This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.[7]
Details on the activity of the N-terminal domain of Mastermind-like protein 1 may be found under MamL-1.
^ abcGRCh38: Ensembl release 89: ENSG00000161021 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000050567 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abWu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD (Dec 2000). "MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors". Nat Genet. 26 (4): 484–9. doi:10.1038/82644. PMID 11101851. S2CID 23335042.
^Kitagawa M, Oyama T, Kawashima T, Yedvobnick B, Kumar A, Matsuno K, Harigaya K (Jun 2001). "A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters". Mol Cell Biol. 21 (13): 4337–46. doi:10.1128/MCB.21.13.4337-4346.2001. PMC87094. PMID 11390662.
^Wallberg AE, Pedersen K, Lendahl U, Roeder RG (Nov 2002). "p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro". Mol. Cell. Biol. 22 (22): 7812–9. doi:10.1128/MCB.22.22.7812-7819.2002. PMC134732. PMID 12391150.
^Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA (Jun 2002). "Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex". Genes Dev. 16 (11): 1397–411. doi:10.1101/gad.991602. PMC186317. PMID 12050117.
^Wu L, Sun T, Kobayashi K, Gao P, Griffin JD (Nov 2002). "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors". Mol. Cell. Biol. 22 (21): 7688–700. doi:10.1128/MCB.22.21.7688-7700.2002. PMC135662. PMID 12370315.
Further readingedit
Alves-Guerra MC, Ronchini C, Capobianco AJ (2007). "Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival". Cancer Res. 67 (18): 8690–8. doi:10.1158/0008-5472.CAN-07-1720. PMID 17875709.
Zhao Y, Katzman RB, Delmolino LM, Bhat I, Zhang Y, Gurumurthy CB, Germaniuk-Kurowska A, Reddi HV, Solomon A, Zeng MS, Kung A, Ma H, Gao Q, Dimri G, Stanculescu A, Miele L, Wu L, Griffin JD, Wazer DE, Band H, Band V (2007). "The notch regulator MAML1 interacts with p53 and functions as a coactivator". J. Biol. Chem. 282 (16): 11969–81. doi:10.1074/jbc.M608974200. PMID 17317671.
Nam Y, Sliz P, Song L, Aster JC, Blacklow SC (2006). "Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes". Cell. 124 (5): 973–83. doi:10.1016/j.cell.2005.12.037. PMID 16530044. S2CID 17809522.
Fryer CJ, White JB, Jones KA (2005). "Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover". Mol. Cell. 16 (4): 509–20. doi:10.1016/j.molcel.2004.10.014. PMID 15546612.
Nam Y, Weng AP, Aster JC, Blacklow SC (2003). "Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex". J. Biol. Chem. 278 (23): 21232–9. doi:10.1074/jbc.M301567200. PMID 12644465.
Wallberg AE, Pedersen K, Lendahl U, Roeder RG (2002). "p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro". Mol. Cell. Biol. 22 (22): 7812–9. doi:10.1128/MCB.22.22.7812-7819.2002. PMC134732. PMID 12391150.
Lin SE, Oyama T, Nagase T, Harigaya K, Kitagawa M (2003). "Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling". J. Biol. Chem. 277 (52): 50612–20. doi:10.1074/jbc.M209529200. PMID 12386158.
Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA (2002). "Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex". Genes Dev. 16 (11): 1397–411. doi:10.1101/gad.991602. PMC186317. PMID 12050117.
Wu G, Lyapina S, Das I, Li J, Gurney M, Pauley A, Chui I, Deshaies RJ, Kitajewski J (2001). "SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation". Mol. Cell. Biol. 21 (21): 7403–15. doi:10.1128/MCB.21.21.7403-7415.2001. PMC99913. PMID 11585921.
April 13, 2024
maml1, mastermind, like, protein, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2f8x, 3nbn, 3v79identifiersaliases, mam1, mastermind, like, transcriptional, coactivator, 1external, idsomim, 605424, 1890504. Mastermind like protein 1 is a protein that in humans is encoded by the MAML1 gene 5 6 7 MAML1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2F8X 3NBN 3V79IdentifiersAliasesMAML1 Mam 1 Mam1 mastermind like transcriptional coactivator 1External IDsOMIM 605424 MGI 1890504 HomoloGene 8845 GeneCards MAML1Gene location Human Chr Chromosome 5 human 1 Band5q35 3Start179 732 822 bp 1 End179 777 283 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 11 B1 3Start50 146 461 bp 2 End50 183 138 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insural nerveganglionic eminencegallbladdergastric mucosaleft uterine tuberectumstromal cell of endometriumpopliteal arterybloodgastrocnemius muscleTop expressed inleft lung lobeexternal carotid arteryinternal carotid arteryendocardial cushionvas deferensabdominal wallfossauretercondylecumulus cellMore reference expression dataBioGPSn aGene ontologyMolecular functionpeptide antigen binding transcription coactivator activity protein binding protein kinase bindingCellular componentnuclear speck intracellular membrane bounded organelle nucleoplasm nucleus MAML1 RBP Jkappa ICN1 complexBiological processNotch signaling pathway positive regulation of myotube differentiation atrioventricular node development regulation of transcription DNA templated positive regulation of muscle cell differentiation atrioventricular node cell development transcription DNA templated protein phosphorylation myoblast differentiation transcription initiation from RNA polymerase II promoter positive regulation of transcription by RNA polymerase II positive regulation of transcription of Notch receptor target positive regulation of Notch signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez9794103806EnsemblENSG00000161021ENSMUSG00000050567UniProtQ92585Q6T264RefSeq mRNA NM 014757NM 175334RefSeq protein NP 055572NP 780543NP 001388483Location UCSC Chr 5 179 73 179 78 MbChr 11 50 15 50 18 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further readingFunction editThis protein is the human homolog of mastermind a Drosophila protein that plays a role in the Notch signaling pathway involved in cell fate determination There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch induced gene This evidence supports its proposed function as a transcriptional co activator in the Notch signaling pathway 7 Details on the activity of the N terminal domain of Mastermind like protein 1 may be found under MamL 1 Interactions editMAML1 has been shown to interact with EP300 8 9 and NOTCH1 5 10 References edit a b c GRCh38 Ensembl release 89 ENSG00000161021 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000050567 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Wu L Aster JC Blacklow SC Lake R Artavanis Tsakonas S Griffin JD Dec 2000 MAML1 a human homologue of Drosophila mastermind is a transcriptional co activator for NOTCH receptors Nat Genet 26 4 484 9 doi 10 1038 82644 PMID 11101851 S2CID 23335042 Kitagawa M Oyama T Kawashima T Yedvobnick B Kumar A Matsuno K Harigaya K Jun 2001 A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters Mol Cell Biol 21 13 4337 46 doi 10 1128 MCB 21 13 4337 4346 2001 PMC 87094 PMID 11390662 a b Entrez Gene MAML1 mastermind like 1 Drosophila Wallberg AE Pedersen K Lendahl U Roeder RG Nov 2002 p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro Mol Cell Biol 22 22 7812 9 doi 10 1128 MCB 22 22 7812 7819 2002 PMC 134732 PMID 12391150 Fryer CJ Lamar E Turbachova I Kintner C Jones KA Jun 2002 Mastermind mediates chromatin specific transcription and turnover of the Notch enhancer complex Genes Dev 16 11 1397 411 doi 10 1101 gad 991602 PMC 186317 PMID 12050117 Wu L Sun T Kobayashi K Gao P Griffin JD Nov 2002 Identification of a family of mastermind like transcriptional coactivators for mammalian notch receptors Mol Cell Biol 22 21 7688 700 doi 10 1128 MCB 22 21 7688 7700 2002 PMC 135662 PMID 12370315 Further reading editAlves Guerra MC Ronchini C Capobianco AJ 2007 Mastermind like 1 Is a specific coactivator of beta catenin transcription activation and is essential for colon carcinoma cell survival Cancer Res 67 18 8690 8 doi 10 1158 0008 5472 CAN 07 1720 PMID 17875709 Zhao Y Katzman RB Delmolino LM Bhat I Zhang Y Gurumurthy CB Germaniuk Kurowska A Reddi HV Solomon A Zeng MS Kung A Ma H Gao Q Dimri G Stanculescu A Miele L Wu L Griffin JD Wazer DE Band H Band V 2007 The notch regulator MAML1 interacts with p53 and functions as a coactivator J Biol Chem 282 16 11969 81 doi 10 1074 jbc M608974200 PMID 17317671 Nam Y Sliz P Song L Aster JC Blacklow SC 2006 Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes Cell 124 5 973 83 doi 10 1016 j cell 2005 12 037 PMID 16530044 S2CID 17809522 Fryer CJ White JB Jones KA 2005 Mastermind recruits CycC CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover Mol Cell 16 4 509 20 doi 10 1016 j molcel 2004 10 014 PMID 15546612 Nam Y Weng AP Aster JC Blacklow SC 2003 Structural requirements for assembly of the CSL intracellular Notch1 Mastermind like 1 transcriptional activation complex J Biol Chem 278 23 21232 9 doi 10 1074 jbc M301567200 PMID 12644465 Wallberg AE Pedersen K Lendahl U Roeder RG 2002 p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro Mol Cell Biol 22 22 7812 9 doi 10 1128 MCB 22 22 7812 7819 2002 PMC 134732 PMID 12391150 Lin SE Oyama T Nagase T Harigaya K Kitagawa M 2003 Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling J Biol Chem 277 52 50612 20 doi 10 1074 jbc M209529200 PMID 12386158 Fryer CJ Lamar E Turbachova I Kintner C Jones KA 2002 Mastermind mediates chromatin specific transcription and turnover of the Notch enhancer complex Genes Dev 16 11 1397 411 doi 10 1101 gad 991602 PMC 186317 PMID 12050117 Wu G Lyapina S Das I Li J Gurney M Pauley A Chui I Deshaies RJ Kitajewski J 2001 SEL 10 is an inhibitor of notch signaling that targets notch for ubiquitin mediated protein degradation Mol Cell Biol 21 21 7403 15 doi 10 1128 MCB 21 21 7403 7415 2001 PMC 99913 PMID 11585921 Retrieved from https en wikipedia org w index php title MAML1 amp oldid 1200501181, wikipedia, wiki, book, books, library,
