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MNAT1

October 15, 2023

CDK-activating kinase assembly factor MAT1 is an enzyme that in humans is encoded by the MNAT1 gene.[5]

MNAT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMNAT1, CAP35, MAT1, RNF66, TFB3, CDK activating kinase assembly factor, MNAT1 component of CDK activating kinase
External IDsOMIM: 602659 MGI: 106207 HomoloGene: 1821 GeneCards: MNAT1
Orthologs
SpeciesHumanMouse
Entrez

4331

17420

Ensembl

ENSG00000020426

ENSMUSG00000021103

UniProt

P51948

P51949

RefSeq (mRNA)

NM_001177963
NM_002431

NM_008612

RefSeq (protein)

NP_001171434
NP_002422

NP_032638

Location (UCSC)Chr 14: 60.73 – 60.97 MbChr 12: 73.17 – 73.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function Edit

Cyclin-dependent kinases (CDKs), which play an essential role in cell cycle control of eukaryotic cells, are phosphorylated and thus activated by the CDK-activating kinase (CAK). CAK is a multisubunit protein that includes CDK7 (MIM 601955), cyclin H (CCNH; MIM 601953), and MAT1. MAT1 (for 'ménage à trois-1') is involved in the assembly of the CAK complex.[supplied by OMIM][6]

Interactions Edit

MNAT1 has been shown to interact with:

References Edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000020426 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021103 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Eki T, Okumura K, Abe M, Kagotani K, Taguchi H, Murakami Y, Pan ZQ, Hanaoka F (April 1998). "Mapping of the human genes encoding cyclin H (CCNH) and the CDK-activating kinase (CAK) assembly factor MAT1 (MNAT1) to chromosome bands 5q13.3-q14 and 14q23, respectively". Genomics. 47 (1): 115–20. doi:10.1006/geno.1997.5053. PMID 9465303.
  6. ^ "Entrez Gene: MNAT1 menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)".
  7. ^ a b c d Talukder AH, Mishra SK, Mandal M, Balasenthil S, Mehta S, Sahin AA, Barnes CJ, Kumar R (March 2003). "MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions". J. Biol. Chem. 278 (13): 11676–85. doi:10.1074/jbc.M209570200. PMID 12527756.
  8. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  9. ^ Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y (December 1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Res. 55 (24): 6058–62. PMID 8521393.
  10. ^ Wang Y, Xu F, Hall FL (October 2000). "The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor". FEBS Lett. 484 (1): 17–21. doi:10.1016/s0014-5793(00)02117-7. PMID 11056214.
  11. ^ Ko LJ, Shieh SY, Chen X, Jayaraman L, Tamai K, Taya Y, Prives C, Pan ZQ (December 1997). "p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner". Mol. Cell. Biol. 17 (12): 7220–9. doi:10.1128/mcb.17.12.7220. PMC 232579. PMID 9372954.
  12. ^ Inamoto S, Segil N, Pan ZQ, Kimura M, Roeder RG (November 1997). "The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors". J. Biol. Chem. 272 (47): 29852–8. doi:10.1074/jbc.272.47.29852. PMID 9368058.

Further reading Edit

  • Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–7. doi:10.1007/BF02253352. PMID 9570510.
  • Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447-9. doi:10.1016/S0960-9822(98)70289-1. PMID 9651670.
  • Le Goff P, Montano MM, Schodin DJ, Katzenellenbogen BS (1994). "Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity". J. Biol. Chem. 269 (6): 4458–66. doi:10.1016/S0021-9258(17)41801-1. PMID 8308015.
  • Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y (1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Res. 55 (24): 6058–62. PMID 8521393.
  • Tassan JP, Jaquenoud M, Fry AM, Frutiger S, Hughes GJ, Nigg EA (1995). "In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein". EMBO J. 14 (22): 5608–17. doi:10.1002/j.1460-2075.1995.tb00248.x. PMC 394676. PMID 8521818.
  • Blau J, Xiao H, McCracken S, O'Hare P, Greenblatt J, Bentley D (1996). "Three functional classes of transcriptional activation domain". Mol. Cell. Biol. 16 (5): 2044–55. doi:10.1128/MCB.16.5.2044. PMC 231191. PMID 8628270.
  • Reardon JT, Ge H, Gibbs E, Sancar A, Hurwitz J, Pan ZQ (1996). "Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6482–7. Bibcode:1996PNAS...93.6482R. doi:10.1073/pnas.93.13.6482. PMC 39049. PMID 8692841.
  • Drapkin R, Le Roy G, Cho H, Akoulitchev S, Reinberg D (1996). "Human cyclin-dependent kinase-activating kinase exists in three distinct complexes". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6488–93. Bibcode:1996PNAS...93.6488D. doi:10.1073/pnas.93.13.6488. PMC 39050. PMID 8692842.
  • Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID 8849451. S2CID 13266489.
  • Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature. 384 (6607): 375–8. Bibcode:1996Natur.384..375P. doi:10.1038/384375a0. PMID 8934526. S2CID 4278432.
  • García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". J. Biol. Chem. 272 (11): 6951–8. doi:10.1074/jbc.272.11.6951. PMID 9054383.
  • Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM (1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH". EMBO J. 16 (5): 1093–102. doi:10.1093/emboj/16.5.1093. PMC 1169708. PMID 9118947.
  • Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Mol. Cell. Biol. 17 (4): 1817–23. doi:10.1128/mcb.17.4.1817. PMC 232028. PMID 9121429.
  • Rossignol M, Kolb-Cheynel I, Egly JM (1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH". EMBO J. 16 (7): 1628–37. doi:10.1093/emboj/16.7.1628. PMC 1169767. PMID 9130708.
  • García-Martínez LF, Mavankal G, Neveu JM, Lane WS, Ivanov D, Gaynor RB (1997). "Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription". EMBO J. 16 (10): 2836–50. doi:10.1093/emboj/16.10.2836. PMC 1169892. PMID 9184228.
  • Nekhai S, Shukla RR, Kumar A (1997). "A human primary T-lymphocyte-derived human immunodeficiency virus type 1 Tat-associated kinase phosphorylates the C-terminal domain of RNA polymerase II and induces CAK activity". J. Virol. 71 (10): 7436–41. doi:10.1128/JVI.71.10.7436-7441.1997. PMC 192089. PMID 9311822.
  • Cujec TP, Okamoto H, Fujinaga K, Meyer J, Chamberlin H, Morgan DO, Peterlin BM (1997). "The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II". Genes Dev. 11 (20): 2645–57. doi:10.1101/gad.11.20.2645. PMC 316603. PMID 9334327.
  • Inamoto S, Segil N, Pan ZQ, Kimura M, Roeder RG (1997). "The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors". J. Biol. Chem. 272 (47): 29852–8. doi:10.1074/jbc.272.47.29852. PMID 9368058.
  • Ko LJ, Shieh SY, Chen X, Jayaraman L, Tamai K, Taya Y, Prives C, Pan ZQ (1997). "p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner". Mol. Cell. Biol. 17 (12): 7220–9. doi:10.1128/mcb.17.12.7220. PMC 232579. PMID 9372954.

External links Edit

  • Overview of all the structural information available in the PDB for UniProt: P51948 (CDK-activating kinase assembly factor MAT1) at the PDBe-KB.

October 15, 2023
mnat1, activating, kinase, assembly, factor, mat1, enzyme, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1g25identifiersaliases, cap35, mat1, rnf66, tfb3, activating, kinase, assembly, factor, component, activating. CDK activating kinase assembly factor MAT1 is an enzyme that in humans is encoded by the MNAT1 gene 5 MNAT1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1G25IdentifiersAliasesMNAT1 CAP35 MAT1 RNF66 TFB3 CDK activating kinase assembly factor MNAT1 component of CDK activating kinaseExternal IDsOMIM 602659 MGI 106207 HomoloGene 1821 GeneCards MNAT1Gene location Human Chr Chromosome 14 human 1 Band14q23 1Start60 734 742 bp 1 End60 969 965 bp 1 Gene location Mouse Chr Chromosome 12 mouse 2 Band12 12 C3Start73 170 491 bp 2 End73 320 762 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inAchilles tendongastrocnemius muscleganglionic eminencepopliteal arteryright uterine tubesural nerveascending aortastromal cell of endometriumleft coronary arteryanterior pituitaryTop expressed inprimitive streakmirroryolk sacabdominal wallmaxillary prominencefacial motor nucleusseminal vesiculaplantaris muscleotic placodemorulaMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionATP dependent activity acting on DNA protein N terminus binding metal ion binding protein binding RNA polymerase II CTD heptapeptide repeat kinase activity cyclin dependent protein serine threonine kinase activator activity zinc ion bindingCellular componentnucleoplasm nucleus cytosol transcription factor TFIIH holo complex cyclin dependent protein kinase activating kinase holoenzyme complexBiological processtermination of RNA polymerase I transcription regulation of cyclin dependent protein serine threonine kinase activity regulation of transcription DNA templated adult heart development regulation of transcription by RNA polymerase II transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase II promoter negative regulation of apoptotic process 7 methylguanosine mRNA capping transcription by RNA polymerase II ventricular system development transcription DNA templated response to calcium ion cell cycle transcription coupled nucleotide excision repair transcription initiation from RNA polymerase II promoter cell population proliferation DNA repair positive regulation of transcription by RNA polymerase II positive regulation of smooth muscle cell proliferation protein phosphorylation nucleotide excision repair preincision complex assembly positive regulation of cyclin dependent protein serine threonine kinase activity nucleotide excision repair protein containing complex assembly G1 S transition of mitotic cell cycle negative regulation of DNA helicase activity G2 M transition of mitotic cell cycle transcription elongation from RNA polymerase I promoterSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez433117420EnsemblENSG00000020426ENSMUSG00000021103UniProtP51948P51949RefSeq mRNA NM 001177963NM 002431NM 008612RefSeq protein NP 001171434NP 002422NP 032638Location UCSC Chr 14 60 73 60 97 MbChr 12 73 17 73 32 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further reading 5 External linksFunction EditCyclin dependent kinases CDKs which play an essential role in cell cycle control of eukaryotic cells are phosphorylated and thus activated by the CDK activating kinase CAK CAK is a multisubunit protein that includes CDK7 MIM 601955 cyclin H CCNH MIM 601953 and MAT1 MAT1 for menage a trois 1 is involved in the assembly of the CAK complex supplied by OMIM 6 Interactions EditMNAT1 has been shown to interact with Cyclin H 7 8 Cyclin dependent kinase 7 7 9 Estrogen receptor alpha 7 MCM7 10 MTA1 7 P53 11 and POU2F1 12 References Edit a b c GRCh38 Ensembl release 89 ENSG00000020426 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000021103 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Eki T Okumura K Abe M Kagotani K Taguchi H Murakami Y Pan ZQ Hanaoka F April 1998 Mapping of the human genes encoding cyclin H CCNH and the CDK activating kinase CAK assembly factor MAT1 MNAT1 to chromosome bands 5q13 3 q14 and 14q23 respectively Genomics 47 1 115 20 doi 10 1006 geno 1997 5053 PMID 9465303 Entrez Gene MNAT1 menage a trois homolog 1 cyclin H assembly factor Xenopus laevis a b c d Talukder AH Mishra SK Mandal M Balasenthil S Mehta S Sahin AA Barnes CJ Kumar R March 2003 MTA1 interacts with MAT1 a cyclin dependent kinase activating kinase complex ring finger factor and regulates estrogen receptor transactivation functions J Biol Chem 278 13 11676 85 doi 10 1074 jbc M209570200 PMID 12527756 Ewing RM Chu P Elisma F Li H Taylor P Climie S McBroom Cerajewski L Robinson MD O Connor L Li M Taylor R Dharsee M Ho Y Heilbut A Moore L Zhang S Ornatsky O Bukhman YV Ethier M Sheng Y Vasilescu J Abu Farha M Lambert JP Duewel HS Stewart II Kuehl B Hogue K Colwill K Gladwish K Muskat B Kinach R Adams SL Moran MF Morin GB Topaloglou T Figeys D 2007 Large scale mapping of human protein protein interactions by mass spectrometry Mol Syst Biol 3 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 Yee A Nichols MA Wu L Hall FL Kobayashi R Xiong Y December 1995 Molecular cloning of CDK7 associated human MAT1 a cyclin dependent kinase activating kinase CAK assembly factor Cancer Res 55 24 6058 62 PMID 8521393 Wang Y Xu F Hall FL October 2000 The MAT1 cyclin dependent kinase activating kinase CAK assembly targeting factor interacts physically with the MCM7 DNA licensing factor FEBS Lett 484 1 17 21 doi 10 1016 s0014 5793 00 02117 7 PMID 11056214 Ko LJ Shieh SY Chen X Jayaraman L Tamai K Taya Y Prives C Pan ZQ December 1997 p53 is phosphorylated by CDK7 cyclin H in a p36MAT1 dependent manner Mol Cell Biol 17 12 7220 9 doi 10 1128 mcb 17 12 7220 PMC 232579 PMID 9372954 Inamoto S Segil N Pan ZQ Kimura M Roeder RG November 1997 The cyclin dependent kinase activating kinase CAK assembly factor MAT1 targets and enhances CAK activity on the POU domains of octamer transcription factors J Biol Chem 272 47 29852 8 doi 10 1074 jbc 272 47 29852 PMID 9368058 Further reading EditJeang KT 1998 Tat Tat associated kinase and transcription J Biomed Sci 5 1 24 7 doi 10 1007 BF02253352 PMID 9570510 Yankulov K Bentley D 1998 Transcriptional control Tat cofactors and transcriptional elongation Curr Biol 8 13 R447 9 doi 10 1016 S0960 9822 98 70289 1 PMID 9651670 Le Goff P Montano MM Schodin DJ Katzenellenbogen BS 1994 Phosphorylation of the human estrogen receptor Identification of hormone regulated sites and examination of their influence on transcriptional activity J Biol Chem 269 6 4458 66 doi 10 1016 S0021 9258 17 41801 1 PMID 8308015 Yee A Nichols MA Wu L Hall FL Kobayashi R Xiong Y 1995 Molecular cloning of CDK7 associated human MAT1 a cyclin dependent kinase activating kinase CAK assembly factor Cancer Res 55 24 6058 62 PMID 8521393 Tassan JP Jaquenoud M Fry AM Frutiger S Hughes GJ Nigg EA 1995 In vitro assembly of a functional human CDK7 cyclin H complex requires MAT1 a novel 36 kDa RING finger protein EMBO J 14 22 5608 17 doi 10 1002 j 1460 2075 1995 tb00248 x PMC 394676 PMID 8521818 Blau J Xiao H McCracken S O Hare P Greenblatt J Bentley D 1996 Three functional classes of transcriptional activation domain Mol Cell Biol 16 5 2044 55 doi 10 1128 MCB 16 5 2044 PMC 231191 PMID 8628270 Reardon JT Ge H Gibbs E Sancar A Hurwitz J Pan ZQ 1996 Isolation and characterization of two human transcription factor IIH TFIIH related complexes ERCC2 CAK and TFIIH Proc Natl Acad Sci U S A 93 13 6482 7 Bibcode 1996PNAS 93 6482R doi 10 1073 pnas 93 13 6482 PMC 39049 PMID 8692841 Drapkin R Le Roy G Cho H Akoulitchev S Reinberg D 1996 Human cyclin dependent kinase activating kinase exists in three distinct complexes Proc Natl Acad Sci U S A 93 13 6488 93 Bibcode 1996PNAS 93 6488D doi 10 1073 pnas 93 13 6488 PMC 39050 PMID 8692842 Zhou Q Sharp PA 1996 Tat SF1 cofactor for stimulation of transcriptional elongation by HIV 1 Tat Science 274 5287 605 10 Bibcode 1996Sci 274 605Z doi 10 1126 science 274 5287 605 PMID 8849451 S2CID 13266489 Parada CA Roeder RG 1996 Enhanced processivity of RNA polymerase II triggered by Tat induced phosphorylation of its carboxy terminal domain Nature 384 6607 375 8 Bibcode 1996Natur 384 375P doi 10 1038 384375a0 PMID 8934526 S2CID 4278432 Garcia Martinez LF Ivanov D Gaynor RB 1997 Association of Tat with purified HIV 1 and HIV 2 transcription preinitiation complexes J Biol Chem 272 11 6951 8 doi 10 1074 jbc 272 11 6951 PMID 9054383 Marinoni JC Roy R Vermeulen W Miniou P Lutz Y Weeda G Seroz T Gomez DM Hoeijmakers JH Egly JM 1997 Cloning and characterization of p52 the fifth subunit of the core of the transcription DNA repair factor TFIIH EMBO J 16 5 1093 102 doi 10 1093 emboj 16 5 1093 PMC 1169708 PMID 9118947 Cujec TP Cho H Maldonado E Meyer J Reinberg D Peterlin BM 1997 The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme Mol Cell Biol 17 4 1817 23 doi 10 1128 mcb 17 4 1817 PMC 232028 PMID 9121429 Rossignol M Kolb Cheynel I Egly JM 1997 Substrate specificity of the cdk activating kinase CAK is altered upon association with TFIIH EMBO J 16 7 1628 37 doi 10 1093 emboj 16 7 1628 PMC 1169767 PMID 9130708 Garcia Martinez LF Mavankal G Neveu JM Lane WS Ivanov D Gaynor RB 1997 Purification of a Tat associated kinase reveals a TFIIH complex that modulates HIV 1 transcription EMBO J 16 10 2836 50 doi 10 1093 emboj 16 10 2836 PMC 1169892 PMID 9184228 Nekhai S Shukla RR Kumar A 1997 A human primary T lymphocyte derived human immunodeficiency virus type 1 Tat associated kinase phosphorylates the C terminal domain of RNA polymerase II and induces CAK activity J Virol 71 10 7436 41 doi 10 1128 JVI 71 10 7436 7441 1997 PMC 192089 PMID 9311822 Cujec TP Okamoto H Fujinaga K Meyer J Chamberlin H Morgan DO Peterlin BM 1997 The HIV transactivator TAT binds to the CDK activating kinase and activates the phosphorylation of the carboxy terminal domain of RNA polymerase II Genes Dev 11 20 2645 57 doi 10 1101 gad 11 20 2645 PMC 316603 PMID 9334327 Inamoto S Segil N Pan ZQ Kimura M Roeder RG 1997 The cyclin dependent kinase activating kinase CAK assembly factor MAT1 targets and enhances CAK activity on the POU domains of octamer transcription factors J Biol Chem 272 47 29852 8 doi 10 1074 jbc 272 47 29852 PMID 9368058 Ko LJ Shieh SY Chen X Jayaraman L Tamai K Taya Y Prives C Pan ZQ 1997 p53 is phosphorylated by CDK7 cyclin H in a p36MAT1 dependent manner Mol Cell Biol 17 12 7220 9 doi 10 1128 mcb 17 12 7220 PMC 232579 PMID 9372954 External links EditOverview of all the structural information available in the PDB for UniProt P51948 CDK activating kinase assembly factor MAT1 at the PDBe KB Retrieved from https en wikipedia org w index php title MNAT1 amp oldid 1142729284, wikipedia, wiki, book, books, library,

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