oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
FAD binding
protein binding
metal ion binding
protein kinase binding
monooxygenase activity
NAD(P)H oxidase H2O2-forming activity
actin filament binding
Cellular component
cytoplasm
cytoskeleton
intermediate filament
hippocampal mossy fiber expansion
cytosol
midbody
intercellular bridge
plasma membrane
actin cytoskeleton
Biological process
negative regulation of protein phosphorylation
actin filament depolymerization
sulfur oxidation
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Iwata S, Ohashi Y, Kamiguchi K, Morimoto C (2000). "Beta 1-integrin-mediated cell signaling in T lymphocytes". J. Dermatol. Sci. 23 (2): 75–86. doi:10.1016/S0923-1811(99)00096-1. PMID 10808124.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
Terman JR, Mao T, Pasterkamp RJ, et al. (2002). "MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion". Cell. 109 (7): 887–900. doi:10.1016/S0092-8674(02)00794-8. PMID 12110185.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Fischer J, Weide T, Barnekow A (2005). "The MICAL proteins and rab1: a possible link to the cytoskeleton?". Biochem. Biophys. Res. Commun. 328 (2): 415–23. doi:10.1016/j.bbrc.2004.12.182. PMID 15694364.
Bayer M, Fischer J, Kremerskothen J, et al. (2006). "Identification and characterization of Iporin as a novel interaction partner for rab1". BMC Cell Biol. 6 (1): 15. doi:10.1186/1471-2121-6-15. PMC1079803. PMID 15796781.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Jin X, Zhang J, Dai H, et al. (2007). "Investigation of the four cooperative unfolding units existing in the MICAL-1 CH domain". Biophys. Chem. 129 (2–3): 269–78. doi:10.1016/j.bpc.2007.06.008. PMID 17662518.
This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.
mical1, nedd9, interacting, protein, with, calponin, homology, domains, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1wyl, 2co8identifiersaliases, mical, mical, nical, microtubule, associated, monooxygena. NEDD9 interacting protein with calponin homology and LIM domains is a protein that in humans is encoded by the MICAL1 gene 4 5 MICAL1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1WYL 2CO8IdentifiersAliasesMICAL1 MICAL MICAL 1 NICAL microtubule associated monooxygenase calponin and LIM domain containing 1External IDsOMIM 607129 MGI 2385847 HomoloGene 11246 GeneCards MICAL1Gene location Mouse Chr Chromosome 10 mouse 1 Band10 10 B1Start41 352 310 bp 1 End41 363 028 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inright coronary arteryleft coronary arterycanal of the cervixspleenleft uterine tubepopliteal arteryganglionic eminencestromal cell of endometriumright lungascending aortaTop expressed inascending aortaexternal carotid arteryintestinal villusinternal carotid arteryfossaPaneth cellsciatic nervecondyleaortic valvetrigeminal ganglionMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionSH3 domain binding oxidoreductase activity actin binding oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen NAD P H as one donor and incorporation of one atom of oxygen FAD binding protein binding metal ion binding protein kinase binding monooxygenase activity NAD P H oxidase H2O2 forming activity actin filament bindingCellular componentcytoplasm cytoskeleton intermediate filament hippocampal mossy fiber expansion cytosol midbody intercellular bridge plasma membrane actin cytoskeletonBiological processnegative regulation of protein phosphorylation actin filament depolymerization sulfur oxidation negative regulation of cysteine type endopeptidase activity involved in apoptotic process negative regulation of apoptotic process cytoskeleton organization signal transduction regulation of regulated secretory pathway blood coagulationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez64780171580Ensembln aENSMUSG00000019823UniProtQ8TDZ2Q8VDP3RefSeq mRNA NM 022765NM 001159291NM 001286613NM 001164433NM 138315NM 001358838NM 001358839RefSeq protein NP 001152763NP 001273542NP 073602NP 001157905NP 612188NP 001345767NP 001345768Location UCSC n aChr 10 41 35 41 36 MbPubMed search 2 3 WikidataView Edit HumanView Edit MouseInteractions EditMICAL1 has been shown to interact with NEDD9 4 and RAB1A 6 References Edit a b c GRCm38 Ensembl release 89 ENSMUSG00000019823 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Suzuki T Nakamoto T Ogawa S Seo S Matsumura T Tachibana K Morimoto C Hirai H Apr 2002 MICAL a novel CasL interacting molecule associates with vimentin J Biol Chem 277 17 14933 41 doi 10 1074 jbc M111842200 PMID 11827972 Entrez Gene MICAL1 microtubule associated monoxygenase calponin and LIM domain containing 1 Weide Thomas Teuber Julia Bayer Michael Barnekow Angelika Jun 2003 MICAL 1 isoforms novel rab1 interacting proteins Biochem Biophys Res Commun United States 306 1 79 86 doi 10 1016 S0006 291X 03 00918 5 ISSN 0006 291X PMID 12788069 Further reading EditIwata S Ohashi Y Kamiguchi K Morimoto C 2000 Beta 1 integrin mediated cell signaling in T lymphocytes J Dermatol Sci 23 2 75 86 doi 10 1016 S0923 1811 99 00096 1 PMID 10808124 Maruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Suzuki Y Yoshitomo Nakagawa K Maruyama K et al 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Hattori A Okumura K Nagase T et al 2001 Characterization of long cDNA clones from human adult spleen DNA Res 7 6 357 66 doi 10 1093 dnares 7 6 357 PMID 11214971 Terman JR Mao T Pasterkamp RJ et al 2002 MICALs a family of conserved flavoprotein oxidoreductases function in plexin mediated axonal repulsion Cell 109 7 887 900 doi 10 1016 S0092 8674 02 00794 8 PMID 12110185 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Weide T Teuber J Bayer M Barnekow A 2003 MICAL 1 isoforms novel rab1 interacting proteins Biochem Biophys Res Commun 306 1 79 86 doi 10 1016 S0006 291X 03 00918 5 PMID 12788069 Mungall AJ Palmer SA Sims SK et al 2003 The DNA sequence and analysis of human chromosome 6 Nature 425 6960 805 11 Bibcode 2003Natur 425 805M doi 10 1038 nature02055 PMID 14574404 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Fischer J Weide T Barnekow A 2005 The MICAL proteins and rab1 a possible link to the cytoskeleton Biochem Biophys Res Commun 328 2 415 23 doi 10 1016 j bbrc 2004 12 182 PMID 15694364 Bayer M Fischer J Kremerskothen J et al 2006 Identification and characterization of Iporin as a novel interaction partner for rab1 BMC Cell Biol 6 1 15 doi 10 1186 1471 2121 6 15 PMC 1079803 PMID 15796781 Olsen JV Blagoev B Gnad F et al 2006 Global in vivo and site specific phosphorylation dynamics in signaling networks Cell 127 3 635 48 doi 10 1016 j cell 2006 09 026 PMID 17081983 S2CID 7827573 Jin X Zhang J Dai H et al 2007 Investigation of the four cooperative unfolding units existing in the MICAL 1 CH domain Biophys Chem 129 2 3 269 78 doi 10 1016 j bpc 2007 06 008 PMID 17662518 This article on a gene on human chromosome 6 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title MICAL1 amp oldid 1079574761, wikipedia, wiki, book, books, library,
