Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is a protein receptor that in humans is encoded by the NOD1gene.[5][6] It recognizes bacterial molecules and stimulates an immune reaction .[7]
NOD1 protein contains a caspase recruitment domain (CARD). NOD1 is a member of NOD-like receptor protein family and is a close relative of NOD2. NOD1 is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants, and mediates innate and acquired immunity by recognizing molecules containing D-glutamyl-meso-diaminopimelic acid (iE-DAP) moiety, including bacterial peptidoglycan. Nod1 interacts with RIPK2 through the CARDs of both molecules (See the structure of the NOD1 CARD in the right panel). Stimulation of NOD1 by iE-DAP containing molecules results in activation of the transcription factor NF-κB.
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000106100 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000038058 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Bertin J, Nir WJ, Fischer CM, Tayber OV, Errada PR, Grant JR, Keilty JJ, Gosselin ML, Robison KE, Wong GH, Glucksmann MA, DiStefano PS (May 1999). "Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB". The Journal of Biological Chemistry. 274 (19): 12955–8. doi:10.1074/jbc.274.19.12955. PMID 10224040.
^Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Núñez G (May 1999). "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB". The Journal of Biological Chemistry. 274 (21): 14560–7. doi:10.1074/jbc.274.21.14560. PMID 10329646.
^Mahla RS, Reddy MC, Prasad DV, Kumar H (September 2013). "Sweeten PAMPs: Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology". Frontiers in Immunology. 4: 248. doi:10.3389/fimmu.2013.00248. PMC3759294. PMID 24032031.
Further readingedit
Martinon F, Tschopp J (August 2005). "NLRs join TLRs as innate sensors of pathogens". Trends in Immunology. 26 (8): 447–54. doi:10.1016/j.it.2005.06.004. PMID 15967716.
Strober W, Murray PJ, Kitani A, Watanabe T (January 2006). "Signalling pathways and molecular interactions of NOD1 and NOD2". Nature Reviews. Immunology. 6 (1): 9–20. doi:10.1038/nri1747. PMID 16493424. S2CID 33505741.
Inohara N, Koseki T, Lin J, del Peso L, Lucas PC, Chen FF, Ogura Y, Núñez G (September 2000). "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways". The Journal of Biological Chemistry. 275 (36): 27823–31. doi:10.1074/jbc.M003415200. PMID 10880512.
Inohara N, Ogura Y, Chen FF, Muto A, Nuñez G (January 2001). "Human Nod1 confers responsiveness to bacterial lipopolysaccharides". The Journal of Biological Chemistry. 276 (4): 2551–4. doi:10.1074/jbc.M009728200. PMID 11058605.
Chu ZL, Pio F, Xie Z, Welsh K, Krajewska M, Krajewski S, Godzik A, Reed JC (March 2001). "A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis". The Journal of Biological Chemistry. 276 (12): 9239–45. doi:10.1074/jbc.M006309200. PMID 11113115.
Yoo NJ, Park WS, Kim SY, Reed JC, Son SG, Lee JY, Lee SH (December 2002). "Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1". Biochemical and Biophysical Research Communications. 299 (4): 652–8. doi:10.1016/S0006-291X(02)02714-6. PMID 12459189.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Stehlik C, Hayashi H, Pio F, Godzik A, Reed JC (August 2003). "CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways". The Journal of Biological Chemistry. 278 (34): 31941–9. doi:10.1074/jbc.M300009200. PMID 12775719.
Girardin SE, Boneca IG, Carneiro LA, Antignac A, Jéhanno M, Viala J, Tedin K, Taha MK, Labigne A, Zähringer U, Coyle AJ, DiStefano PS, Bertin J, Sansonetti PJ, Philpott DJ (June 2003). "Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan". Science. 300 (5625): 1584–7. Bibcode:2003Sci...300.1584G. doi:10.1126/science.1084677. PMID 12791997. S2CID 1320864.
Hisamatsu T, Suzuki M, Podolsky DK (August 2003). "Interferon-gamma augments CARD4/NOD1 gene and protein expression through interferon regulatory factor-1 in intestinal epithelial cells". The Journal of Biological Chemistry. 278 (35): 32962–8. doi:10.1074/jbc.M304355200. PMID 12813035.
Girardin SE, Travassos LH, Hervé M, Blanot D, Boneca IG, Philpott DJ, Sansonetti PJ, Mengin-Lecreulx D (October 2003). "Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2". The Journal of Biological Chemistry. 278 (43): 41702–8. doi:10.1074/jbc.M307198200. PMID 12871942.
Kim JG, Lee SJ, Kagnoff MF (March 2004). "Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors". Infection and Immunity. 72 (3): 1487–95. doi:10.1128/IAI.72.3.1487-1495.2004. PMC356064. PMID 14977954.
Damiano JS, Oliveira V, Welsh K, Reed JC (July 2004). "Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses". The Biochemical Journal. 381 (Pt 1): 213–9. doi:10.1042/BJ20031506. PMC1133779. PMID 15107016.
nod1, nucleotide, binding, oligomerization, domain, containing, protein, protein, receptor, that, humans, encoded, gene, recognizes, bacterial, molecules, stimulates, immune, reaction, available, structurespdbortholog, search, pdbe, rcsblist, codes2b1w, 2dbd, . Nucleotide binding oligomerization domain containing protein 1 NOD1 is a protein receptor that in humans is encoded by the NOD1 gene 5 6 It recognizes bacterial molecules and stimulates an immune reaction 7 NOD1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2B1W 2DBD 2NSN 2NZ7 4E9M 4JQWIdentifiersAliasesNOD1 CARD4 CLR7 1 NLRC1 nucleotide binding oligomerization domain containing 1External IDsOMIM 605980 MGI 1341839 HomoloGene 4440 GeneCards NOD1Gene location Human Chr Chromosome 7 human 1 Band7p14 3Start30 424 527 bp 1 End30 478 784 bp 1 Gene location Mouse Chr Chromosome 6 mouse 2 Band6 6 B3Start54 900 934 bp 2 End54 949 597 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insural nerveright lobe of thyroid glandupper lobe of left lungleft lobe of thyroid glandsubcutaneous adipose tissuespleenright lungleft uterine tubesecondary oocyteleft ventricleTop expressed insubcutaneous adipose tissuesciatic nerveright lungspleencervixmyocardium of ventricleislet of Langerhansright lung lobeotolith organwhite adipose tissueMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionnucleotide binding protein homodimerization activity protein binding peptidoglycan binding identical protein binding cysteine type endopeptidase activator activity involved in apoptotic process CARD domain binding ATP binding protein containing complex bindingCellular componentcytoplasm cytosol membrane plasma membrane basolateral plasma membrane apical plasma membraneBiological processregulation of apoptotic process defense response detection of biotic stimulus intracellular signal transduction positive regulation of cell death immune system process positive regulation of JNK cascade positive regulation of xenophagy positive regulation of NIK NF kappaB signaling cellular response to muramyl dipeptide JNK cascade positive regulation of cysteine type endopeptidase activity involved in apoptotic process positive regulation of dendritic cell antigen processing and presentation positive regulation of nitric oxide synthase activity defense response to bacterium positive regulation of NF kappaB transcription factor activity protein complex oligomerization detection of bacterium positive regulation of interleukin 1 beta production positive regulation of ERK1 and ERK2 cascade positive regulation of interleukin 6 production positive regulation of tumor necrosis factor production positive regulation of I kappaB kinase NF kappaB signaling inflammatory response activation of cysteine type endopeptidase activity involved in apoptotic process nucleotide binding oligomerization domain containing signaling pathway signal transduction positive regulation of stress activated MAPK cascade defense response to Gram positive bacterium apoptotic process innate immune response interleukin 1 mediated signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez10392107607EnsemblENSG00000106100ENSMUSG00000038058UniProtQ9Y239Q8BHB0RefSeq mRNA NM 006092NM 001354849NM 001171007NM 172729RefSeq protein NP 006083NP 001341778NP 001164478NP 766317Location UCSC Chr 7 30 42 30 48 MbChr 6 54 9 54 95 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseNOD1 protein contains a caspase recruitment domain CARD NOD1 is a member of NOD like receptor protein family and is a close relative of NOD2 NOD1 is an intracellular pattern recognition receptor which is similar in structure to resistant proteins of plants and mediates innate and acquired immunity by recognizing molecules containing D glutamyl meso diaminopimelic acid iE DAP moiety including bacterial peptidoglycan Nod1 interacts with RIPK2 through the CARDs of both molecules See the structure of the NOD1 CARD in the right panel Stimulation of NOD1 by iE DAP containing molecules results in activation of the transcription factor NF kB References edit a b c GRCh38 Ensembl release 89 ENSG00000106100 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000038058 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Bertin J Nir WJ Fischer CM Tayber OV Errada PR Grant JR Keilty JJ Gosselin ML Robison KE Wong GH Glucksmann MA DiStefano PS May 1999 Human CARD4 protein is a novel CED 4 Apaf 1 cell death family member that activates NF kappaB The Journal of Biological Chemistry 274 19 12955 8 doi 10 1074 jbc 274 19 12955 PMID 10224040 Inohara N Koseki T del Peso L Hu Y Yee C Chen S Carrio R Merino J Liu D Ni J Nunez G May 1999 Nod1 an Apaf 1 like activator of caspase 9 and nuclear factor kappaB The Journal of Biological Chemistry 274 21 14560 7 doi 10 1074 jbc 274 21 14560 PMID 10329646 Mahla RS Reddy MC Prasad DV Kumar H September 2013 Sweeten PAMPs Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology Frontiers in Immunology 4 248 doi 10 3389 fimmu 2013 00248 PMC 3759294 PMID 24032031 Further reading editMartinon F Tschopp J August 2005 NLRs join TLRs as innate sensors of pathogens Trends in Immunology 26 8 447 54 doi 10 1016 j it 2005 06 004 PMID 15967716 Strober W Murray PJ Kitani A Watanabe T January 2006 Signalling pathways and molecular interactions of NOD1 and NOD2 Nature Reviews Immunology 6 1 9 20 doi 10 1038 nri1747 PMID 16493424 S2CID 33505741 Inohara N Koseki T Lin J del Peso L Lucas PC Chen FF Ogura Y Nunez G September 2000 An induced proximity model for NF kappa B activation in the Nod1 RICK and RIP signaling pathways The Journal of Biological Chemistry 275 36 27823 31 doi 10 1074 jbc M003415200 PMID 10880512 Inohara N Ogura Y Chen FF Muto A Nunez G January 2001 Human Nod1 confers responsiveness to bacterial lipopolysaccharides The Journal of Biological Chemistry 276 4 2551 4 doi 10 1074 jbc M009728200 PMID 11058605 Chu ZL Pio F Xie Z Welsh K Krajewska M Krajewski S Godzik A Reed JC March 2001 A novel enhancer of the Apaf1 apoptosome involved in cytochrome c dependent caspase activation and apoptosis The Journal of Biological Chemistry 276 12 9239 45 doi 10 1074 jbc M006309200 PMID 11113115 Yoo NJ Park WS Kim SY Reed JC Son SG Lee JY Lee SH December 2002 Nod1 a CARD protein enhances pro interleukin 1beta processing through the interaction with pro caspase 1 Biochemical and Biophysical Research Communications 299 4 652 8 doi 10 1016 S0006 291X 02 02714 6 PMID 12459189 Matsuda A Suzuki Y Honda G Muramatsu S Matsuzaki O Nagano Y Doi T Shimotohno K Harada T Nishida E Hayashi H Sugano S May 2003 Large scale identification and characterization of human genes that activate NF kappaB and MAPK signaling pathways Oncogene 22 21 3307 18 doi 10 1038 sj onc 1206406 PMID 12761501 Stehlik C Hayashi H Pio F Godzik A Reed JC August 2003 CARD6 is a modulator of NF kappa B activation by Nod1 and Cardiak mediated pathways The Journal of Biological Chemistry 278 34 31941 9 doi 10 1074 jbc M300009200 PMID 12775719 Girardin SE Boneca IG Carneiro LA Antignac A Jehanno M Viala J Tedin K Taha MK Labigne A Zahringer U Coyle AJ DiStefano PS Bertin J Sansonetti PJ Philpott DJ June 2003 Nod1 detects a unique muropeptide from gram negative bacterial peptidoglycan Science 300 5625 1584 7 Bibcode 2003Sci 300 1584G doi 10 1126 science 1084677 PMID 12791997 S2CID 1320864 Hisamatsu T Suzuki M Podolsky DK August 2003 Interferon gamma augments CARD4 NOD1 gene and protein expression through interferon regulatory factor 1 in intestinal epithelial cells The Journal of Biological Chemistry 278 35 32962 8 doi 10 1074 jbc M304355200 PMID 12813035 Girardin SE Travassos LH Herve M Blanot D Boneca IG Philpott DJ Sansonetti PJ Mengin Lecreulx D October 2003 Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2 The Journal of Biological Chemistry 278 43 41702 8 doi 10 1074 jbc M307198200 PMID 12871942 Kim JG Lee SJ Kagnoff MF March 2004 Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll like receptors Infection and Immunity 72 3 1487 95 doi 10 1128 IAI 72 3 1487 1495 2004 PMC 356064 PMID 14977954 Damiano JS Oliveira V Welsh K Reed JC July 2004 Heterotypic interactions among NACHT domains implications for regulation of innate immune responses The Biochemical Journal 381 Pt 1 213 9 doi 10 1042 BJ20031506 PMC 1133779 PMID 15107016 External links editNOD1 human gene location in the UCSC Genome Browser NOD1 human gene details in the UCSC Genome Browser nbsp This article on a gene on human chromosome 7 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title NOD1 amp oldid 1171103802, wikipedia, wiki, book, books, library,
