Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L32 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome Xp.[6]
ReferencesEdit
^ abcGRCh38: Ensembl release 89: ENSG00000106591 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000015672 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
^ ab"Entrez Gene: MRPL32 mitochondrial ribosomal protein L32".
Further readingEdit
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria". J. Biol. Chem. 276 (24): 21724–36. doi:10.1074/jbc.M100432200. PMID 11279069.
Koc EC, Burkhart W, Blackburn K, et al. (2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present". J. Biol. Chem. 276 (47): 43958–69. doi:10.1074/jbc.M106510200. PMID 11551941.
Bommel H, Xie G, Rossoll W, et al. (2003). "Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease". J. Cell Biol. 159 (4): 563–9. doi:10.1083/jcb.200208001. PMC2173089. PMID 12446740.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC2882961. PMID 12690205.
Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.
mitochondrial, ribosomal, protein, ribosomal, protein, mitochondrial, protein, that, humans, encoded, mrpl32, gene, mrpl32available, structurespdbortholog, search, pdbe, rcsblist, codes3j7y, 3j9midentifiersaliasesmrpl32, l32mt, bmrp, hspc283, mitochondrial, ri. 39S ribosomal protein L32 mitochondrial is a protein that in humans is encoded by the MRPL32 gene 5 6 MRPL32Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes3J7Y 3J9MIdentifiersAliasesMRPL32 L32mt MRP L32 bMRP 59b HSPC283 mitochondrial ribosomal protein L32External IDsOMIM 611839 MGI 2137226 HomoloGene 32711 GeneCards MRPL32Gene location Human Chr Chromosome 7 human 1 Band7p14 1Start42 932 376 bp 1 End42 948 958 bp 1 Gene location Mouse Chr Chromosome 13 mouse 2 Band13 13 A1Start14 782 769 bp 2 End14 787 750 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inoocytecardiapancreatic epithelial cellright ventriclerenal medullapylorusleft adrenal glandmetanephrosadrenal cortexbody of pancreasTop expressed ininterventricular septummedial ganglionic eminenceatrioventricular valveolfactory epitheliumendocardial cushionmyocardium of ventricleabdominal wallsoleus muscleintercostal musclebrown adipose tissueMore reference expression dataBioGPSn aGene ontologyMolecular functionstructural constituent of ribosome RNA bindingCellular componentmitochondrial inner membrane large ribosomal subunit ribosome mitochondrial ribosome mitochondrion mitochondrial large ribosomal subunitBiological processmitochondrial translational elongation mitochondrial translational termination protein biosynthesisSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez6498375398EnsemblENSG00000106591ENSMUSG00000015672UniProtQ9BYC8Q9DCI9RefSeq mRNA NM 031903NM 029271RefSeq protein NP 114109NP 083547Location UCSC Chr 7 42 93 42 95 MbChr 13 14 78 14 79 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseMammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion Mitochondrial ribosomes mitoribosomes consist of a small 28S subunit and a large 39S subunit They have an estimated 75 protein to rRNA composition compared to prokaryotic ribosomes where this ratio is reversed Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA Among different species the proteins comprising the mitoribosome differ greatly in sequence and sometimes in biochemical properties which prevents easy recognition by sequence homology This gene encodes a 39S subunit protein that belongs to the L32 ribosomal protein family A pseudogene corresponding to this gene is found on chromosome Xp 6 References Edit a b c GRCh38 Ensembl release 89 ENSG00000106591 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000015672 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Kenmochi N Suzuki T Uechi T Magoori M Kuniba M Higa S Watanabe K Tanaka T Sep 2001 The human mitochondrial ribosomal protein genes mapping of 54 genes to the chromosomes and implications for human disorders Genomics 77 1 2 65 70 doi 10 1006 geno 2001 6622 PMID 11543634 a b Entrez Gene MRPL32 mitochondrial ribosomal protein L32 Further reading EditBonaldo MF Lennon G Soares MB 1997 Normalization and subtraction two approaches to facilitate gene discovery Genome Res 6 9 791 806 doi 10 1101 gr 6 9 791 PMID 8889548 Suzuki T Terasaki M Takemoto Hori C et al 2001 Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria J Biol Chem 276 24 21724 36 doi 10 1074 jbc M100432200 PMID 11279069 Koc EC Burkhart W Blackburn K et al 2001 The large subunit of the mammalian mitochondrial ribosome Analysis of the complement of ribosomal proteins present J Biol Chem 276 47 43958 69 doi 10 1074 jbc M106510200 PMID 11551941 Bommel H Xie G Rossoll W et al 2003 Missense mutation in the tubulin specific chaperone E Tbce gene in the mouse mutant progressive motor neuronopathy a model of human motoneuron disease J Cell Biol 159 4 563 9 doi 10 1083 jcb 200208001 PMC 2173089 PMID 12446740 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Scherer SW Cheung J MacDonald JR et al 2003 Human chromosome 7 DNA sequence and biology Science 300 5620 767 72 Bibcode 2003Sci 300 767S doi 10 1126 science 1083423 PMC 2882961 PMID 12690205 Zhang Z Gerstein M 2003 Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome Genomics 81 5 468 80 doi 10 1016 S0888 7543 03 00004 1 PMID 12706105 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Oh JH Yang JO Hahn Y et al 2006 Transcriptome analysis of human gastric cancer Mamm Genome 16 12 942 54 doi 10 1007 s00335 005 0075 2 PMID 16341674 S2CID 69278 This article on a gene on human chromosome 7 is a stub You can help Wikipedia by expanding it vte This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Mitochondrial ribosomal protein L32 amp oldid 1142711299, wikipedia, wiki, book, books, library,
