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Motile sperm domain containing 2

Motile sperm domain containing 2 is a protein that in humans is encoded by the MOSPD2 gene.[5] It is an endoplasmic reticulum–resident protein involved in membrane contact site formation.[6] Its domain homologous to Major Sperm Protein (MSP domain) is very similar to VAPA/VAPB, so it has been described as the third human member of the VAP protein family.

MOSPD2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMOSPD2, Motile sperm domain containing 2
External IDsMGI: 1924013 HomoloGene: 22125 GeneCards: MOSPD2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001177475
NM_152581
NM_001330241

NM_001290523
NM_001290524
NM_029730

RefSeq (protein)

NP_001170946
NP_001317170
NP_689794

NP_001277452
NP_001277453
NP_084006

Location (UCSC)Chr X: 14.87 – 14.92 MbChr X: 163.72 – 163.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130150 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061778 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Motile sperm domain containing 2".
  6. ^ Di Mattia T, Wilhelm LP, Ikhlef S, Wendling C, Spehner D, Nominé Y, Giordano F, Mathelin C, Drin G, Tomasetto C, Alpy F (June 2018). "Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites". EMBO Reports. 19 (7): e45453. doi:10.15252/embr.201745453. PMC 6030701. PMID 29858488.

Further reading edit

  • Velez Edwards DR, Naj AC, Monda K, North KE, Neuhouser M, Magvanjav O, Kusimo I, Vitolins MZ, Manson JE, O'Sullivan MJ, Rampersaud E, Edwards TL (March 2013). "Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study". Human Genetics. 132 (3): 323–36. doi:10.1007/s00439-012-1246-3. PMC 3704217. PMID 23192594.

External links edit

  • PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Motile sperm domain-containing protein 2

motile, sperm, domain, containing, protein, that, humans, encoded, mospd2, gene, endoplasmic, reticulum, resident, protein, involved, membrane, contact, site, formation, domain, homologous, major, sperm, protein, domain, very, similar, vapa, vapb, been, descri. Motile sperm domain containing 2 is a protein that in humans is encoded by the MOSPD2 gene 5 It is an endoplasmic reticulum resident protein involved in membrane contact site formation 6 Its domain homologous to Major Sperm Protein MSP domain is very similar to VAPA VAPB so it has been described as the third human member of the VAP protein family MOSPD2Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1WICIdentifiersAliasesMOSPD2 Motile sperm domain containing 2External IDsMGI 1924013 HomoloGene 22125 GeneCards MOSPD2Gene location Human Chr X chromosome human 1 BandXp22 2Start14 873 421 bp 1 End14 922 327 bp 1 Gene location Mouse Chr X chromosome mouse 2 BandX X F5Start163 719 165 bp 2 End163 763 371 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insecondary oocytecorpus callosuminferior ganglion of vagus nervemonocytesubthalamic nucleusvisceral pleurabloodponssuperior vestibular nucleusventral tegmental areaTop expressed inparotid glandcarotid bodyciliary bodysciatic nerveirisleft lung lobeconjunctival fornixseminal vesiculacalvariasubmandibular glandMore reference expression dataBioGPSn aOrthologsSpeciesHumanMouseEntrez15874776763EnsemblENSG00000130150ENSMUSG00000061778UniProtQ8NHP6Q9CWP6RefSeq mRNA NM 001177475NM 152581NM 001330241NM 001290523NM 001290524NM 029730RefSeq protein NP 001170946NP 001317170NP 689794NP 001277452NP 001277453NP 084006Location UCSC Chr X 14 87 14 92 MbChr X 163 72 163 76 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseReferences edit a b c GRCh38 Ensembl release 89 ENSG00000130150 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000061778 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene Motile sperm domain containing 2 Di Mattia T Wilhelm LP Ikhlef S Wendling C Spehner D Nomine Y Giordano F Mathelin C Drin G Tomasetto C Alpy F June 2018 Identification of MOSPD2 a novel scaffold for endoplasmic reticulum membrane contact sites EMBO Reports 19 7 e45453 doi 10 15252 embr 201745453 PMC 6030701 PMID 29858488 Further reading editVelez Edwards DR Naj AC Monda K North KE Neuhouser M Magvanjav O Kusimo I Vitolins MZ Manson JE O Sullivan MJ Rampersaud E Edwards TL March 2013 Gene environment interactions and obesity traits among postmenopausal African American and Hispanic women in the Women s Health Initiative SHARe Study Human Genetics 132 3 323 36 doi 10 1007 s00439 012 1246 3 PMC 3704217 PMID 23192594 External links editPDBe KB provides an overview of all the structure information available in the PDB for Mouse Motile sperm domain containing protein 2 nbsp This article on a gene on the human X chromosome and or its associated protein is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Motile sperm domain containing 2 amp oldid 1079536711, wikipedia, wiki, book, books, library,

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