Cleavage and polyadenylation specificity factor subunit 5 (CPSF5) is an enzyme that in humans is encoded by the NUDT21gene.[5][6] It belongs to the Nudix family of hydrolases.
The protein encoded by this gene is one subunit of the cleavage factor Im complex required for 3' RNA cleavage and polyadenylation processing.[7] The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides.[6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000167005 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000031754 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ruegsegger U, Blank D, Keller W (Jul 1998). "Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits". Mol Cell. 1 (2): 243–53. doi:10.1016/S1097-2765(00)80025-8. PMID 9659921.
^Hardy, J. G.; Norbury, C. J. (15 August 2016). "Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation". Biochemical Society Transactions. 44 (4): 1051–1057. doi:10.1042/BST20160078. PMID 27528751. S2CID 206156045.
Further readingedit
Rüegsegger U, Beyer K, Keller W (1996). "Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors". J. Biol. Chem. 271 (11): 6107–13. doi:10.1074/jbc.271.11.6107. PMID 8626397.
de Vries H, Rüegsegger U, Hübner W, et al. (2000). "Human pre-mRNA cleavage factor IIm contains homologs of yeast proteins and bridges two other cleavage factors". EMBO J. 19 (21): 5895–904. doi:10.1093/emboj/19.21.5895. PMC305781. PMID 11060040.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC1083732. PMID 11256614.
Kim H, Lee Y (2002). "Interaction of poly(A) polymerase with the 25-kDa subunit of cleavage factor I". Biochem. Biophys. Res. Commun. 289 (2): 513–8. doi:10.1006/bbrc.2001.5992. PMID 11716503.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Awasthi S, Alwine JC (2003). "Association of polyadenylation cleavage factor I with U1 snRNP". RNA. 9 (11): 1400–9. doi:10.1261/rna.5104603. PMC1287061. PMID 14561889.
Brown KM, Gilmartin GM (2004). "A mechanism for the regulation of pre-mRNA 3' processing by human cleavage factor Im". Mol. Cell. 12 (6): 1467–76. doi:10.1016/S1097-2765(03)00453-2. PMID 14690600.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Dettwiler S, Aringhieri C, Cardinale S, et al. (2005). "Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization" (PDF). J. Biol. Chem. 279 (34): 35788–97. doi:10.1074/jbc.M403927200. PMID 15169763. S2CID 39752996.
Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC442147. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC528930. PMID 15489336.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC1347501. PMID 16381901.
This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.
nudt21, cleavage, polyadenylation, specificity, factor, subunit, cpsf5, enzyme, that, humans, encoded, gene, belongs, nudix, family, hydrolases, available, structurespdbortholog, search, pdbe, rcsblist, codes2cl3, 2j8q, 3bap, 3bho, 3mdg, 3mdi, 3n9u, 3p5t, 3p6y. Cleavage and polyadenylation specificity factor subunit 5 CPSF5 is an enzyme that in humans is encoded by the NUDT21 gene 5 6 It belongs to the Nudix family of hydrolases NUDT21Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2CL3 2J8Q 3BAP 3BHO 3MDG 3MDI 3N9U 3P5T 3P6Y 3Q2S 3Q2TIdentifiersAliasesNUDT21 CFIM25 CPSF5 nudix hydrolase 21External IDsOMIM 604978 MGI 1915469 HomoloGene 5090 GeneCards NUDT21Gene location Human Chr Chromosome 16 human 1 Band16q13Start56 429 133 bp 1 End56 452 199 bp 1 Gene location Mouse Chr Chromosome 8 mouse 2 Band8 8 C5Start94 742 124 bp 2 End94 763 659 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inganglionic eminenceponscaput epididymisgerminal epitheliumsuperior vestibular nucleusAchilles tendonendometriumcorpus epididymisoocytetrigeminal ganglionTop expressed insuperior cervical ganglionspermatocytespermatidyolk sachandganglionic eminencehabenulamorulaneural tubedorsomedial hypothalamic nucleusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein homodimerization activity histone deacetylase binding protein binding mRNA binding hydrolase activity RNA binding identical protein binding chromatin binding mRNA 3 UTR AU rich region bindingCellular componentparaspeckles centrosome nucleoplasm microtubule organizing center mRNA cleavage factor complex nucleus nuclear body cytoplasm mRNA cleavage and polyadenylation specificity factor complexBiological processmRNA splicing via spliceosome termination of RNA polymerase II transcription protein tetramerization mRNA 3 end processing mRNA polyadenylation mRNA processing posttranscriptional regulation of gene expression cell differentiation positive regulation of mRNA cleavage protein heterotetramerization pre mRNA cleavage required for polyadenylation mRNA alternative polyadenylation positive regulation of mRNA polyadenylation messenger ribonucleoprotein complex assembly positive regulation of stem cell differentiation positive regulation of pro B cell differentiationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1105168219EnsemblENSG00000167005ENSMUSG00000031754UniProtO43809Q9CQF3RefSeq mRNA NM 007006NM 026623RefSeq protein NP 008937NP 080899Location UCSC Chr 16 56 43 56 45 MbChr 8 94 74 94 76 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe protein encoded by this gene is one subunit of the cleavage factor Im complex required for 3 RNA cleavage and polyadenylation processing 7 The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3 end processing complex and facilitates the recruitment of other processing factors This gene encodes the 25kD subunit of the protein complex which is composed of four polypeptides 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000167005 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000031754 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Ruegsegger U Blank D Keller W Jul 1998 Human pre mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits Mol Cell 1 2 243 53 doi 10 1016 S1097 2765 00 80025 8 PMID 9659921 a b Entrez Gene NUDT21 nudix nucleoside diphosphate linked moiety X type motif 21 Hardy J G Norbury C J 15 August 2016 Cleavage factor Im CFIm as a regulator of alternative polyadenylation Biochemical Society Transactions 44 4 1051 1057 doi 10 1042 BST20160078 PMID 27528751 S2CID 206156045 Further reading editRuegsegger U Beyer K Keller W 1996 Purification and characterization of human cleavage factor Im involved in the 3 end processing of messenger RNA precursors J Biol Chem 271 11 6107 13 doi 10 1074 jbc 271 11 6107 PMID 8626397 de Vries H Ruegsegger U Hubner W et al 2000 Human pre mRNA cleavage factor IIm contains homologs of yeast proteins and bridges two other cleavage factors EMBO J 19 21 5895 904 doi 10 1093 emboj 19 21 5895 PMC 305781 PMID 11060040 Hartley JL Temple GF Brasch MA 2001 DNA Cloning Using In Vitro Site Specific Recombination Genome Res 10 11 1788 95 doi 10 1101 gr 143000 PMC 310948 PMID 11076863 Wiemann S Weil B Wellenreuther R et al 2001 Toward a Catalog of Human Genes and Proteins Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs Genome Res 11 3 422 35 doi 10 1101 gr GR1547R PMC 311072 PMID 11230166 Simpson JC Wellenreuther R Poustka A et al 2001 Systematic subcellular localization of novel proteins identified by large scale cDNA sequencing EMBO Rep 1 3 287 92 doi 10 1093 embo reports kvd058 PMC 1083732 PMID 11256614 Kim H Lee Y 2002 Interaction of poly A polymerase with the 25 kDa subunit of cleavage factor I Biochem Biophys Res Commun 289 2 513 8 doi 10 1006 bbrc 2001 5992 PMID 11716503 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Awasthi S Alwine JC 2003 Association of polyadenylation cleavage factor I with U1 snRNP RNA 9 11 1400 9 doi 10 1261 rna 5104603 PMC 1287061 PMID 14561889 Brown KM Gilmartin GM 2004 A mechanism for the regulation of pre mRNA 3 processing by human cleavage factor Im Mol Cell 12 6 1467 76 doi 10 1016 S1097 2765 03 00453 2 PMID 14690600 Bouwmeester T Bauch A Ruffner H et al 2004 A physical and functional map of the human TNF alpha NF kappa B signal transduction pathway Nat Cell Biol 6 2 97 105 doi 10 1038 ncb1086 PMID 14743216 S2CID 11683986 Dettwiler S Aringhieri C Cardinale S et al 2005 Distinct sequence motifs within the 68 kDa subunit of cleavage factor Im mediate RNA binding protein protein interactions and subcellular localization PDF J Biol Chem 279 34 35788 97 doi 10 1074 jbc M403927200 PMID 15169763 S2CID 39752996 Lehner B Sanderson CM 2004 A Protein Interaction Framework for Human mRNA Degradation Genome Res 14 7 1315 23 doi 10 1101 gr 2122004 PMC 442147 PMID 15231747 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Wiemann S Arlt D Huber W et al 2004 From ORFeome to Biology A Functional Genomics Pipeline Genome Res 14 10B 2136 44 doi 10 1101 gr 2576704 PMC 528930 PMID 15489336 Rush J Moritz A Lee KA et al 2005 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells Nat Biotechnol 23 1 94 101 doi 10 1038 nbt1046 PMID 15592455 S2CID 7200157 Andersen JS Lam YW Leung AK et al 2005 Nucleolar proteome dynamics Nature 433 7021 77 83 Bibcode 2005Natur 433 77A doi 10 1038 nature03207 PMID 15635413 S2CID 4344740 Stelzl U Worm U Lalowski M et al 2005 A human protein protein interaction network a resource for annotating the proteome Cell 122 6 957 68 doi 10 1016 j cell 2005 08 029 hdl 11858 00 001M 0000 0010 8592 0 PMID 16169070 S2CID 8235923 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Mehrle A Rosenfelder H Schupp I et al 2006 The LIFEdb database in 2006 Nucleic Acids Res 34 Database issue D415 8 doi 10 1093 nar gkj139 PMC 1347501 PMID 16381901 nbsp This article on a gene on human chromosome 16 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title NUDT21 amp oldid 1118745960, wikipedia, wiki, book, books, library,
