This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000106511 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000036144 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^LePage DF, Altomare DA, Testa JR, Walsh K (May 1995). "Molecular cloning and localization of the human GAX gene to 7p21". Genomics. 24 (3): 535–40. doi:10.1006/geno.1994.1663. PMID 7713505.
^ abStamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (Jun 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. S2CID 40668112.
Further readingedit
Grigoriou M, Kastrinaki MC, Modi WS, Theodorakis K, Mankoo B, Pachnis V, Karagogeos D (1995). "Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3". Genomics. 26 (3): 550–5. doi:10.1016/0888-7543(95)80174-K. PMID 7607679.
Reardon W, McManus SP, Summers D, Winter RM (1994). "Cytogenetic evidence that the Saethre-Chotzen gene maps to 7p21.2". Am. J. Med. Genet. 47 (5): 633–6. doi:10.1002/ajmg.1320470510. PMID 8266988.
Quinn LM, Latham SE, Kalionis B (2000). "The homeobox genes MSX2 and MOX2 are candidates for regulating epithelial-mesenchymal cell interactions in the human placenta". Placenta. 21 Suppl A: S50–4. doi:10.1053/plac.1999.0514. PMID 10831122.
Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. S2CID 40668112.
Gorski DH, Leal AJ (2003). "Inhibition of endothelial cell activation by the homeobox gene Gax". J. Surg. Res. 111 (1): 91–9. doi:10.1016/S0022-4804(03)00042-8. PMID 12842453.
Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks AI, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetzki R, Song X, Hofman F, Zlokovic BV (2005). "Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease". Nat. Med. 11 (9): 959–65. doi:10.1038/nm1287. PMID 16116430. S2CID 12998034.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Lin J, Friesen MT, Bocangel P, Cheung D, Rawszer K, Wigle JT (2006). "Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10". Mol. Cell. Biochem. 275 (1–2): 75–84. doi:10.1007/s11010-005-0823-3. PMID 16335786. S2CID 30515981.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC1356129. PMID 16344560.
Chen Y, Leal AD, Patel S, Gorski DH (2007). "The homeobox gene Gax activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences". J. Biol. Chem. 282 (1): 507–17. doi:10.1074/jbc.M606604200. PMC1865102. PMID 17074759.
meox2, homeobox, protein, protein, that, humans, encoded, gene, identifiersaliases, mox2, mesenchyme, homeobox, 2external, idsomim, 600535, 103219, homologene, 4330, genecards, gene, location, human, chromosome, human, band7p21, 2start15, end15, gene, location. Homeobox protein MOX 2 is a protein that in humans is encoded by the MEOX2 gene 5 6 MEOX2IdentifiersAliasesMEOX2 GAX MOX2 mesenchyme homeobox 2External IDsOMIM 600535 MGI 103219 HomoloGene 4330 GeneCards MEOX2Gene location Human Chr Chromosome 7 human 1 Band7p21 2Start15 611 212 bp 1 End15 686 683 bp 1 Gene location Mouse Chr Chromosome 12 mouse 2 Band12 A3 12 16 84 cMStart37 158 539 bp 2 End37 229 533 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inAchilles tendonparietal pleuraspinal gangliatibial nervesynovial jointsubcutaneous adipose tissuesaphenous veinsural nervetrigeminal ganglionvena cavaTop expressed inleft lung lobesciatic nervedermishandfootanklecarotid bodysoleus muscleplantaris muscledigastric muscleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionRNA polymerase II cis regulatory region sequence specific DNA binding sequence specific DNA binding DNA binding DNA binding transcription factor activity DNA binding transcription activator activity RNA polymerase II specific protein binding DNA binding transcription factor activity RNA polymerase II specificCellular componentcytoplasm nuclear speck nucleusBiological processneuron death roof of mouth development regulation of transcription DNA templated somite specification blood circulation transcription DNA templated limb development multicellular organism development angiogenesis skeletal muscle tissue development positive regulation of transcription by RNA polymerase II negative regulation of cell migration involved in sprouting angiogenesis transcription by RNA polymerase II somite developmentSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez422317286EnsemblENSG00000106511ENSMUSG00000036144UniProtP50222P32443RefSeq mRNA NM 005924NM 008584RefSeq protein NP 005915NP 032610Location UCSC Chr 7 15 61 15 69 MbChr 12 37 16 37 23 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further reading 5 External linksFunction editThis gene encodes a member of a subfamily of non clustered diverged antennapedia like homeobox containing genes The encoded protein may play a role in the regulation of vertebrate limb myogenesis Mutations in the related mouse protein may be associated with craniofacial and or skeletal abnormalities in addition to neurovascular dysfunction observed in Alzheimer s disease 6 Interactions editMEOX2 has been shown to interact with PAX1 7 and PAX3 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000106511 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000036144 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine LePage DF Altomare DA Testa JR Walsh K May 1995 Molecular cloning and localization of the human GAX gene to 7p21 Genomics 24 3 535 40 doi 10 1006 geno 1994 1663 PMID 7713505 a b Entrez Gene MEOX2 mesenchyme homeobox 2 a b Stamataki D Kastrinaki M Mankoo BS Pachnis V Karagogeos D Jun 2001 Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors FEBS Lett 499 3 274 8 doi 10 1016 S0014 5793 01 02556 X PMID 11423130 S2CID 40668112 Further reading editGrigoriou M Kastrinaki MC Modi WS Theodorakis K Mankoo B Pachnis V Karagogeos D 1995 Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22 1 p21 3 Genomics 26 3 550 5 doi 10 1016 0888 7543 95 80174 K PMID 7607679 Reardon W McManus SP Summers D Winter RM 1994 Cytogenetic evidence that the Saethre Chotzen gene maps to 7p21 2 Am J Med Genet 47 5 633 6 doi 10 1002 ajmg 1320470510 PMID 8266988 Quinn LM Latham SE Kalionis B 2000 The homeobox genes MSX2 and MOX2 are candidates for regulating epithelial mesenchymal cell interactions in the human placenta Placenta 21 Suppl A S50 4 doi 10 1053 plac 1999 0514 PMID 10831122 Stamataki D Kastrinaki M Mankoo BS Pachnis V Karagogeos D 2001 Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors FEBS Lett 499 3 274 8 doi 10 1016 S0014 5793 01 02556 X PMID 11423130 S2CID 40668112 Gorski DH Leal AJ 2003 Inhibition of endothelial cell activation by the homeobox gene Gax J Surg Res 111 1 91 9 doi 10 1016 S0022 4804 03 00042 8 PMID 12842453 Wu Z Guo H Chow N Sallstrom J Bell RD Deane R Brooks AI Kanagala S Rubio A Sagare A Liu D Li F Armstrong D Gasiewicz T Zidovetzki R Song X Hofman F Zlokovic BV 2005 Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease Nat Med 11 9 959 65 doi 10 1038 nm1287 PMID 16116430 S2CID 12998034 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Lin J Friesen MT Bocangel P Cheung D Rawszer K Wigle JT 2006 Characterization of Mesenchyme Homeobox 2 MEOX2 transcription factor binding to RING finger protein 10 Mol Cell Biochem 275 1 2 75 84 doi 10 1007 s11010 005 0823 3 PMID 16335786 S2CID 30515981 Kimura K Wakamatsu A Suzuki Y Ota T Nishikawa T Yamashita R Yamamoto J Sekine M Tsuritani K Wakaguri H Ishii S Sugiyama T Saito K Isono Y Irie R Kushida N Yoneyama T Otsuka R Kanda K Yokoi T Kondo H Wagatsuma M Murakawa K Ishida S Ishibashi T Takahashi Fujii A Tanase T Nagai K Kikuchi H Nakai K Isogai T Sugano S 2006 Diversification of transcriptional modulation Large scale identification and characterization of putative alternative promoters of human genes Genome Res 16 1 55 65 doi 10 1101 gr 4039406 PMC 1356129 PMID 16344560 Chen Y Leal AD Patel S Gorski DH 2007 The homeobox gene Gax activates p21WAF1 CIP1 expression in vascular endothelial cells through direct interaction with upstream AT rich sequences J Biol Chem 282 1 507 17 doi 10 1074 jbc M606604200 PMC 1865102 PMID 17074759 External links editMEOX2 protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 7 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title MEOX2 amp oldid 1086381262, wikipedia, wiki, book, books, library,
