This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells.[7]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000114857 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032525 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Young HA, Jenkins NA, Copeland NG, Simek S, Lerman MI, Zbar B, Glenn G, Ortaldo JR, Anderson SK (Jul 1993). "Localization of a novel natural killer triggering receptor locus to human chromosome 3p23-p21 and mouse chromosome 9". Genomics. 16 (2): 548–549. doi:10.1006/geno.1993.1229. PMID 8314596.
^Chambers CA, Gallinger S, Anderson SK, Giardina S, Ortaldo JR, Hozumi N, Roder J (May 1994). "Expression of the NK-TR gene is required for NK-like activity in human T cells". J Immunol. 152 (6): 2669–74. doi:10.4049/jimmunol.152.6.2669. PMID 8144875. S2CID 20265645.
Frey JL, Bino T, Kantor RR, et al. (1992). "Mechanism of target cell recognition by natural killer cells: characterization of a novel triggering molecule restricted to CD3- large granular lymphocytes". J. Exp. Med. 174 (6): 1527–1536. doi:10.1084/jem.174.6.1527. PMC2119033. PMID 1720812.
Rinfret A, Anderson SK (1993). "IL-2 regulates the expression of the NK-TR gene via an alternate RNA splicing mechanism". Mol. Immunol. 30 (14): 1307–1313. doi:10.1016/0161-5890(93)90047-F. PMID 8413330.
Anderson SK, Gallinger S, Roder J, et al. (1993). "A cyclophilin-related protein involved in the function of natural killer cells". Proc. Natl. Acad. Sci. U.S.A. 90 (2): 542–546. Bibcode:1993PNAS...90..542A. doi:10.1073/pnas.90.2.542. PMC45699. PMID 8421688.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Sakashita E, Tatsumi S, Werner D, et al. (2004). "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo". Mol. Cell. Biol. 24 (3): 1174–1187. doi:10.1128/MCB.24.3.1174-1187.2004. PMC321435. PMID 14729963.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Davis TL, Walker JR, Campagna-Slater V, et al. (2010). "Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases". PLOS Biol. 8 (7): e1000439. doi:10.1371/journal.pbio.1000439. PMC2911226. PMID 20676357.
This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.
nktr, tumor, recognition, protein, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2he9identifiersaliases, p104, natural, killer, cell, triggering, receptorexternal, idsomim, 161565, 97346, homologene, 12214. NK tumor recognition protein is a protein that in humans is encoded by the NKTR gene 5 6 7 NKTRAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes2HE9IdentifiersAliasesNKTR p104 natural killer cell triggering receptorExternal IDsOMIM 161565 MGI 97346 HomoloGene 122148 GeneCards NKTRGene location Human Chr Chromosome 3 human 1 Band3p22 1Start42 600 655 bp 1 End42 648 735 bp 1 Gene location Mouse Chr Chromosome 9 mouse 2 Band9 F4 9 72 57 cMStart121 719 169 bp 2 End121 756 843 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inpyloruscardiacaput epididymisoptic nerveAchilles tendoncorpus epididymissuperior surface of tonguevisceral pleuracorpus callosumsuperficial temporal arteryTop expressed inascending aortaaortic valvecerebellar cortexdorsomedial hypothalamic nucleushabenulasuperior frontal gyruspineal glandspermatocytecerebellar vermissalivary glandMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionisomerase activity peptidyl prolyl cis trans isomerase activity cyclosporin A binding unfolded protein bindingCellular componentmembrane nucleoplasm mitochondrion cytosol plasma membrane nucleusBiological processprotein folding protein peptidyl prolyl isomerization protein refoldingSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez482018087EnsemblENSG00000114857ENSMUSG00000032525UniProtP30414P30415RefSeq mRNA NM 001012651NM 005385NM 001349124NM 001349125NM 001349126NM 010918RefSeq protein NP 005376NP 001336053NP 001336054NP 001336055NP 035048Location UCSC Chr 3 42 6 42 65 MbChr 9 121 72 121 76 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene encodes a membrane anchored protein with a hydrophobic amino terminal domain and a cyclophilin like PPIase domain It is present on the surface of natural killer cells and facilitates their binding to targets Its expression is regulated by IL2 activation of the cells 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000114857 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000032525 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Young HA Jenkins NA Copeland NG Simek S Lerman MI Zbar B Glenn G Ortaldo JR Anderson SK Jul 1993 Localization of a novel natural killer triggering receptor locus to human chromosome 3p23 p21 and mouse chromosome 9 Genomics 16 2 548 549 doi 10 1006 geno 1993 1229 PMID 8314596 Chambers CA Gallinger S Anderson SK Giardina S Ortaldo JR Hozumi N Roder J May 1994 Expression of the NK TR gene is required for NK like activity in human T cells J Immunol 152 6 2669 74 doi 10 4049 jimmunol 152 6 2669 PMID 8144875 S2CID 20265645 a b Entrez Gene NKTR natural killer tumor recognition sequence Further reading editFrey JL Bino T Kantor RR et al 1992 Mechanism of target cell recognition by natural killer cells characterization of a novel triggering molecule restricted to CD3 large granular lymphocytes J Exp Med 174 6 1527 1536 doi 10 1084 jem 174 6 1527 PMC 2119033 PMID 1720812 Rinfret A Anderson SK 1993 IL 2 regulates the expression of the NK TR gene via an alternate RNA splicing mechanism Mol Immunol 30 14 1307 1313 doi 10 1016 0161 5890 93 90047 F PMID 8413330 Anderson SK Gallinger S Roder J et al 1993 A cyclophilin related protein involved in the function of natural killer cells Proc Natl Acad Sci U S A 90 2 542 546 Bibcode 1993PNAS 90 542A doi 10 1073 pnas 90 2 542 PMC 45699 PMID 8421688 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 16903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 45 doi 10 1038 ng1285 PMID 14702039 Sakashita E Tatsumi S Werner D et al 2004 Human RNPS1 and its associated factors a versatile alternative pre mRNA splicing regulator in vivo Mol Cell Biol 24 3 1174 1187 doi 10 1128 MCB 24 3 1174 1187 2004 PMC 321435 PMID 14729963 Olsen JV Blagoev B Gnad F et al 2006 Global in vivo and site specific phosphorylation dynamics in signaling networks Cell 127 3 635 648 doi 10 1016 j cell 2006 09 026 PMID 17081983 S2CID 7827573 Davis TL Walker JR Campagna Slater V et al 2010 Structural and biochemical characterization of the human cyclophilin family of peptidyl prolyl isomerases PLOS Biol 8 7 e1000439 doi 10 1371 journal pbio 1000439 PMC 2911226 PMID 20676357 nbsp This article on a gene on human chromosome 3 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title NKTR amp oldid 1189328284, wikipedia, wiki, book, books, library,
