Membrane stabilizing effects involve the inhibition or total abolishing of action potentials from being propagated across the membrane. This phenomenon is common in nerve tissues as they are the carrier of impulses from the periphery to the central nervous system. Membrane stabilization is the method through which local anesthetics work. They block the propagation of action potentials across nerve cells, thereby producing a nerve block.
Some beta-blockers also possess what is referred to as membrane stabilizing activity (MSA). This effect is similar to the membrane stabilizing activity of sodium channel blockers that represent Class I antiarrhythmics. MSA agents produced by beta-blockers reduce the increase of cardiac action potential, while also leading to other electrophysiological effects. However, MSA occurs only at very high concentrations and is not of clinical relevance, except after large doses of MSA compounds.[1]
Referencesedit
^Aronson, JK (2008). "Changing beta-blockers in heart failure: when is a class not a class?". The British Journal of General Practice. 58 (551): 387–389. doi:10.3399/bjgp08X299317. PMC2418988. PMID 18505613.
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membrane, stabilizing, effect, this, article, needs, additional, citations, verification, please, help, improve, this, article, adding, citations, reliable, sources, unsourced, material, challenged, removed, find, sources, news, newspapers, books, scholar, jst. This article needs additional citations for verification Please help improve this article by adding citations to reliable sources Unsourced material may be challenged and removed Find sources Membrane stabilizing effect news newspapers books scholar JSTOR March 2017 Learn how and when to remove this template message Membrane stabilizing effects involve the inhibition or total abolishing of action potentials from being propagated across the membrane This phenomenon is common in nerve tissues as they are the carrier of impulses from the periphery to the central nervous system Membrane stabilization is the method through which local anesthetics work They block the propagation of action potentials across nerve cells thereby producing a nerve block Some beta blockers also possess what is referred to as membrane stabilizing activity MSA This effect is similar to the membrane stabilizing activity of sodium channel blockers that represent Class I antiarrhythmics MSA agents produced by beta blockers reduce the increase of cardiac action potential while also leading to other electrophysiological effects However MSA occurs only at very high concentrations and is not of clinical relevance except after large doses of MSA compounds 1 References edit Aronson JK 2008 Changing beta blockers in heart failure when is a class not a class The British Journal of General Practice 58 551 387 389 doi 10 3399 bjgp08X299317 PMC 2418988 PMID 18505613 nbsp This article related to medical imaging is a stub You can help Wikipedia by expanding it vte nbsp This biology article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Membrane stabilizing effect amp oldid 1166042335, wikipedia, wiki, book, books, library,
