There are five known mammalian neuropeptide Y receptors designated Y1 through Y5.[9] Four neuropeptide Y receptors each encoded by a different gene have been identified in humans, all of which may represent therapeutic targets for obesity and other disorders.[10][11][12]
^Michel MC, Beck-Sickinger A, Cox H, Doods HN, Herzog H, Larhammar D, Quirion R, Schwartz T, Westfall T (March 1998). "XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors". Pharmacol. Rev. 50 (1): 143–50. PMID 9549761.
^Heilig M (August 2004). "The NPY system in stress, anxiety and depression". Neuropeptides. 38 (4): 213–24. doi:10.1016/j.npep.2004.05.002. PMID 15337373. S2CID 37034137.
^Harro J (October 2006). "CCK and NPY as anti-anxiety treatment targets: promises, pitfalls, and strategies". Amino Acids. 31 (3): 215–30. doi:10.1007/s00726-006-0334-x. PMID 16738800. S2CID 2017793.
^Eaton K, Sallee FR, Sah R (2007). "Relevance of neuropeptide Y (NPY) in psychiatry". Current Topics in Medicinal Chemistry. 7 (17): 1645–59. doi:10.2174/156802607782341037. PMID 17979774.
^Xapelli S, Agasse F, Ferreira R, Silva AP, Malva JO (November 2006). "Neuropeptide Y as an endogenous antiepileptic, neuroprotective and pro-neurogenic peptide". Recent Patents on CNS Drug Discovery. 1 (3): 315–24. doi:10.2174/157488906778773689. PMID 18221213.
^Vona-Davis LC, McFadden DW (2007). "NPY family of hormones: clinical relevance and potential use in gastrointestinal disease". Current Topics in Medicinal Chemistry. 7 (17): 1710–20. doi:10.2174/156802607782340966. PMID 17979780.
^Lindner D, Stichel J, Beck-Sickinger AG (September 2008). "Molecular recognition of the NPY hormone family by their receptors". Nutrition (Burbank, Los Angeles County, Calif.). 24 (9): 907–17. doi:10.1016/j.nut.2008.06.025. PMID 18725086.
^Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B (April 2018). "1 receptor". Nature. 556 (7702): 520–524. doi:10.1038/s41586-018-0046-x. PMC5920736. PMID 29670288.
^Larhammar D, Salaneck E (2004). "Molecular evolution of NPY receptor subtypes". Neuropeptides. 38 (4): 141–51. doi:10.1016/j.npep.2004.06.002. PMID 15337367. S2CID 43696257.
^Kamiji MM, Inui A (October 2007). "Neuropeptide y receptor selective ligands in the treatment of obesity". Endocrine Reviews. 28 (6): 664–84. doi:10.1210/er.2007-0003. PMID 17785427.
^MacNeil DJ (2007). "NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs". Current Topics in Medicinal Chemistry. 7 (17): 1721–33. doi:10.2174/156802607782341028. PMID 17979781.
^Kamiji MM, Inui A (2007). "NPY Y2 and Y4 receptors selective ligands: promising anti-obesity drugs?". Current Topics in Medicinal Chemistry. 7 (17): 1734–42. doi:10.2174/156802607782340957. PMID 17979782.
External linksedit
. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
Neuropeptide+Y+Receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
neuropeptide, receptor, family, receptors, belonging, class, protein, coupled, receptors, they, activated, closely, related, peptide, hormones, neuropeptide, peptide, pancreatic, polypeptide, these, receptors, involved, control, diverse, behavioral, processes,. Neuropeptide Y receptors are a family of receptors belonging to class A G protein coupled receptors and they are activated by the closely related peptide hormones neuropeptide Y peptide YY and pancreatic polypeptide 1 These receptors are involved in the control of a diverse set of behavioral processes including appetite circadian rhythm and anxiety 2 3 4 5 6 7 neuropeptide Y receptor Y1IdentifiersSymbolNPY1RAlt symbolsNPYRNCBI gene4886HGNC7956OMIM162641RefSeqNM 000909UniProtP25929Other dataLocusChr 4 q31 3 q32Search forStructuresSwiss modelDomainsInterPro neuropeptide Y receptor Y2IdentifiersSymbolNPY2RNCBI gene4887HGNC7957OMIM162642RefSeqNM 000910UniProtP49146Other dataLocusChr 4 q31Search forStructuresSwiss modelDomainsInterPro pancreatic polypeptide receptor 1IdentifiersSymbolPPYR1Alt symbolsNPY4R Y4 PP1NCBI gene5540HGNC9329OMIM601790RefSeqNM 005972UniProtP50391Other dataLocusChr 10 q11 2Search forStructuresSwiss modelDomainsInterPro neuropeptide Y receptor Y5IdentifiersSymbolNPY5RNCBI gene4889HGNC7958OMIM602001RefSeqNM 006174UniProtQ15761Other dataLocusChr 4 q31 q32Search forStructuresSwiss modelDomainsInterPro Activated neuropeptide receptors release the Gi subunit from the heterotrimeric G protein complex The Gi subunit in turn inhibits the production of the second messenger cAMP from ATP Only the crystal structure of Y1 in complex with two antagonist is available 8 Contents 1 Types 2 Antagonists 3 References 4 External linksTypes editThere are five known mammalian neuropeptide Y receptors designated Y1 through Y5 9 Four neuropeptide Y receptors each encoded by a different gene have been identified in humans all of which may represent therapeutic targets for obesity and other disorders 10 11 12 Y1 NPY1R Y2 NPY2R Y4 PPYR1 Y5 NPY5RAntagonists editBIBP 3226 Lu AA 33810 BIIE 0246 UR AK49References edit Michel MC Beck Sickinger A Cox H Doods HN Herzog H Larhammar D Quirion R Schwartz T Westfall T March 1998 XVI International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y peptide YY and pancreatic polypeptide receptors Pharmacol Rev 50 1 143 50 PMID 9549761 Heilig M August 2004 The NPY system in stress anxiety and depression Neuropeptides 38 4 213 24 doi 10 1016 j npep 2004 05 002 PMID 15337373 S2CID 37034137 Harro J October 2006 CCK and NPY as anti anxiety treatment targets promises pitfalls and strategies Amino Acids 31 3 215 30 doi 10 1007 s00726 006 0334 x PMID 16738800 S2CID 2017793 Eaton K Sallee FR Sah R 2007 Relevance of neuropeptide Y NPY in psychiatry Current Topics in Medicinal Chemistry 7 17 1645 59 doi 10 2174 156802607782341037 PMID 17979774 Xapelli S Agasse F Ferreira R Silva AP Malva JO November 2006 Neuropeptide Y as an endogenous antiepileptic neuroprotective and pro neurogenic peptide Recent Patents on CNS Drug Discovery 1 3 315 24 doi 10 2174 157488906778773689 PMID 18221213 Vona Davis LC McFadden DW 2007 NPY family of hormones clinical relevance and potential use in gastrointestinal disease Current Topics in Medicinal Chemistry 7 17 1710 20 doi 10 2174 156802607782340966 PMID 17979780 Lindner D Stichel J Beck Sickinger AG September 2008 Molecular recognition of the NPY hormone family by their receptors Nutrition Burbank Los Angeles County Calif 24 9 907 17 doi 10 1016 j nut 2008 06 025 PMID 18725086 Yang Z Han S Keller M Kaiser A Bender BJ Bosse M Burkert K Kogler LM Wifling D Bernhardt G Plank N Littmann T Schmidt P Yi C Li B Ye S Zhang R Xu B Larhammar D Stevens RC Huster D Meiler J Zhao Q Beck Sickinger AG Buschauer A Wu B April 2018 1 receptor Nature 556 7702 520 524 doi 10 1038 s41586 018 0046 x PMC 5920736 PMID 29670288 Larhammar D Salaneck E 2004 Molecular evolution of NPY receptor subtypes Neuropeptides 38 4 141 51 doi 10 1016 j npep 2004 06 002 PMID 15337367 S2CID 43696257 Kamiji MM Inui A October 2007 Neuropeptide y receptor selective ligands in the treatment of obesity Endocrine Reviews 28 6 664 84 doi 10 1210 er 2007 0003 PMID 17785427 MacNeil DJ 2007 NPY Y1 and Y5 receptor selective antagonists as anti obesity drugs Current Topics in Medicinal Chemistry 7 17 1721 33 doi 10 2174 156802607782341028 PMID 17979781 Kamiji MM Inui A 2007 NPY Y2 and Y4 receptors selective ligands promising anti obesity drugs Current Topics in Medicinal Chemistry 7 17 1734 42 doi 10 2174 156802607782340957 PMID 17979782 External links edit Neuropeptide Y Receptors IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology Archived from the original on 2016 03 03 Retrieved 2007 10 25 Neuropeptide Y Receptor at the U S National Library of Medicine Medical Subject Headings MeSH nbsp This transmembrane receptor related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Neuropeptide Y receptor amp oldid 1212960976, wikipedia, wiki, book, books, library,
