This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000112559 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032717 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kraut N (Sep 1997). "The gene encoding I-mf (Mdfi) maps to human chromosome 6p21 and mouse chromosome 17". Mamm Genome. 8 (8): 618–9. doi:10.1007/s003359900517. PMID 9250874. S2CID 25160364.
^Wang Q, Young TM, Mathews MB, Pe'ery T (Mar 2007). "Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription". J Mol Biol. 367 (3): 630–46. doi:10.1016/j.jmb.2007.01.020. PMC1868487. PMID 17289077.
^ abcRual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
^ abChen CM, Kraut N, Groudine M, Weintraub H (Sep 1996). "I-mf, a novel myogenic repressor, interacts with members of the MyoD family". Cell. 86 (5): 731–41. doi:10.1016/s0092-8674(00)80148-8. PMID 8797820. S2CID 16252710.
Further readingedit
Chen CM, Kraut N, Groudine M, Weintraub H (1996). "I-mf, a novel myogenic repressor, interacts with members of the MyoD family". Cell. 86 (5): 731–41. doi:10.1016/S0092-8674(00)80148-8. PMID 8797820. S2CID 16252710.
Kraut N, Snider L, Chen CM, Tapscott SJ, Groudine M (1999). "Requirement of the mouse I-mfa gene for placental development and skeletal patterning". EMBO J. 17 (21): 6276–88. doi:10.1093/emboj/17.21.6276. PMC1170953. PMID 9799236.
Snider L, Thirlwell H, Miller JR, Moon RT, Groudine M, Tapscott SJ (2001). "Inhibition of Tcf3 binding by I-mfa domain proteins". Mol. Cell. Biol. 21 (5): 1866–73. doi:10.1128/MCB.21.5.1866-1873.2001. PMC86756. PMID 11238923.
Ma R, Rundle D, Jacks J, Koch M, Downs T, Tsiokas L (2004). "Inhibitor of myogenic family, a novel suppressor of store-operated currents through an interaction with TRPC1". J. Biol. Chem. 278 (52): 52763–72. doi:10.1074/jbc.M309610200. PMID 14530267.
Mizugishi K, Hatayama M, Tohmonda T, Ogawa M, Inoue T, Mikoshiba K, Aruga J (2004). "Myogenic repressor I-mfa interferes with the function of Zic family proteins". Biochem. Biophys. Res. Commun. 320 (1): 233–40. doi:10.1016/j.bbrc.2004.05.158. PMID 15207726.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.
mdfi, myod, family, inhibitor, protein, that, humans, encoded, gene, identifiersaliases, myod, family, inhibitor, mfaexternal, idsomim, 604971, 107687, homologene, 21150, genecards, gene, location, human, chromosome, human, band6p21, 1start41, end41, gene, loc. MyoD family inhibitor is a protein that in humans is encoded by the MDFI gene 5 6 7 MDFIIdentifiersAliasesMDFI MyoD family inhibitor I MF I mfaExternal IDsOMIM 604971 MGI 107687 HomoloGene 21150 GeneCards MDFIGene location Human Chr Chromosome 6 human 1 Band6p21 1Start41 636 882 bp 1 End41 654 244 bp 1 Gene location Mouse Chr Chromosome 17 mouse 2 Band17 C 17 23 99 cMStart48 126 253 bp 2 End48 145 616 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inganglionic eminenceminor salivary glandbody of tonguegallbladdercanal of the cervixvaginaupper lobe of left lunginferior ganglion of vagus nervesuperior surface of tongueleft uterine tubeTop expressed inyolk sacbasilar part of occipital boneexternal carotid arteryinternal carotid arteryhumerusMeckel s cartilagelipesophagusmaxillary prominencesphenoid boneMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding identical protein binding transcription factor bindingCellular componentcytoplasm nucleusBiological processcytoplasmic sequestering of transcription factor embryonic skeletal system morphogenesis multicellular organism development trophoblast giant cell differentiation cell differentiation negative regulation of transcription DNA templated negative regulation of transcription by RNA polymerase II dorsal ventral axis specification negative regulation of Wnt signaling pathway negative regulation of DNA bindingSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez418817240EnsemblENSG00000112559ENSMUSG00000032717UniProtQ99750P70331RefSeq mRNA NM 001300804NM 001300805NM 001300806NM 005586NM 001109973NM 001276390NM 001276391NM 010783RefSeq protein NP 001287733NP 001287734NP 001287735NP 005577NP 001103443NP 001263319NP 001263320NP 034913Location UCSC Chr 6 41 64 41 65 MbChr 17 48 13 48 15 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further readingFunction editThis protein is a transcription factor that negatively regulates other myogenic family proteins Studies of the mouse homolog I mf show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures 7 Interactions editMDFI has been shown to interact with C9orf86 8 GNAI2 8 MyoD 9 Myogenin 9 and SIX1 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000112559 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000032717 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Kraut N Sep 1997 The gene encoding I mf Mdfi maps to human chromosome 6p21 and mouse chromosome 17 Mamm Genome 8 8 618 9 doi 10 1007 s003359900517 PMID 9250874 S2CID 25160364 Wang Q Young TM Mathews MB Pe ery T Mar 2007 Developmental regulators containing the I mfa domain interact with T cyclins and Tat and modulate transcription J Mol Biol 367 3 630 46 doi 10 1016 j jmb 2007 01 020 PMC 1868487 PMID 17289077 a b Entrez Gene MDFI MyoD family inhibitor a b c Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M Oct 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 a b Chen CM Kraut N Groudine M Weintraub H Sep 1996 I mf a novel myogenic repressor interacts with members of the MyoD family Cell 86 5 731 41 doi 10 1016 s0092 8674 00 80148 8 PMID 8797820 S2CID 16252710 Further reading editChen CM Kraut N Groudine M Weintraub H 1996 I mf a novel myogenic repressor interacts with members of the MyoD family Cell 86 5 731 41 doi 10 1016 S0092 8674 00 80148 8 PMID 8797820 S2CID 16252710 Kraut N Snider L Chen CM Tapscott SJ Groudine M 1999 Requirement of the mouse I mfa gene for placental development and skeletal patterning EMBO J 17 21 6276 88 doi 10 1093 emboj 17 21 6276 PMC 1170953 PMID 9799236 Snider L Thirlwell H Miller JR Moon RT Groudine M Tapscott SJ 2001 Inhibition of Tcf3 binding by I mfa domain proteins Mol Cell Biol 21 5 1866 73 doi 10 1128 MCB 21 5 1866 1873 2001 PMC 86756 PMID 11238923 Ma R Rundle D Jacks J Koch M Downs T Tsiokas L 2004 Inhibitor of myogenic family a novel suppressor of store operated currents through an interaction with TRPC1 J Biol Chem 278 52 52763 72 doi 10 1074 jbc M309610200 PMID 14530267 Mizugishi K Hatayama M Tohmonda T Ogawa M Inoue T Mikoshiba K Aruga J 2004 Myogenic repressor I mfa interferes with the function of Zic family proteins Biochem Biophys Res Commun 320 1 233 40 doi 10 1016 j bbrc 2004 05 158 PMID 15207726 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Lim J Hao T Shaw C Patel AJ Szabo G Rual JF Fisk CJ Li N Smolyar A Hill DE Barabasi AL Vidal M Zoghbi HY 2006 A protein protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration Cell 125 4 801 14 doi 10 1016 j cell 2006 03 032 PMID 16713569 S2CID 13709685 nbsp This article on a gene on human chromosome 6 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title MDFI amp oldid 1142707748, wikipedia, wiki, book, books, library,
