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MCF-7

January 31, 2023

MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old White woman.[1] MCF-7 is the acronym of Michigan Cancer Foundation-7, referring to the institute in Detroit where the cell line was established in 1973 by Herbert Soule and co-workers.[2] The Michigan Cancer Foundation is now known as the Barbara Ann Karmanos Cancer Institute.[3]ESRAA AHMED

MCF-7 Cells

Prior to MCF-7, it was not possible for cancer researchers to obtain a mammary cell line that was capable of living longer than a few months.[4]

The patient, Frances Mallon died in 1970. Her cells were the source of much of current knowledge about breast cancer.[2][5] At the time of sampling, she was a nun in the convent of Immaculate Heart of Mary in Monroe, Michigan under the name of Sister Catherine Frances.

MCF-7 and two other breast cancer cell lines, named T-47D and MDA-MB-231, account for more than two-thirds of all abstracts reporting studies on mentioned breast cancer cell lines, as concluded from a Medline-based survey.[6]

Characteristics of MCF-7 cells

MCF-7 cells have the following characteristics:[2][5][6][7][8][9]

This cell line retained several characteristics of differentiated mammary epithelium, including the ability to process estradiol via cytoplasmic estrogen receptors and the capability of forming domes.[citation needed]

Tumor necrosis factor alpha (TNF alpha) inhibits the growth of MCF-7 breast cancer cells. Treatment with anti-estrogens can modulate the secretion of insulin-like growth factor binding proteins. Omega-3 and 6 fatty acids such as EPA, DHA and AA has been reported to inhibit MCF-7 cell line growth and proliferation.[12]

PIK3CA helical mutations were identified in MCF-7,[13] but with low AKT activation.[14]

References

  1. ^ Lee, Adrian V.; et al. (1 July 2015). "MCF-7 Cells—Changing the Course of Breast Cancer Research and Care for 45 Years". Journal of the National Cancer Institute. 107 (7): djv073. doi:10.1093/jnci/djv073. PMID 25828948.
  2. ^ a b c Soule, HD; Vazquez J; Long A; Albert S; Brennan M. (1973). "A human cell line from a pleural effusion derived from a breast carcinoma". Journal of the National Cancer Institute. 51 (5): 1409–1416. doi:10.1093/jnci/51.5.1409. PMID 4357757.
  3. ^ http://www.cancer.gov . Archived from the original on 2010-05-27. Retrieved 2010-04-28. Retrieved on 2010-04-28
  4. ^ Glodek, Cass, Ph.D., "A History of the Michigan Cancer Foundation, the Beginnings & Growth of Detroit's Anticancer Movement," 1990, page 68, Michigan Cancer Foundation, Detroit.
  5. ^ a b Levenson, AS; Jordan VC. (1997). "MCF-7: the first hormone-responsive breast cancer cell line". Cancer Research. 57 (15): 3071–3078. PMID 9242427.
  6. ^ a b Lacroix, M; Leclercq G. (2004). "Relevance of breast cancer cell lines as models for breast tumours: an update". Breast Research and Treatment. 83 (3): 249–289. doi:10.1023/B:BREA.0000014042.54925.cc. PMID 14758095. S2CID 207628369.
  7. ^ Ross, DT; Perou CM. (2001). "A comparison of gene expression signatures from breast tumors and breast tissue derived cell lines". Disease Markers. 17 (2): 99–109. doi:10.1155/2001/850531. PMC 3850857. PMID 11673656.
  8. ^ Charafe-Jauffret, E; Ginestier C; Monville F; Finetti P; Adelaide J; Cervera N; Fekairi S; Xerri L; Jacquemier J; Birnbaum D; Bertucci F. (2006). "Gene expression profiling of breast cell lines identifies potential new basal markers". Oncogene. 25 (15): 2273–2284. doi:10.1038/sj.onc.1209254. PMID 16288205.
  9. ^ Lacroix, M; Toillon RA; Leclercq G. (2006). "p53 and breast cancer, an update". Endocrine-Related Cancer. Bioscientifica. 13 (2): 293–325. doi:10.1677/erc.1.01172. PMID 16728565.
  10. ^ Fanelli, Alex (2016). "MCF-7 Cells: human breast adenocarcinoma cell line". Retrieved 3 December 2017.
  11. ^ Sflomos, George; Dormoy, Valerian; Metsalu, Tauno; Jeitziner, Rachel; Battista, Laura; Scabia, Valentina; Raffoul, Wassim; Delaloye, Jean-Francois; Treboux, Assya (2016). "A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response". Cancer Cell. 29 (3): 407–422. doi:10.1016/j.ccell.2016.02.002. PMID 26947176.
  12. ^ Mansara, Prakash P.; Deshpande, Rashmi A.; Vaidya, Milind M.; Kaul-Ghanekar, Ruchika (1 September 2015). "Differential Ratios of Omega Fatty Acids (AA/EPA+DHA) Modulate Growth, Lipid Peroxidation and Expression of Tumor Regulatory MARBPs in Breast Cancer Cell Lines MCF7 and MDA-MB-231". PLOS ONE. 10 (9): e0136542. Bibcode:2015PLoSO..1036542M. doi:10.1371/journal.pone.0136542. ISSN 1932-6203. PMC 4556657. PMID 26325577.
  13. ^ Cosmic. "COSMIC: Sample overview for 1289391". cancer.sanger.ac.uk. Retrieved 2017-05-10.
  14. ^ Vasudevan, Krishna M.; Barbie, David A.; Davies, Michael A.; Rabinovsky, Rosalia; McNear, Chontelle J.; Kim, Jessica J.; Hennessy, Bryan T.; Tseng, Hsiuyi; Pochanard, Panisa (2009-07-07). "AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer". Cancer Cell. 16 (1): 21–32. doi:10.1016/j.ccr.2009.04.012. ISSN 1878-3686. PMC 2752826. PMID 19573809.

External links

 
Wikimedia Commons has media related to MCF-7 cells.
  • The University of Texas MD Anderson Breast Cancer Cell Line Data Base
  • Cellosaurus entry for MCF-7

January 31, 2023
breast, cancer, cell, line, isolated, 1970, from, year, white, woman, acronym, michigan, cancer, foundation, referring, institute, detroit, where, cell, line, established, 1973, herbert, soule, workers, michigan, cancer, foundation, known, barbara, karmanos, c. MCF 7 is a breast cancer cell line isolated in 1970 from a 69 year old White woman 1 MCF 7 is the acronym of Michigan Cancer Foundation 7 referring to the institute in Detroit where the cell line was established in 1973 by Herbert Soule and co workers 2 The Michigan Cancer Foundation is now known as the Barbara Ann Karmanos Cancer Institute 3 ESRAA AHMEDMCF 7 Cells Prior to MCF 7 it was not possible for cancer researchers to obtain a mammary cell line that was capable of living longer than a few months 4 The patient Frances Mallon died in 1970 Her cells were the source of much of current knowledge about breast cancer 2 5 At the time of sampling she was a nun in the convent of Immaculate Heart of Mary in Monroe Michigan under the name of Sister Catherine Frances MCF 7 and two other breast cancer cell lines named T 47D and MDA MB 231 account for more than two thirds of all abstracts reporting studies on mentioned breast cancer cell lines as concluded from a Medline based survey 6 Characteristics of MCF 7 cells EditMCF 7 cells have the following characteristics 2 5 6 7 8 9 Primary tumor invasive breast ductal carcinoma Originate from pleural effusion Estrogen receptors present 10 Proliferative response to estrogens Presence of progesterone receptors Cannot have ERBB2 gene amplification with Her2 neu protein overexpression Tumorigenic in mice but only with estrogen supplementation if engrafted into the subcutaneous fat or mammary fat pad Tumorigenic in mice without estrogen supplementation if engrafted intraductally 11 Luminal epithelial phenotypeThis cell line retained several characteristics of differentiated mammary epithelium including the ability to process estradiol via cytoplasmic estrogen receptors and the capability of forming domes citation needed Tumor necrosis factor alpha TNF alpha inhibits the growth of MCF 7 breast cancer cells Treatment with anti estrogens can modulate the secretion of insulin like growth factor binding proteins Omega 3 and 6 fatty acids such as EPA DHA and AA has been reported to inhibit MCF 7 cell line growth and proliferation 12 PIK3CA helical mutations were identified in MCF 7 13 but with low AKT activation 14 References Edit Lee Adrian V et al 1 July 2015 MCF 7 Cells Changing the Course of Breast Cancer Research and Care for 45 Years Journal of the National Cancer Institute 107 7 djv073 doi 10 1093 jnci djv073 PMID 25828948 a b c Soule HD Vazquez J Long A Albert S Brennan M 1973 A human cell line from a pleural effusion derived from a breast carcinoma Journal of the National Cancer Institute 51 5 1409 1416 doi 10 1093 jnci 51 5 1409 PMID 4357757 http www cancer gov NCI Cancer Bulletin for April 29 2008 National Cancer Institute Archived from the original on 2010 05 27 Retrieved 2010 04 28 Retrieved on 2010 04 28 Glodek Cass Ph D A History of the Michigan Cancer Foundation the Beginnings amp Growth of Detroit s Anticancer Movement 1990 page 68 Michigan Cancer Foundation Detroit a b Levenson AS Jordan VC 1997 MCF 7 the first hormone responsive breast cancer cell line Cancer Research 57 15 3071 3078 PMID 9242427 a b Lacroix M Leclercq G 2004 Relevance of breast cancer cell lines as models for breast tumours an update Breast Research and Treatment 83 3 249 289 doi 10 1023 B BREA 0000014042 54925 cc PMID 14758095 S2CID 207628369 Ross DT Perou CM 2001 A comparison of gene expression signatures from breast tumors and breast tissue derived cell lines Disease Markers 17 2 99 109 doi 10 1155 2001 850531 PMC 3850857 PMID 11673656 Charafe Jauffret E Ginestier C Monville F Finetti P Adelaide J Cervera N Fekairi S Xerri L Jacquemier J Birnbaum D Bertucci F 2006 Gene expression profiling of breast cell lines identifies potential new basal markers Oncogene 25 15 2273 2284 doi 10 1038 sj onc 1209254 PMID 16288205 Lacroix M Toillon RA Leclercq G 2006 p53 and breast cancer an update Endocrine Related Cancer Bioscientifica 13 2 293 325 doi 10 1677 erc 1 01172 PMID 16728565 Fanelli Alex 2016 MCF 7 Cells human breast adenocarcinoma cell line Retrieved 3 December 2017 Sflomos George Dormoy Valerian Metsalu Tauno Jeitziner Rachel Battista Laura Scabia Valentina Raffoul Wassim Delaloye Jean Francois Treboux Assya 2016 A Preclinical Model for ERa Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response Cancer Cell 29 3 407 422 doi 10 1016 j ccell 2016 02 002 PMID 26947176 Mansara Prakash P Deshpande Rashmi A Vaidya Milind M Kaul Ghanekar Ruchika 1 September 2015 Differential Ratios of Omega Fatty Acids AA EPA DHA Modulate Growth Lipid Peroxidation and Expression of Tumor Regulatory MARBPs in Breast Cancer Cell Lines MCF7 and MDA MB 231 PLOS ONE 10 9 e0136542 Bibcode 2015PLoSO 1036542M doi 10 1371 journal pone 0136542 ISSN 1932 6203 PMC 4556657 PMID 26325577 Cosmic COSMIC Sample overview for 1289391 cancer sanger ac uk Retrieved 2017 05 10 Vasudevan Krishna M Barbie David A Davies Michael A Rabinovsky Rosalia McNear Chontelle J Kim Jessica J Hennessy Bryan T Tseng Hsiuyi Pochanard Panisa 2009 07 07 AKT independent signaling downstream of oncogenic PIK3CA mutations in human cancer Cancer Cell 16 1 21 32 doi 10 1016 j ccr 2009 04 012 ISSN 1878 3686 PMC 2752826 PMID 19573809 External links Edit Wikimedia Commons has media related to MCF 7 cells The University of Texas MD Anderson Breast Cancer Cell Line Data Base Cellosaurus entry for MCF 7 Retrieved from https en wikipedia org w index php title MCF 7 amp oldid 1135087822, wikipedia, wiki, book, books, library,

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