Molecular cellular cognition (MCC) is a branch of neuroscience that involves the study of cognitive processes with approaches that integrate molecular, cellular and behavioral mechanisms. Key goals of MCC studies include the derivation of molecular and cellular explanations of cognitive processes, as well as finding mechanisms and treatments for cognitive disorders.
Although closely connected with behavioral genetics, MCC emphasizes the integration of molecular and cellular explanations of behavior, instead of focusing on the connections between genes and behavior.
Unlike cognitive neuroscience, which historically has focused on the connection between human brain systems and behavior, the field of MCC has used model organisms, such as mice, to study how molecular (i.e. receptor, kinase activation, phosphatase regulation), intra-cellular (i.e. dendritic processes), and inter-cellular processes (i.e. synaptic plasticity; network representations such as place fields) modulate cognitive function.
Methods employed in MCC include (but are not limited to) transgenic organisms (i.e. mice), viral vectors, pharmacology, in vitro and in vivoelectrophysiology, optogenetics, in vivo imaging, and behavioral analysis. Modeling has become an essential component of the field because of the complexity of the multilevel data generated.
MCC became an organized field with the formation of the Molecular Cellular Cognition Society, an organization with no membership fees and meetings that emphasize the participation of junior scientists. Its first meeting took place in Orlando, Florida on November first, 2002. As of 2012[update], the society had organized numerous meetings in North America, Europe, and Asia, and included more than 4000 members.
Referencesedit
^Morris RG, Anderson E, Lynch GS, Baudry M (1986). "Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5". Nature. 319 (6056): 774–6. Bibcode:1986Natur.319..774M. doi:10.1038/319774a0. PMID 2869411. S2CID 4356601.
^Silva AJ, Paylor R, Wehner JM, Tonegawa S (1992). "Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice". Science. 257 (5067): 206–11. Bibcode:1992Sci...257..206S. doi:10.1126/science.1321493. PMID 1321493.
^Silva AJ, Stevens CF, Tonegawa S, Wang Y (1992). "Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice". Science. 257 (5067): 201–6. Bibcode:1992Sci...257..201S. doi:10.1126/science.1378648. PMID 1378648.
^Grant SG, O'Dell TJ, Karl KA, Stein PL, Soriano P, Kandel ER (1992). "Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice". Science. 258 (5090): 1903–10. Bibcode:1992Sci...258.1903G. doi:10.1126/science.1361685. PMID 1361685. S2CID 21065410.
^Silva AJ (2003). "Molecular and cellular cognitive studies of the role of synaptic plasticity in memory". J. Neurobiol. 54 (1): 224–37. doi:10.1002/neu.10169. PMID 12486706.
External linksedit
April 11, 2024
molecular, cellular, cognition, branch, neuroscience, that, involves, study, cognitive, processes, with, approaches, that, integrate, molecular, cellular, behavioral, mechanisms, goals, studies, include, derivation, molecular, cellular, explanations, cognitive. Molecular cellular cognition MCC is a branch of neuroscience that involves the study of cognitive processes with approaches that integrate molecular cellular and behavioral mechanisms Key goals of MCC studies include the derivation of molecular and cellular explanations of cognitive processes as well as finding mechanisms and treatments for cognitive disorders Although closely connected with behavioral genetics MCC emphasizes the integration of molecular and cellular explanations of behavior instead of focusing on the connections between genes and behavior Unlike cognitive neuroscience which historically has focused on the connection between human brain systems and behavior the field of MCC has used model organisms such as mice to study how molecular i e receptor kinase activation phosphatase regulation intra cellular i e dendritic processes and inter cellular processes i e synaptic plasticity network representations such as place fields modulate cognitive function Methods employed in MCC include but are not limited to transgenic organisms i e mice viral vectors pharmacology in vitro and in vivo electrophysiology optogenetics in vivo imaging and behavioral analysis Modeling has become an essential component of the field because of the complexity of the multilevel data generated Contents 1 Scientific roots 2 Foundation of the field 3 References 4 External linksScientific roots editThe field of MCC has its roots in the pioneering pharmacological studies of the role of NMDA receptor in long term potentiation and spatial learning 1 and in studies that used knockout mice to look at the role of the alpha calcium calmodulin kinase II 2 3 and FYN kinase 4 in hippocampal long term potentiation and spatial learning The field has since expanded to include a large array of molecules including CREB 5 Foundation of the field editMCC became an organized field with the formation of the Molecular Cellular Cognition Society an organization with no membership fees and meetings that emphasize the participation of junior scientists Its first meeting took place in Orlando Florida on November first 2002 As of 2012 update the society had organized numerous meetings in North America Europe and Asia and included more than 4000 members References edit Morris RG Anderson E Lynch GS Baudry M 1986 Selective impairment of learning and blockade of long term potentiation by an N methyl D aspartate receptor antagonist AP5 Nature 319 6056 774 6 Bibcode 1986Natur 319 774M doi 10 1038 319774a0 PMID 2869411 S2CID 4356601 Silva AJ Paylor R Wehner JM Tonegawa S 1992 Impaired spatial learning in alpha calcium calmodulin kinase II mutant mice Science 257 5067 206 11 Bibcode 1992Sci 257 206S doi 10 1126 science 1321493 PMID 1321493 Silva AJ Stevens CF Tonegawa S Wang Y 1992 Deficient hippocampal long term potentiation in alpha calcium calmodulin kinase II mutant mice Science 257 5067 201 6 Bibcode 1992Sci 257 201S doi 10 1126 science 1378648 PMID 1378648 Grant SG O Dell TJ Karl KA Stein PL Soriano P Kandel ER 1992 Impaired long term potentiation spatial learning and hippocampal development in fyn mutant mice Science 258 5090 1903 10 Bibcode 1992Sci 258 1903G doi 10 1126 science 1361685 PMID 1361685 S2CID 21065410 Silva AJ 2003 Molecular and cellular cognitive studies of the role of synaptic plasticity in memory J Neurobiol 54 1 224 37 doi 10 1002 neu 10169 PMID 12486706 External links editMolecular and Cellular Cognition Society Retrieved from https en wikipedia org w index php title Molecular cellular cognition amp oldid 1181730170, wikipedia, wiki, book, books, library,
