This article needs more reliable medical references for verification or relies too heavily on primary sources. Please review the contents of the article and add the appropriate references if you can. Unsourced or poorly sourced material may be challenged and removed. Find sources: "MOPP" chemotherapy – news · newspapers · books · scholar · JSTOR(November 2021)
The treatment is usually administered in four week cycles, often for six cycles. MSD and VCR are administered intravenously, while procarbazine and prednisone are pills taken orally. A newer Hodgkin lymphoma treatment is ABVD.
C-MOPP involves switching the nitrogen mustard from mechlorethamine to cyclophosphamide. C-MOPP is thus very similar to COPP, using the same 4 agents and differing at most in dosages and timing.
MOPP was the first combination chemotherapy brought in that achieved a high success rate. It was developed at the National Cancer Institute in the 1960s by a team that included Vincent DeVita, Jr.
Although no longer the most effective combination, MOPP is still used after relapse or where the patient has certain allergies or lung or heart problems which prevents the use of another regimen.
Side effectsedit
There is 20% chance of developing a second cancer within 20 years of MOPP treatment. As a result, MOPP is rarely used any more for treatment for Hodgkin lymphoma.[1] MOPP has been known to cause alopecia (hair loss) and skin sensitivity (especially to sunlight). Nausea, vomiting, and stomach ache are common, as are chills, constipation, and frequent urination. Permanent sterility is a frequent side effect.
mopp, chemotherapy, this, article, needs, more, reliable, medical, references, verification, relies, heavily, primary, sources, please, review, contents, article, appropriate, references, unsourced, poorly, sourced, material, challenged, removed, find, sources. This article needs more reliable medical references for verification or relies too heavily on primary sources Please review the contents of the article and add the appropriate references if you can Unsourced or poorly sourced material may be challenged and removed Find sources MOPP chemotherapy news newspapers books scholar JSTOR November 2021 MOPP is a combination chemotherapy regimen used to treat Hodgkin lymphoma The acronym is derived from the component drugs of the regimen M ustargen also known as mechlorethamine chlormethine mustine nitrogen mustard or MSD O ncovin also known as Vincristine or VCR P rocarbazine also known as Matulane or Natulan P rednisone also known as Deltasone or Orasone Contents 1 Process 2 Dosage 3 History 4 Side effects 5 See also 6 ReferencesProcess editThe treatment is usually administered in four week cycles often for six cycles MSD and VCR are administered intravenously while procarbazine and prednisone are pills taken orally A newer Hodgkin lymphoma treatment is ABVD C MOPP involves switching the nitrogen mustard from mechlorethamine to cyclophosphamide C MOPP is thus very similar to COPP using the same 4 agents and differing at most in dosages and timing Dosage editDrug Dose Mode Days M ustargen 6 mg m2 IV bolus Days 1 and 8 O ncovin 1 4 mg m2 max 2 mg IV bolus Days 1 and 8 P rocarbazine 100 mg m2 PO qd Days 1 14 P rednisone 40 mg m2 PO qd Days 1 14History editMOPP was the first combination chemotherapy brought in that achieved a high success rate It was developed at the National Cancer Institute in the 1960s by a team that included Vincent DeVita Jr Although no longer the most effective combination MOPP is still used after relapse or where the patient has certain allergies or lung or heart problems which prevents the use of another regimen Side effects editThere is 20 chance of developing a second cancer within 20 years of MOPP treatment As a result MOPP is rarely used any more for treatment for Hodgkin lymphoma 1 MOPP has been known to cause alopecia hair loss and skin sensitivity especially to sunlight Nausea vomiting and stomach ache are common as are chills constipation and frequent urination Permanent sterility is a frequent side effect See also editABVD BEACOPP CHOP Stanford VReferences edit Hodgkin s Chemtherapy MOPP Retrieved from https en wikipedia org w index php title MOPP chemotherapy amp oldid 1155007200, wikipedia, wiki, book, books, library,
