The metanephrogenic blastema or metanephric blastema (or metanephric mesenchyme, or metanephric mesoderm) is one of the two embryological structures that give rise to the kidney, the other being the ureteric bud.
The system of tissue induction between the ureteric bud and the metanephric blastema is a reciprocal control system. GDNF, glial cell-derived neurotrophic factor, is produced by the metanephric blastema and is essential in binding to the Ret receptor on the ureteric bud,[1] which bifurcates and coalesces as a result to form the renal pelvis, major and minor calyces and collecting ducts. Mutations in the EYA1 gene, whose product regulates GDNF expression in the developing kidney,[2] lead to the renal abnormalities of BOR syndrome (branchio-oto-renal syndrome).
^Tang, Ming-Jer; Worley, Dane; Sanicola, Michele; Dressler, Gregory R. (1998). "The RET–Glial Cell-derived Neurotrophic Factor (GDNF) Pathway Stimulates Migration and Chemoattraction of Epithelial Cells". Journal of Cell Biology. 142 (5): 1337–1345. doi:10.1083/jcb.142.5.1337.
^Ruf, Rainer G.; Xu, Pin-Xian; Silvius, Derek; Otto, Edgar A.; Beekmann, Frank; Muerb, Ulla T.; et al. (2004). "SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes". Proceedings of the National Academy of Sciences. 101 (21): 8090–8095. doi:10.1073/pnas.0308475101.
Qiao J, Cohen D, Herzlinger D (1995). "The metanephric blastema differentiates into collecting system and nephron epithelia in vitro". Development. 121 (10): 3207–14. PMID 7588055.
December 15, 2023
metanephrogenic, blastema, metanephrogenic, blastema, metanephric, blastema, metanephric, mesenchyme, metanephric, mesoderm, embryological, structures, that, give, rise, kidney, other, being, ureteric, detailscarnegie, stage14days35precursorwolffian, ductgives. The metanephrogenic blastema or metanephric blastema or metanephric mesenchyme or metanephric mesoderm is one of the two embryological structures that give rise to the kidney the other being the ureteric bud Metanephrogenic blastemaDetailsCarnegie stage14Days35PrecursorWolffian ductGives rise tonephron Bowman s capsule connecting tubule distal convoluted tubule glomerulus loop of Henle proximal convoluted tubule but not collecting ductIdentifiersLatinblastema metanephrogenicumTEblastema by E5 6 3 2 0 0 1 E5 6 3 2 0 0 1Anatomical terminology edit on Wikidata The metanephric blastema mostly develops into nephrons but can also form parts of the collecting duct system The system of tissue induction between the ureteric bud and the metanephric blastema is a reciprocal control system GDNF glial cell derived neurotrophic factor is produced by the metanephric blastema and is essential in binding to the Ret receptor on the ureteric bud 1 which bifurcates and coalesces as a result to form the renal pelvis major and minor calyces and collecting ducts Mutations in the EYA1 gene whose product regulates GDNF expression in the developing kidney 2 lead to the renal abnormalities of BOR syndrome branchio oto renal syndrome See also editMesenchyme Metanephros Blastema Kidney developmentReferences edit Tang Ming Jer Worley Dane Sanicola Michele Dressler Gregory R 1998 The RET Glial Cell derived Neurotrophic Factor GDNF Pathway Stimulates Migration and Chemoattraction of Epithelial Cells Journal of Cell Biology 142 5 1337 1345 doi 10 1083 jcb 142 5 1337 Ruf Rainer G Xu Pin Xian Silvius Derek Otto Edgar A Beekmann Frank Muerb Ulla T et al 2004 SIX1 mutations cause branchio oto renal syndrome by disruption of EYA1 SIX1 DNA complexes Proceedings of the National Academy of Sciences 101 21 8090 8095 doi 10 1073 pnas 0308475101 External links editSwiss embryology from UL UB and UF turinary urinhaute01 genital 017a Embryo Images at University of North Carolina Diagram at mcgill ca 1 Diagram at mcgill ca 2 Qiao J Cohen D Herzlinger D 1995 The metanephric blastema differentiates into collecting system and nephron epithelia in vitro Development 121 10 3207 14 PMID 7588055 Retrieved from https en wikipedia org w index php title Metanephrogenic blastema amp oldid 1146254679, wikipedia, wiki, book, books, library,
