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Wikipedia

Myosin-2

January 26, 2023

Myosin-2 (myosin heavy chain 2) is a protein that in humans is encoded by the MYH2 gene.[5][6]

MYH2
Identifiers
AliasesMYH2, IBM3, MYH2A, MYHSA2, MYHas8, MyHC-2A, MyHC-IIa, MYPOP, myosin, heavy chain 2, skeletal muscle, adult, myosin heavy chain 2
External IDsOMIM: 160740 MGI: 1339710 HomoloGene: 23019 GeneCards: MYH2
Orthologs
SpeciesHumanMouse
Entrez

4620

17882

Ensembl

ENSG00000125414

ENSMUSG00000033196

UniProt

Q9UKX2

G3UW82

RefSeq (mRNA)

NM_017534
NM_001100112

NM_001039545
NM_144961

RefSeq (protein)

NP_001093582
NP_060004

NP_001034634

Location (UCSC)Chr 17: 10.52 – 10.55 MbChr 11: 67.06 – 67.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125414 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033196 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Smerdu V, Karsch-Mizrachi I, Campione M, Leinwand L, Schiaffino S (Jan 1995). "Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle". Am J Physiol. 267 (6 Pt 1): C1723–8. doi:10.1152/ajpcell.1994.267.6.C1723. PMID 7545970.
  6. ^ "Entrez Gene: MYH2 myosin, heavy chain 2, skeletal muscle, adult".

Further reading

  • Schwartz CE, McNally E, Leinwand L, Skolnick MH (1987). "A polymorphic human myosin heavy chain locus is linked to an anonymous single copy locus (D17S1) at 17p13". Cytogenet. Cell Genet. 43 (1–2): 117–20. doi:10.1159/000132307. PMID 2877813.
  • Ennion S, Sant'ana Pereira J, Sargeant AJ, et al. (1995). "Characterization of human skeletal muscle fibres according to the myosin heavy chains they express". J. Muscle Res. Cell. Motil. 16 (1): 35–43. doi:10.1007/BF00125308. PMID 7751403. S2CID 22270940.
  • Hisatome I, Morisaki T, Kamma H, et al. (1998). "Control of AMP deaminase 1 binding to myosin heavy chain". Am. J. Physiol. 275 (3 Pt 1): C870–81. doi:10.1152/ajpcell.1998.275.3.C870. PMID 9730972.
  • Weiss A, McDonough D, Wertman B, et al. (1999). "Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2958–63. Bibcode:1999PNAS...96.2958W. doi:10.1073/pnas.96.6.2958. PMC 15877. PMID 10077619.
  • Weiss A, Schiaffino S, Leinwand LA (1999). "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity". J. Mol. Biol. 290 (1): 61–75. doi:10.1006/jmbi.1999.2865. PMID 10388558.
  • Onuoha GN, Alpar EK, Laprade M, et al. (1999). "Effects of bone fracture and surgery on plasma myosin heavy chain fragments of skeletal muscle". Clinical and Investigative Medicine. 22 (5): 180–4. PMID 10579056.
  • Martinsson T, Oldfors A, Darin N, et al. (2001). "Autosomal dominant myopathy: missense mutation (Glu-706 --> Lys) in the myosin heavy chain IIa gene". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14614–9. doi:10.1073/pnas.250289597. PMC 18967. PMID 11114175.
  • Tajsharghi H, Thornell LE, Darin N, et al. (2002). "Myosin heavy chain IIa gene mutation E706K is pathogenic and its expression increases with age". Neurology. 58 (5): 780–6. doi:10.1212/wnl.58.5.780. PMID 11889243. S2CID 31098150.
  • England K, Ashford D, Kidd D, Rumsby M (2002). "PKC epsilon is associated with myosin IIA and actin in fibroblasts". Cell. Signal. 14 (6): 529–36. doi:10.1016/S0898-6568(01)00277-7. PMID 11897493.
  • Allen DL, Leinwand LA (2003). "Intracellular calcium and myosin isoform transitions. Calcineurin and calcium-calmodulin kinase pathways regulate preferential activation of the IIa myosin heavy chain promoter". J. Biol. Chem. 277 (47): 45323–30. doi:10.1074/jbc.M208302200. PMID 12235157.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kim EJ, Helfman DM (2003). "Characterization of the metastasis-associated protein, S100A4. Roles of calcium binding and dimerization in cellular localization and interaction with myosin". J. Biol. Chem. 278 (32): 30063–73. doi:10.1074/jbc.M304909200. PMID 12756252.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Chung MC, Kawamoto S (2005). "IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression during phorbol ester-induced promyelocytic HL-60 differentiation". J. Biol. Chem. 279 (53): 56042–52. doi:10.1074/jbc.M404791200. PMID 15496418.
  • Tajsharghi H, Darin N, Rekabdar E, et al. (2005). "Mutations and sequence variation in the human myosin heavy chain IIa gene (MYH2)". Eur. J. Hum. Genet. 13 (5): 617–22. doi:10.1038/sj.ejhg.5201375. PMID 15741996.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Li M, Lionikas A, Yu F, et al. (2006). "Muscle cell and motor protein function in patients with a IIa myosin missense mutation (Glu-706 to Lys)". Neuromuscul. Disord. 16 (11): 782–91. doi:10.1016/j.nmd.2006.07.023. PMC 1693964. PMID 17005402.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


 

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

January 26, 2023
myosin, myosin, heavy, chain, protein, that, humans, encoded, myh2, gene, myh2identifiersaliasesmyh2, ibm3, myh2a, myhsa2, myhas8, myhc, myhc, mypop, myosin, heavy, chain, skeletal, muscle, adult, myosin, heavy, chain, 2external, idsomim, 160740, 1339710, homo. Myosin 2 myosin heavy chain 2 is a protein that in humans is encoded by the MYH2 gene 5 6 MYH2IdentifiersAliasesMYH2 IBM3 MYH2A MYHSA2 MYHas8 MyHC 2A MyHC IIa MYPOP myosin heavy chain 2 skeletal muscle adult myosin heavy chain 2External IDsOMIM 160740 MGI 1339710 HomoloGene 23019 GeneCards MYH2Gene location Human Chr Chromosome 17 human 1 Band17p13 1Start10 521 148 bp 1 End10 549 700 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 B3 11 40 59 cMStart67 061 853 bp 2 End67 088 343 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inbody of tonguevastus lateralis musclethoracic diaphragmtriceps brachii muscledeltoid musclegastrocnemius muscletibialis anterior musclelarynxsuperior surface of tonguecavity of mouthTop expressed insoleus muscleintercostal musclesternocleidomastoid muscleanklemasseter muscletemporal muscleextraocular muscledigastric musclevastus lateralis musclebody of femurMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionnucleotide binding actin binding microfilament motor activity protein binding cytoskeletal motor activity ATP binding calmodulin binding actin filament binding microtubule motor activity microtubule bindingCellular componentcytoplasm myosin filament cytosol myofibril sarcomere myosin complex A band protein containing complex Golgi apparatus actomyosin contractile ring muscle myosin complex cell cell junctionBiological processFc gamma receptor signaling pathway involved in phagocytosis muscle filament sliding microtubule based movement plasma membrane repair muscle contraction response to activity actin mediated cell contractionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez462017882EnsemblENSG00000125414ENSMUSG00000033196UniProtQ9UKX2G3UW82RefSeq mRNA NM 017534NM 001100112NM 001039545NM 144961RefSeq protein NP 001093582NP 060004NP 001034634Location UCSC Chr 17 10 52 10 55 MbChr 11 67 06 67 09 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseReferences Edit a b c GRCh38 Ensembl release 89 ENSG00000125414 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000033196 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Smerdu V Karsch Mizrachi I Campione M Leinwand L Schiaffino S Jan 1995 Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle Am J Physiol 267 6 Pt 1 C1723 8 doi 10 1152 ajpcell 1994 267 6 C1723 PMID 7545970 Entrez Gene MYH2 myosin heavy chain 2 skeletal muscle adult Further reading EditSchwartz CE McNally E Leinwand L Skolnick MH 1987 A polymorphic human myosin heavy chain locus is linked to an anonymous single copy locus D17S1 at 17p13 Cytogenet Cell Genet 43 1 2 117 20 doi 10 1159 000132307 PMID 2877813 Ennion S Sant ana Pereira J Sargeant AJ et al 1995 Characterization of human skeletal muscle fibres according to the myosin heavy chains they express J Muscle Res Cell Motil 16 1 35 43 doi 10 1007 BF00125308 PMID 7751403 S2CID 22270940 Hisatome I Morisaki T Kamma H et al 1998 Control of AMP deaminase 1 binding to myosin heavy chain Am J Physiol 275 3 Pt 1 C870 81 doi 10 1152 ajpcell 1998 275 3 C870 PMID 9730972 Weiss A McDonough D Wertman B et al 1999 Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved Proc Natl Acad Sci U S A 96 6 2958 63 Bibcode 1999PNAS 96 2958W doi 10 1073 pnas 96 6 2958 PMC 15877 PMID 10077619 Weiss A Schiaffino S Leinwand LA 1999 Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family implications for functional diversity J Mol Biol 290 1 61 75 doi 10 1006 jmbi 1999 2865 PMID 10388558 Onuoha GN Alpar EK Laprade M et al 1999 Effects of bone fracture and surgery on plasma myosin heavy chain fragments of skeletal muscle Clinical and Investigative Medicine 22 5 180 4 PMID 10579056 Martinsson T Oldfors A Darin N et al 2001 Autosomal dominant myopathy missense mutation Glu 706 gt Lys in the myosin heavy chain IIa gene Proc Natl Acad Sci U S A 97 26 14614 9 doi 10 1073 pnas 250289597 PMC 18967 PMID 11114175 Tajsharghi H Thornell LE Darin N et al 2002 Myosin heavy chain IIa gene mutation E706K is pathogenic and its expression increases with age Neurology 58 5 780 6 doi 10 1212 wnl 58 5 780 PMID 11889243 S2CID 31098150 England K Ashford D Kidd D Rumsby M 2002 PKC epsilon is associated with myosin IIA and actin in fibroblasts Cell Signal 14 6 529 36 doi 10 1016 S0898 6568 01 00277 7 PMID 11897493 Allen DL Leinwand LA 2003 Intracellular calcium and myosin isoform transitions Calcineurin and calcium calmodulin kinase pathways regulate preferential activation of the IIa myosin heavy chain promoter J Biol Chem 277 47 45323 30 doi 10 1074 jbc M208302200 PMID 12235157 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Kim EJ Helfman DM 2003 Characterization of the metastasis associated protein S100A4 Roles of calcium binding and dimerization in cellular localization and interaction with myosin J Biol Chem 278 32 30063 73 doi 10 1074 jbc M304909200 PMID 12756252 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Chung MC Kawamoto S 2005 IRF 2 is involved in up regulation of nonmuscle myosin heavy chain II A gene expression during phorbol ester induced promyelocytic HL 60 differentiation J Biol Chem 279 53 56042 52 doi 10 1074 jbc M404791200 PMID 15496418 Tajsharghi H Darin N Rekabdar E et al 2005 Mutations and sequence variation in the human myosin heavy chain IIa gene MYH2 Eur J Hum Genet 13 5 617 22 doi 10 1038 sj ejhg 5201375 PMID 15741996 Kimura K Wakamatsu A Suzuki Y et al 2006 Diversification of transcriptional modulation large scale identification and characterization of putative alternative promoters of human genes Genome Res 16 1 55 65 doi 10 1101 gr 4039406 PMC 1356129 PMID 16344560 Li M Lionikas A Yu F et al 2006 Muscle cell and motor protein function in patients with a IIa myosin missense mutation Glu 706 to Lys Neuromuscul Disord 16 11 782 91 doi 10 1016 j nmd 2006 07 023 PMC 1693964 PMID 17005402 Ewing RM Chu P Elisma F et al 2007 Large scale mapping of human protein protein interactions by mass spectrometry Mol Syst Biol 3 1 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 This article on a gene on human chromosome 17 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Myosin 2 amp oldid 1115910047, wikipedia, wiki, book, books, library,

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