MCHB-1 is a benzimidazole derived drug which was researched as an analgesic but never developed for medical use. It acts as a potent agonist of the CB2 receptor, with an EC50 of 0.52nM at CB2, and ~30x selectivity over CB1 (Ki of 110nM at CB1 vs 3.7nM at CB2).[1][2] It has been sold online as a designer drug, first being identified in Germany in December 2013.[3]
mchb, benzimidazole, derived, drug, which, researched, analgesic, never, developed, medical, acts, potent, agonist, receptor, with, ec50, 52nm, selectivity, over, 110nm, been, sold, online, designer, drug, first, being, identified, germany, december, 2013, ide. MCHB 1 is a benzimidazole derived drug which was researched as an analgesic but never developed for medical use It acts as a potent agonist of the CB2 receptor with an EC50 of 0 52nM at CB2 and 30x selectivity over CB1 Ki of 110nM at CB1 vs 3 7nM at CB2 1 2 It has been sold online as a designer drug first being identified in Germany in December 2013 3 MCHB 1IdentifiersIUPAC name 2 4 ethoxybenzyl 1 cyclohexylmethyl N N diethyl 1H benzo d imidazole 5 carboxamideCAS Number1046140 32 2PubChem CID44561533UNIIW8QNY2T4YCChEMBLChEMBL470965Chemical and physical dataFormulaC 28H 37N 3O 2Molar mass447 623 g mol 13D model JSmol Interactive imageSMILES CCN CC C O C1 CC2 C C C1 N C N2 CC3 CC C C C3 OCC CC4CCCCC4InChI InChI 1S C28H37N3O2 c1 4 30 5 2 28 32 23 14 17 26 25 19 23 29 27 31 26 20 22 10 8 7 9 11 22 18 21 12 15 24 16 13 21 33 6 3 h12 17 19 22H 4 11 18 20H2 1 3H3Key WRVZBXHTUOPQJS UHFFFAOYSA NSee also EditAZD1940 AZ 11713908 BIM 018 EtazenReferences Edit Page D Balaux E Boisvert L Liu Z Milburn C Tremblay M et al July 2008 Novel benzimidazole derivatives as selective CB2 agonists Bioorganic amp Medicinal Chemistry Letters 18 13 3695 700 doi 10 1016 j bmcl 2008 05 073 PMID 18522867 Yu XH Cao CQ Martino G Puma C Morinville A St Onge S et al November 2010 A peripherally restricted cannabinoid receptor agonist produces robust anti nociceptive effects in rodent models of inflammatory and neuropathic pain Pain 151 2 337 44 doi 10 1016 j pain 2010 07 019 PMID 20696525 S2CID 27731273 Westphal F Sonnichsen FD Knecht S Auwarter V Huppertz L April 2015 Two thiazolylindoles and a benzimidazole novel compounds on the designer drug market with potential cannabinoid receptor activity Forensic Science International 249 133 47 doi 10 1016 j forsciint 2015 01 014 PMID 25698514 This cannabinoid related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title MCHB 1 amp oldid 1082424618, wikipedia, wiki, book, books, library,