The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.[6]
LPS exposure induces LBP production.[8] LBP is synthesized by the liver, adipose tissue, and intestinal cells.[8] Dietary glucose and saturated fats acutely increase plasma LBP.[8]
The proinflammatory activity of plasma LPS is increased by LBP, which is higher in obesity.[9]
Plasma LBP is used as a better biomarker of plasma LPS than LPS itself due to the short half-life of LPS.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000129988 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000016024 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Gray PW, Corcorran AE, Eddy RL Jr, Byers MG, Shows TB (March 1993). "The genes for the lipopolysaccharide binding protein (LBP) and the bactericidal permeability increasing protein (BPI) are encoded in the same region of human chromosome 20". Genomics. 15 (1): 188–90. doi:10.1006/geno.1993.1030. PMID 8432532.
^Muta T, Takeshige K (2001). "Essential roles of CD14 and lipopolysaccharide-binding protein for activation of toll-like receptor (TLR)2 as well as TLR4 Reconstitution of TLR2- and TLR4-activation by distinguishable ligands in LPS preparations". Eur. J. Biochem. 268 (16): 4580–9. doi:10.1046/j.1432-1327.2001.02385.x. PMID 11502220.
^ abcdDjuric Z (2017). "Obesity-associated cancer risk: the role of intestinal microbiota in the etiology of the host proinflammatory state". Translational Research. 179: 155–167. doi:10.1016/j.trsl.2016.07.017. PMC5164980. PMID 27522986.
^Tuomi K, Logomarsino JV (2016). "Bacterial Lipopolysaccharide, Lipopolysaccharide-Binding Protein, and Other Inflammatory Markers in Obesity and After Bariatric Surgery". Metabolic Syndrome and Related Disorders. 14 (6): 279–288. doi:10.1089/met.2015.0170. PMID 27228236.
^Thomas, Celestine J; Kapoor Mili; Sharma Shilpi; Bausinger Huguette; Zyilan Umit; Lipsker Dan; Hanau Daniel; Surolia Avadhesha (November 2002). "Evidence of a trimolecular complex involving LPS, LPS binding protein and soluble CD14 as an effector of LPS response". FEBS Lett. 531 (2): 184–8. doi:10.1016/S0014-5793(02)03499-3. ISSN 0014-5793. PMID 12417309. S2CID 25135963.
^Yu, B; Wright S D (1995). "LPS-dependent interaction of Mac-2-binding protein with immobilized CD14". J. Inflamm. 45 (2): 115–25. ISSN 1078-7852. PMID 7583357.
^Erridge, C; Pridmore, A; Eley, A; Stewart, J; Poxton, IR (2004). "Lipopolysaccharides of Bacteroides fragilis, Chlamydia trachomatis and Pseudomonas aeruginosa signal via toll-like receptor 2". Journal of Medical Microbiology. 53 (Pt 8): 735–40. doi:10.1099/jmm.0.45598-0. PMID 15272059.
Further readingEdit
Schumann RR, Leong SR, Flaggs GW, et al. (1990). "Structure and function of lipopolysaccharide binding protein". Science. 249 (4975): 1429–31. Bibcode:1990Sci...249.1429S. doi:10.1126/science.2402637. PMID 2402637.
Wilde CG, Seilhamer JJ, McGrogan M, et al. (1994). "Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation". J. Biol. Chem. 269 (26): 17411–6. doi:10.1016/S0021-9258(17)32454-7. PMID 7517398.
Park CT, Wright SD (1996). "Plasma lipopolysaccharide-binding protein is found associated with a particle containing apolipoprotein A-I, phospholipid, and factor H-related proteins". J. Biol. Chem. 271 (30): 18054–60. doi:10.1074/jbc.271.30.18054. PMID 8663389.
Nanbo A, Nishimura H, Nagasawa S (1997). "Lipopolysaccharide binding protein from normal human plasma purified with high efficiency". Protein Expr. Purif. 10 (1): 55–60. doi:10.1006/prep.1996.0712. PMID 9179291.
Hubacek JA, Büchler C, Aslanidis C, Schmitz G (1997). "The genomic organization of the genes for human lipopolysaccharide binding protein (LBP) and bactericidal permeability increasing protein (BPI) is highly conserved". Biochem. Biophys. Res. Commun. 236 (2): 427–30. doi:10.1006/bbrc.1997.6970. PMID 9240454.
Jack RS, Fan X, Bernheiden M, et al. (1997). "Lipopolysaccharide-binding protein is required to combat a murine gram-negative bacterial infection". Nature. 389 (6652): 742–5. Bibcode:1997Natur.389..742J. doi:10.1038/39622. PMID 9338787. S2CID 205027151.
Kirschning CJ, Au-Young J, Lamping N, et al. (1998). "Similar organization of the lipopolysaccharide-binding protein (LBP) and phospholipid transfer protein (PLTP) genes suggests a common gene family of lipid-binding proteins". Genomics. 46 (3): 416–25. doi:10.1006/geno.1997.5030. PMID 9441745.
Beamer LJ, Carroll SF, Eisenberg D (1998). "The BPI/LBP family of proteins: a structural analysis of conserved regions". Protein Sci. 7 (4): 906–14. doi:10.1002/pro.5560070408. PMC2143972. PMID 9568897.
Sato M, Saeki Y, Tanaka K, Kaneda Y (1999). "Ribosome-associated protein LBP/p40 binds to S21 protein of 40S ribosome: analysis using a yeast two-hybrid system". Biochem. Biophys. Res. Commun. 256 (2): 385–90. doi:10.1006/bbrc.1999.0343. PMID 10079194.
Vreugdenhil AC, Dentener MA, Snoek AM, et al. (1999). "Lipopolysaccharide binding protein and serum amyloid A secretion by human intestinal epithelial cells during the acute phase response". Journal of Immunology. 163 (5): 2792–8. PMID 10453023.
Vesy CJ, Kitchens RL, Wolfbauer G, et al. (2000). "Lipopolysaccharide-Binding Protein and Phospholipid Transfer Protein Release Lipopolysaccharides from Gram-Negative Bacterial Membranes". Infect. Immun. 68 (5): 2410–7. doi:10.1128/IAI.68.5.2410-2417.2000. PMC97439. PMID 10768924.
Labéta MO, Vidal K, Nores JE, et al. (2000). "Innate Recognition of Bacteria in Human Milk Is Mediated by a Milk-Derived Highly Expressed Pattern Recognition Receptor, Soluble Cd14". J. Exp. Med. 191 (10): 1807–12. doi:10.1084/jem.191.10.1807. PMC2193148. PMID 10811873.
Dentener MA, Vreugdenhil AC, Hoet PH, et al. (2000). "Production of the acute-phase protein lipopolysaccharide-binding protein by respiratory type II epithelial cells: implications for local defense to bacterial endotoxins". Am. J. Respir. Cell Mol. Biol. 23 (2): 146–53. doi:10.1165/ajrcmb.23.2.3855. PMID 10919979.
Nagaoka I, Hirota S, Niyonsaba F, et al. (2001). "Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF-alpha by blocking the binding of LPS to CD14(+) cells". Journal of Immunology. 167 (6): 3329–38. doi:10.4049/jimmunol.167.6.3329. PMID 11544322.
Gutsmann T, Müller M, Carroll SF, et al. (2001). "Dual Role of Lipopolysaccharide (LPS)-Binding Protein in Neutralization of LPS and Enhancement of LPS-Induced Activation of Mononuclear Cells". Infect. Immun. 69 (11): 6942–50. doi:10.1128/IAI.69.11.6942-6950.2001. PMC100074. PMID 11598069.
Iovine N, Eastvold J, Elsbach P, et al. (2002). "The carboxyl-terminal domain of closely related endotoxin-binding proteins determines the target of protein-lipopolysaccharide complexes". J. Biol. Chem. 277 (10): 7970–8. doi:10.1074/jbc.M109622200. PMID 11773072.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Kaden J, Zwerenz P, Lambrecht HG, Dostatni R (2002). "Lipopolysaccharide-binding protein as a new and reliable infection marker after kidney transplantation". Transpl. Int. 15 (4): 163–72. doi:10.1007/s00147-002-0392-2. PMID 11976738. S2CID 23593715.
Reyes O, Vallespi MG, Garay HE, et al. (2002). "Identification of single amino acid residues essential for the binding of lipopolysaccharide (LPS) to LPS binding protein (LBP) residues 86-99 by using an Ala-scanning library". J. Pept. Sci. 8 (4): 144–50. doi:10.1002/psc.375. PMID 11991204. S2CID 28803013.
External linksEdit
lipopolysaccharide-binding+protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
lipopolysaccharide, binding, protein, protein, that, humans, encoded, gene, lbpavailable, structurespdbortholog, search, pdbe, rcsblist, codes4m4didentifiersaliaseslbp, bpifd2, lipopolysaccharide, binding, proteinexternal, idsomim, 151990, 1098776, homologene,. Lipopolysaccharide binding protein LBP is a protein that in humans is encoded by the LBP gene 5 6 LBPAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes4M4DIdentifiersAliasesLBP BPIFD2 lipopolysaccharide binding proteinExternal IDsOMIM 151990 MGI 1098776 HomoloGene 3055 GeneCards LBPGene location Human Chr Chromosome 20 human 1 Band20q11 23Start38 346 482 bp 1 End38 377 013 bp 1 Gene location Mouse Chr Chromosome 2 mouse 2 Band2 H1 2 78 72 cMStart158 148 413 bp 2 End158 174 772 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright lobe of livertibialis anterior musclegastrocnemius muscleappendixdeltoid musclesubcutaneous adipose tissueright lobe of thyroid glandpericardiumkidneysynovial membraneTop expressed inankleankle jointleft lobe of liveruterusparotid glandwhite adipose tissuestria vasculariscarotid bodyright lung lobeoptic nerveMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionlipoteichoic acid binding protein binding lipid binding signaling receptor binding lipopolysaccharide binding lipopeptide bindingCellular componentmembrane extracellular exosome extracellular region cell surface extracellular spaceBiological processdetection of molecule of bacterial origin lipid transport toll like receptor 4 signaling pathway immune system process leukocyte chemotaxis involved in inflammatory response cellular defense response cellular response to lipoteichoic acid defense response to bacterium lipopolysaccharide transport positive regulation of interleukin 8 production positive regulation of interleukin 6 production positive regulation of neutrophil chemotaxis positive regulation of toll like receptor 4 signaling pathway positive regulation of chemokine production negative regulation of tumor necrosis factor production lipopolysaccharide mediated signaling pathway opsonization defense response to Gram negative bacterium positive regulation of tumor necrosis factor production response to lipopolysaccharide macrophage activation involved in immune response positive regulation of respiratory burst involved in inflammatory response acute phase response innate immune response defense response to Gram positive bacterium cellular response to lipopolysaccharide positive regulation of macrophage activation toll like receptor signaling pathway macromolecule localization positive regulation of cytolysis transport cytokine mediated signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez392916803EnsemblENSG00000129988ENSMUSG00000016024UniProtP18428Q61805RefSeq mRNA NM 004139NM 008489RefSeq protein NP 004130NP 032515Location UCSC Chr 20 38 35 38 38 MbChr 2 158 15 158 17 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseLBP is a soluble acute phase protein that binds to bacterial lipopolysaccharide or LPS to elicit immune responses by presenting the LPS to important cell surface pattern recognition receptors called CD14 and TLR4 7 The protein encoded by this gene is involved in the acute phase immunologic response to gram negative bacterial infections Gram negative bacteria contain a glycolipid lipopolysaccharide LPS on their outer cell wall Together with bactericidal permeability increasing protein BPI the encoded protein binds LPS and interacts with the CD14 receptor probably playing a role in regulating LPS dependent monocyte responses Studies in mice suggest that the encoded protein is necessary for the rapid acute phase response to LPS but not for the clearance of LPS from circulation This protein is part of a family of structurally and functionally related proteins including BPI plasma cholesteryl ester transfer protein CETP and phospholipid transfer protein PLTP Finally this gene is found on chromosome 20 immediately downstream of the BPI gene 6 Contents 1 Clinical significance 2 Interactions 3 References 4 Further reading 5 External linksClinical significance EditLPS exposure induces LBP production 8 LBP is synthesized by the liver adipose tissue and intestinal cells 8 Dietary glucose and saturated fats acutely increase plasma LBP 8 The proinflammatory activity of plasma LPS is increased by LBP which is higher in obesity 9 Plasma LBP is used as a better biomarker of plasma LPS than LPS itself due to the short half life of LPS 8 Interactions EditLipopolysaccharide binding protein has been shown to interact with CD14 TLR2 TLR4 and the co receptor MD 2 10 11 12 References Edit a b c GRCh38 Ensembl release 89 ENSG00000129988 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000016024 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Gray PW Corcorran AE Eddy RL Jr Byers MG Shows TB March 1993 The genes for the lipopolysaccharide binding protein LBP and the bactericidal permeability increasing protein BPI are encoded in the same region of human chromosome 20 Genomics 15 1 188 90 doi 10 1006 geno 1993 1030 PMID 8432532 a b Entrez Gene LBP lipopolysaccharide binding protein Muta T Takeshige K 2001 Essential roles of CD14 and lipopolysaccharide binding protein for activation of toll like receptor TLR 2 as well as TLR4 Reconstitution of TLR2 and TLR4 activation by distinguishable ligands in LPS preparations Eur J Biochem 268 16 4580 9 doi 10 1046 j 1432 1327 2001 02385 x PMID 11502220 a b c d Djuric Z 2017 Obesity associated cancer risk the role of intestinal microbiota in the etiology of the host proinflammatory state Translational Research 179 155 167 doi 10 1016 j trsl 2016 07 017 PMC 5164980 PMID 27522986 Tuomi K Logomarsino JV 2016 Bacterial Lipopolysaccharide Lipopolysaccharide Binding Protein and Other Inflammatory Markers in Obesity and After Bariatric Surgery Metabolic Syndrome and Related Disorders 14 6 279 288 doi 10 1089 met 2015 0170 PMID 27228236 Thomas Celestine J Kapoor Mili Sharma Shilpi Bausinger Huguette Zyilan Umit Lipsker Dan Hanau Daniel Surolia Avadhesha November 2002 Evidence of a trimolecular complex involving LPS LPS binding protein and soluble CD14 as an effector of LPS response FEBS Lett 531 2 184 8 doi 10 1016 S0014 5793 02 03499 3 ISSN 0014 5793 PMID 12417309 S2CID 25135963 Yu B Wright S D 1995 LPS dependent interaction of Mac 2 binding protein with immobilized CD14 J Inflamm 45 2 115 25 ISSN 1078 7852 PMID 7583357 Erridge C Pridmore A Eley A Stewart J Poxton IR 2004 Lipopolysaccharides of Bacteroides fragilis Chlamydia trachomatis and Pseudomonas aeruginosa signal via toll like receptor 2 Journal of Medical Microbiology 53 Pt 8 735 40 doi 10 1099 jmm 0 45598 0 PMID 15272059 Further reading EditSchumann RR Leong SR Flaggs GW et al 1990 Structure and function of lipopolysaccharide binding protein Science 249 4975 1429 31 Bibcode 1990Sci 249 1429S doi 10 1126 science 2402637 PMID 2402637 Wilde CG Seilhamer JJ McGrogan M et al 1994 Bactericidal permeability increasing protein and lipopolysaccharide LPS binding protein LPS binding properties and effects on LPS mediated cell activation J Biol Chem 269 26 17411 6 doi 10 1016 S0021 9258 17 32454 7 PMID 7517398 Park CT Wright SD 1996 Plasma lipopolysaccharide binding protein is found associated with a particle containing apolipoprotein A I phospholipid and factor H related proteins J Biol Chem 271 30 18054 60 doi 10 1074 jbc 271 30 18054 PMID 8663389 Nanbo A Nishimura H Nagasawa S 1997 Lipopolysaccharide binding protein from normal human plasma purified with high efficiency Protein Expr Purif 10 1 55 60 doi 10 1006 prep 1996 0712 PMID 9179291 Hubacek JA Buchler C Aslanidis C Schmitz G 1997 The genomic organization of the genes for human lipopolysaccharide binding protein LBP and bactericidal permeability increasing protein BPI is highly conserved Biochem Biophys Res Commun 236 2 427 30 doi 10 1006 bbrc 1997 6970 PMID 9240454 Jack RS Fan X Bernheiden M et al 1997 Lipopolysaccharide binding protein is required to combat a murine gram negative bacterial infection Nature 389 6652 742 5 Bibcode 1997Natur 389 742J doi 10 1038 39622 PMID 9338787 S2CID 205027151 Kirschning CJ Au Young J Lamping N et al 1998 Similar organization of the lipopolysaccharide binding protein LBP and phospholipid transfer protein PLTP genes suggests a common gene family of lipid binding proteins Genomics 46 3 416 25 doi 10 1006 geno 1997 5030 PMID 9441745 Beamer LJ Carroll SF Eisenberg D 1998 The BPI LBP family of proteins a structural analysis of conserved regions Protein Sci 7 4 906 14 doi 10 1002 pro 5560070408 PMC 2143972 PMID 9568897 Sato M Saeki Y Tanaka K Kaneda Y 1999 Ribosome associated protein LBP p40 binds to S21 protein of 40S ribosome analysis using a yeast two hybrid system Biochem Biophys Res Commun 256 2 385 90 doi 10 1006 bbrc 1999 0343 PMID 10079194 Vreugdenhil AC Dentener MA Snoek AM et al 1999 Lipopolysaccharide binding protein and serum amyloid A secretion by human intestinal epithelial cells during the acute phase response Journal of Immunology 163 5 2792 8 PMID 10453023 Vesy CJ Kitchens RL Wolfbauer G et al 2000 Lipopolysaccharide Binding Protein and Phospholipid Transfer Protein Release Lipopolysaccharides from Gram Negative Bacterial Membranes Infect Immun 68 5 2410 7 doi 10 1128 IAI 68 5 2410 2417 2000 PMC 97439 PMID 10768924 Labeta MO Vidal K Nores JE et al 2000 Innate Recognition of Bacteria in Human Milk Is Mediated by a Milk Derived Highly Expressed Pattern Recognition Receptor Soluble Cd14 J Exp Med 191 10 1807 12 doi 10 1084 jem 191 10 1807 PMC 2193148 PMID 10811873 Dentener MA Vreugdenhil AC Hoet PH et al 2000 Production of the acute phase protein lipopolysaccharide binding protein by respiratory type II epithelial cells implications for local defense to bacterial endotoxins Am J Respir Cell Mol Biol 23 2 146 53 doi 10 1165 ajrcmb 23 2 3855 PMID 10919979 Nagaoka I Hirota S Niyonsaba F et al 2001 Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF alpha by blocking the binding of LPS to CD14 cells Journal of Immunology 167 6 3329 38 doi 10 4049 jimmunol 167 6 3329 PMID 11544322 Gutsmann T Muller M Carroll SF et al 2001 Dual Role of Lipopolysaccharide LPS Binding Protein in Neutralization of LPS and Enhancement of LPS Induced Activation of Mononuclear Cells Infect Immun 69 11 6942 50 doi 10 1128 IAI 69 11 6942 6950 2001 PMC 100074 PMID 11598069 Iovine N Eastvold J Elsbach P et al 2002 The carboxyl terminal domain of closely related endotoxin binding proteins determines the target of protein lipopolysaccharide complexes J Biol Chem 277 10 7970 8 doi 10 1074 jbc M109622200 PMID 11773072 Deloukas P Matthews LH Ashurst J et al 2002 The DNA sequence and comparative analysis of human chromosome 20 Nature 414 6866 865 71 Bibcode 2001Natur 414 865D doi 10 1038 414865a PMID 11780052 Kaden J Zwerenz P Lambrecht HG Dostatni R 2002 Lipopolysaccharide binding protein as a new and reliable infection marker after kidney transplantation Transpl Int 15 4 163 72 doi 10 1007 s00147 002 0392 2 PMID 11976738 S2CID 23593715 Reyes O Vallespi MG Garay HE et al 2002 Identification of single amino acid residues essential for the binding of lipopolysaccharide LPS to LPS binding protein LBP residues 86 99 by using an Ala scanning library J Pept Sci 8 4 144 50 doi 10 1002 psc 375 PMID 11991204 S2CID 28803013 External links Editlipopolysaccharide binding protein at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain Retrieved from https en wikipedia org w index php title Lipopolysaccharide binding protein amp oldid 1149211361, wikipedia, wiki, book, books, library,
