NS-2710 (LS-193,970) is an anxiolytic drug with a novel chemical structure, developed by the small pharmaceutical company NeuroSearch. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. NS-2710 is a potent but non-selective partial agonist at GABAA receptors, although with little efficacy at the α1 subtype and more at α2 and α3. It has anxiolytic effects comparable to chlordiazepoxide,[1] and while it is a less potent anticonvulsant than the related drug NS-2664, it has a much longer duration of action, and similarly to other α2/α3-preferring partial agonists produces little sedative effects or physical dependence.[2]
^Evenden J, Duncan B, Ko T (February 2006). "A comparison of the effects of psychotomimetics and anxiolytics on punished and unpunished responding maintained by fixed interval schedules of food reinforcement in the rat". Behavioural Pharmacology. 17 (1): 87–99. doi:10.1097/01.fbp.0000189812.77049.e5. PMID 16377966. S2CID 12424100.
^Mirza NR, Nielsen EØ (March 2006). "Do subtype-selective gamma-aminobutyric acid A receptor modulators have a reduced propensity to induce physical dependence in mice?". The Journal of Pharmacology and Experimental Therapeutics. 316 (3): 1378–85. doi:10.1124/jpet.105.094474. PMID 16352707. S2CID 22700422.
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2710, anxiolytic, drug, with, novel, chemical, structure, developed, small, pharmaceutical, company, neurosearch, similar, effects, benzodiazepine, drugs, structurally, distinct, classed, nonbenzodiazepine, anxiolytic, potent, selective, partial, agonist, gaba. NS 2710 LS 193 970 is an anxiolytic drug with a novel chemical structure developed by the small pharmaceutical company NeuroSearch It has similar effects to benzodiazepine drugs but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic NS 2710 is a potent but non selective partial agonist at GABAA receptors although with little efficacy at the a1 subtype and more at a2 and a3 It has anxiolytic effects comparable to chlordiazepoxide 1 and while it is a less potent anticonvulsant than the related drug NS 2664 it has a much longer duration of action and similarly to other a2 a3 preferring partial agonists produces little sedative effects or physical dependence 2 NS 2710IdentifiersIUPAC name 1 1 3 3 pyridyl phenyl benzimidazol 5 yl ethanone O ethyloximePubChem CID9863520ChemSpider8039216UNIIJ0WHC91NJOChemical and physical dataFormulaC 22H 20N 4OMolar mass356 429 g mol 13D model JSmol Interactive imageSMILES c4ncccc4 c c2 cccc2 n3c1ccc cc1nc3 C C NOCCInChI InChI 1S C22H20N4O c1 3 27 25 16 2 17 9 10 22 21 13 17 24 15 26 22 20 8 4 6 18 12 20 19 7 5 11 23 14 19 h4 15H 3H2 1 2H3 b25 16 Key NHJFEXZXSCFYRX PCLIKHOPSA N verify References Edit Evenden J Duncan B Ko T February 2006 A comparison of the effects of psychotomimetics and anxiolytics on punished and unpunished responding maintained by fixed interval schedules of food reinforcement in the rat Behavioural Pharmacology 17 1 87 99 doi 10 1097 01 fbp 0000189812 77049 e5 PMID 16377966 S2CID 12424100 Mirza NR Nielsen EO March 2006 Do subtype selective gamma aminobutyric acid A receptor modulators have a reduced propensity to induce physical dependence in mice The Journal of Pharmacology and Experimental Therapeutics 316 3 1378 85 doi 10 1124 jpet 105 094474 PMID 16352707 S2CID 22700422 This article about an anxiolytic is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title NS 2710 amp oldid 1120554850, wikipedia, wiki, book, books, library,
