Huggins believed that he had been the first to suggest the concept of the hydrogen bond, while he was a student under G. N. Lewis at the Chemical Laboratory of the University of California, Berkeley. According to his account, he wrote a thesis in 1919 in which the H-bond was introduced and applied to tautomerism in acetoacetic acid. Unfortunately, no hard copy of the thesis remains. The first extant publication of the H-bond was that of Wendell Latimer and Worth Rodebush in 1920, who cite Huggins' unpublished work in a footnote. (They were fellow scientists at the Chemical Laboratory.)
Structure of the peptide bond
In 1937, Huggins analyzed the β-sheet models of William Astbury and realized that the hydrogen bonding could not work as described since the bond geometry of the amide nitrogen (then presumed to be tetrahedral) would deflect the hydrogen away from the carbonyl oxygen. He further suggested that resonance might play a role in changing the geometry of the peptide bond to make the hydrogen bonds more linear. However, he did not state explicitly that the peptide bond was planar, as emphasized by Pauling in a nearly simultaneous paper.
Huggins was born in 1897 to Amos Williamson Huggins and Mary Abigail Hackley. He had at least two sisters, Dorothea Harriet Huggins (born 22 September 1894) and Mary Abigail Huggins (born 2 October 1904).
Huggins earned his Ph.D. in 1922 under Charles Walter Porter (known as Walter Porter) in the Chemistry Laboratory of the University of California, Berkeley.[1] In 1941 he was elected a Fellow of the American Physical Society.[2] He was employed as a chemist by Eastman Kodak Research Laboratories.[3][4]
References
^Calvin, Melvin; Seaborg, Glenn T. (1984). "The College of Chemistry in the G. N. Lewis Era: 1912-1946". Journal of Chemical Education. 61 (1): 11. Bibcode:1984JChEd..61...11C. doi:10.1021/ed061p11.
^"APS Fellow Archive". American Physical Society. (search on year 1941 and Eastman Kodak Company)
^"Science: Portrait of a Molecule". Time Magazine. January 22, 1945.
^"Maurice Huggins, interviewed by J. Knox". Oral History Interviews, American Institute of Physics. January 11, 1976.
Latimer WM and Rodebush WH. (1920) "Polarity and Ionization from the Standpoint of the Lewis Theory of Valence", J. Am. Chem. Soc., 42, 1419–1433.
Huggins ML. (1936) J. Org. Chem., 1, 407–456.
Pauling L and Niemann C. (1939) J. Am. Chem. Soc., 61, 1860–1867.
Huggins M. (1943) "The structure of fibrous proteins", Chem. Rev., 32, 195–218.
maurice, loyal, huggins, september, 1897, berkeley, county, west, virginia, december, 1981, scientist, independently, conceived, idea, hydrogen, bonding, early, advocate, their, role, stabilizing, protein, secondary, structure, important, polymer, theory, flor. Maurice Loyal Huggins 19 September 1897 Berkeley County West Virginia 17 December 1981 was a scientist who independently conceived the idea of hydrogen bonding and who was an early advocate for their role in stabilizing protein secondary structure An important polymer theory Flory Huggins theory is also named after him Contents 1 Controversies over the hydrogen bond 2 Structure of the peptide bond 3 Structure of the a helix 4 Flory Huggins theory 5 Personal history 6 ReferencesControversies over the hydrogen bond EditHuggins believed that he had been the first to suggest the concept of the hydrogen bond while he was a student under G N Lewis at the Chemical Laboratory of the University of California Berkeley According to his account he wrote a thesis in 1919 in which the H bond was introduced and applied to tautomerism in acetoacetic acid Unfortunately no hard copy of the thesis remains The first extant publication of the H bond was that of Wendell Latimer and Worth Rodebush in 1920 who cite Huggins unpublished work in a footnote They were fellow scientists at the Chemical Laboratory Structure of the peptide bond EditIn 1937 Huggins analyzed the b sheet models of William Astbury and realized that the hydrogen bonding could not work as described since the bond geometry of the amide nitrogen then presumed to be tetrahedral would deflect the hydrogen away from the carbonyl oxygen He further suggested that resonance might play a role in changing the geometry of the peptide bond to make the hydrogen bonds more linear However he did not state explicitly that the peptide bond was planar as emphasized by Pauling in a nearly simultaneous paper Structure of the a helix EditHuggins also produced a model of the a helix in 1943 roughly eight years ahead of the modern model of Linus Pauling Robert Corey and Herman Branson Flory Huggins theory EditMain article Flory Huggins solution theoryPersonal history EditHuggins was born in 1897 to Amos Williamson Huggins and Mary Abigail Hackley He had at least two sisters Dorothea Harriet Huggins born 22 September 1894 and Mary Abigail Huggins born 2 October 1904 Huggins earned his Ph D in 1922 under Charles Walter Porter known as Walter Porter in the Chemistry Laboratory of the University of California Berkeley 1 In 1941 he was elected a Fellow of the American Physical Society 2 He was employed as a chemist by Eastman Kodak Research Laboratories 3 4 References Edit Calvin Melvin Seaborg Glenn T 1984 The College of Chemistry in the G N Lewis Era 1912 1946 Journal of Chemical Education 61 1 11 Bibcode 1984JChEd 61 11C doi 10 1021 ed061p11 APS Fellow Archive American Physical Society search on year 1941 and Eastman Kodak Company Science Portrait of a Molecule Time Magazine January 22 1945 Maurice Huggins interviewed by J Knox Oral History Interviews American Institute of Physics January 11 1976 Latimer WM and Rodebush WH 1920 Polarity and Ionization from the Standpoint of the Lewis Theory of Valence J Am Chem Soc 42 1419 1433 Huggins ML 1936 J Org Chem 1 407 456 Pauling L and Niemann C 1939 J Am Chem Soc 61 1860 1867 Huggins M 1943 The structure of fibrous proteins Chem Rev 32 195 218 Huggins ML 1971 Angew Chem Int Ed 10 147 152 Huggins ML 1980 Chem Tech 10 422 Retrieved from https en wikipedia org w index php title Maurice Loyal Huggins amp oldid 1155439432, wikipedia, wiki, book, books, library,
