O-806 is a drug which is a cannabinoid derivative that is used in scientific research. It is described as a mixed agonist/antagonist at the cannabinoid receptorCB1, meaning that it acts as an antagonist when co-administered alongside a more potent CB1 agonist, but exhibits weak partial agonist effects when administered by itself.[1][2]
^Griffin G, Wray EJ, Rorrer WK, Crocker PJ, Ryan WJ, Saha B, et al. (April 1999). "An investigation into the structural determinants of cannabinoid receptor ligand efficacy". British Journal of Pharmacology. 126 (7): 1575–84. doi:10.1038/sj.bjp.0702469. PMC1565939. PMID 10323589.
^Griffin G, Wray EJ, Martin BR, Abood ME (October 1999). "Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum". British Journal of Pharmacology. 128 (3): 684–8. doi:10.1038/sj.bjp.0702806. PMC1571656. PMID 10516649.
This cannabinoid related article is a stub. You can help Wikipedia by expanding it.
drug, which, cannabinoid, derivative, that, used, scientific, research, described, mixed, agonist, antagonist, cannabinoid, receptor, meaning, that, acts, antagonist, when, administered, alongside, more, potent, agonist, exhibits, weak, partial, agonist, effec. O 806 is a drug which is a cannabinoid derivative that is used in scientific research It is described as a mixed agonist antagonist at the cannabinoid receptor CB1 meaning that it acts as an antagonist when co administered alongside a more potent CB1 agonist but exhibits weak partial agonist effects when administered by itself 1 2 O 806IdentifiersIUPAC name 6aR 3 6 bromohex 2 ynyl 6 6 9 trimethyl 6a 7 10 10a tetrahydrobenzo c chromen 1 olPubChem CID10549140ChemSpider26001356 YChemical and physical dataFormulaC 22H 27Br O 2Molar mass403 360 g mol 13D model JSmol Interactive imageSMILES C3C1C CC C3C C C C Oc c2 c1c O cc2CC CCCCBrInChI InChI 1S C22H27BrO2 c1 15 9 10 18 17 12 15 21 19 24 13 16 8 6 4 5 7 11 23 14 20 21 25 22 18 2 3 h9 13 14 17 18 24H 5 7 8 10 12H2 1 3H3 t17 18 m1 s1 YKey QHFROVGTWNPDOW QZTJIDSGSA N Y verify References Edit Griffin G Wray EJ Rorrer WK Crocker PJ Ryan WJ Saha B et al April 1999 An investigation into the structural determinants of cannabinoid receptor ligand efficacy British Journal of Pharmacology 126 7 1575 84 doi 10 1038 sj bjp 0702469 PMC 1565939 PMID 10323589 Griffin G Wray EJ Martin BR Abood ME October 1999 Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum British Journal of Pharmacology 128 3 684 8 doi 10 1038 sj bjp 0702806 PMC 1571656 PMID 10516649 This cannabinoid related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title O 806 amp oldid 1082425149, wikipedia, wiki, book, books, library,
