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Wikipedia

MAP3K11

October 15, 2023

"MLK3" redirects here. For the American activist, see Martin Luther King III.

Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene.[5][6]

MAP3K11
Identifiers
AliasesMAP3K11, MEKK11, MLK-3, MLK3, PTK1, SPRK, mitogen-activated protein kinase kinase kinase 11
External IDsOMIM: 600050 MGI: 1346880 HomoloGene: 37618 GeneCards: MAP3K11
Orthologs
SpeciesHumanMouse
Entrez

4296

26403

Ensembl

ENSG00000173327

ENSMUSG00000004054

UniProt

Q16584

Q80XI6

RefSeq (mRNA)

NM_002419

NM_022012

RefSeq (protein)

NP_002410
NP_002410.1

NP_071295

Location (UCSC)Chr 11: 65.6 – 65.62 MbChr 19: 5.74 – 5.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function Edit

The protein encoded by this gene is called MLK3 and it is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates JNK and p38, and is found to be involved in the transcription activity of AP1 mediated by Rho family GTPases and CDC42.[7][8]

Interactions Edit

MAP3K11 has been shown to interact with:

References Edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173327 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004054 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Smith CM, Ma NS, Nowak NJ, Shows TB, Gerhard DS (October 1997). "A 3-Mb Contig from D11S987 to MLK3, a Gene-Rich Region in 11q13". Genome Res. 7 (8): 835–42. doi:10.1101/gr.7.8.835. PMC 310665. PMID 9267807.
  6. ^ Ing YL, Leung IW, Heng HH, Tsui LC, Lassam NJ (June 1994). "MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain". Oncogene. 9 (6): 1745–50. PMID 8183572.
  7. ^ Kant S, Swat W, Zhang S, Zhang ZY, Neel BG, Flavell RA, Davis RJ (Oct 1, 2011). "TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway". Genes Dev. 25 (19): 2069–78. doi:10.1101/gad.17224711. PMC 3197205. PMID 21979919.
  8. ^ "Entrez Gene: MAP3K11 mitogen-activated protein kinase kinase kinase 11".
  9. ^ Barthwal MK, Sathyanarayana P, Kundu CN, Rana B, Pradeep A, Sharma C, Woodgett JR, Rana A (February 2003). "Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival". J. Biol. Chem. 278 (6): 3897–902. doi:10.1074/jbc.M211598200. PMID 12458207.
  10. ^ Nagata Ki, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A (January 1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.
  11. ^ Böck BC, Vacratsis PO, Qamirani E, Gallo KA (May 2000). "Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation". J. Biol. Chem. 275 (19): 14231–41. doi:10.1074/jbc.275.19.14231. PMID 10799501.
  12. ^ a b Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ (October 1999). "The JIP group of mitogen-activated protein kinase scaffold proteins". Mol. Cell. Biol. 19 (10): 7245–54. doi:10.1128/mcb.19.10.7245. PMC 84717. PMID 10490659.
  13. ^ Figueroa C, Tarras S, Taylor J, Vojtek AB (November 2003). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. 278 (48): 47922–7. doi:10.1074/jbc.M307357200. PMID 14504284.

Further reading Edit

  • van de Bovenkamp M, Nottet HS, Pereira CF (2003). "Interactions of human immunodeficiency virus-1 proteins with neurons: possible role in the development of human immunodeficiency virus-1-associated dementia". Eur. J. Clin. Invest. 32 (8): 619–27. doi:10.1046/j.1365-2362.2002.01029.x. PMID 12190962. S2CID 37260932.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Gallo KA, Mark MR, Scadden DT, Wang Z, Gu Q, Godowski PJ (1994). "Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity". J. Biol. Chem. 269 (21): 15092–100. doi:10.1016/S0021-9258(17)36578-X. PMID 8195146.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Tanaka S, Hanafusa H (1998). "Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases". J. Biol. Chem. 273 (3): 1281–4. doi:10.1074/jbc.273.3.1281. PMID 9430657.
  • Leung IW, Lassam N (1999). "Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3". J. Biol. Chem. 273 (49): 32408–15. doi:10.1074/jbc.273.49.32408. PMID 9829970.
  • Merritt SE, Mata M, Nihalani D, Zhu C, Hu X, Holzman LB (1999). "The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate". J. Biol. Chem. 274 (15): 10195–202. doi:10.1074/jbc.274.15.10195. PMID 10187804.
  • Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ (2000). "The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins". Mol. Cell. Biol. 19 (10): 7245–54. doi:10.1128/mcb.19.10.7245. PMC 84717. PMID 10490659.
  • Kelkar N, Gupta S, Dickens M, Davis RJ (2000). "Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3". Mol. Cell. Biol. 20 (3): 1030–43. doi:10.1128/MCB.20.3.1030-1043.2000. PMC 85220. PMID 10629060.
  • Hehner SP, Hofmann TG, Ushmorov A, Dienz O, Wing-Lan Leung I, Lassam N, Scheidereit C, Dröge W, Schmitz ML (2000). "Mixed-Lineage Kinase 3 Delivers CD3/CD28-Derived Signals into the IκB Kinase Complex". Mol. Cell. Biol. 20 (7): 2556–68. doi:10.1128/MCB.20.7.2556-2568.2000. PMC 85472. PMID 10713178.
  • Böck BC, Vacratsis PO, Qamirani E, Gallo KA (2000). "Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation". J. Biol. Chem. 275 (19): 14231–41. doi:10.1074/jbc.275.19.14231. PMID 10799501.
  • Leung IW, Lassam N (2001). "The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation". J. Biol. Chem. 276 (3): 1961–7. doi:10.1074/jbc.M004092200. PMID 11053428.
  • Svensson AC, Raudsepp T, Larsson C, Di Cristofano A, Chowdhary B, La Mantia G, Rask L, Andersson G (2001). "Chromosomal distribution, localization and expression of the human endogenous retrovirus ERV9". Cytogenet. Cell Genet. 92 (1–2): 89–96. doi:10.1159/000056875. PMID 11306803. S2CID 19266745.
  • Zhang H, Gallo KA (2002). "Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain". J. Biol. Chem. 276 (49): 45598–603. doi:10.1074/jbc.M107176200. PMID 11590155.
  • Lambert JM, Karnoub AE, Graves LM, Campbell SL, Der CJ (2002). "Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation". J. Biol. Chem. 277 (7): 4770–7. doi:10.1074/jbc.M109379200. PMID 11713255.
  • Chadee DN, Yuasa T, Kyriakis JM (2002). "Direct Activation of Mitogen-Activated Protein Kinase Kinase Kinase MEKK1 by the Ste20p Homologue GCK and the Adapter Protein TRAF2". Mol. Cell. Biol. 22 (3): 737–49. doi:10.1128/MCB.22.3.737-749.2002. PMC 133545. PMID 11784851.
  • Vacratsis PO, Phinney BS, Gage DA, Gallo KA (2002). "Identification of in vivo phosphorylation sites of MLK3 by mass spectrometry and phosphopeptide mapping". Biochemistry. 41 (17): 5613–24. CiteSeerX 10.1.1.381.6228. doi:10.1021/bi016075c. PMID 11969422.


 

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

October 15, 2023
map3k11, mlk3, redirects, here, american, activist, martin, luther, king, mitogen, activated, protein, kinase, kinase, kinase, enzyme, that, humans, encoded, gene, identifiersaliases, mekk11, mlk3, ptk1, sprk, mitogen, activated, protein, kinase, kinase, kinas. MLK3 redirects here For the American activist see Martin Luther King III Mitogen activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene 5 6 MAP3K11IdentifiersAliasesMAP3K11 MEKK11 MLK 3 MLK3 PTK1 SPRK mitogen activated protein kinase kinase kinase 11External IDsOMIM 600050 MGI 1346880 HomoloGene 37618 GeneCards MAP3K11Gene location Human Chr Chromosome 11 human 1 Band11q13 1Start65 597 756 bp 1 End65 615 382 bp 1 Gene location Mouse Chr Chromosome 19 mouse 2 Band19 A 19 4 34 cMStart5 738 770 bp 2 End5 752 893 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insural nerveright lobe of livermonocyteright lungspleenupper lobe of left lungleft uterine tubebloodbody of stomachright lobe of thyroid glandTop expressed inyolk saclipexternal carotid arteryinternal carotid arteryintestinal villusthymuscrypt of lieberkuhn of small intestinesecondary oocyteproximal tubuleduodenumMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontransferase activity nucleotide binding protein homodimerization activity mitogen activated protein kinase kinase kinase binding kinase activity protein binding identical protein binding mitogen activated protein kinase kinase binding ATP binding MAP kinase kinase kinase activity protein serine threonine kinase activity protein kinase activity JUN kinase kinase kinase activity protein tyrosine kinase activityCellular componentcentrosome membrane microtubule organizing center microtubule cytoskeleton cytoplasm intracellular anatomical structureBiological processphosphorylation positive regulation of JUN kinase activity cell death positive regulation of JNK cascade positive regulation of neuron apoptotic process microtubule based process cell population proliferation protein autophosphorylation JNK cascade protein phosphorylation positive regulation of apoptotic process MAPK cascade peptidyl tyrosine phosphorylationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez429626403EnsemblENSG00000173327ENSMUSG00000004054UniProtQ16584Q80XI6RefSeq mRNA NM 002419NM 022012RefSeq protein NP 002410NP 002410 1NP 071295Location UCSC Chr 11 65 6 65 62 MbChr 19 5 74 5 75 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further readingFunction EditThe protein encoded by this gene is called MLK3 and it is a member of the serine threonine kinase family This kinase contains a SH3 domain and a leucine zipper basic motif This kinase preferentially activates MAPK8 JNK kinase and functions as a positive regulator of JNK signaling pathway This kinase can directly phosphorylate and activates JNK and p38 and is found to be involved in the transcription activity of AP1 mediated by Rho family GTPases and CDC42 7 8 Interactions EditMAP3K11 has been shown to interact with AKT1 9 CDC42 10 11 MAPK8IP1 12 MAPK8IP2 12 and SH3RF1 13 References Edit a b c GRCh38 Ensembl release 89 ENSG00000173327 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000004054 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Smith CM Ma NS Nowak NJ Shows TB Gerhard DS October 1997 A 3 Mb Contig from D11S987 to MLK3 a Gene Rich Region in 11q13 Genome Res 7 8 835 42 doi 10 1101 gr 7 8 835 PMC 310665 PMID 9267807 Ing YL Leung IW Heng HH Tsui LC Lassam NJ June 1994 MLK 3 identification of a widely expressed protein kinase bearing an SH3 domain and a leucine zipper basic region domain Oncogene 9 6 1745 50 PMID 8183572 Kant S Swat W Zhang S Zhang ZY Neel BG Flavell RA Davis RJ Oct 1 2011 TNF stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway Genes Dev 25 19 2069 78 doi 10 1101 gad 17224711 PMC 3197205 PMID 21979919 Entrez Gene MAP3K11 mitogen activated protein kinase kinase kinase 11 Barthwal MK Sathyanarayana P Kundu CN Rana B Pradeep A Sharma C Woodgett JR Rana A February 2003 Negative regulation of mixed lineage kinase 3 by protein kinase B AKT leads to cell survival J Biol Chem 278 6 3897 902 doi 10 1074 jbc M211598200 PMID 12458207 Nagata Ki Puls A Futter C Aspenstrom P Schaefer E Nakata T Hirokawa N Hall A January 1998 The MAP kinase kinase kinase MLK2 co localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3 EMBO J 17 1 149 58 doi 10 1093 emboj 17 1 149 PMC 1170366 PMID 9427749 Bock BC Vacratsis PO Qamirani E Gallo KA May 2000 Cdc42 induced activation of the mixed lineage kinase SPRK in vivo Requirement of the Cdc42 Rac interactive binding motif and changes in phosphorylation J Biol Chem 275 19 14231 41 doi 10 1074 jbc 275 19 14231 PMID 10799501 a b Yasuda J Whitmarsh AJ Cavanagh J Sharma M Davis RJ October 1999 The JIP group of mitogen activated protein kinase scaffold proteins Mol Cell Biol 19 10 7245 54 doi 10 1128 mcb 19 10 7245 PMC 84717 PMID 10490659 Figueroa C Tarras S Taylor J Vojtek AB November 2003 Akt2 negatively regulates assembly of the POSH MLK JNK signaling complex J Biol Chem 278 48 47922 7 doi 10 1074 jbc M307357200 PMID 14504284 Further reading Editvan de Bovenkamp M Nottet HS Pereira CF 2003 Interactions of human immunodeficiency virus 1 proteins with neurons possible role in the development of human immunodeficiency virus 1 associated dementia Eur J Clin Invest 32 8 619 27 doi 10 1046 j 1365 2362 2002 01029 x PMID 12190962 S2CID 37260932 Maruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Gallo KA Mark MR Scadden DT Wang Z Gu Q Godowski PJ 1994 Identification and characterization of SPRK a novel src homology 3 domain containing proline rich kinase with serine threonine kinase activity J Biol Chem 269 21 15092 100 doi 10 1016 S0021 9258 17 36578 X PMID 8195146 Suzuki Y Yoshitomo Nakagawa K Maruyama K Suyama A Sugano S 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Tanaka S Hanafusa H 1998 Guanine nucleotide exchange protein C3G activates JNK1 by a ras independent mechanism JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases J Biol Chem 273 3 1281 4 doi 10 1074 jbc 273 3 1281 PMID 9430657 Leung IW Lassam N 1999 Dimerization via tandem leucine zippers is essential for the activation of the mitogen activated protein kinase kinase kinase MLK 3 J Biol Chem 273 49 32408 15 doi 10 1074 jbc 273 49 32408 PMID 9829970 Merritt SE Mata M Nihalani D Zhu C Hu X Holzman LB 1999 The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate J Biol Chem 274 15 10195 202 doi 10 1074 jbc 274 15 10195 PMID 10187804 Yasuda J Whitmarsh AJ Cavanagh J Sharma M Davis RJ 2000 The JIP Group of Mitogen Activated Protein Kinase Scaffold Proteins Mol Cell Biol 19 10 7245 54 doi 10 1128 mcb 19 10 7245 PMC 84717 PMID 10490659 Kelkar N Gupta S Dickens M Davis RJ 2000 Interaction of a Mitogen Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3 Mol Cell Biol 20 3 1030 43 doi 10 1128 MCB 20 3 1030 1043 2000 PMC 85220 PMID 10629060 Hehner SP Hofmann TG Ushmorov A Dienz O Wing Lan Leung I Lassam N Scheidereit C Droge W Schmitz ML 2000 Mixed Lineage Kinase 3 Delivers CD3 CD28 Derived Signals into the IkB Kinase Complex Mol Cell Biol 20 7 2556 68 doi 10 1128 MCB 20 7 2556 2568 2000 PMC 85472 PMID 10713178 Bock BC Vacratsis PO Qamirani E Gallo KA 2000 Cdc42 induced activation of the mixed lineage kinase SPRK in vivo Requirement of the Cdc42 Rac interactive binding motif and changes in phosphorylation J Biol Chem 275 19 14231 41 doi 10 1074 jbc 275 19 14231 PMID 10799501 Leung IW Lassam N 2001 The kinase activation loop is the key to mixed lineage kinase 3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation J Biol Chem 276 3 1961 7 doi 10 1074 jbc M004092200 PMID 11053428 Svensson AC Raudsepp T Larsson C Di Cristofano A Chowdhary B La Mantia G Rask L Andersson G 2001 Chromosomal distribution localization and expression of the human endogenous retrovirus ERV9 Cytogenet Cell Genet 92 1 2 89 96 doi 10 1159 000056875 PMID 11306803 S2CID 19266745 Zhang H Gallo KA 2002 Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain J Biol Chem 276 49 45598 603 doi 10 1074 jbc M107176200 PMID 11590155 Lambert JM Karnoub AE Graves LM Campbell SL Der CJ 2002 Role of MLK3 mediated activation of p70 S6 kinase in Rac1 transformation J Biol Chem 277 7 4770 7 doi 10 1074 jbc M109379200 PMID 11713255 Chadee DN Yuasa T Kyriakis JM 2002 Direct Activation of Mitogen Activated Protein Kinase Kinase Kinase MEKK1 by the Ste20p Homologue GCK and the Adapter Protein TRAF2 Mol Cell Biol 22 3 737 49 doi 10 1128 MCB 22 3 737 749 2002 PMC 133545 PMID 11784851 Vacratsis PO Phinney BS Gage DA Gallo KA 2002 Identification of in vivo phosphorylation sites of MLK3 by mass spectrometry and phosphopeptide mapping Biochemistry 41 17 5613 24 CiteSeerX 10 1 1 381 6228 doi 10 1021 bi016075c PMID 11969422 Portal nbsp Biology nbsp This article on a gene on human chromosome 11 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title MAP3K11 amp oldid 1168463238, wikipedia, wiki, book, books, library,

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