Lisa Gunaydin is an American neuroscientist and assistant professor at the Weill Institute for Neurosciences at the University of California San Francisco. Gunaydin helped discover optogenetics in the lab of Karl Deisseroth and now uses this technique in combination with neural and behavioral recordings to probe the neural circuits underlying emotional behaviors.
Lisa Gunaydin
Nationality
American
Alma mater
B.A. Swarthmore College, Ph.D. Stanford University
Known for
Optogenetics
Awards
2017 Chan Zuckerberg Biohub Investigator Program Investigator, 2016 UCSF Weill Institute for Neurosciences Innovation Award, 2008 Bio-X Bowes Fellow Stanford
Scientific career
Fields
Neuroscience
Institutions
Weill Institute for Neurosciences, University of California, San Francisco
Gunaydin completed her undergraduate education at Swarthmore College with a degree in biological sciences.[1] Gunaydin then continued on an academic path by pursuing a Ph.D. at Stanford University. Under the mentorship of Dr. Karl Deisseroth, Gunaydin helped to discover optogenetic technology and apply it to Systems Neuroscience by dissecting neural circuits that drive a variety of complex behaviors in rodents.[2][3]Optogenetics is a tool used in Systems Neuroscience to activate or inhibit specific neural circuits using transgenically expressed light-activated opsins, originally derived from bacterial opsins.[4] Shining lasers of specific wavelengths causes the channels to open.[4] In the case of Channelrhodopsins, cations ions flow into the neuron to depolarize it, while in the case of Halorhodopsins, anions flow into the neuron to hyperpolarize it.[4] This can effectively allow a scientist to activate or inhibit specific neurons or neural circuits in an organism expressing the transgenic protein.
In 2008, Gunaydin was named the Bio-X Bowes Fellow at Stanford for her work developing new optogenetic technologies and applying them to probe dopaminergic circuitry implicated in social behaviors.[3] In 2009, Gunaydin co-first authored a paper in Nature Neuroscience where she helped to test and optimize step-function opsins which allow longer lasting membrane depolarization than regular opsins providing extended effects on neural circuits.[5] In 2010, Gunaydin published a first author paper in Nature Neuroscience highlighting her optimization of a new opsin based tool for ultrafast neural circuit control.[6] In this work Gunaydin showed that this novel opsin does not produce unwanted spikes nor persistent depolarizations like what might occur when a cell over-expresses Channelrhodopsin.[6] In 2015, Gunaydin and her colleagues in the Deisseroth Lab published a paper in the journal Cell, where they used fiber photometry to observe calcium dynamics in dopaminergic neural circuits involved in social behavior.[7] She and her colleagues also found that the neural projection from the Ventral Tegmental Area (VTA) to the Nucleus Accumbens (NAc) encodes and predicts social behaviors.[7] Using optogenetics, Gunaydin probed the causal effects of stimulating the dopaminergic projection from the VTA to the NAc and found that modulation of this projection bi-directionally affected social behaviors.[6] Gunaydin went on to present this work at the Cold Spring Harbour Symposia on Quantitative Biology.[8] This was one of the first studies ever to manipulate social neural circuits in real time, using optogenetics, and observe changes in social behavior.[8] After her PhD, Gunaydin pursued her postdoctoral work with Dr. Anatol Kreitzer at the University of California San Francisco’s Gladstone Institute of Neurological Disease.[1] Under Kreitzer's mentorship, Gunaydin brought her experience and expertise with optogenetics to explore fronto-striatal circuitry and its implications in anxiety-like behavior.[9]
Career and researchedit
Gunaydin started her lab at the University of California, San Francisco in 2016 and has since held an assistant professorship in Psychiatry as well as an appointment at the Institute for Neurodegenerative Diseases.[10][11] In addition, Gunaydin is a member of the UCSF Neuroscience Graduate Program, the Kavli Institute for Fundamental Neuroscience, and in 2017 was named a Chan Zuckerberg Biohub Investigator.[12] Gunaydin's lab aims to investigate the neural circuits underlying motivated behaviors and further understand how they aberrantly function in disease states.[13] Gunaydin's lab is currently focusing on three main projects to address this aim. The first project involves probing the role of cortico-striatal circuitry in modulating anxiety-like behavior as well as elucidating the potential of this circuit as a target of chronic therapeutic stimulation.[11] In line with this project, the Gunaydin Lab published their first paper in 2020 highlighting their discovery of a subpopulation of striatal projecting prefrontal neurons that regulate approach-avoidance conflict in rodents.[14] The other two projects her lab is working on explore the roles of cortical neural subpopulations in obsessive-compulsive disorder behaviors as well as the mechanisms of circuit defects in genetic mouse models for obsessive-compulsive disorder and autism.[11]
Awards and honorsedit
2017 Chan Zuckerberg Biohub Investigator Program Investigator[15]
2016 UCSF Weill Institute for Neurosciences Innovation Award[16]
Loewke AC, Minerva AR, Nelson AB, Kreitzer AC, Gunaydin LA (2020). Fronto-striatal projections regulate approach-avoidance conflict. bioRxiv.[14]
Gunaydin LA, Kreitzer AC (2016). Cortico-basal ganglia circuit function in psychiatric disease. Annual Review of Physiology 78: 327–350.[17]
Adhikari A, Lerner TN, Finkelstein J, Pak S, Jennings JH, Davidson TJ, Ferenczi E, Gunaydin LA, Mirzabekov JJ, Ye L, Kim SY, Lei A, Deisseroth K (2015). Basomedial amygdala mediates top-down control of anxiety and fear. Nature 527: 179–185.[17]
Gunaydin LA, Deisseroth K (2015). Dopaminergic Dynamics Contributing to Social Behavior. In Cold Spring Harbor Symposia on Quantitative Biology 221–227. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.[17]
Fenno LE, Gunaydin LA, Deisseroth K (2015). Mapping Anatomy to Behavior in Thy1:18 ChR2-YFP Transgenic Mice Using Optogenetics. In Molecular Neuroscience: A Laboratory Manual 594–606. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.[17]
Gunaydin LA, Grosenick L, Finkelstein JC, Kauvar I, Fenno LE, Adhikari A, Lammel S, Mirzabekov J, Airan RD, Zalocusky KA, Tye KM, Anikeeva P, Malenka R, Deisseroth K (2014). Natural neural projection dynamics underlying social behavior. Cell 157(7): 1535–51.[17]
Tye KM, Mirzabekov JJ, Warden MR, Ferenczi EA, Tsai HC, Finkelstein J, Kim SY, Adhikari A, Thompson KR, Andalman AS, Gunaydin LA, Witten IB, Deisseroth K (2012). Dopamine neurons modulate neural encoding and expression of depression-related behavior. Nature 493(7433):537-41.[17]
Mattis J, Tye KM, Ferenczi EA, Ramakrishnan C, O’Shea DJ, Prakash R, Gunaydin LA, Hyun M, Fenno LE, Gradinaru V, Yizhar O, Deisseroth K (2011). Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins. Nature Methods 9(2):159-72.[17]
Anikeeva P, Andalman AS, Witten IB, Warden MR, Goshen I, Grosenick L, Gunaydin LA, Frank L, Deisseroth K. (2011). Optetrode: a multichannel readout for optogenetic control in freely moving mice. Nature Neuroscience 15(1):163-70.[17]
Berndt A*, Yizhar O*, Gunaydin LA*, Hegemann P, and Deisseroth K. Bi-stable neural state switches (2009). Nature Neuroscience 12(2):229-34. *co-first authors[17]
Westberg L, Sawa E, Wang AY, Gunaydin LA, Ribeiro AC, Pfaff DW (2009). Colocalization of connexin 36 and corticotropin-releasing hormone in the mouse brain. BMC Neuroscience 10:41.[17]
Referencesedit
^ ab"Lisa Gunaydin, PhD | Institute for Neurodegenerative Diseases". ind.ucsf.edu. Retrieved 2020-03-31.
^"Breakthrough Prize – Life Sciences Breakthrough Prize Laureates – Karl Deisseroth". breakthroughprize.org. Retrieved 2020-03-31.
^ abGunaydin, Lisa A.; Grosenick, Logan; Finkelstein, Joel C.; Kauvar, Isaac V.; Fenno, Lief E.; Adhikari, Avishek; Lammel, Stephan; Mirzabekov, Julie J.; Airan, Raag D.; Zalocusky, Kelly A.; Tye, Kay M. (2014-06-19). "Natural Neural Projection Dynamics Underlying Social Behavior". Cell. 157 (7): 1535–1551. doi:10.1016/j.cell.2014.05.017. ISSN 0092-8674. PMC4123133. PMID 24949967.
^ abGunaydin, Lisa A.; Deisseroth, Karl (2014-01-01). "Dopaminergic Dynamics Contributing to Social Behavior". Cold Spring Harbor Symposia on Quantitative Biology. 79: 221–227. doi:10.1101/sqb.2014.79.024711. ISSN 0091-7451. PMID 25943769.
^"15 UCSF Researchers Named to First Cohort of Chan Zuckerberg Biohub Investigators". 15 UCSF Researchers Named to First Cohort of Chan Zuckerberg Biohub Investigators | UC San Francisco. Retrieved 2020-03-31.
^ abLoewke, Adrienne C.; Minerva, Adelaide R.; Nelson, Alexandra B.; Kreitzer, Anatol C.; Gunaydin, Lisa A. (2020-03-06). "Fronto-striatal projections regulate approach-avoidance conflict". bioRxiv: 2020.03.05.979708. doi:10.1101/2020.03.05.979708.
^Gorrell, Sasha; Collins, Anne G.E.; Daniel, Le Grange; Yang, Tony T. (2020-03-23). "Dopaminergic Activity and Exercise Behavior in Anorexia Nervosa". OBM Neurobiology. 4 (1): 1–19. doi:10.21926/obm.neurobiol.2001053. PMC7872149. PMID 33569542.
^"UCSF Weill Institute for Neurosciences Announces Innovation, Scholar Awards". UCSF Neurosciences. Retrieved 2020-03-31.
lisa, gunaydin, american, neuroscientist, assistant, professor, weill, institute, neurosciences, university, california, francisco, gunaydin, helped, discover, optogenetics, karl, deisseroth, uses, this, technique, combination, with, neural, behavioral, record. Lisa Gunaydin is an American neuroscientist and assistant professor at the Weill Institute for Neurosciences at the University of California San Francisco Gunaydin helped discover optogenetics in the lab of Karl Deisseroth and now uses this technique in combination with neural and behavioral recordings to probe the neural circuits underlying emotional behaviors Lisa GunaydinNationalityAmericanAlma materB A Swarthmore College Ph D Stanford UniversityKnown forOptogeneticsAwards2017 Chan Zuckerberg Biohub Investigator Program Investigator 2016 UCSF Weill Institute for Neurosciences Innovation Award 2008 Bio X Bowes Fellow StanfordScientific careerFieldsNeuroscienceInstitutionsWeill Institute for Neurosciences University of California San Francisco Contents 1 Early life and education 2 Career and research 3 Awards and honors 4 Select publications 5 ReferencesEarly life and education editGunaydin completed her undergraduate education at Swarthmore College with a degree in biological sciences 1 Gunaydin then continued on an academic path by pursuing a Ph D at Stanford University Under the mentorship of Dr Karl Deisseroth Gunaydin helped to discover optogenetic technology and apply it to Systems Neuroscience by dissecting neural circuits that drive a variety of complex behaviors in rodents 2 3 Optogenetics is a tool used in Systems Neuroscience to activate or inhibit specific neural circuits using transgenically expressed light activated opsins originally derived from bacterial opsins 4 Shining lasers of specific wavelengths causes the channels to open 4 In the case of Channelrhodopsins cations ions flow into the neuron to depolarize it while in the case of Halorhodopsins anions flow into the neuron to hyperpolarize it 4 This can effectively allow a scientist to activate or inhibit specific neurons or neural circuits in an organism expressing the transgenic protein In 2008 Gunaydin was named the Bio X Bowes Fellow at Stanford for her work developing new optogenetic technologies and applying them to probe dopaminergic circuitry implicated in social behaviors 3 In 2009 Gunaydin co first authored a paper in Nature Neuroscience where she helped to test and optimize step function opsins which allow longer lasting membrane depolarization than regular opsins providing extended effects on neural circuits 5 In 2010 Gunaydin published a first author paper in Nature Neuroscience highlighting her optimization of a new opsin based tool for ultrafast neural circuit control 6 In this work Gunaydin showed that this novel opsin does not produce unwanted spikes nor persistent depolarizations like what might occur when a cell over expresses Channelrhodopsin 6 In 2015 Gunaydin and her colleagues in the Deisseroth Lab published a paper in the journal Cell where they used fiber photometry to observe calcium dynamics in dopaminergic neural circuits involved in social behavior 7 She and her colleagues also found that the neural projection from the Ventral Tegmental Area VTA to the Nucleus Accumbens NAc encodes and predicts social behaviors 7 Using optogenetics Gunaydin probed the causal effects of stimulating the dopaminergic projection from the VTA to the NAc and found that modulation of this projection bi directionally affected social behaviors 6 Gunaydin went on to present this work at the Cold Spring Harbour Symposia on Quantitative Biology 8 This was one of the first studies ever to manipulate social neural circuits in real time using optogenetics and observe changes in social behavior 8 After her PhD Gunaydin pursued her postdoctoral work with Dr Anatol Kreitzer at the University of California San Francisco s Gladstone Institute of Neurological Disease 1 Under Kreitzer s mentorship Gunaydin brought her experience and expertise with optogenetics to explore fronto striatal circuitry and its implications in anxiety like behavior 9 Career and research editGunaydin started her lab at the University of California San Francisco in 2016 and has since held an assistant professorship in Psychiatry as well as an appointment at the Institute for Neurodegenerative Diseases 10 11 In addition Gunaydin is a member of the UCSF Neuroscience Graduate Program the Kavli Institute for Fundamental Neuroscience and in 2017 was named a Chan Zuckerberg Biohub Investigator 12 Gunaydin s lab aims to investigate the neural circuits underlying motivated behaviors and further understand how they aberrantly function in disease states 13 Gunaydin s lab is currently focusing on three main projects to address this aim The first project involves probing the role of cortico striatal circuitry in modulating anxiety like behavior as well as elucidating the potential of this circuit as a target of chronic therapeutic stimulation 11 In line with this project the Gunaydin Lab published their first paper in 2020 highlighting their discovery of a subpopulation of striatal projecting prefrontal neurons that regulate approach avoidance conflict in rodents 14 The other two projects her lab is working on explore the roles of cortical neural subpopulations in obsessive compulsive disorder behaviors as well as the mechanisms of circuit defects in genetic mouse models for obsessive compulsive disorder and autism 11 Awards and honors edit2017 Chan Zuckerberg Biohub Investigator Program Investigator 15 2016 UCSF Weill Institute for Neurosciences Innovation Award 16 2008 Bio X Bowes Fellow Stanford 3 Select publications editLoewke AC Minerva AR Nelson AB Kreitzer AC Gunaydin LA 2020 Fronto striatal projections regulate approach avoidance conflict bioRxiv 14 Gunaydin LA Kreitzer AC 2016 Cortico basal ganglia circuit function in psychiatric disease Annual Review of Physiology 78 327 350 17 Adhikari A Lerner TN Finkelstein J Pak S Jennings JH Davidson TJ Ferenczi E Gunaydin LA Mirzabekov JJ Ye L Kim SY Lei A Deisseroth K 2015 Basomedial amygdala mediates top down control of anxiety and fear Nature 527 179 185 17 Gunaydin LA Deisseroth K 2015 Dopaminergic Dynamics Contributing to Social Behavior In Cold Spring Harbor Symposia on Quantitative Biology 221 227 Cold Spring Harbor NY Cold Spring Harbor Laboratory Press 17 Fenno LE Gunaydin LA Deisseroth K 2015 Mapping Anatomy to Behavior in Thy1 18 ChR2 YFP Transgenic Mice Using Optogenetics In Molecular Neuroscience A Laboratory Manual 594 606 Cold Spring Harbor NY Cold Spring Harbor Laboratory Press 17 Gunaydin LA Grosenick L Finkelstein JC Kauvar I Fenno LE Adhikari A Lammel S Mirzabekov J Airan RD Zalocusky KA Tye KM Anikeeva P Malenka R Deisseroth K 2014 Natural neural projection dynamics underlying social behavior Cell 157 7 1535 51 17 Tye KM Mirzabekov JJ Warden MR Ferenczi EA Tsai HC Finkelstein J Kim SY Adhikari A Thompson KR Andalman AS Gunaydin LA Witten IB Deisseroth K 2012 Dopamine neurons modulate neural encoding and expression of depression related behavior Nature 493 7433 537 41 17 Mattis J Tye KM Ferenczi EA Ramakrishnan C O Shea DJ Prakash R Gunaydin LA Hyun M Fenno LE Gradinaru V Yizhar O Deisseroth K 2011 Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins Nature Methods 9 2 159 72 17 Anikeeva P Andalman AS Witten IB Warden MR Goshen I Grosenick L Gunaydin LA Frank L Deisseroth K 2011 Optetrode a multichannel readout for optogenetic control in freely moving mice Nature Neuroscience 15 1 163 70 17 Gunaydin LA Yizhar O Berndt A Sohal VS Deisseroth K Hegemann P 2010 Ultrafast optogenetic control Nature Neuroscience 13 3 387 92 17 Berndt A Yizhar O Gunaydin LA Hegemann P and Deisseroth K Bi stable neural state switches 2009 Nature Neuroscience 12 2 229 34 co first authors 17 Westberg L Sawa E Wang AY Gunaydin LA Ribeiro AC Pfaff DW 2009 Colocalization of connexin 36 and corticotropin releasing hormone in the mouse brain BMC Neuroscience 10 41 17 References edit a b Lisa Gunaydin PhD Institute for Neurodegenerative Diseases ind ucsf edu Retrieved 2020 03 31 Breakthrough Prize Life Sciences Breakthrough Prize Laureates Karl Deisseroth breakthroughprize org Retrieved 2020 03 31 a b c University c Stanford Stanford California 94305 2014 03 05 Lisa Gunaydin Bio X Bowes Fellow Welcome to Bio X Retrieved 2020 03 31 a href Template Cite web html title Template Cite web cite web a CS1 maint numeric names authors list link a b c Deisseroth Karl January 2011 Optogenetics Nature Methods 8 1 26 29 doi 10 1038 nmeth f 324 ISSN 1548 7105 PMC 6814250 PMID 21191368 Berndt Andre Yizhar Ofer Gunaydin Lisa A Hegemann Peter Deisseroth Karl February 2009 Bi stable neural state switches Nature Neuroscience 12 2 229 234 doi 10 1038 nn 2247 ISSN 1546 1726 PMID 19079251 S2CID 15125498 a b c Gunaydin Lisa A Yizhar Ofer Berndt Andre Sohal Vikaas S Deisseroth Karl Hegemann Peter March 2010 Ultrafast optogenetic control Nature Neuroscience 13 3 387 392 doi 10 1038 nn 2495 ISSN 1546 1726 PMID 20081849 S2CID 7457755 a b Gunaydin Lisa A Grosenick Logan Finkelstein Joel C Kauvar Isaac V Fenno Lief E Adhikari Avishek Lammel Stephan Mirzabekov Julie J Airan Raag D Zalocusky Kelly A Tye Kay M 2014 06 19 Natural Neural Projection Dynamics Underlying Social Behavior Cell 157 7 1535 1551 doi 10 1016 j cell 2014 05 017 ISSN 0092 8674 PMC 4123133 PMID 24949967 a b Gunaydin Lisa A Deisseroth Karl 2014 01 01 Dopaminergic Dynamics Contributing to Social Behavior Cold Spring Harbor Symposia on Quantitative Biology 79 221 227 doi 10 1101 sqb 2014 79 024711 ISSN 0091 7451 PMID 25943769 Gunaydin Lisa Nelson Alexandra Kreitzer Anatol 2017 05 15 500 Fronto Striatal Modulation of Anxiety Like Behaviors Biological Psychiatry 81 10 203 210 doi 10 1016 j biopsych 2017 02 1108 ISSN 0006 3223 PMC 4909599 PMID 26853120 People Gunaydin Lab Retrieved 2020 03 31 a b c Lisa Gunaydin PhD Neuroscience Graduate Program Retrieved 2020 03 31 15 UCSF Researchers Named to First Cohort of Chan Zuckerberg Biohub Investigators 15 UCSF Researchers Named to First Cohort of Chan Zuckerberg Biohub Investigators UC San Francisco Retrieved 2020 03 31 Research Gunaydin Lab Retrieved 2020 03 31 a b Loewke Adrienne C Minerva Adelaide R Nelson Alexandra B Kreitzer Anatol C Gunaydin Lisa A 2020 03 06 Fronto striatal projections regulate approach avoidance conflict bioRxiv 2020 03 05 979708 doi 10 1101 2020 03 05 979708 Gorrell Sasha Collins Anne G E Daniel Le Grange Yang Tony T 2020 03 23 Dopaminergic Activity and Exercise Behavior in Anorexia Nervosa OBM Neurobiology 4 1 1 19 doi 10 21926 obm neurobiol 2001053 PMC 7872149 PMID 33569542 UCSF Weill Institute for Neurosciences Announces Innovation Scholar Awards UCSF Neurosciences Retrieved 2020 03 31 a b c d e f g h i j k Publications Gunaydin Lab Retrieved 2020 03 31 Retrieved from https en wikipedia org w index php title Lisa Gunaydin amp oldid 1139789778, wikipedia, wiki, book, books, library,
