NLRC3, short for NOD-like receptor family CARD domain containing 3, is an intracellular protein that plays a role in the immune system.[5] It was previously known as nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 (NOD3) and CLR16.2. NLRC3 inhibits the activity of T cells.[6] NLRC3 also inhibits the mTOR signalling pathway to block cellular proliferation.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000167984 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000049871 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ting JP, Lovering RC, Alnemri ES, et al. (March 2008). "The NLR gene family: a standard nomenclature". Immunity. 28 (3): 285–7. doi:10.1016/j.immuni.2008.02.005. PMC2630772. PMID 18341998.
^Conti BJ, Davis BK, Zhang J, O'connor W, Williams KL, Ting JP (May 2005). "CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function". J. Biol. Chem. 280 (18): 18375–85. doi:10.1074/jbc.M413169200. PMID 15705585.
^Karki R, Man SM, Malireddi RK, Kesavardhana S, Zhu Q, Burton AR, Sharma BR, Qi X, Pelletier S, Vogel P, Rosenstiel P (December 2016). "NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer". Nature. 540 (7634): 583–587. Bibcode:2016Natur.540..583K. doi:10.1038/nature20597. ISSN 1476-4687. PMC5468516. PMID 27951586.
nlrc3, short, like, receptor, family, card, domain, containing, intracellular, protein, that, plays, role, immune, system, previously, known, nucleotide, binding, oligomerization, domain, leucine, rich, repeat, card, domain, containing, nod3, clr16, inhibits, . NLRC3 short for NOD like receptor family CARD domain containing 3 is an intracellular protein that plays a role in the immune system 5 It was previously known as nucleotide binding oligomerization domain leucine rich repeat and CARD domain containing 3 NOD3 and CLR16 2 NLRC3 inhibits the activity of T cells 6 NLRC3 also inhibits the mTOR signalling pathway to block cellular proliferation 7 NLRC3IdentifiersAliasesNLRC3 CLR16 2 NOD3 NLR family CARD domain containing 3 NLR family CARD domain containing 3External IDsOMIM 615648 MGI 2444070 HomoloGene 18720 GeneCards NLRC3Gene location Human Chr Chromosome 16 human 1 Band16p13 3Start3 539 033 bp 1 End3 577 403 bp 1 Gene location Mouse Chr Chromosome 16 mouse 2 Band16 16 A1Start3 762 871 bp 2 End3 794 496 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inthymusbloodlymph nodeendothelial cellspleenappendixthymusamniotic fluidpancreatic epithelial cellsuperficial temporal arteryTop expressed inbloodthymussoleus musclespleensubmandibular glandsubcutaneous adipose tissuemorulaaortic valveciliary bodyascending aortaMore reference expression dataBioGPSn aGene ontologyMolecular functionnucleotide binding ATP binding protein binding phosphatidylinositol 3 kinase regulatory subunit binding molecular functionCellular componentcytoplasm microtubule organizing center cytosol perinuclear region of cytoplasmBiological processnegative regulation of interleukin 6 production negative regulation of tumor necrosis factor production I kappaB kinase NF kappaB signaling negative regulation of NF kappaB transcription factor activity T cell activation negative regulation of I kappaB kinase NF kappaB signaling negative regulation of phosphatidylinositol 3 kinase signaling negative regulation of interferon alpha production negative regulation of interferon beta production negative regulation of innate immune response negative regulation of fibroblast proliferation negative regulation of epithelial cell proliferation negative regulation of inflammatory response negative regulation of cytokine production involved in inflammatory response negative regulation of NLRP3 inflammasome complex assembly negative regulation of NIK NF kappaB signaling intracellular signal transductionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez197358268857EnsemblENSG00000167984ENSMUSG00000049871UniProtQ7RTR2Q5DU56RefSeq mRNA NM 178844NM 001081280NM 175547RefSeq protein NP 849172NP 001074749NP 780756Location UCSC Chr 16 3 54 3 58 MbChr 16 3 76 3 79 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseReferences edit a b c GRCh38 Ensembl release 89 ENSG00000167984 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000049871 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Ting JP Lovering RC Alnemri ES et al March 2008 The NLR gene family a standard nomenclature Immunity 28 3 285 7 doi 10 1016 j immuni 2008 02 005 PMC 2630772 PMID 18341998 Conti BJ Davis BK Zhang J O connor W Williams KL Ting JP May 2005 CATERPILLER 16 2 CLR16 2 a novel NBD LRR family member that negatively regulates T cell function J Biol Chem 280 18 18375 85 doi 10 1074 jbc M413169200 PMID 15705585 Karki R Man SM Malireddi RK Kesavardhana S Zhu Q Burton AR Sharma BR Qi X Pelletier S Vogel P Rosenstiel P December 2016 NLRC3 is an inhibitory sensor of PI3K mTOR pathways in cancer Nature 540 7634 583 587 Bibcode 2016Natur 540 583K doi 10 1038 nature20597 ISSN 1476 4687 PMC 5468516 PMID 27951586 nbsp This transmembrane receptor related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title NLRC3 amp oldid 1196791176, wikipedia, wiki, book, books, library,
