This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternate splicing of this gene results in three transcript variants encoding two different isoforms.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000084453 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000063975 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kullak-Ublick GA, Beuers U, Meier PJ, Domdey H, Paumgartner G (Apr 1997). "Assignment of the human organic anion transporting polypeptide (OATP) gene to chromosome 12p12 by fluorescence in situ hybridization". J Hepatol. 25 (6): 985–7. doi:10.1016/S0168-8278(96)80307-2. PMID 9007731.
Meier PJ, Eckhardt U, Schroeder A, et al. (1998). "Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver". Hepatology. 26 (6): 1667–77. doi:10.1002/hep.510260641. PMID 9398014. S2CID 20039812.
Kullak-Ublick GA, Hagenbuch B, Stieger B, et al. (1995). "Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver". Gastroenterology. 109 (4): 1274–82. doi:10.1016/0016-5085(95)90588-X. PMID 7557095.
Kullak-Ublick GA, Beuers U, Fahney C, et al. (1997). "Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene". Hepatology. 26 (4): 991–7. doi:10.1002/hep.510260429. PMID 9328325. S2CID 43606355.
Kullak-Ublick GA, Fisch T, Oswald M, et al. (1998). "Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain". FEBS Lett. 424 (3): 173–6. doi:10.1016/S0014-5793(98)00168-9. PMID 9539145. S2CID 21231745.
König J, Cui Y, Nies AT, Keppler D (2000). "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide". J. Biol. Chem. 275 (30): 23161–8. doi:10.1074/jbc.M001448200. PMID 10779507.
Tamai I, Nezu J, Uchino H, et al. (2000). "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family". Biochem. Biophys. Res. Commun. 273 (1): 251–60. doi:10.1006/bbrc.2000.2922. PMID 10873595.
Speek M (2001). "Antisense Promoter of Human L1 Retrotransposon Drives Transcription of Adjacent Cellular Genes". Mol. Cell. Biol. 21 (6): 1973–85. doi:10.1128/MCB.21.6.1973-1985.2001. PMC86790. PMID 11238933.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Lee W, Glaeser H, Smith LH, et al. (2005). "Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry". J. Biol. Chem. 280 (10): 9610–7. doi:10.1074/jbc.M411092200. PMID 15632119.
Su Y, Zhang X, Sinko PJ (2005). "Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells". Mol. Pharm. 1 (1): 49–56. doi:10.1021/mp0340136. PMID 15832500.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC1356129. PMID 16344560.
solute, carrier, organic, anion, transporter, family, member, protein, that, humans, encoded, slco1a2, gene, slco1a2identifiersaliasesslco1a2, oatp, oatp, oatp1a2, slc21a3, solute, carrier, organic, anion, transporter, family, member, 1a2external, idsomim, 602. Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene 5 6 SLCO1A2IdentifiersAliasesSLCO1A2 OATP OATP A OATP1A2 SLC21A3 solute carrier organic anion transporter family member 1A2External IDsOMIM 602883 MGI 1351865 HomoloGene 56603 GeneCards SLCO1A2Gene location Human Chr Chromosome 12 human 1 Band12p12 1Start21 264 600 bp 1 End21 419 594 bp 1 Gene location Mouse Chr Chromosome 6 mouse 2 Band6 6 G2Start142 179 953 bp 2 End142 268 707 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed incorpus callosumamygdalaoptic nerveputamensubstantia nigrahypothalamuscaudate nucleushippocampus properBrodmann area 9nucleus accumbensTop expressed inseminal vesiculastria vascularissalivary glandchoroid plexusolfactory epitheliumsubmandibular glandlacrimal glandparotid glandmorulasecondary oocyteMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontransporter activity organic anion transmembrane transporter activity bile acid transmembrane transporter activity sodium independent organic anion transmembrane transporter activityCellular componentintegral component of membrane membrane plasma membrane integral component of plasma membraneBiological procession transport organic anion transport bile acid and bile salt transport sodium independent organic anion transport transmembrane transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez6579108096EnsemblENSG00000084453ENSMUSG00000063975UniProtP46721Q91YY5RefSeq mRNA NM 005075NM 021094NM 134431NM 001267707NM 130861RefSeq protein NP 066580NP 602307NP 001254636NP 570931Location UCSC Chr 12 21 26 21 42 MbChr 6 142 18 142 27 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene encodes a sodium independent transporter which mediates cellular uptake of organic ions in the liver Its substrates include bile acids bromosulphophthalein and some steroidal compounds The protein is a member of the SLC21A family of solute carriers Alternate splicing of this gene results in three transcript variants encoding two different isoforms 6 See also EditSolute carrier familyReferences Edit a b c GRCh38 Ensembl release 89 ENSG00000084453 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000063975 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Kullak Ublick GA Beuers U Meier PJ Domdey H Paumgartner G Apr 1997 Assignment of the human organic anion transporting polypeptide OATP gene to chromosome 12p12 by fluorescence in situ hybridization J Hepatol 25 6 985 7 doi 10 1016 S0168 8278 96 80307 2 PMID 9007731 a b Entrez Gene SLCO1A2 solute carrier organic anion transporter family member 1A2 Further reading EditMeier PJ Eckhardt U Schroeder A et al 1998 Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver Hepatology 26 6 1667 77 doi 10 1002 hep 510260641 PMID 9398014 S2CID 20039812 Kullak Ublick GA Hagenbuch B Stieger B et al 1995 Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver Gastroenterology 109 4 1274 82 doi 10 1016 0016 5085 95 90588 X PMID 7557095 Kullak Ublick GA Beuers U Fahney C et al 1997 Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene Hepatology 26 4 991 7 doi 10 1002 hep 510260429 PMID 9328325 S2CID 43606355 Kullak Ublick GA Fisch T Oswald M et al 1998 Dehydroepiandrosterone sulfate DHEAS identification of a carrier protein in human liver and brain FEBS Lett 424 3 173 6 doi 10 1016 S0014 5793 98 00168 9 PMID 9539145 S2CID 21231745 Konig J Cui Y Nies AT Keppler D 2000 Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide J Biol Chem 275 30 23161 8 doi 10 1074 jbc M001448200 PMID 10779507 Tamai I Nezu J Uchino H et al 2000 Molecular identification and characterization of novel members of the human organic anion transporter OATP family Biochem Biophys Res Commun 273 1 251 60 doi 10 1006 bbrc 2000 2922 PMID 10873595 Speek M 2001 Antisense Promoter of Human L1 Retrotransposon Drives Transcription of Adjacent Cellular Genes Mol Cell Biol 21 6 1973 85 doi 10 1128 MCB 21 6 1973 1985 2001 PMC 86790 PMID 11238933 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Lee W Glaeser H Smith LH et al 2005 Polymorphisms in human organic anion transporting polypeptide 1A2 OATP1A2 implications for altered drug disposition and central nervous system drug entry J Biol Chem 280 10 9610 7 doi 10 1074 jbc M411092200 PMID 15632119 Su Y Zhang X Sinko PJ 2005 Human organic anion transporting polypeptide OATP A SLC21A3 acts in concert with P glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells Mol Pharm 1 1 49 56 doi 10 1021 mp0340136 PMID 15832500 Kimura K Wakamatsu A Suzuki Y et al 2006 Diversification of transcriptional modulation Large scale identification and characterization of putative alternative promoters of human genes Genome Res 16 1 55 65 doi 10 1101 gr 4039406 PMC 1356129 PMID 16344560 This article incorporates text from the United States National Library of Medicine which is in the public domain This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Solute carrier organic anion transporter family member 1A2 amp oldid 1170583865, wikipedia, wiki, book, books, library,
