Target of rapamycin complex 2 subunit MAPKAP1 is a protein that in humans is encoded by the MAPKAP1gene.[5][6] As the name indicates, it is a subunit of mTOR complex 2.
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.[6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000119487 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000038696 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Schroder W, Cloonan N, Bushell G, Sculley T (Sep 2004). "Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene". Gene. 339: 17–23. doi:10.1016/j.gene.2004.07.001. PMID 15363842.
^ ab"Entrez Gene: MAPKAP1 mitogen-activated protein kinase associated protein 1".
Further readingedit
Colicelli J, Nicolette C, Birchmeier C, et al. (1991). "Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2913–7. Bibcode:1991PNAS...88.2913C. doi:10.1073/pnas.88.7.2913. PMC51350. PMID 1849280.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Schroder W, Bushell G, Sculley T (2005). "The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins". Cell. Signal. 17 (6): 761–7. doi:10.1016/j.cellsig.2004.10.015. PMID 15722200.
Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.{{cite journal}}: CS1 maint: numeric names: authors list (link)
Cheng J, Zhang D, Kim K, et al. (2005). "Mip1, an MEKK2-Interacting Protein, Controls MEKK2 Dimerization and Activation". Mol. Cell. Biol. 25 (14): 5955–64. doi:10.1128/MCB.25.14.5955-5964.2005. PMC1168836. PMID 15988011.
Venables JP, Bourgeois CF, Dalgliesh C, et al. (2005). "Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon". Hum. Mol. Genet. 14 (16): 2289–303. doi:10.1093/hmg/ddi233. PMID 16000324.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Frias MA, Thoreen CC, Jaffe JD, et al. (2006). "mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s". Curr. Biol. 16 (18): 1865–70. doi:10.1016/j.cub.2006.08.001. PMID 16919458. S2CID 8239162.
Jacinto E, Facchinetti V, Liu D, et al. (2006). "SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity". Cell. 127 (1): 125–37. doi:10.1016/j.cell.2006.08.033. PMID 16962653. S2CID 230319.
Yang Q, Inoki K, Ikenoue T, Guan KL (2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity". Genes Dev. 20 (20): 2820–32. doi:10.1101/gad.1461206. PMC1619946. PMID 17043309.
Makino C, Sano Y, Shinagawa T, et al. (2007). "Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway". Genes Cells. 11 (11): 1239–51. doi:10.1111/j.1365-2443.2006.01016.x. PMID 17054722. S2CID 10605647.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Schroder WA, Buck M, Cloonan N, et al. (2007). "Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling". Cell. Signal. 19 (6): 1279–89. doi:10.1016/j.cellsig.2007.01.013. PMID 17303383.
This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.
mapkap1, target, rapamycin, complex, subunit, protein, that, humans, encoded, gene, name, indicates, subunit, mtor, complex, available, structurespdbortholog, search, pdbe, rcsblist, codes3voqidentifiersaliases, jc310, mip1, sin1, sin1b, sin1g, mitogen, activa. Target of rapamycin complex 2 subunit MAPKAP1 is a protein that in humans is encoded by the MAPKAP1 gene 5 6 As the name indicates it is a subunit of mTOR complex 2 MAPKAP1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes3VOQIdentifiersAliasesMAPKAP1 JC310 MIP1 SIN1 SIN1b SIN1g mitogen activated protein kinase associated protein 1 MAPK associated protein 1External IDsOMIM 610558 MGI 2444554 HomoloGene 11473 GeneCards MAPKAP1Gene location Human Chr Chromosome 9 human 1 Band9q33 3Start125 437 393 bp 1 End125 707 234 bp 1 Gene location Mouse Chr Chromosome 2 mouse 2 Band2 2 BStart34 406 771 bp 2 End34 624 950 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed instromal cell of endometriumoocytegastrocnemius musclesecondary oocyteleft ventriclerectumislet of Langerhansgallbladdernucleus accumbenscaudate nucleusTop expressed insecondary oocytespermatocyteinterventricular septumspermatidparotid glandseminiferous tubuleolfactory epitheliumsternocleidomastoid muscletemporal muscleseminal vesiculaMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionphosphatidylinositol 3 5 bisphosphate binding phosphatidylinositol 3 4 bisphosphate binding phosphatidic acid binding protein binding phosphatidylinositol 4 5 bisphosphate binding protein kinase binding phosphatidylinositol 3 4 5 trisphosphate bindingCellular componentGolgi apparatus membrane plasma membrane nucleoplasm cytoplasmic vesicle nucleus cytosol TORC2 complex cytoplasmBiological processsubstantia nigra development negative regulation of Ras protein signal transduction establishment or maintenance of actin cytoskeleton polarity stress activated protein kinase signaling cascade TORC2 signaling activation of protein kinase B activity positive regulation of peptidyl serine phosphorylation regulation of cellular response to oxidative stressSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez79109227743EnsemblENSG00000119487ENSMUSG00000038696UniProtQ9BPZ7Q8BKH7RefSeq mRNA NM 001006617NM 001006618NM 001006619NM 001006620NM 001006621NM 024117NM 001290625NM 001290626NM 177345NM 001362919NM 001362920NM 001362921RefSeq protein NP 001006618NP 001006619NP 001006620NP 001006621NP 001006622NP 077022NP 001277554NP 001277555NP 796319NP 001349848NP 001349849NP 001349850Location UCSC Chr 9 125 44 125 71 MbChr 2 34 41 34 62 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene encodes a protein that is highly similar to the yeast SIN1 protein a stress activated protein kinase Alternatively spliced transcript variants encoding distinct isoforms have been described Alternate polyadenylation sites as well as alternate 3 UTRs have been identified for transcripts of this gene 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000119487 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000038696 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Schroder W Cloonan N Bushell G Sculley T Sep 2004 Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene Gene 339 17 23 doi 10 1016 j gene 2004 07 001 PMID 15363842 a b Entrez Gene MAPKAP1 mitogen activated protein kinase associated protein 1 Further reading editColicelli J Nicolette C Birchmeier C et al 1991 Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae Proc Natl Acad Sci U S A 88 7 2913 7 Bibcode 1991PNAS 88 2913C doi 10 1073 pnas 88 7 2913 PMC 51350 PMID 1849280 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Jin J Smith FD Stark C et al 2004 Proteomic functional and domain based analysis of in vivo 14 3 3 binding proteins involved in cytoskeletal regulation and cellular organization Curr Biol 14 16 1436 50 doi 10 1016 j cub 2004 07 051 PMID 15324660 S2CID 2371325 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Schroder W Bushell G Sculley T 2005 The human stress activated protein kinase interacting 1 gene encodes JNK binding proteins Cell Signal 17 6 761 7 doi 10 1016 j cellsig 2004 10 015 PMID 15722200 Benzinger A Muster N Koch HB et al 2005 Targeted proteomic analysis of 14 3 3 sigma a p53 effector commonly silenced in cancer Mol Cell Proteomics 4 6 785 95 doi 10 1074 mcp M500021 MCP200 PMID 15778465 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint numeric names authors list link Cheng J Zhang D Kim K et al 2005 Mip1 an MEKK2 Interacting Protein Controls MEKK2 Dimerization and Activation Mol Cell Biol 25 14 5955 64 doi 10 1128 MCB 25 14 5955 5964 2005 PMC 1168836 PMID 15988011 Venables JP Bourgeois CF Dalgliesh C et al 2005 Up regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell specific exon Hum Mol Genet 14 16 2289 303 doi 10 1093 hmg ddi233 PMID 16000324 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Frias MA Thoreen CC Jaffe JD et al 2006 mSin1 is necessary for Akt PKB phosphorylation and its isoforms define three distinct mTORC2s Curr Biol 16 18 1865 70 doi 10 1016 j cub 2006 08 001 PMID 16919458 S2CID 8239162 Jacinto E Facchinetti V Liu D et al 2006 SIN1 MIP1 maintains rictor mTOR complex integrity and regulates Akt phosphorylation and substrate specificity Cell 127 1 125 37 doi 10 1016 j cell 2006 08 033 PMID 16962653 S2CID 230319 Yang Q Inoki K Ikenoue T Guan KL 2006 Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity Genes Dev 20 20 2820 32 doi 10 1101 gad 1461206 PMC 1619946 PMID 17043309 Makino C Sano Y Shinagawa T et al 2007 Sin1 binds to both ATF 2 and p38 and enhances ATF 2 dependent transcription in an SAPK signaling pathway Genes Cells 11 11 1239 51 doi 10 1111 j 1365 2443 2006 01016 x PMID 17054722 S2CID 10605647 Olsen JV Blagoev B Gnad F et al 2006 Global in vivo and site specific phosphorylation dynamics in signaling networks Cell 127 3 635 48 doi 10 1016 j cell 2006 09 026 PMID 17081983 S2CID 7827573 Schroder WA Buck M Cloonan N et al 2007 Human Sin1 contains Ras binding and pleckstrin homology domains and suppresses Ras signalling Cell Signal 19 6 1279 89 doi 10 1016 j cellsig 2007 01 013 PMID 17303383 nbsp This article on a gene on human chromosome 9 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title MAPKAP1 amp oldid 1171918534, wikipedia, wiki, book, books, library,
