receptor genes on human chromosome 11 Genomics 53 1 56 68 doi 10 1006 geno 1998 5422 PMID 9787077 Lane RP Cutforth T Young J et al 2001 Genomic analysis of orthologous mouse and human olfactory receptor loci Proc Natl Acad Sci U S A 98 13 7390 5 Bibcode 2001PNAS 98 7390L doi 10 1073 pnas 131215398 PMC 34679 PMID 11416212 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Malnic B Godfrey PA Buck LB 2004 The human olfactory receptor gene family Proc Natl Acad Sci U S A 101 8 2584 9 Bibcode 2004PNAS 101 2584M doi 10 1073 pnas 0307882100 PMC 356993 PMID 14983052 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 External links editOR6A2 protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This transmembrane receptor related article is a stub You can help Wikipedia by expanding it vte 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