Mafenide (INN; usually as mafenide acetate, trade name Sulfamylon) is a sulfonamide-type medication used as an antibiotic. It was approved by the FDA in 1948.[citation needed]
Mafenide is used to treat severe burns.[1][2] It is used topically as an adjunctive therapy for second- and third-degree burns. It is bacteriostatic against many gram-positive and gram-negative organisms, including Pseudomonas aeruginosa. Some sources state that mafenide is more appropriate for non-facial burns, while chloramphenicol/prednisolone or bacitracin are more appropriate for facial burns.[3]
Mechanism of action
Mafenide works by reducing the bacterial population present in the avascular tissues of burns and permits spontaneous healing of deep partial-thickness burns.[citation needed]
Adverse reactions
Adverse reactions can include superinfection, pain or burning upon application, rash, pruritus, tachypnea, or hyperventilation. Mafenide is metabolized to a carbonic anhydrase inhibitor, which could potentially result in metabolic acidosis.[4]
Mafenide is contraindicated in those with sulfonamide hypersensitivity or renal impairment.
Dosage
For use as adjunctive therapy for second- and third-degree burns to prevent infection, adults and children should apply topically to a thickness of approximately 1.6 mm to cleaned and debrided wound once or twice per day with a sterile gloved hand. The burned area should be covered with cream at all times.[citation needed]
References
^Siuda J. F.; Cihonski C. D. (1972). "New compounds: carbamate derivatives of mafenide (homosulfanilamide)". J. Pharm. Sci. 61 (11): 1856–1857. doi:10.1002/jps.2600611143. PMID 4652670.
^Haynes B. (1971). "Mafenide acetate in Burn Treatment". New England Journal of Medicine. 284 (23): 1324. doi:10.1056/NEJM197106102842310. PMID 5576444.
^Haik J, Ashkenazy O, Sinai S, et al. (November 2005). "Burn care standards in Israel: lack of consensus". Burns. 31 (7): 845–9. doi:10.1016/j.burns.2005.04.012. PMID 15967581.
^"Sulfamylon (Mafenide Acetate)". RxList. Retrieved 22 December 2022.
External links
May 04, 2023
mafenide, this, article, needs, additional, citations, verification, please, help, improve, this, article, adding, citations, reliable, sources, unsourced, material, challenged, removed, find, sources, news, newspapers, books, scholar, jstor, september, 2022, . This article needs additional citations for verification Please help improve this article by adding citations to reliable sources Unsourced material may be challenged and removed Find sources Mafenide news newspapers books scholar JSTOR September 2022 Learn how and when to remove this template message Mafenide INN usually as mafenide acetate trade name Sulfamylon is a sulfonamide type medication used as an antibiotic It was approved by the FDA in 1948 citation needed MafenideClinical dataTrade namesSulfamylon MafylonAHFS Drugs comMonographRoutes ofadministrationTopicalATC codeD06BA03 WHO Legal statusLegal statusIn general Prescription only IdentifiersIUPAC name 4 Aminomethyl benzenesulfonamideCAS Number138 39 6 NPubChem CID3998ChemSpider3858 YUNII58447S8P4LKEGGD02351 YChEMBLChEMBL419 YCompTox Dashboard EPA DTXSID6047860ECHA InfoCard100 004 843Chemical and physical dataFormulaC 7H 10N 2O 2SMolar mass186 23 g mol 13D model JSmol Interactive imageSMILES O S O c1ccc cc1 CN NInChI InChI 1S C7H10N2O2S c8 5 6 1 3 7 4 2 6 12 9 10 11 h1 4H 5 8H2 H2 9 10 11 YKey TYMRLRRVMHJFTF UHFFFAOYSA N Y N Y what is this verify Contents 1 Uses 2 Mechanism of action 3 Adverse reactions 4 Drug interactions 5 Contraindications 6 Dosage 7 References 8 External linksUses EditMafenide is used to treat severe burns 1 2 It is used topically as an adjunctive therapy for second and third degree burns It is bacteriostatic against many gram positive and gram negative organisms including Pseudomonas aeruginosa Some sources state that mafenide is more appropriate for non facial burns while chloramphenicol prednisolone or bacitracin are more appropriate for facial burns 3 Mechanism of action EditMafenide works by reducing the bacterial population present in the avascular tissues of burns and permits spontaneous healing of deep partial thickness burns citation needed Adverse reactions EditAdverse reactions can include superinfection pain or burning upon application rash pruritus tachypnea or hyperventilation Mafenide is metabolized to a carbonic anhydrase inhibitor which could potentially result in metabolic acidosis 4 Drug interactions EditThere are no significant interactions citation needed Contraindications EditMafenide is contraindicated in those with sulfonamide hypersensitivity or renal impairment Dosage EditFor use as adjunctive therapy for second and third degree burns to prevent infection adults and children should apply topically to a thickness of approximately 1 6 mm to cleaned and debrided wound once or twice per day with a sterile gloved hand The burned area should be covered with cream at all times citation needed References Edit Siuda J F Cihonski C D 1972 New compounds carbamate derivatives of mafenide homosulfanilamide J Pharm Sci 61 11 1856 1857 doi 10 1002 jps 2600611143 PMID 4652670 Haynes B 1971 Mafenide acetate in Burn Treatment New England Journal of Medicine 284 23 1324 doi 10 1056 NEJM197106102842310 PMID 5576444 Haik J Ashkenazy O Sinai S et al November 2005 Burn care standards in Israel lack of consensus Burns 31 7 845 9 doi 10 1016 j burns 2005 04 012 PMID 15967581 Sulfamylon Mafenide Acetate RxList Retrieved 22 December 2022 External links EditMafenide information on RxList Retrieved from https en wikipedia org w index php title Mafenide amp oldid 1128920551, wikipedia, wiki, book, books, library,
