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Wikipedia

MAML2

January 01, 1970

Mastermind-like protein 2 is a protein that in humans is encoded by the MAML2 gene.[3][4][5]

MAML2
Identifiers
AliasesMAML2, MAM-3, MAM2, MAM3, MLL-mastermind like transcriptional coactivator 2
External IDsOMIM: 607537; GeneCards: MAML2; OMA:MAML2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

84441

n/a

Ensembl

ENSG00000184384

n/a

UniProt

Q8IZL2

n/a

RefSeq (mRNA)

NM_032427

n/a

RefSeq (protein)

NP_115803

n/a

Location (UCSC)Chr 11: 95.98 – 96.34 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

See also edit

Details on the activity of the N-terminal domain of Mastermind-like protein 2 may be found under MamL-1.

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184384 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Wu L, Sun T, Kobayashi K, Gao P, Griffin JD (Oct 2002). "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors". Mol Cell Biol. 22 (21): 7688–700. doi:10.1128/MCB.22.21.7688-7700.2002. PMC 135662. PMID 12370315.
  4. ^ Lin SE, Oyama T, Nagase T, Harigaya K, Kitagawa M (Dec 2002). "Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling". J Biol Chem. 277 (52): 50612–20. doi:10.1074/jbc.M209529200. PMID 12386158.
  5. ^ "Entrez Gene: MAML2 mastermind-like 2 (Drosophila)".

Further reading edit

  • Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
  • Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ (2003). "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway". Nat. Genet. 33 (2): 208–13. doi:10.1038/ng1083. PMID 12539049. S2CID 23417795.
  • Enlund F, Behboudi A, Andrén Y, Oberg C, Lendahl U, Mark J, Stenman G (2004). "Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors". Exp. Cell Res. 292 (1): 21–8. doi:10.1016/j.yexcr.2003.09.007. PMID 14720503.
  • Behboudi A, Winnes M, Gorunova L, van den Oord JJ, Mertens F, Enlund F, Stenman G (2005). "Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion". Genes Chromosomes Cancer. 43 (2): 202–5. doi:10.1002/gcc.20168. PMID 15729701. S2CID 39267344.
  • Wu L, Liu J, Gao P, Nakamura M, Cao Y, Shen H, Griffin JD (2005). "Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation". EMBO J. 24 (13): 2391–402. doi:10.1038/sj.emboj.7600719. PMC 1173159. PMID 15961999.
  • Okabe M, Miyabe S, Nagatsuka H, Terada A, Hanai N, Yokoi M, Shimozato K, Eimoto T, Nakamura S, Nagai N, Hasegawa Y, Inagaki H (2007). "MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma". Clin. Cancer Res. 12 (13): 3902–7. doi:10.1158/1078-0432.CCR-05-2376. PMID 16818685.
  • Winnes M, Mölne L, Suurküla M, Andrén Y, Persson F, Enlund F, Stenman G (2007). "Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas". Genes Chromosomes Cancer. 46 (6): 559–63. doi:10.1002/gcc.20440. PMID 17334997. S2CID 39594598.
  • Tirado Y, Williams MD, Hanna EY, Kaye FJ, Batsakis JG, El-Naggar AK (2007). "CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior". Genes Chromosomes Cancer. 46 (7): 708–15. doi:10.1002/gcc.20458. PMID 17437281. S2CID 24634433.
  • Nemoto N, Suzukawa K, Shimizu S, Shinagawa A, Takei N, Taki T, Hayashi Y, Kojima H, Kawakami Y, Nagasawa T (2007). "Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23)". Genes Chromosomes Cancer. 46 (9): 813–9. doi:10.1002/gcc.20467. PMID 17551948. S2CID 42629564.


 

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

January 01, 1970
maml2, mastermind, like, protein, protein, that, humans, encoded, gene, identifiersaliases, mam2, mam3, mastermind, like, transcriptional, coactivator, 2external, idsomim, 607537, genecards, orthologsgene, location, human, chromosome, human, band11q21start95, . Mastermind like protein 2 is a protein that in humans is encoded by the MAML2 gene 3 4 5 MAML2IdentifiersAliasesMAML2 MAM 3 MAM2 MAM3 MLL mastermind like transcriptional coactivator 2External IDsOMIM 607537 GeneCards MAML2 OMA MAML2 orthologsGene location Human Chr Chromosome 11 human 1 Band11q21Start95 976 598 bp 1 End96 343 195 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inlactiferous ductparietal pleurabronchial epithelial cellvisceral pleurarenal medullasynovial membranepancreatic epithelial celltibiacerebellar vermissuperficial temporal arteryn aMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontranscription coactivator activityCellular componentnuclear speck nucleus nucleoplasmBiological processNotch signaling pathway transcription initiation from RNA polymerase II promoter regulation of transcription DNA templated transcription DNA templated positive regulation of transcription by RNA polymerase II positive regulation of transcription of Notch receptor target positive regulation of Notch signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez84441n aEnsemblENSG00000184384n aUniProtQ8IZL2n aRefSeq mRNA NM 032427n aRefSeq protein NP 115803n aLocation UCSC Chr 11 95 98 96 34 Mbn aPubMed search 2 n aWikidataView Edit HumanSee also editDetails on the activity of the N terminal domain of Mastermind like protein 2 may be found under MamL 1 References edit a b c GRCh38 Ensembl release 89 ENSG00000184384 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Wu L Sun T Kobayashi K Gao P Griffin JD Oct 2002 Identification of a family of mastermind like transcriptional coactivators for mammalian notch receptors Mol Cell Biol 22 21 7688 700 doi 10 1128 MCB 22 21 7688 7700 2002 PMC 135662 PMID 12370315 Lin SE Oyama T Nagase T Harigaya K Kitagawa M Dec 2002 Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling J Biol Chem 277 52 50612 20 doi 10 1074 jbc M209529200 PMID 12386158 Entrez Gene MAML2 mastermind like 2 Drosophila Further reading editNagase T Nakayama M Nakajima D Kikuno R Ohara O 2001 Prediction of the coding sequences of unidentified human genes XX The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro DNA Res 8 2 85 95 doi 10 1093 dnares 8 2 85 PMID 11347906 Tonon G Modi S Wu L Kubo A Coxon AB Komiya T O Neil K Stover K El Naggar A Griffin JD Kirsch IR Kaye FJ 2003 t 11 19 q21 p13 translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway Nat Genet 33 2 208 13 doi 10 1038 ng1083 PMID 12539049 S2CID 23417795 Enlund F Behboudi A Andren Y Oberg C Lendahl U Mark J Stenman G 2004 Altered Notch signaling resulting from expression of a WAMTP1 MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin s tumors Exp Cell Res 292 1 21 8 doi 10 1016 j yexcr 2003 09 007 PMID 14720503 Behboudi A Winnes M Gorunova L van den Oord JJ Mertens F Enlund F Stenman G 2005 Clear cell hidradenoma of the skin a third tumor type with a t 11 19 associated TORC1 MAML2 gene fusion Genes Chromosomes Cancer 43 2 202 5 doi 10 1002 gcc 20168 PMID 15729701 S2CID 39267344 Wu L Liu J Gao P Nakamura M Cao Y Shen H Griffin JD 2005 Transforming activity of MECT1 MAML2 fusion oncoprotein is mediated by constitutive CREB activation EMBO J 24 13 2391 402 doi 10 1038 sj emboj 7600719 PMC 1173159 PMID 15961999 Okabe M Miyabe S Nagatsuka H Terada A Hanai N Yokoi M Shimozato K Eimoto T Nakamura S Nagai N Hasegawa Y Inagaki H 2007 MECT1 MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma Clin Cancer Res 12 13 3902 7 doi 10 1158 1078 0432 CCR 05 2376 PMID 16818685 Winnes M Molne L Suurkula M Andren Y Persson F Enlund F Stenman G 2007 Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas Genes Chromosomes Cancer 46 6 559 63 doi 10 1002 gcc 20440 PMID 17334997 S2CID 39594598 Tirado Y Williams MD Hanna EY Kaye FJ Batsakis JG El Naggar AK 2007 CRTC1 MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin s tumors implications for histogenesis and biologic behavior Genes Chromosomes Cancer 46 7 708 15 doi 10 1002 gcc 20458 PMID 17437281 S2CID 24634433 Nemoto N Suzukawa K Shimizu S Shinagawa A Takei N Taki T Hayashi Y Kojima H Kawakami Y Nagasawa T 2007 Identification of a novel fusion gene MLL MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv 11 q21q23 Genes Chromosomes Cancer 46 9 813 9 doi 10 1002 gcc 20467 PMID 17551948 S2CID 42629564 nbsp This article on a gene on human chromosome 11 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title MAML2 amp oldid 1188146642, wikipedia, wiki, book, books, library,

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