MB-3 is a drug which acts as a potent and selective inhibitor of the histone acetyltransferaseenzymeGCN5, which usually functions as a negative modulator of PGC-1α, and so MB-3 acts to indirectly activate PGC-1α. It is used in research into the role of the GCN5/PGC-1α pathway in the regulation of metabolism and cell differentiation.[1][2][3]
^Biel M, Kretsovali A, Karatzali E, Papamatheakis J, Giannis A (July 2004). "Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5". Angewandte Chemie. 43 (30): 3974–6. doi:10.1002/anie.200453879. PMID 15274229.
^Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, et al. (November 2006). "Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties". Journal of Medicinal Chemistry. 49 (23): 6897–907. doi:10.1021/jm060601m. PMID 17154519.
^Xu H, Zhou Q, Yi Q, Tan B, Tian J, Chen X, et al. (February 2020). "Islet-1 synergizes with Gcn5 to promote MSC differentiation into cardiomyocytes". Scientific Reports. 10 (1): 1817. Bibcode:2020NatSR..10.1817X. doi:10.1038/s41598-020-58387-8. PMC7000709. PMID 32019948.
This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
drug, drug, which, acts, potent, selective, inhibitor, histone, acetyltransferase, enzyme, gcn5, which, usually, functions, negative, modulator, acts, indirectly, activate, used, research, into, role, gcn5, pathway, regulation, metabolism, cell, differentiatio. MB 3 is a drug which acts as a potent and selective inhibitor of the histone acetyltransferase enzyme GCN5 which usually functions as a negative modulator of PGC 1a and so MB 3 acts to indirectly activate PGC 1a It is used in research into the role of the GCN5 PGC 1a pathway in the regulation of metabolism and cell differentiation 1 2 3 MB 3 drug IdentifiersIUPAC name 2R 3S 4 methylidene 5 oxo 2 propyloxolane 3 carboxylic acidPubChem CID21579153Chemical and physical dataFormulaC 9H 12O 4Molar mass184 191 g mol 13D model JSmol Interactive imageSMILES CCC C H 1 C H C C C O O1 C O OInChI InChI 1S C9H12O4 c1 3 4 6 7 8 10 11 5 2 9 12 13 6 h6 7H 2 4H2 1H3 H 10 11 t6 7 m1 s1Key SRQUTZJZABSZRQ RQJHMYQMSA NSee also editHY 124798References edit Biel M Kretsovali A Karatzali E Papamatheakis J Giannis A July 2004 Design synthesis and biological evaluation of a small molecule inhibitor of the histone acetyltransferase Gcn5 Angewandte Chemie 43 30 3974 6 doi 10 1002 anie 200453879 PMID 15274229 Mai A Rotili D Tarantino D Ornaghi P Tosi F Vicidomini C et al November 2006 Small molecule inhibitors of histone acetyltransferase activity identification and biological properties Journal of Medicinal Chemistry 49 23 6897 907 doi 10 1021 jm060601m PMID 17154519 Xu H Zhou Q Yi Q Tan B Tian J Chen X et al February 2020 Islet 1 synergizes with Gcn5 to promote MSC differentiation into cardiomyocytes Scientific Reports 10 1 1817 Bibcode 2020NatSR 10 1817X doi 10 1038 s41598 020 58387 8 PMC 7000709 PMID 32019948 nbsp This pharmacology related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title MB 3 drug amp oldid 1136350488, wikipedia, wiki, book, books, library,
