Mitochondrial DNA encodes 13 proteins that play essential roles in the respiratory chain, while all proteins involved in mitochondrial translation are encoded by nuclear genes that are imported from the cytoplasm. MTRF1L is a nuclear-encoded protein that functions as a releasing factor that recognizes termination codons and releases mitochondrial ribosomes from the synthesized protein (summary by Nozaki et al., 2008 [PubMed 18429816]).[supplied by OMIM].[5]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000112031 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000019774 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Soleimanpour-Lichaei, H. R.; Kühl, I.; Gaisne, M.; Passos, J. F.; Wydro, M.; Rorbach, J.; Temperley, R.; Bonnefoy, N.; Tate, W.; Lightowlers, R.; Chrzanowska-Lightowlers, Z. (2007). "MtRF1a is a Human Mitochondrial Translation Release Factor Decoding the Major Termination Codons UAA and UAG". Molecular Cell. 27 (5): 745–757. doi:10.1016/j.molcel.2007.06.031. PMC1976341. PMID 17803939. Nozaki, Y.; Matsunaga, N.; Ishizawa, T.; Ueda, T.; Takeuchi, N. (2008). "HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG". Genes to Cells. 13 (5): 429–438. doi:10.1111/j.1365-2443.2008.01181.x. PMID 18429816. S2CID 21204094. Ishizawa, T.; Nozaki, Y.; Ueda, T.; Takeuchi, N. (2008). "The human mitochondrial translation release factor HMRF1L is methylated in the GGQ motif by the methyltransferase HMPrmC". Biochemical and Biophysical Research Communications. 373 (1): 99–103. doi:10.1016/j.bbrc.2008.05.176. PMID 18541145. Vieira, A. R.; McHenry, T. G.; Daack-Hirsch, S.; Murray, J. C.; Marazita, M. L. (2008). "Candidate Gene/Loci Studies in Cleft Lip/Palate and Dental Anomalies Finds Novel Susceptibility Genes for Clefts". Genetics in Medicine. 10 (9): 668–674. doi:10.1097/GIM.0b013e3181833793. PMC2734954. PMID 18978678. Antonicka, H.; Østergaard, E.; Sasarman, F.; Weraarpachai, W.; Wibrand, F.; Pedersen, A. M. B.; Rodenburg, R. J.; Van Der Knaap, M. S.; Smeitink, J. A. M.; Chrzanowska-Lightowlers, Z. M.; Shoubridge, E. A. (2010). "Mutations in C12orf65 in Patients with Encephalomyopathy and a Mitochondrial Translation Defect". The American Journal of Human Genetics. 87 (1): 115–122. doi:10.1016/j.ajhg.2010.06.004. PMC2896764. PMID 20598281.
This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.
mtrf1l, mitochondrial, translational, release, factor, like, protein, that, humans, encoded, gene, identifiersaliases, hmrf1l, mrf1l, mtrf1a, mitochondrial, translational, release, factor, like, mitochondrial, translation, release, factor, likeexternal, idsomi. Mitochondrial translational release factor 1 like is a protein that in humans is encoded by the MTRF1L gene 5 MTRF1LIdentifiersAliasesMTRF1L HMRF1L MRF1L mtRF1a mitochondrial translational release factor 1 like mitochondrial translation release factor 1 likeExternal IDsOMIM 613542 MGI 1918830 HomoloGene 5905 GeneCards MTRF1LGene location Human Chr Chromosome 6 human 1 Band6q25 2Start152 987 362 bp 1 End153 002 709 bp 1 Gene location Mouse Chr Chromosome 10 mouse 2 Band10 10 A1Start5 761 887 bp 2 End5 773 910 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inendothelial cellpancreatic ductal cellinternal globus pallidustibialis anterior muscledeltoid musclebody of tonguepericardiuminferior ganglion of vagus nervesuperior surface of tongueright ventricleTop expressed inPaneth cellmedullary collecting ductotolith organutriclerenal corpusclefossaascending aortahandcondylevas deferensMore reference expression dataBioGPSn aGene ontologyMolecular functiontranslation release factor activity translation release factor activity codon specific ribosome bindingCellular componentmitochondrial matrix mitochondrion cytoplasmBiological processtranslational termination protein biosynthesis mitochondrial translational terminationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez54516108853EnsemblENSG00000112031ENSMUSG00000019774UniProtQ9UGC7Q8BJU9RefSeq mRNA NM 001114184NM 001301047NM 001301870NM 001301871NM 001301872NM 019041NM 175374RefSeq protein NP 001107656NP 001287976NP 001288799NP 001288800NP 001288801NP 061914NP 780583Location UCSC Chr 6 152 99 153 MbChr 10 5 76 5 77 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseMitochondrial DNA encodes 13 proteins that play essential roles in the respiratory chain while all proteins involved in mitochondrial translation are encoded by nuclear genes that are imported from the cytoplasm MTRF1L is a nuclear encoded protein that functions as a releasing factor that recognizes termination codons and releases mitochondrial ribosomes from the synthesized protein summary by Nozaki et al 2008 PubMed 18429816 supplied by OMIM 5 References edit a b c GRCh38 Ensembl release 89 ENSG00000112031 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000019774 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene Mitochondrial translational release factor 1 like Retrieved 2011 09 20 Further reading editSoleimanpour Lichaei H R Kuhl I Gaisne M Passos J F Wydro M Rorbach J Temperley R Bonnefoy N Tate W Lightowlers R Chrzanowska Lightowlers Z 2007 MtRF1a is a Human Mitochondrial Translation Release Factor Decoding the Major Termination Codons UAA and UAG Molecular Cell 27 5 745 757 doi 10 1016 j molcel 2007 06 031 PMC 1976341 PMID 17803939 Nozaki Y Matsunaga N Ishizawa T Ueda T Takeuchi N 2008 HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG Genes to Cells 13 5 429 438 doi 10 1111 j 1365 2443 2008 01181 x PMID 18429816 S2CID 21204094 Ishizawa T Nozaki Y Ueda T Takeuchi N 2008 The human mitochondrial translation release factor HMRF1L is methylated in the GGQ motif by the methyltransferase HMPrmC Biochemical and Biophysical Research Communications 373 1 99 103 doi 10 1016 j bbrc 2008 05 176 PMID 18541145 Vieira A R McHenry T G Daack Hirsch S Murray J C Marazita M L 2008 Candidate Gene Loci Studies in Cleft Lip Palate and Dental Anomalies Finds Novel Susceptibility Genes for Clefts Genetics in Medicine 10 9 668 674 doi 10 1097 GIM 0b013e3181833793 PMC 2734954 PMID 18978678 Antonicka H Ostergaard E Sasarman F Weraarpachai W Wibrand F Pedersen A M B Rodenburg R J Van Der Knaap M S Smeitink J A M Chrzanowska Lightowlers Z M Shoubridge E A 2010 Mutations in C12orf65 in Patients with Encephalomyopathy and a Mitochondrial Translation Defect The American Journal of Human Genetics 87 1 115 122 doi 10 1016 j ajhg 2010 06 004 PMC 2896764 PMID 20598281 nbsp This article on a gene on human chromosome 6 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title MTRF1L amp oldid 1190502515, wikipedia, wiki, book, books, library,
