^Petretto E, Sarwar R, Grieve I, Lu H, Kumaran MK, Muckett PJ, Mangion J, Schroen B, Benson M, Punjabi PP, Prasad SK, Pennell DJ, Kiesewetter C, Tasheva ES, Corpuz LM, Webb MD, Conrad GW, Kurtz TW, Kren V, Fischer J, Hubner N, Pinto YM, Pravenec M, Aitman TJ, Cook SA (May 2008). "Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass". Nat. Genet. 40 (5): 546–52. doi:10.1038/ng.134. PMC2742198. PMID 18443592.
Further readingedit
Kukita A, Bonewald L, Rosen D, et al. (1990). "Osteoinductive factor inhibits formation of human osteoclast-like cells". Proc. Natl. Acad. Sci. U.S.A. 87 (8): 3023–6. Bibcode:1990PNAS...87.3023K. doi:10.1073/pnas.87.8.3023. PMC53826. PMID 2326263.
Madisen L, Neubauer M, Plowman G, et al. (1990). "Molecular cloning of a novel bone-forming compound: osteoinductive factor". DNA Cell Biol. 9 (5): 303–9. doi:10.1089/dna.1990.9.303. PMID 2372374.
Tasheva ES, Funderburgh ML, McReynolds J, et al. (1999). "The bovine mimecan gene. Molecular cloning and characterization of two major RNA transcripts generated by alternative use of two splice acceptor sites in the third exon". J. Biol. Chem. 274 (26): 18693–701. doi:10.1074/jbc.274.26.18693. PMID 10373482.
Matsushima N, Ohyanagi T, Tanaka T, Kretsinger RH (2000). "Super-motifs and evolution of tandem leucine-rich repeats within the small proteoglycans--biglycan, decorin, lumican, fibromodulin, PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin". Proteins. 38 (2): 210–25. doi:10.1002/(SICI)1097-0134(20000201)38:2<210::AID-PROT9>3.0.CO;2-1. PMID 10656267. S2CID 39643243.
Pellegata NS, Dieguez-Lucena JL, Joensuu T, et al. (2000). "Mutations in KERA, encoding keratocan, cause cornea plana". Nat. Genet. 25 (1): 91–5. doi:10.1038/75664. PMID 10802664. S2CID 8837115.
Tasheva ES, Pettenati M, Von Kap-Her C, Conrad GW (2000). "Assignment of mimecan gene (OGN) to human chromosome band 9q22 by in situ hybridization". Cytogenet. Cell Genet. 88 (3–4): 326–7. doi:10.1159/000015521. PMID 10828622. S2CID 39568354.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC16901. PMID 10931946.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Tasheva ES, Conrad GW (2003). "The UV responsive elements in the human mimecan promoter: a functional characterization". Mol. Vis. 9: 1–9. PMID 12533723.
Luijendijk MW, van de Pol TJ, van Duijnhoven G, et al. (2004). "Cloning, characterization, and mRNA expression analysis of novel human fetal cochlear cDNAs". Genomics. 82 (4): 480–90. doi:10.1016/S0888-7543(03)00150-2. PMID 13679028.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC2734081. PMID 15164053.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC528930. PMID 15489336.
Hu SM, Li F, Yu HM, et al. (2006). "The mimecan gene expressed in human pituitary and regulated by pituitary transcription factor-1 as a marker for diagnosing pituitary tumors". J. Clin. Endocrinol. Metab. 90 (12): 6657–64. doi:10.1210/jc.2005-0322. PMID 16189248.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC1347501. PMID 16381901.
April 15, 2024
osteoglycin, also, called, mimecan, encoded, gene, human, protein, ognidentifiersaliasesogn, slrr3a, osteoglycinexternal, idsomim, 602383, 109278, homologene, 8542, genecards, ogngene, location, human, chromosome, human, band9q22, 31start92, end92, gene, locat. Osteoglycin also called mimecan encoded by the OGN gene is a human protein 5 OGNIdentifiersAliasesOGN OG OIF SLRR3A osteoglycinExternal IDsOMIM 602383 MGI 109278 HomoloGene 8542 GeneCards OGNGene location Human Chr Chromosome 9 human 1 Band9q22 31Start92 383 268 bp 1 End92 404 696 bp 1 Gene location Mouse Chr Chromosome 13 mouse 2 Band13 13 A5Start49 761 522 bp 2 End49 777 977 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright coronary arteryparietal pleuraascending aortagallbladderleft coronary arteryvena cavatrigeminal gangliongerminal epitheliumsuperficial temporal arterylactiferous ductTop expressed insciatic nervecalvariaciliary bodycervixleft lungcarotid bodyexternal carotid arteryintercostal muscleleft lung lobedermisMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding growth factor activity extracellular matrix structural constituent conferring compression resistanceCellular componentextracellular vesicle extracellular matrix lysosomal lumen Golgi lumen extracellular exosome extracellular space extracellular region collagen containing extracellular matrixBiological processnegative regulation of smooth muscle cell proliferation axonogenesis keratan sulfate catabolic process keratan sulfate biosynthetic process regulation of signaling receptor activity signal transductionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez496918295EnsemblENSG00000106809ENSMUSG00000021390UniProtP20774Q62000RefSeq mRNA NM 033014NM 014057NM 024416NM 008760RefSeq protein NP 054776NP 077727NP 148935NP 054776 1NP 148935 1NP 032786Location UCSC Chr 9 92 38 92 4 MbChr 13 49 76 49 78 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta This protein is a small keratan sulfate proteoglycan 6 which contains tandem leucine rich repeats LRR The gene expresses three transcript variants 5 The level of expression of this gene has been correlated with enlarged hearts and more specifically left ventricular hypertrophy 7 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000106809 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000021390 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene OGN osteoglycin Funderburgh JL Corpuz LM Roth MR Funderburgh ML Tasheva ES Conrad GW 1997 Mimecan the 25 kDa corneal keratan sulfate proteoglycan is a product of the gene producing osteoglycin J Biol Chem 272 44 28089 95 doi 10 1074 jbc 272 44 28089 PMID 9346963 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Big hearts have genetic problem Health BBC News 2008 06 06 Retrieved 2008 06 07 Petretto E Sarwar R Grieve I Lu H Kumaran MK Muckett PJ Mangion J Schroen B Benson M Punjabi PP Prasad SK Pennell DJ Kiesewetter C Tasheva ES Corpuz LM Webb MD Conrad GW Kurtz TW Kren V Fischer J Hubner N Pinto YM Pravenec M Aitman TJ Cook SA May 2008 Integrated genomic approaches implicate osteoglycin Ogn in the regulation of left ventricular mass Nat Genet 40 5 546 52 doi 10 1038 ng 134 PMC 2742198 PMID 18443592 Further reading editKukita A Bonewald L Rosen D et al 1990 Osteoinductive factor inhibits formation of human osteoclast like cells Proc Natl Acad Sci U S A 87 8 3023 6 Bibcode 1990PNAS 87 3023K doi 10 1073 pnas 87 8 3023 PMC 53826 PMID 2326263 Madisen L Neubauer M Plowman G et al 1990 Molecular cloning of a novel bone forming compound osteoinductive factor DNA Cell Biol 9 5 303 9 doi 10 1089 dna 1990 9 303 PMID 2372374 Tasheva ES Funderburgh ML McReynolds J et al 1999 The bovine mimecan gene Molecular cloning and characterization of two major RNA transcripts generated by alternative use of two splice acceptor sites in the third exon J Biol Chem 274 26 18693 701 doi 10 1074 jbc 274 26 18693 PMID 10373482 Matsushima N Ohyanagi T Tanaka T Kretsinger RH 2000 Super motifs and evolution of tandem leucine rich repeats within the small proteoglycans biglycan decorin lumican fibromodulin PRELP keratocan osteoadherin epiphycan and osteoglycin Proteins 38 2 210 25 doi 10 1002 SICI 1097 0134 20000201 38 2 lt 210 AID PROT9 gt 3 0 CO 2 1 PMID 10656267 S2CID 39643243 Pellegata NS Dieguez Lucena JL Joensuu T et al 2000 Mutations in KERA encoding keratocan cause cornea plana Nat Genet 25 1 91 5 doi 10 1038 75664 PMID 10802664 S2CID 8837115 Tasheva ES Pettenati M Von Kap Her C Conrad GW 2000 Assignment of mimecan gene OGN to human chromosome band 9q22 by in situ hybridization Cytogenet Cell Genet 88 3 4 326 7 doi 10 1159 000015521 PMID 10828622 S2CID 39568354 Hu RM Han ZG Song HD et al 2000 Gene expression profiling in the human hypothalamus pituitary adrenal axis and full length cDNA cloning Proc Natl Acad Sci U S A 97 17 9543 8 Bibcode 2000PNAS 97 9543H doi 10 1073 pnas 160270997 PMC 16901 PMID 10931946 Hartley JL Temple GF Brasch MA 2001 DNA Cloning Using In Vitro Site Specific Recombination Genome Res 10 11 1788 95 doi 10 1101 gr 143000 PMC 310948 PMID 11076863 Wiemann S Weil B Wellenreuther R et al 2001 Toward a Catalog of Human Genes and Proteins Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs Genome Res 11 3 422 35 doi 10 1101 gr GR1547R PMC 311072 PMID 11230166 Simpson JC Wellenreuther R Poustka A et al 2001 Systematic subcellular localization of novel proteins identified by large scale cDNA sequencing EMBO Rep 1 3 287 92 doi 10 1093 embo reports kvd058 PMC 1083732 PMID 11256614 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Tasheva ES Conrad GW 2003 The UV responsive elements in the human mimecan promoter a functional characterization Mol Vis 9 1 9 PMID 12533723 Luijendijk MW van de Pol TJ van Duijnhoven G et al 2004 Cloning characterization and mRNA expression analysis of novel human fetal cochlear cDNAs Genomics 82 4 480 90 doi 10 1016 S0888 7543 03 00150 2 PMID 13679028 Humphray SJ Oliver K Hunt AR et al 2004 DNA sequence and analysis of human chromosome 9 Nature 429 6990 369 74 Bibcode 2004Natur 429 369H doi 10 1038 nature02465 PMC 2734081 PMID 15164053 Zhang Z Henzel WJ 2005 Signal peptide prediction based on analysis of experimentally verified cleavage sites Protein Sci 13 10 2819 24 doi 10 1110 ps 04682504 PMC 2286551 PMID 15340161 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Wiemann S Arlt D Huber W et al 2004 From ORFeome to Biology A Functional Genomics Pipeline Genome Res 14 10B 2136 44 doi 10 1101 gr 2576704 PMC 528930 PMID 15489336 Hu SM Li F Yu HM et al 2006 The mimecan gene expressed in human pituitary and regulated by pituitary transcription factor 1 as a marker for diagnosing pituitary tumors J Clin Endocrinol Metab 90 12 6657 64 doi 10 1210 jc 2005 0322 PMID 16189248 Otsuki T Ota T Nishikawa T et al 2007 Signal sequence and keyword trap in silico for selection of full length human cDNAs encoding secretion or membrane proteins from oligo capped cDNA libraries DNA Res 12 2 117 26 doi 10 1093 dnares 12 2 117 PMID 16303743 Mehrle A Rosenfelder H Schupp I et al 2006 The LIFEdb database in 2006 Nucleic Acids Res 34 Database issue D415 8 doi 10 1093 nar gkj139 PMC 1347501 PMID 16381901 Retrieved from https en wikipedia org w index php title Osteoglycin amp oldid 1161355764, wikipedia, wiki, book, books, library,
