mb21d1, cyclic, synthase, protein, that, humans, encoded, cgas, gene, enzyme, nucleotidyltransferase, cyclic, synthase, cgasavailable, structurespdbortholog, search, pdbe, rcsblist, codes4lew, 4km5, 4o67, 4mkp, 4lev, 4o68, 4o69identifiersaliasescgas, c6orf150,. Cyclic GMP AMP synthase is a protein that in humans is encoded by the CGAS gene 5 It s an enzyme a nucleotidyltransferase a cyclic GMP AMP synthase CGASAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes4LEW 4KM5 4O67 4MKP 4LEV 4O68 4O69IdentifiersAliasesCGAS C6orf150 cGAS h cGAS Mab 21 domain containing 1 MB21D1 cyclic GMP AMP synthase Cyclic GMP AMP synthaseExternal IDsOMIM 613973 MGI 2442261 HomoloGene 51384 GeneCards CGASGene location Human Chr Chromosome 6 human 1 Band6q13Start73 413 515 bp 1 End73 452 297 bp 1 Gene location Mouse Chr Chromosome 9 mouse 2 Band9 9 E1Start78 337 808 bp 2 End78 350 519 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inpancreatic ductal cellendothelial cellmonocytebone marrow cellsbloodlymph nodeexternal globus palliduscardianipplesuperior surface of tongueTop expressed insecondary oocytespermatocytePaneth cellvas deferenscondylefossaconjunctival fornixbone marrowbloodesophagusMore reference expression dataBioGPSn aGene ontologyMolecular functionnucleotidyltransferase activity nucleotide binding metal ion binding GTP binding transferase activity ATP binding DNA binding 2 3 cyclic GMP AMP synthase activity double stranded DNA binding chromatin binding protein bindingCellular componentcytoplasm cytosolBiological processimmune system process cyclic nucleotide biosynthetic process cellular response to exogenous dsRNA innate immune response activation of innate immune response defense response to virus positive regulation of defense response to virus by host cellular response to DNA damage stimulus positive regulation of type I interferon production paracrine signaling positive regulation of cellular senescence positive regulation of cGMP mediated signaling positive regulation of cAMP mediated signaling regulation of immunoglobulin production determination of adult lifespan regulation of type I interferon production regulation of immune response regulation of T cell activationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez115004214763EnsemblENSG00000164430ENSMUSG00000032344UniProtQ8N884Q8C6L5RefSeq mRNA NM 138441NM 173386RefSeq protein NP 612450NP 775562Location UCSC Chr 6 73 41 73 45 MbChr 9 78 34 78 35 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseReferences edit a b c GRCh38 Ensembl release 89 ENSG00000164430 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000032344 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine CGAS cyclic GMP AMP synthase Homo sapiens human Retrieved 2020 09 12 Further reading editExternal links editPDBe KB provides an overview of all the structure information available in the PDB for Human Cyclic GMP AMP synthase MB21D1 nbsp This article on a gene on human chromosome 6 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title MB21D1 amp oldid 1142674237, wikipedia, wiki, book, books, library,
