The Moco RNA motif is a conserved RNA structure [1] that is presumed to be a riboswitch that binds molybdenum cofactor or the related tungsten cofactor. Genetic experiments support the hypothesis that the Moco RNA motif corresponds to a genetic control element that responds to changing concentrations of molybdenum or tungsten cofactor.[2] As these cofactors are not available in purified form, in vitro binding assays cannot be performed. However, the genetic data, complex structure of the RNA and the failure to detect a protein involved in the regulation suggest that the Moco RNA motif corresponds to a class of riboswitches.
Consensus secondary structure of Moco RNAs. Layout is similar to a previously published figure.[2]
Referencesedit
^Weinberg Z, Barrick JE, Yao Z, et al. (2007). "Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline". Nucleic Acids Res. 35 (14): 4809–4819. doi:10.1093/nar/gkm487. PMC1950547. PMID 17621584.
^ abRegulski EE, Moy RH, Weinberg Z, et al. (2008). "A widespread riboswitch candidate that controls bacterial genes involved in molybdenum cofactor and tungsten cofactor metabolism". Mol. Microbiol. 68 (4): 918–932. doi:10.1111/j.1365-2958.2008.06208.x. PMC2408646. PMID 18363797.
moco, motif, conserved, structure, that, presumed, riboswitch, that, binds, molybdenum, cofactor, related, tungsten, cofactor, genetic, experiments, support, hypothesis, that, corresponds, genetic, control, element, that, responds, changing, concentrations, mo. The Moco RNA motif is a conserved RNA structure 1 that is presumed to be a riboswitch that binds molybdenum cofactor or the related tungsten cofactor Genetic experiments support the hypothesis that the Moco RNA motif corresponds to a genetic control element that responds to changing concentrations of molybdenum or tungsten cofactor 2 As these cofactors are not available in purified form in vitro binding assays cannot be performed However the genetic data complex structure of the RNA and the failure to detect a protein involved in the regulation suggest that the Moco RNA motif corresponds to a class of riboswitches Moco molybdenum cofactor riboswitchPredicted secondary structure and sequence conservation of MOCO RNA motifIdentifiersSymbolMOCO RNA motifRfamRF01055Other dataRNA typeCis reg riboswitchDomain s BacteriaSOSO 0005836PDB structuresPDBe Consensus secondary structure of Moco RNAs Layout is similar to a previously published figure 2 References edit Weinberg Z Barrick JE Yao Z et al 2007 Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline Nucleic Acids Res 35 14 4809 4819 doi 10 1093 nar gkm487 PMC 1950547 PMID 17621584 a b Regulski EE Moy RH Weinberg Z et al 2008 A widespread riboswitch candidate that controls bacterial genes involved in molybdenum cofactor and tungsten cofactor metabolism Mol Microbiol 68 4 918 932 doi 10 1111 j 1365 2958 2008 06208 x PMC 2408646 PMID 18363797 External links editPage for Moco RNA motif at Rfam nbsp This molecular or cell biology article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Moco RNA motif amp oldid 1059159877, wikipedia, wiki, book, books, library,
